Functional implications of macromolecular recognition: assembly of adhesive pili and enzyme substrate interactions
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Uppsala
Swedish Univ. of Agricultural Sciences
2001
|
| Schriftenreihe: | Acta Universitatis Agriculturae Sueciae / Swedish Univ. of Agricultural Sciences : Agraria
280 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Uppsala, Swedish Univ. of Agricultural Sciences, Diss., 2001 |
| Beschreibung: | Getr. Zählung Ill., graph. Darst. |
| ISBN: | 915765820X |
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| 650 | 4 | |a Bacteria |x Adhesion | |
| 650 | 4 | |a Molecular chaperones |x Structure | |
| 650 | 4 | |a Molecular recognition | |
| 650 | 4 | |a Pili (Microbiology) | |
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Datensatz im Suchindex
| _version_ | 1804128935257047040 |
|---|---|
| adam_text | Titel: Functional implications of macromolecular recognition
Autor: Choudhury, Devapriya
Jahr: 2001
Contents
INTRODUCTION...................................................................8
GENERAL ASPECTS OF METHODOLOGY................................................................9
X-ray crystallography...................................................................................9
Simulated docking of small molecules into macromolecular binding sites.............11
PILI AND THEIR ROLE IN PATHOGENESIS OF ESCHERICHIA COLI
INFECTIONS (PAPERS I - III)................................................ 12
Background...............................................................................................12
Pilus ultrastructure.....................................................................................14
Pilus biogenesis: The Chaperone/Usherpathway..............................................15
The structure ofPapD: The prototypical periplasmic chaperone...........................15
The structure ofFimC: the chaperone responsible for type-1 pilus biosynthesis.....17
The structure of SfaE: the chaperone responsible for the biogenesis of S-
FIMBRIAE (PAPERl)........................................................................................18
Overall structure of SfaE..............................................................................18
Residues with possible functional importance..................................................20
Dimerisation in SfaE..................................................................................21
The structure of FimC-FimH: a periplasmic chaperone in action (paperII).....23
The structure ofFimH: the type-1 pilus adhesin...............................................24
FimC and its interactions with FimH in the complex........................................25
The structure of PapD-PapK: reiteration of a general theme?...............................26
The lectin domain and carbohydrate-protein interactions in the FimH adhesin.........27
Chaperone-subunit complexes suggest a model for the mature pilus.....................28
Implications for folding...............................................................................30
Carbohydrate binding by the FimH lectin: how many binding sites? (paperin)
..................................................................................................................30
An algorithm for the detection of surface cavities in macromolecules....................32
The docking protocol..................................................................................33
Choice of ligands for docking.......................................................................34
Cavities in the lectin domain........................................................................35
Testing the cavities for carbohydrate binding....................................................36
MOLECULAR RECOGNITION IN PROMISCUOUS ENZYMES: CASE
STUDIES OF NAPHTHALENE DIOXYGENASE AND
DEOXYRIBONUCLEOSIDE KINASES (PAPERS IV AND V)...........40
Naphthalene dioxygenase.............................................................................40
Substrate binding by NDO...........................................................................45
Deoxyribonucleoside Kinases........................................................................46
Stereoisomeric selectivity of human deoxyribonucleoside kinases........................48
GENERAL CONCLUSIONS AND FUTURE OUTLOOK..................52
REFERENCES.................................................................... 54
ACKNOWLEDGEMENTS.......................................................64
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| indexdate | 2024-07-09T18:57:09Z |
| institution | BVB |
| isbn | 915765820X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009638281 |
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| physical | Getr. Zählung Ill., graph. Darst. |
| publishDate | 2001 |
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| publisher | Swedish Univ. of Agricultural Sciences |
| record_format | marc |
| series2 | Acta Universitatis Agriculturae Sueciae / Swedish Univ. of Agricultural Sciences : Agraria |
| spelling | Choudhury, Devapriya Verfasser aut Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions Devapriya Choudhury Uppsala Swedish Univ. of Agricultural Sciences 2001 Getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Acta Universitatis Agriculturae Sueciae / Swedish Univ. of Agricultural Sciences : Agraria 280 Zugl.: Uppsala, Swedish Univ. of Agricultural Sciences, Diss., 2001 Bacteria Adhesion Molecular chaperones Structure Molecular recognition Pili (Microbiology) (DE-588)4113937-9 Hochschulschrift gnd-content Swedish Univ. of Agricultural Sciences Acta Universitatis Agriculturae Sueciae Agraria ; 280 (DE-604)BV010948960 280 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009638281&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Choudhury, Devapriya Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions Bacteria Adhesion Molecular chaperones Structure Molecular recognition Pili (Microbiology) |
| subject_GND | (DE-588)4113937-9 |
| title | Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions |
| title_auth | Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions |
| title_exact_search | Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions |
| title_full | Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions Devapriya Choudhury |
| title_fullStr | Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions Devapriya Choudhury |
| title_full_unstemmed | Functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions Devapriya Choudhury |
| title_short | Functional implications of macromolecular recognition |
| title_sort | functional implications of macromolecular recognition assembly of adhesive pili and enzyme substrate interactions |
| title_sub | assembly of adhesive pili and enzyme substrate interactions |
| topic | Bacteria Adhesion Molecular chaperones Structure Molecular recognition Pili (Microbiology) |
| topic_facet | Bacteria Adhesion Molecular chaperones Structure Molecular recognition Pili (Microbiology) Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009638281&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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