Verfügbarkeit: Small stress proteins

Small stress proteins:

Gespeichert in:

Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	Berlin [u.a.] Springer 2002
Schriftenreihe:	Progress in molecular and subcellular biology 28
Schlagworte:	Hitzeschock-Proteine Aufsatzsammlung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XV, 270 S. Ill., graph. Darst.
ISBN:	3540425209

Internformat

MARC


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245	1	0	\|a Small stress proteins \|c A.-P. Arrigo ... (eds.)
264		1	\|a Berlin [u.a.] \|b Springer \|c 2002
300			\|a XV, 270 S. \|b Ill., graph. Darst.
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490	1		\|a Progress in molecular and subcellular biology \|v 28
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Datensatz im Suchindex

_version_	1804128909715832832
adam_text	CONTENTS EVOLUTION AND DIVERSITY OF PROKARYOTIC SMALL HEAT SHOCK PROTEINS G. KAPP, J.A.M. LEUNISSEN, AND W.W. DE JONG 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 SHSPS IN PROKARYOTES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3 ARE SHSPS DISPENSABLE IN SOME PATHOGENIC BACTERIA? . . . . . . . . 3 4 PHYLOGENETIC ANALYSIS OF PROKARYOTIC SHSPS . . . . . . . . . . . . . . . . 7 5 LATERAL TRANSFER OR CONVERGENT EVOLUTION OF PROKARYOTIC SHSP GENES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 6 SECONDARY STRUCTURE PREDICTION OF THE A -CRYSTALLIN DOMAIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 7 ALIGNMENT AND SECONDARY STRUCTURE PREDICTION OF THE N-TERMINAL DOMAIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 8 SUMMARY AND CONCLUDING REMARKS . . . . . . . . . . . . . . . . . . . . . . 15 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 DISCOVERY OF TWO DISTINCT SMALL HEAT SHOCK PROTEIN (HSP) FAMILIES IN THE DESERT FISH POECILIOPSIS C.E. NORRIS AND L.E. HIGHTOWER 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2 VARIATION IN SMALL HSPS AMONG DESERT SPECIES OF POECILIOPSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 2.1 RESULTS OF SURVEY AMONG SPECIES . . . . . . . . . . . . . . . . . . . . . . . . 20 2.2 HSP ISOFORMS AS PRIMARY GENE PRODUCTS . . . . . . . . . . . . . . . . . . 21 2.3 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 3 VARIATION IN SMALL HSPS WITHIN POECILIOPSIS SPECIES . . . . . . . . . . 24 3.1 RESULTS OF WITHIN-SPECIES SURVEY . . . . . . . . . . . . . . . . . . . . . . . . . 24 3.2 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 4 DISCOVERY OF TWO CLASSES OF SMALL HSPS IN A SINGLE TAXON . . . . 26 4.1 DIFFERENTIAL SYNTHESIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4.2 PHOSPHORYLATION STATE OF THE SMALL HSPS . . . . . . . . . . . . . . . . . . 28 4.3 SEQUENCE ANALYSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 4.4 EVOLUTIONARY ANALYSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 4.5 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 CHAPERONE FUNCTION OF SHSPS M. HASLBECK AND J. BUCHNER 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 2 GENERAL ASPECT OF CHAPERONE FUNCTION . . . . . . . . . . . . . . . . . . . . 37 2.1 CHAPERONES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 2.2 ANALYSIS OF CHAPERONE FUNCTION . . . . . . . . . . . . . . . . . . . . . . . . . 39 3 THE CHAPERONE PROPERTIES OF SHSPS . . . . . . . . . . . . . . . . . . . . . . 41 3.1 IN VIVO FUNCTIONS OF SHSPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 3.2 SHSPS BIND NON-NATIVE PROTEIN . . . . . . . . . . . . . . . . . . . . . . . . . . 44 3.3 COMPLEX FORMATION AND SUBSTRATE RANGE . . . . . . . . . . . . . . . . . . 45 3.4 THE SUBSTRATE BINDING SITE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 3.5 MECHANISM OF SUBSTRATE BINDING . . . . . . . . . . . . . . . . . . . . . . . . . 47 3.6 REGULATION OF FUNCTIONAL PROPERTIES . . . . . . . . . . . . . . . . . . . . . . 48 3.7 SHSPS IN THE CONTEXT OF THE CELLULAR CHAPERONE MACHINERY . . . . 49 4 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 THE SMALL HEAT SHOCK PROTEINS OF THE NEMATODE CAENORHABDITIS ELEGANS : STRUCTURE, REGULATION AND BIOLOGY E. PETER M. CANDIDO 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 2 THE SMALL HEAT SHOCK PROTEIN FAMILY OF C. ELEGANS . . . . . . . . . . 61 3 THE 16-KDA STRESS PROTEINS (HSP16S) . . . . . . . . . . . . . . . . . . . . . 63 3.1 HSP16 GENE ORGANIZATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 3.2 HSP16 REGULATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 3.3 BIOCHEMICAL PROPERTIES OF HSP16S . . . . . . . . . . . . . . . . . . . . . . . . 68 3.4 USES OF HSP16 PROMOTERS IN C. ELEGANS RESEARCH . . . . . . . . . . . . 69 4 THE 12-KDA SMALL HEAT SHOCK PROTEINS (HSP12S) . . . . . . . . . . . . 70 5 SIP-1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 6 HSP17.5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 7 HSP25 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 8 HSP43 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 9 CONCLUSIONS AND PROSPECTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 DROSOPHILA SMALL HEAT SHOCK PROTEINS: CELL AND ORGANELLE-SPECIFIC CHAPERONES? S. MICHAUD, G. MORROW, J. MARCHAND, AND R.M. TANGUAY 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 2 MEMBERS OF THE SMALL HEAT SHOCK PROTEINS FAMILY . . . . . . . . . . 80 3 TRANSCRIPTIONAL REGULATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 3.1 ORGANISATION OF CHROMATIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 3.2 STRESS-INDUCED ACTIVATION BY THE HEAT SHOCK FACTOR . . . . . . . . . 82 X CONTENTS 3.3 DEVELOPMENTAL TRANSCRIPTION OF SHSP GENES . . . . . . . . . . . . . . . . 83 3.3.1 REGULATION CASCADE INDUCED BY ECDYSONE . . . . . . . . . . . . . . . . . . 83 3.3.2 TISSUE- AND CELL-SPECIFIC ENHANCERS . . . . . . . . . . . . . . . . . . . . . . 85 4 INTRACELLULAR LOCALISATIONANALYSIS OF TARGETING SIGNALS . . . . . . 85 5 BIOCHEMICAL PROPERTIES AND POST-TRANSLATIONAL MODIFICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 6 STRESS-INDUCED EXPRESSION OF SHSP . . . . . . . . . . . . . . . . . . . . . . . 87 6.1 CELL-SPECIFIC RESPONSE OF SHSP . . . . . . . . . . . . . . . . . . . . . . . . . . 88 6.2 FUNCTIONS OF SHSP UNDER STRESS CONDITIONS . . . . . . . . . . . . . . . . 88 7 DEVELOPMENTAL EXPRESSION OF SHSP . . . . . . . . . . . . . . . . . . . . . . . 90 7.1 STAGE, TISSUE, AND CELL SPECIFICITY . . . . . . . . . . . . . . . . . . . . . . . . 90 7.1.1 EMBRYOGENESIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 7.1.2 GERM LINE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92 7.1.3 AGEING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92 7.2 FUNCTIONS OF SHSP DURING NORMAL DEVELOPMENT . . . . . . . . . . . . 93 7.2.1 INTERACTION WITH THE SUMO-CONJUGATING ENZYME UBC9 . . . . . . . 94 7.2.2 MODULATION OF SPECIFIC BIOLOGICAL ACTIVITY . . . . . . . . . . . . . . . . . 94 8 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 THE DEVELOPMENTAL EXPRESSION OF SMALL HSP S.M. DAVIDSON, M.-T. LOONES, O. DUVERGER, AND M. MORANGE 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 2 SMALL HSP IN EXTRAEMBRYONIC DEVELOPMENT . . . . . . . . . . . . . . . . 104 3 SMALL HSP IN ECTODERMAL LINEAGES . . . . . . . . . . . . . . . . . . . . . . . 104 3.1 NEURAL CREST CELL DERIVATIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104 3.2 NEURECTODERM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 3.3 EXPRESSION IN THE SKIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106 4 SMALL HSP IN MESODERMAL LINEAGES . . . . . . . . . . . . . . . . . . . . . . 107 4.1 SMALL HSP IN MUSCLE DEVELOPMENT . . . . . . . . . . . . . . . . . . . . . . . 107 4.1.1 THE EXPRESSION PATTERN OF SHSP IN THE HEART . . . . . . . . . . . . . . . 107 4.1.2 THE EXPRESSION PATTERN OF SHSP IN SKELETAL AND SMOOTH MUSCLE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 4.1.3 THE SUBCELLULAR LOCALIZATION OF SHSP IN MUSCLE . . . . . . . . . . . . . 110 4.2 SMALL HSP IN OTHER MESODERMAL LINEAGES . . . . . . . . . . . . . . . . . 110 4.2.1 EXPRESSION IN CARTILAGE AND BONES . . . . . . . . . . . . . . . . . . . . . . . 110 4.2.2 EXPRESSION IN THE DERIVATIVES OF THE NOTOCHORD . . . . . . . . . . . . . 111 4.2.3 EXPRESSION IN THE KIDNEY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111 4.2.4 EXPRESSION IN THE ADRENAL GLANDS . . . . . . . . . . . . . . . . . . . . . . . . 111 4.2.5 EXPRESSION IN THE GONADS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112 4.2.6 EXPRESSION IN THE BLOOD CELLS . . . . . . . . . . . . . . . . . . . . . . . . . . . 112 5 SMALL HSP IN ENDODERMAL LINEAGES . . . . . . . . . . . . . . . . . . . . . . 112 5.1 EXPRESSION IN THE UPPER DIGESTIVE TRACT . . . . . . . . . . . . . . . . . . . 112 5.2 EXPRESSION IN THE STOMACH AND INTESTINE . . . . . . . . . . . . . . . . . . 112 CONTENTS XI 5.3 EXPRESSION IN THE BLADDER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 6 PHOSPHORYLATION OF SHSP DURING DEVELOPMENT . . . . . . . . . . . . . 113 7 DEVELOPMENTAL REGULATION OF SMALL HSP GENE EXPRESSION . . . . 114 7.1 REGULATION OF A A-CRYSTALLIN GENE TRANSCRIPTION . . . . . . . . . . . . 115 7.2 REGULATION OF A B-CRYSTALLIN GENE TRANSCRIPTION . . . . . . . . . . . . . 115 7.3 REGULATION OF HSP25 GENE TRANSCRIPTION . . . . . . . . . . . . . . . . . . 116 8 THE ROLE OF SMALL HSP IN DEVELOPMENT AND DIFFERENTIATION . . . 117 8.1 THE CHAPERONE FUNCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 8.2 THE DIRECT OR INDIRECT ACTIN-BINDING PROPERTY . . . . . . . . . . . . . . 118 8.3 SMALL HSP AND INTERMEDIATE FILAMENTS . . . . . . . . . . . . . . . . . . . . 119 8.4 SMALL HSP AND APOPTOSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 8.5 SMALL HSP AND THE RESPONSE TO STRESS . . . . . . . . . . . . . . . . . . . . 120 8.6 SMALL HSP AND PROTEIN DEGRADATION . . . . . . . . . . . . . . . . . . . . . . 120 9 SMALL HSP IN THE DEVELOPMENT OF NON-MAMMALS . . . . . . . . . . . 121 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122 EXPRESSION AND PHOSPHORYLATION OF MAMMALIAN SMALL HEAT SHOCK PROTEINS K. KATO, H. I TO, AND Y. I NAGUMA 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129 2 MODIFICATION OF THE EXPRESSION OF HSP27 AND A B-CRYSTALLIN . . . 130 2.1 STIMULATION OF STRESS-INDUCED EXPRESSION OF HSP27 AND A B-CRYSTALLIN BY MODULATORS OF THE ARACHIDONIC ACID CASCADE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 2.2 MODULATION OF EXPRESSION OF HSP27 AND A B-CRYSTALLIN BY PROTEIN KINASES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133 2.3 MODULATION OF EXPRESSION OF HSP27 AND A B-CRYSTALLIN BY THE CELLULAR REDOX STATE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135 3 PHOSPHORYLATION OF SMALL HSPS . . . . . . . . . . . . . . . . . . . . . . . . . . 137 3.1 PHOSPHORYLATION OF HSP27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 3.1.1 PHOSPHORYLATION AND DISSOCIATION OF HSP27 . . . . . . . . . . . . . . . . 138 3.2 PHOSPHORYLATION OF HSP20 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140 3.3 PHOSPHORYLATION OF A B-CRYSTALLIN . . . . . . . . . . . . . . . . . . . . . . . . 140 3.3.1 PHOSPHORYLATION OF A B-CRYSTALLIN IN RESPONSE TO STRESS AND ENZYMATIC ACTIVITIES RESPONSIBLE FOR PHOSPHORYLATION . . . . 141 3.3.2 PHOSPHORYLATION OF A B-CRYSTALLIN IN MITOTIC CELLS . . . . . . . . . . . 143 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144 SHSP-PHOSPHORYLATION: ENZYMES, SIGNALING PATHWAYS AND FUNCTIONAL IMPLICATIONS M. GAESTEL 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 2 IDENTIFICATION OF PHOSPHORYLATED SHSPS . . . . . . . . . . . . . . . . . . . . 151 3 THE MAJOR PATHWAY FOR SHSP PHOSPHORYLATION VIA P38 MAPK AND MAPKAP KINASE 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 154 XII CONTENTS 4 OTHER PATHWAYS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157 5 FUNCTIONAL ASPECTS OF SHSPS-PHOSPHORYLATION . . . . . . . . . . . . . . 158 5.1 PHOSPHORYLATION AND OLIGOMERISATION . . . . . . . . . . . . . . . . . . . . . 159 5.2 SPECULATIONS ABOUT THE FUNCTION OF SHSP PHOSPHORYLATION . . . . 160 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 162 SMALL STRESS PROTEINS: MODULATION OF INTRACELLULAR REDOX STATE AND PROTECTION AGAINST OXIDATIVE STRESS A.-P. ARRIGO, C. PAUL, C. DUCASSE, O. SAUVAGEOT, AND C. KRETZ-REMY 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171 2 CELL DEATH INDUCED IN RESPONSE TO OXIDATIVE STRESS . . . . . . . . . . 172 3 SHSP EXPRESSION PROTECTS AGAINST OXIDATIVE STRESS-INDUCED CELL DEATH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 3.1 EXPRESSION OF SHSP CAN MODULATE THE INTRACELLULAR REDOX STATE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 3.2 IN MURINE FIBROBLASTS HSP27 MODULATES GLUTATHIONE LEVEL AND INTRACELLULAR REDOX STATE THROUGH UPREGULATION OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE ACTIVITY . . . . . . . . . . . . . . . . . . . . . 176 3.3 HSP27 EXPRESSION PROTECTS AGAINST PROTEIN OXIDATION AND THE INACTIVATION OF KEY ANTI-OXIDANT ENZYMES . . . . . . . . . . 177 3.4 OLIGOMERIZATION AS A KEY PROPERTY REGULATING SHSP PROTECTIVE ACTIVITY AGAINST OXIDATIVE STRESS . . . . . . . . . . . . . . . . 177 4 SHSP EXPRESSION CAN ALSO ENHANCE OXIDATIVE STRESS INDUCED CELL DEATH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179 5 CONCLUSIONS AND FUTURE PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . 180 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 SMALL STRESS PROTEINS: NOVEL NEGATIVE MODULATORS OF APOPTOSIS INDUCED INDEPENDENTLY OF REACTIVE OXYGEN SPECIES P. ARRIGO, C. PAUL, C. DUCASSE, F. MANERO, C. KRETZ-REMY, S. VIROT, E. JAVOUHEY, N. MOUNIER, AND C. DIAZ-LATOUD 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185 2 SHSP EXPRESSION PROTECTS AGAINST APOPTOSIS INDUCED INDEPENDENTLY OF ROS FORMATION . . . . . . . . . . . . . . . . . . . . . . . . 186 2.1 HSP27 INTERFERES WITH THE APOPTOTIC MACHINERY DOWNSTREAM OF CYTOCHROME C RELEASE FROM MITOCHONDRIA . . . . . . . . . . . . . . . 187 2.2 HSP27 INTERFERES WITH THE RELEASE OF CYTOCHROME C FROM THE MITOCHONDRIA: A POSSIBLE CONSEQUENCE OF THE MODULATION OF A CYTOSKELETON TO THE MITOCHONDRIA APOPTOTIC PATHWAY . . . . . 190 2.3 HSP27 INTERFERES WITH APOPTOSIS INDUCED BY DEATH LIGANDS . . . 190 2.4 HSP27 EXPRESSION GENERATES PROTECTION AGAINST HEAT SHOCK-INDUCED APOPTOSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 2.5 ROLE OF HSP27 PHOSPHORYLATION AND OLIGOMERIZATION IN THE PROTECTION AGAINST APOPTOSIS . . . . . . . . . . . . . . . . . . . . . . 191 CONTENTS XIII 3 HSP27 AS ESSENTIAL ANTI-APOPTOTIC PROTEIN DURING EARLY CELL DIFFERENTIATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 192 4 HSP27 MODULATES APOPTOSIS IN VIVO AND ENHANCES THE TUMORIGENICITY OF TRANSFORMED CELLS . . . . . . . . . . . . . . . . . . 193 5 CONCLUSIONS AND FUTURE PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . 197 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200 HSP27 AS A PROGNOSTIC AND PREDICTIVE FACTOR IN CANCER D.R. CIOCCA AND L.M. VARGAS-ROIG 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 2 FEMALE GENITAL TRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 2.1 BREAST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 2.2 ENDOMETRIUM, OVARY/UTERINE CERVIX . . . . . . . . . . . . . . . . . . . . . 210 3 NERVOUS SYSTEM AND DIGESTIVE TRACT . . . . . . . . . . . . . . . . . . . . . . 211 4 HEMATOLOGICAL MALIGNANCIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . 212 5 GENITOURINARY TRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 212 6 TUMORS FROM OTHERS TISSUES . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 7 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 CYTOSKELETAL COMPETENCE REQUIRES PROTEIN CHAPERONES R. QUINLAN 1 SYMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 2 HUMAN DISEASES CAUSED BY SHSF MUTATIONS . . . . . . . . . . . . . . . 220 2.1 PROTEIN INCLUSIONS INVOLVING THE CYTOSKELETON AND SHSPS . . . . . 220 2.2 CARDIOMYOPATHIES AND EYE LENS CATARACT . . . . . . . . . . . . . . . . . . 220 3 SHSP INTERACTION WITH THE CYTOSKELETON . . . . . . . . . . . . . . . . . . . 222 3.1 ASSOCIATION WITH ACTIN AND REGULATION OF THE INTERACTION . . . . . 222 3.2 INTERACTION WITH CYTOSKELETON ASSOCIATED PROTEINS . . . . . . . . . . . 223 3.3 INTERMEDIATE FILAMENT AND MICROTUBULE ASSOCIATION . . . . . . . . . 224 4 FUNCTIONAL IMPLICATIONS OF THE INTERACTIONS . . . . . . . . . . . . . . . . 225 4.1 CELL STRESS IDENTIFIES AN IMPORTANT LINK BETWEEN CHAPERONES AND THE CYTOSKELETON . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 226 4.2 SHSP REGULATION OF THE CYTOSKELETON IN UNSTRESSED CELLS . . . . . 226 5 THE CHAPERONECYTOSKELETON COMPLEX. THE GUARDIAN OF THE CYTOPLASM? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 228 HSP27 IN THE NERVOUS SYSTEM: EXPRESSION IN PATHOPHYSIOLOGY AND IN THE AGING BRAIN A.M.R. KRUEGER-NAUG, J.-C.L. PLUMIER, D.A. HOPKINS, AND R.W. CURRIE 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235 2 CONSTITUTIVE EXPRESSION OF HSP27 IN THE NERVOUS SYSTEM . . . . . 235 XIV CONTENTS 2.1 CENTRAL NERVOUS SYSTEM: HSP27 IN THE BRAIN AND SPINAL CORD . . 235 2.2 PERIPHERAL NERVOUS SYSTEM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 236 2.2.1 DORSAL ROOT GANGLIA AND NODOSE GANGLION . . . . . . . . . . . . . . . . . 236 2.2.2 CARDIAC NEURONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238 3 EXPRESSION OF HSP27 IN PATHOPHYSIOLOGY . . . . . . . . . . . . . . . . . . 238 3.1 HEAT SHOCK AND FEVER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238 3.2 KAINIC ACID-INDUCED SEIZURES . . . . . . . . . . . . . . . . . . . . . . . . . . . 240 3.3 CORTICAL SPREADING DEPRESSION . . . . . . . . . . . . . . . . . . . . . . . . . . 240 3.4 ISCHEMIA/PRECONDITIONING AND CELL SURVIVAL . . . . . . . . . . . . . . . . 241 3.5 PERIPHERAL NERVE INJURY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 242 4 EXPRESSION OF HSP27 IN DISEASES OF THE AGING BRAIN . . . . . . . . . 243 4.1 NEURODEGENERATIVE DISEASES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 4.2 BRAIN TUMORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 246 5 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 PROTECTION OF NEURONAL AND CARDIAC CELLS BY HSP27 D.S. LATCHMAN 1 PROTECTIVE EFFECT OF HEAT SHOCK PROTEINS . . . . . . . . . . . . . . . . . . . 253 2 PROTECTIVE EFFECT OF HSP27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 3 PROTECTIVE EFFECT OF HSP27 IN NEURONAL AND CARDIAC CELLS . . . . . 257 3.1 NEURONAL CELLS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 3.2 CARDIAC CELLS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259 4 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 262 SUBJECT INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 267 CONTENTS XV
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spelling	Small stress proteins A.-P. Arrigo ... (eds.) Berlin [u.a.] Springer 2002 XV, 270 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in molecular and subcellular biology 28 Hitzeschock-Proteine (DE-588)4255487-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hitzeschock-Proteine (DE-588)4255487-1 s DE-604 Arrigo, André-Patrick Sonstige oth Progress in molecular and subcellular biology 28 (DE-604)BV002534931 28 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009621217&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Small stress proteins Progress in molecular and subcellular biology Hitzeschock-Proteine (DE-588)4255487-1 gnd
subject_GND	(DE-588)4255487-1 (DE-588)4143413-4
title	Small stress proteins
title_auth	Small stress proteins
title_exact_search	Small stress proteins
title_full	Small stress proteins A.-P. Arrigo ... (eds.)
title_fullStr	Small stress proteins A.-P. Arrigo ... (eds.)
title_full_unstemmed	Small stress proteins A.-P. Arrigo ... (eds.)
title_short	Small stress proteins
title_sort	small stress proteins
topic	Hitzeschock-Proteine (DE-588)4255487-1 gnd
topic_facet	Hitzeschock-Proteine Aufsatzsammlung
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009621217&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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