Molecular mechanism and therapeutics of amyotrophic lateral sclerosis: proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2001
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Excerpta medica
International congress series ; 1221 : Neurology |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 382 S. Ill. |
| ISBN: | 0444506136 |
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| 245 | 1 | 0 | |a Molecular mechanism and therapeutics of amyotrophic lateral sclerosis |b proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 |c ed.: Koji Abe |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2001 | |
| 300 | |a XII, 382 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Excerpta medica : International congress series |v 1221 : Neurology | |
| 650 | 7 | |a Amyotrofe laterale sclerose |2 gtt | |
| 650 | 4 | |a Amyotrophic Lateral Sclerosis |x etiology |v Congresses | |
| 650 | 4 | |a Amyotrophic Lateral Sclerosis |x pathology |v Congresses | |
| 650 | 4 | |a Amyotrophic Lateral Sclerosis |x therapy |v Congresses | |
| 650 | 4 | |a Amyotrophic lateral sclerosis |v Congresses | |
| 650 | 0 | 7 | |a Myatrophische Lateralsklerose |0 (DE-588)4132340-3 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Abe, Kōji |e Sonstige |4 oth | |
| 711 | 2 | |a International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis |d 2000 |c Okayama |j Sonstige |0 (DE-588)6033978-0 |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804128890476560384 |
|---|---|
| adam_text | ix
Contents
Preface v
Acknowledgements vii
1. Pathological Characteristics and an Epidemiology of ALS
Pyramidal tract pathology in amyotrophic lateral sclerosis—axon
staining reveals degeneration undisclosed on myelin staining
/ Nakano 3
Molecular pathology of axonal spheroids in ALS
T. Kato 13
Basophilic cytoplasmic inclusions in amyotrophic lateral sclerosis
K. Okamoto, Y. Fujita, H. Aizawa, H. Kusaka and B. Mihara 21
Expression of cathepsins in the motor neurons of amyotrophic lateral
sclerosis
H. Kikuchi, T. Yamada, T. Iwaki and J. I. Kira 27
Epidemiology of Motor Neuron Disease in Miyakonojo Basin, Kyushu,
Japan
R. Okubo, H. Arata, T. Murakami, K. Abe, T. Arisato and M. Nakagawa 35
Intracytoplasmic inclusions with overexpressed mutant SOD1 gene
R. Nakano, T. Koide and S. Tsuji 41
2. Selective Vulnerability of Spinal Motor Neurons
Induction of Cell cycle dependent proteins in spinal motor neurons
M. Sakurai, T. Hayashi, K. Abe and K. Tabayashi 51
Apoptosis of spinal motor neuron after ischemia
T. Hayashi, M. Sakurai, H. Warita, K. Sato, Y. Manabe, T. Murakami,
I. Nagano and K. Abe 59
Motor neuron apoptosis by glutamate
Y. Manabe, T. Murakami, T. Hayashi, H. Warita, K. Sato, I. Nagano
and K. Abe 67
Subcellular localization of Cu,Zn SOD and its role in the pathogenesis
of FALS
Y. Kira, E. Sato, M. Teramura, J. Fujii and M. Inoue 71
Zinc deficient superoxide dismutase: A possible mechanism for ALS
A.G. Estevez 79
X
ROS/RNS/dicarbonyl stress to spinal motor neurons in vitro
K. Shinpo, S. Kikuchi, A. Ogata, H. Sasaki, F. Moriwaka and K. Tashiro 87
An experimental model of Kii ALS. A chronic low CaMg high Al diet
induces neuronal loss and skin changes
T. Kihira, S. Yoshid, T. Kondo, Y. Yase and S. Ono 95
Establishment of local cooling model against transient spinal cord ischemia
N. Motoyoshi, M. Sakurai and K. Tabayashi 105
3. Genetic Abnormality of ALS and Neurotrophin
SOD 1 mutation and clinical features of familial amyotrophic lateral
sclerosis
K. Abe, H. Warita, T. Murakami, T. Hayashi, K. Sato and Y. Manabe 117
A two base deletion of SOD1 gene in a Japanese FALS family
Y. Watanabe, T. Nakano, Y Adachi and K. Nakashima 123
A family with a novel SOD1 gene mutation
T. Murakami, H. Warita, T. Hayashi, K. Sato, Y. Manabe, S. Mizuno,
K. Yamane and K. Abe 129
Familial ALS with a novel homozygous mutation of Cu/Zn SOD gene
M. Kato, M. Aoki, M. Ohta, M. Nagai and Y. Itoyama 133
CAG/CTG repeat expansions are not commonly involved in the
pathogenesis of amyotrophic lateral sclerosis
M. Morita, M. Aoki, P. Sapp, D. McKenna Yasek, H. Horvitz and
R.H. Brown Jr 139
Association study in a synuclein polymorphism in sporadic amyotrophic
lateral sclerosis
Y. Izumi, T. Kazuta, H. Morino, S. Nakamura and H. Kawakami 151
The response of motor neurons to brain derived neurotrophic factor
C. Nakayama and A. Kishino 157
GDNF and RET induction in motor neurons after spinal cord ischemia
M. Sakurai, T. Hayashi, K. Abe, and K. Tabayashi 161
4. Mechanism of Motor Neuron Death and GlutamateToxicity
Reduction of survival signal related protein immunoreactivities in spinal
motoneurons of transgenic ALS model
H. Warita, T. Murakami, Y. Manabe, T. Hayashi, K. Sato, I. Nagano,
Y. Itoyama and K. Abe 169
Downregulation of GluR2 subunit in spinal motoneurons following
ventral root avulsion in adult rats
/. Nagano, Y. Manabe, K. Sato, T. Hayashi, H. Warita, T. Murakami,
K. Abe and Y. Itoyama 179
Mutations in the glutamate transporter EAAT2 gene
M. Aoki, J.D. Rothstein, Y. Itoyama and R.H. Brown Jr 189
xi
Molecular changes of AMPA receptor subunits in ALS spinal cord
S. Kwak, H. Takuma and I. Kanazawa 197
Motor neuron death in GluR2 receptor knockout
/. Nagano, Y. Manabe, K. Sato, T. Hayashi, H. Warita, T. Murakami,
K. Abe and Y. Itoyama 203
Expression of metabotropic glutamate receptor mRNAs in the human
spinal cord: Implications for selective vulnerability of motor neurons
M. Tomiyama, T. Kimura, K. Furusawa, H. Tanaka and M. Matsunaga 217
Glutamate enhances caspase 3 and TUNEL immunoreactivities in
cultured rat spinal motor neurons
Y. Manabe, T. Murakami, T. Hayashi, H. Warita, K. Sato, I. Nagano
and K. Abe 223
Iron and oxidative stress in nigral neurons of Guamanian ALS/PDC:
chemical state imaging using synchrotron radiation
S. Yoshida, A. Ektessabi, N. Kitamura, S. Shikine, S. Fujisawa,
I. Wakayama and T. Kondo 227
5. Motor Axon, Axonal Transport, Neurofilament, and Glycation
Gangliosides of isolated bovine spinal motoneurons
H. Yoshino 237
Impaired axonal transport in transgenic ALS model
H. Warita, T. Murakami, Y. Manabe, T. Hayashi, K. Sato, I. Nagano,
Y. Itoyama and K. Abe 243
Abnormal glycation in ALS
S. Kikuchi, K. Shinpo, J. Fujii, Z. Makita, M. Takeuchi, N. Taniguchi
and K. Tashiro 255
Formation of advanced glycation endproduct (AGE) modified superoxide
dismutase 1 (SOD1) is common to familial amyotrophic lateral
sclerosis (FALS) patients with SOD1 gene mutation and G85R
transgenic mice
S. Kato, K. Nakashima, S. Horiuchi, D.W. Cleveland, A. Hirano,
M. Takikawa, M. Kato, I. Nakano, S. Sakoda, K. Asayama and
E. Ohama 265
Transgenic mice expressing an H46R mutant of human Cu/Zn
superoxide dismutase
M. Nagai, M. Aoki, I. Miyoshi, T. Okamura, M. Kato, M. Ohira,
A. Nakagawara, N. Kasai and Y. Itoyama 273
Increases in mRNA expression forT od tubulin following systemic
administration of kainate in rat
K. Sato, Y. Manabe, T. Hayashi, H. Warita, T. Murakami, I. Nagano
and K. Abe 281
xii
6. Basic Therapeutic Approach
Neurotrophic factor delivery by encapsulated cell grafting technique
/. Date, T. Shingo and T. Ohmoto 289
Potential of XIAP for motor neuron rescue
R. Takahashi, Y. Suzuki and Y. Nakabayashi 297
Amelioration of motor neuron disease model with molecular
chaperones with special reference to spinal and bulbar muscular
atrophy
Y. Kobayashi, H. Takeuchi, M. Li, M. Doyu, K. Ohtsuka
and G. Sobue 307
Neurotrophic factor gene therapy for motor neuron disease
G. Haase 317
Protective effect of cyclic GMP against acute, but not against chronic
oxidative injury of spinal motor neurons
M. Urushitani, T. Nakamizo, A. Akaike, R. Takahashi
and S. Shimohama 325
7. Clinical Therapeutic Approach
Treatment of wobbler mice with free radical scavenger
K. Ikeda, Y. Iwasaki and M. Kinoshita 335
Potential of immunophilin ligands for neuronal cell rescue
N. Ogawa and K. I. Tanaka 341
Expression of adenovirus mediated E. coli lacZ gene in skeletal muscles
and spinal motoneurons of mutant SOD1 transgenic mice
H. Warita, T. Murakami, Y. Manabe, T. Hayashi, K. Sato, I. Nagano,
Y. Setoguchi, Y. Itoyama and K. Abe 349
Adenoviral GDNF gene therapy for injured adult motoneurons
K. Watabe, T. Sakamoto, T. Ohashi, Y. Kawazoe, K. Oyanagi,
T. Takeshima, K. Inoue, Y. Eto and S. U. Kim 355
BDNF treatment in Amyotrophic Lateral Sclerosis
H. Mitsumoto 365
What is the contribtuion of riluzole to the treatment of ALS?
R. Genthon 375
Index of authors 381
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| spelling | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 ed.: Koji Abe 1. ed. Amsterdam [u.a.] Elsevier 2001 XII, 382 S. Ill. txt rdacontent n rdamedia nc rdacarrier Excerpta medica : International congress series 1221 : Neurology Amyotrofe laterale sclerose gtt Amyotrophic Lateral Sclerosis etiology Congresses Amyotrophic Lateral Sclerosis pathology Congresses Amyotrophic Lateral Sclerosis therapy Congresses Amyotrophic lateral sclerosis Congresses Myatrophische Lateralsklerose (DE-588)4132340-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2000 Okayama gnd-content Myatrophische Lateralsklerose (DE-588)4132340-3 s DE-604 Abe, Kōji Sonstige oth International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis 2000 Okayama Sonstige (DE-588)6033978-0 oth Excerpta medica International congress series ; 1221 : Neurology (DE-604)BV000000592 1221 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009608052&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 Excerpta medica Amyotrofe laterale sclerose gtt Amyotrophic Lateral Sclerosis etiology Congresses Amyotrophic Lateral Sclerosis pathology Congresses Amyotrophic Lateral Sclerosis therapy Congresses Amyotrophic lateral sclerosis Congresses Myatrophische Lateralsklerose (DE-588)4132340-3 gnd |
| subject_GND | (DE-588)4132340-3 (DE-588)1071861417 |
| title | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 |
| title_auth | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 |
| title_exact_search | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 |
| title_full | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 ed.: Koji Abe |
| title_fullStr | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 ed.: Koji Abe |
| title_full_unstemmed | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 ed.: Koji Abe |
| title_short | Molecular mechanism and therapeutics of amyotrophic lateral sclerosis |
| title_sort | molecular mechanism and therapeutics of amyotrophic lateral sclerosis proceedings of the international symposium on molecular mechanism and therapeutics of amyotrophic lateral sclerosis japan 22 24 september 2000 |
| title_sub | proceedings of the International Symposium on Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Japan, 22 - 24 September 2000 |
| topic | Amyotrofe laterale sclerose gtt Amyotrophic Lateral Sclerosis etiology Congresses Amyotrophic Lateral Sclerosis pathology Congresses Amyotrophic Lateral Sclerosis therapy Congresses Amyotrophic lateral sclerosis Congresses Myatrophische Lateralsklerose (DE-588)4132340-3 gnd |
| topic_facet | Amyotrofe laterale sclerose Amyotrophic Lateral Sclerosis etiology Congresses Amyotrophic Lateral Sclerosis pathology Congresses Amyotrophic Lateral Sclerosis therapy Congresses Amyotrophic lateral sclerosis Congresses Myatrophische Lateralsklerose Konferenzschrift 2000 Okayama |
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