Recent advances in psoriasis: the role of the immune system
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Imperial College Press
2000
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 172 S. Ill. |
| ISBN: | 1860941206 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804128934701301760 |
|---|---|
| adam_text | Contents
Preface v
Chapter 1 Aetiology, Clinical and Histological Features
of Psoriasis 1
1.1 Clinical Features 1
1.2 Genetics 3
1.2.1 Epidemiology 3
1.2.2 Mode of Inheritance 3
1.2.3 Genomic Imprinting 4
1.2.4 HLA Associations 4
1.2.5 Gene Linkage 6
1.2.6 Candidate Genes 8
1.3 Environmental Factors 9
1.4 Histological Features 10
Chapter 2 Skin Immune System in Psoriasis 14
2.1 Skin Immune System (SIS) 14
2.2 T Cell Subpopulations: Normal Skin 16
2.3 T Cell Subpopulations: Psoriatic Skin 17
2.4 Antigen Presenting Cells: Normal Skin 21
2.4.1 Epidermal Dendritic Cells 21
2.4.2 Dermal Dendritic Cells (DDC) 23
2.4.3 Indeterminate Cells 23
2.4.4 Macrophages 24
vii
viii Recent Advances in Psoriasis: The Role of the Immune System
2.5 Antigen Presenting Cells: Psoriatic Skin 24
2.5.1 Epidermal Dendritic Cells 24
2.5.2 Dermal Dendritic Cells (DDC) 28
2.6 Endothelial Cells 29
2.7 Neutrophils 30
2.8 Mast Cells 31
2.9 Keratinocytes 31
Chapter 3 Immune Cell Function in Psoriasis 34
3.1 T Lymphocytes: Peripheral Blood 34
3.2 T Lymphocytes: Skin 36
3.2.1 T Cell Homing 36
3.2.2 T Cell Proliferation 40
3.2.3 Cytokine Production 45
3.3 Antigen Presenting Cells 47
3.3.1 Epidermal Dendritic Cells 47
3.3.2 Dermal Dendritic Cells (DDC) 47
Chapter 4 Psoriasis is a T Cell Mediated Disease 50
4.1 Anti Psoriatic Treatments 50
4.2 Anti CD4 Monoclonal Antibodies 53
4.3 Lymphocyte Selective Toxin (DAB389IL 2) 54
4.4 SCID Mouse Models 54
4.5 Bone Marrow Transplantation 56
4.6 T Cell Supernatants Promote Keratinocyte
Proliferation 57
4.7 Low CD4+/HIV Infection 58
Chapter 5 p Haemolytic Streptococci and Psoriasis 61
5.1 Group A Streptococci as a Trigger for
Guttate Psoriasis 61
5.2 Group A Streptococci and CP Psoriasis 63
5.3 Induction of Psoriatic Lesions by
Streptococci 63
Contents ix
5.4 Streptococcal Antigens 64
5.4.1 Extracellular Products 64
5.4.1.1 Streptococcal pyrogenic
exotoxins (SPEs) 64
5.4.1.2 Streptococcal cytolytic
toxins (haemolysins) 67
5.4.1.3 Streptococcal enzymes 68
5.4.2 Cellular Proteins 69
5.4.2.1 M and M like proteins 70
5.4.2.2 Other cell wall proteins 71
5.4.2.3 Membrane proteins 72
5.5 Immune Response to Extracellular
Streptococcal Proteins and Superantigens 73
5.5.1 Humoral Response 73
5.5.2 In vivo/In vitro Response to SK/SD 74
5.5.3 Superantigens 74
5.6 Immune Response to Streptococcal
Cellular Proteins 76
5.6.1 Streptococcal Cell Walls and
Membranes 76
5.6.2 Streptococcal M Protein 81
5.6.3 Streptococcal Membrane Proteins 85
5.6.4 CLA Induction by Group A
Streptococcal Antigens 86
Chapter 6 Immune Function of Psoriatic Keratinocytes 90
6.1 Cytokine Production 90
6.1.1 Interleukin 1 (IL 1) 92
6.1.2 Interleukin 6 (IL 6) 94
6.1.3 Interleukin 7 (IL 7) 95
6.1.4 Interleukin 8 (IL 8) 95
6.1.5 Interleukin 10 (IL 10) 97
6.1.6 Interleukin 12 (IL 12) 97
6.1.7 Interleukin 15 (IL 15) and
Interleukin 18 (IL 18) 98
6.1.8 Tumor Necrosis Factor a (TNF a) 99
i
x Recent Advances in Psoriasis: The Role of the Immune System
6.1.9 Growth Factors 100
6.1.9.1 Transforming growth
factor oc (TGF a)/Epidermal
growth factor (EGF) 100
6.1.9.2 Amphiregulin (AR)/
Heparin binding EGF like
growth factor (HB EGF) 101
6.1.9.3 Keratinocyte growth
factor (KGF) 101
6.1.9.4 Insulin like growth
factor I (IGF I) receptor 102
6.1.9.5 Transforming growth
factor p (TGF p) 102
6.1.10 Monocyte Chemotactic Protein 1
(MCP l)/Monocyte Chemoattractant
and Activating Factor (MCAF) 103
6.2 Response to Cytokines 103
6.2.1 Increased Proliferation 103
6.2.2 Decreased Proliferation 105
6.2.3 Surface Molecule Expression 107
6.2.4 Cytokine Production 108
6.3 Antigen/Superantigen Presentation 109
6.4 Integrins 110
6.5 Apoptosis 113
Chapter 7 Current and Future Immunological
Approaches to Treatment of Psoriasis 119
7.1 Current Treatments 119
7.1.1 PUVA and UVB 120
7.1.2 CyA and FK506 121
7.1.3 Steroid Hormones 124
7.1.3.1 Vitamin D analogues 124
7.1.3.2 Vitamin A analogues 127
7.1.3.3 Corticosteroids 128
7.1.4 Methotrexate 129
7.1.5 Dithranol 129
Contents xi
7.2 Future Treatments 130
7.2.1 Cell Surface Molecule Directed 130
7.2.1.1 CD4 130
7.2.1.2 Costimulatory molecules 132
7.2.1.3 TCR 134
7.2.1.4 MHC Class II 135
7.2.1.5 Homing receptors 137
7.2.2 Cytokine Directed 137
7.2.2.1 IFN y 137
7.2.2.2 TNF a 138
7.2.2.3 IL 10 138
7.2.2.4 IL 4 139
7.2.2.5 Toxin conjugated cytokines 139
7.2.2.6 Conversion of THi to
TH2 cytokine profile 140
7.2.3 Induction of Regulatory T Cells 141
7.2.3.1 T cell vaccination 141
7.2.3.2 TCR peptides 142
7.2.3.3 DNA encoding TCR Vp 143
7.2.3.4 Oral tolerance 143
7.2.4 Apoptosis Based Therapy 144
7.2.5 Gene Therapy 144
7.2.6 Purine Nucleoside Phosphorylase
Inhibitors /Ascomycins 145
Chapter 8 Model for the Immunopathogenesis of Psoriasis 150
8.1 Outline of Proposed Model 150
8.2 Antigen Trigger: Group A Streptococci (GAS) 152
8.2.1 Streptococcal Superantigens
Induce Psoriasis 153
8.2.2 Antigen Specific Response 154
8.2.3 Perpetuation of the Psoriatic Process 155
8.2.3.1 Pathway 1 156
8.2.3.2 Pathway 2 157
8.2.3.3 Pathway 3 159
i
xii Recent Advances in Psoriasis: The Role of the Immune System
8.3 CD4+ T Lymphocyte/KC Interaction 160
8.3.1 Surface Molecules 160
8.3.2 Cytokines 161
8.4 Role of CD8+ T Lymphocytes 161
8.5 Site of Altered Gene Expression 163
8.6 Other Antigenic Triggers 163
Index 167
|
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| isbn | 1860941206 |
| language | English |
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| spelling | Baker, Barbara S. Verfasser aut Recent advances in psoriasis the role of the immune system Barbara S. Baker London Imperial College Press 2000 XII, 172 S. Ill. txt rdacontent n rdamedia nc rdacarrier Immune system Psoriasis Autoimmunität (DE-588)4319435-7 gnd rswk-swf Schuppenflechte (DE-588)4077221-4 gnd rswk-swf Schuppenflechte (DE-588)4077221-4 s Autoimmunität (DE-588)4319435-7 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009637905&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Baker, Barbara S. Recent advances in psoriasis the role of the immune system Immune system Psoriasis Autoimmunität (DE-588)4319435-7 gnd Schuppenflechte (DE-588)4077221-4 gnd |
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| title | Recent advances in psoriasis the role of the immune system |
| title_auth | Recent advances in psoriasis the role of the immune system |
| title_exact_search | Recent advances in psoriasis the role of the immune system |
| title_full | Recent advances in psoriasis the role of the immune system Barbara S. Baker |
| title_fullStr | Recent advances in psoriasis the role of the immune system Barbara S. Baker |
| title_full_unstemmed | Recent advances in psoriasis the role of the immune system Barbara S. Baker |
| title_short | Recent advances in psoriasis |
| title_sort | recent advances in psoriasis the role of the immune system |
| title_sub | the role of the immune system |
| topic | Immune system Psoriasis Autoimmunität (DE-588)4319435-7 gnd Schuppenflechte (DE-588)4077221-4 gnd |
| topic_facet | Immune system Psoriasis Autoimmunität Schuppenflechte |
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