Neuronal growth cones:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge [u.a.]
Cambridge Univ. Press
2000
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Developmental and cell biology series
37 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 260 S. Ill., graph. Darst. |
| ISBN: | 0521444918 |
Internformat
MARC
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| 100 | 1 | |a Gordon-Weeks, Phillip R. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Neuronal growth cones |c Phillip R. Gordon-Weeks |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Cambridge [u.a.] |b Cambridge Univ. Press |c 2000 | |
| 300 | |a XII, 260 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Developmental and cell biology series |v 37 | |
| 650 | 7 | |a Axon |2 swd | |
| 650 | 7 | |a Développement neurologique |2 ram | |
| 650 | 7 | |a Nervenzelle |2 swd | |
| 650 | 7 | |a Neurones - Croissance |2 ram | |
| 650 | 7 | |a Neurones - Développement |2 ram | |
| 650 | 7 | |a Psychologie du développement |2 ram | |
| 650 | 7 | |a Wachstum |2 swd | |
| 650 | 7 | |a Wachstumskonus |2 swd | |
| 650 | 7 | |a Zellskelett |2 swd | |
| 650 | 4 | |a Developmental neurophysiology | |
| 650 | 4 | |a Growth Cones |x physiology | |
| 650 | 4 | |a Neurons |x Growth | |
| 830 | 0 | |a Developmental and cell biology series |v 37 |w (DE-604)BV002791391 |9 37 | |
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Datensatz im Suchindex
| _version_ | 1804128937796698112 |
|---|---|
| adam_text | Contents
Preface xi
Abbreviations xii
1 Introduction 1
What are growth cones? 1
Growth cone morphology and behaviour 3
Appearance and behaviour under the light microscope 4
Methodological advances 12
Factors influencing growth cone shape 15
Decision regions 17
Fasciculation 19
Developmental age and type of substratum 19
Growth cone collapse/contact inhibition 20
Leader (pioneer) and follower growth cones 21
Appearance under the electron microscope: organelles of the
growth cone 21
Membrane bounded organelles 22
Cytoskeletal elements 26
Axonal versus dendritic growth cones 27
2 Motility and Neurite Extension: The Growth Cone Cytoskeleton 30
Introduction 30
vii
viii CONTENTS
Organisation of the growth cone cytoskeleton 31
Microtubules 31
Microtubule organisation in neurites and growth cones 32
Neurite extension and microtubule dynamics 33
Location of microtubule assembly 39
Direct visualisation of microtubule dynamics 40
Post translational modifications of tubulin 42
Assembly competent tubulin in growth cones 44
A model for the organisation of microtubules in neurites
and growth cones 45
A role for microtubules in growth cone pathfinding 46
Microtubule associated proteins 49
Microfilaments 52
Microfilament organisation in neurites and growth cones 53
Growth cone motility and actin filament dynamics 59
Do growth cones push or pull ? 64
Differential adhesivity and growth cone pathfinding 65
Actin binding proteins 68
Neurofilaments 70
Neurite extension and surface membrane growth 71
Membrane recycling in growth cones 74
3 Pathfinding 75
Introduction 75
Decision regions and pathfinding 76
Suitable animals and appropriate techniques 78
Pathfinding is a property of growth cones 79
Guidance cues 80
Pioneers 81
How can guidance cues be identified? 86
Channels and tunnels 87
Electric fields 88
Extracellular matrix molecules 90
Laminins 93
Laminin receptors: integrins 96
Tenascins 100
Proteoglycans 102
Do extracellular matrix molecules have permissive or instructive
roles in pathfinding? 102
Cell surface molecules 103
Neural cell adhesion molecule and the immunoglobulin
superfamily 104
The labelled pathways hypothesis 109
Molecules mediating growth cone cell surface interactions
in invertebrates 110 j
i
k. 1
(JONlfclNlS IX
Fasciclins 111
Cadherins 112
Growth cone collapse and retraction 114
Collapsing factors 116
Collapsins/semaphorins 116
Collapsin/semaphorin receptors 119
Eph receptors and their ligands (ephrins) 120
Chemotropic (diffusible) factors 123
Nerve growth factor 124
Can growth cones detect chemical gradients and with what
steepness? 126
Demonstration of chemotropic factors in vitro 126
Molecular characterisation of chemotropic factors 130
Netrins and their receptors 130
Summary 136
4 Intracellular Signalling in Growth Cones 137
Introduction 137
Calcium 139
Calcium is implicated in neurite growth 139
The calcium set point hypothesis 141
Calcium regulation in growth cones 141
Do changes in growth cone calcium regulate pathfinding events? 143
Physiological agents affecting growth cone calcium levels 144
Down stream targets for calcium in growth cones 149
Growth cone calcium concentration and the cytoskeleton 150
Growth associated protein 43 151
Widespread expresssion of GAP 43 in the developing
nervous system 151
GAP 43 is a calmodulin and actin binding phosphoprotein 152
GAP 43 regulates phosphatidylinositol 4 phosphate kinase and
G protein activity 153
GAP 43 function 154
Non receptor tyrosine kinases and phosphatases 155
Heterotrimeric G proteins, small GTP binding proteins
and GTPases 157
Rho subgroup of the Ras superfamily 158
5 Synaptogenesis 160
Introduction 160
Morphological differentiation of synapses 161
Acquisition of synaptic properties by growth cones 163
Neurotransmitter release from growth cones 163
Neurotransmitter storage in growth cones 165
X CONTENTS
Neurotransmitter receptors 165
Molecular mechanisms underlying synaptogenesis at the
neuromuscular junction 166
Motoneuron growth cones release factors that
induce synaptogenesis 170
Agrin induces neurotransmitter receptor aggregation at the
synapse 171
MuSK and rapsyn 172
References 174
Index 255
i
|
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| id | DE-604.BV014074910 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:57:11Z |
| institution | BVB |
| isbn | 0521444918 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009639884 |
| oclc_num | 41464897 |
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| owner_facet | DE-20 |
| physical | XII, 260 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Cambridge Univ. Press |
| record_format | marc |
| series | Developmental and cell biology series |
| series2 | Developmental and cell biology series |
| spelling | Gordon-Weeks, Phillip R. Verfasser aut Neuronal growth cones Phillip R. Gordon-Weeks 1. publ. Cambridge [u.a.] Cambridge Univ. Press 2000 XII, 260 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Developmental and cell biology series 37 Axon swd Développement neurologique ram Nervenzelle swd Neurones - Croissance ram Neurones - Développement ram Psychologie du développement ram Wachstum swd Wachstumskonus swd Zellskelett swd Developmental neurophysiology Growth Cones physiology Neurons Growth Developmental and cell biology series 37 (DE-604)BV002791391 37 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009639884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gordon-Weeks, Phillip R. Neuronal growth cones Developmental and cell biology series Axon swd Développement neurologique ram Nervenzelle swd Neurones - Croissance ram Neurones - Développement ram Psychologie du développement ram Wachstum swd Wachstumskonus swd Zellskelett swd Developmental neurophysiology Growth Cones physiology Neurons Growth |
| title | Neuronal growth cones |
| title_auth | Neuronal growth cones |
| title_exact_search | Neuronal growth cones |
| title_full | Neuronal growth cones Phillip R. Gordon-Weeks |
| title_fullStr | Neuronal growth cones Phillip R. Gordon-Weeks |
| title_full_unstemmed | Neuronal growth cones Phillip R. Gordon-Weeks |
| title_short | Neuronal growth cones |
| title_sort | neuronal growth cones |
| topic | Axon swd Développement neurologique ram Nervenzelle swd Neurones - Croissance ram Neurones - Développement ram Psychologie du développement ram Wachstum swd Wachstumskonus swd Zellskelett swd Developmental neurophysiology Growth Cones physiology Neurons Growth |
| topic_facet | Axon Développement neurologique Nervenzelle Neurones - Croissance Neurones - Développement Psychologie du développement Wachstum Wachstumskonus Zellskelett Developmental neurophysiology Growth Cones physiology Neurons Growth |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009639884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002791391 |
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