Genes and the environment:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Taylor & Francis
1999
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 243 S. graph. Darst. |
| ISBN: | 0748408274 0748408266 |
Internformat
MARC
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| 650 | 7 | |a Moleculaire biologie |2 gtt | |
| 650 | 4 | |a DNA Damage | |
| 650 | 4 | |a DNA Repair | |
| 650 | 4 | |a DNA damage | |
| 650 | 4 | |a DNA repair | |
| 650 | 4 | |a Environmental Pollutants |x adverse effects | |
| 650 | 4 | |a Gene Expression Regulation |x physiology | |
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Mutation | |
| 650 | 4 | |a Mutation (Biology) | |
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Datensatz im Suchindex
| _version_ | 1804128869614092288 |
|---|---|
| adam_text | Contents
Preface ix
chapter 1 introduction: genes and the impact of
the Environment 1
1.1 Genes, Genotypes and Phenotypes 2
1.2 Gene Activity and the Environment 3
1.3 Genes and the Tolerance of Environmental Stress 4
1.4 DNA Stability and the Environment 4
1.5 Scope of the Book 6
Gene Damage: Its Limitation, Repair and
Consequences i
chapter 2 Environmental Factors that Damage dna 9
2.1 Synthetic Chemicals 10
2.2 Nuclear Radiation 15
2.3 Ultraviolet Radiation 21
2.4 Atmospheric Pollutants 23
2.5 Food Components 28
2.6 Therapeutic Drugs 31
2.7 Microbial and Viral Pathogens 34
2.8 Literature Sources and Additional Reading 38
Chapter 3 spontaneous alterations to dna 41
3.1 Gene Replication and Proof reading Mechanisms for Error
Correction 42
3.2 Errors during DNA Replication Arising from Base
Tautomerization 48
3.3 Errors due to Deamination of DNA Bases 49
3.4 The Spontaneous Loss of Bases from DNA 52
3.5 Literature Sources and Additional Reading 54
Chapter 4 Possible Oxidative DNA Damage from
Cellular Free Radicals 55
4.1 Neutrophils, Macrophages and the Oxidative Burst 56
4.2 Superoxide Generation and Release from Non phagocytic
Mammalian Cells 57
4.3 Other Cellular Sources of Superoxide or Hydrogen Peroxide 58
4.4 Singlet Oxygen 60
4.5 Nitric Oxide 60
4.6 The Potential for Superoxide, Hydrogen Peroxide and Nitric
Oxide to cause DNA Damage 61
4.7 The Extent of Oxidative Damage to DNA 64
4.8 Literature Sources and Additional Reading 66
Chapter 5 Detoxification and antioxidant defences 69
5.1 Systems for the Detoxification of Environmental Chemicals 70
5.2 Cellular Antioxidant Defence Systems 74
5.3 Literature Sources and Additional Reading 82
Chapter 6 DNA Repair Mechanisms 85
6.1 Photolyases 86
6.2 Alkyltransferases 86
6.3 Nucleotide Excision Repair 87
6.4 Base Excision Repair Pathways 89
6.5 Mismatch Repair 90
6.6 Error prone Replication 92
6.7 Recombination Repair 93
6.8 Double strand Break Repair 95
6.9 Repair of Damage to Mitochondrial DNA 97
6.10 Literature Sources and Additional Reading 98
Chapter 7 Genetic information Flow 101
7.1 Transcription 102
7.2 Translation 105
7.3 Gene Transcription and its Regulation in Bacteria 108
7.4 Eukaryotic Genes their Structure and Transcription 113
7.5 The Control of Gene Expression in Eukaryotes 115
7.6 DNA Control Sequences 119
7.7 Literature Sources and Additional Reading 121
Chapter 8 DNA damage, Mutation, Cancer and Ageing 123
8.1 Cellular Responses to DNA Damage 124
8.2 Mutation 128
8.3 Human Diseases and Gene Repair 136
8.4 Cancer Development 138
8.5 The Environment and Cancer 141
8.6 Markers of Cancer Risk from Environmental Carcinogens 145
8.7 Ageing 145
8.8 Literature Sources and Additional Reading 148
Environmental Stress: Genomk Responses 153
Chapter 9 Gene Activation and Environmental Stress 155
9.1 High temperature Stress 156
9.2 Low temperature Stress 165
9.3 Water Stress 168
9.4 Toxic Metal Stress 172
9.5 Oxidative Stress 177
9.6 Hypoxic and Anoxic Stress 181
9.7 Sunlight and Ultraviolet Radiation Stress 183
9.8 Toxic Chemical Stress 186
9.9 Nutrient Stress 191
9.10 Pathogen and Wounding Stress 194
9.11 Literature Sources and Additional Reading 197
Chapter 1O Stress Genes and Biotechnology 207
10.1 Genetic Engineering for Stress Tolerance 208
10.2 Biomarkers of Environmental Stress 211
10.3 Genes from Organisms Living in Extreme Environments 213
10.4 Bioremediation 214
10.5 Literature Sources and Additional Reading 217
(5)
The Environment, Genes, Biodiversity
and Cancer 221
Chapter 11 Prospects 223
11.1 Genes and Biodiversity 224
11.2 Genes for Environmental Adversity 225
11.3 The Environment, Gene Damage and Mutation 225
11.4 Genes, Cancer and the Environment 228
11.5 The Environment and Epigenetic Inheritance Mechanisms 232
11.6 Environmental Stress Genes and Evolution 233
11.7 Postscript 233
11.8 Literature Sources and Additional Reading 235
Index 237
|
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| isbn | 0748408274 0748408266 |
| language | English |
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| spelling | Burdon, Roy H. Verfasser aut Genes and the environment Roy H. Burdon London [u.a.] Taylor & Francis 1999 X, 243 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genen gtt Milieuverontreiniging gtt Moleculaire biologie gtt DNA Damage DNA Repair DNA damage DNA repair Environmental Pollutants adverse effects Gene Expression Regulation physiology Genetics Mutation Mutation (Biology) Gen (DE-588)4128987-0 gnd rswk-swf Mutation (DE-588)4170883-0 gnd rswk-swf Umwelttoxizität (DE-588)4577864-4 gnd rswk-swf Umweltbelastung (DE-588)4061619-8 gnd rswk-swf Epigenetik (DE-588)7566079-9 gnd rswk-swf Gen (DE-588)4128987-0 s Mutation (DE-588)4170883-0 s Epigenetik (DE-588)7566079-9 s Umweltbelastung (DE-588)4061619-8 s Umwelttoxizität (DE-588)4577864-4 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009594018&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Burdon, Roy H. Genes and the environment Genen gtt Milieuverontreiniging gtt Moleculaire biologie gtt DNA Damage DNA Repair DNA damage DNA repair Environmental Pollutants adverse effects Gene Expression Regulation physiology Genetics Mutation Mutation (Biology) Gen (DE-588)4128987-0 gnd Mutation (DE-588)4170883-0 gnd Umwelttoxizität (DE-588)4577864-4 gnd Umweltbelastung (DE-588)4061619-8 gnd Epigenetik (DE-588)7566079-9 gnd |
| subject_GND | (DE-588)4128987-0 (DE-588)4170883-0 (DE-588)4577864-4 (DE-588)4061619-8 (DE-588)7566079-9 |
| title | Genes and the environment |
| title_auth | Genes and the environment |
| title_exact_search | Genes and the environment |
| title_full | Genes and the environment Roy H. Burdon |
| title_fullStr | Genes and the environment Roy H. Burdon |
| title_full_unstemmed | Genes and the environment Roy H. Burdon |
| title_short | Genes and the environment |
| title_sort | genes and the environment |
| topic | Genen gtt Milieuverontreiniging gtt Moleculaire biologie gtt DNA Damage DNA Repair DNA damage DNA repair Environmental Pollutants adverse effects Gene Expression Regulation physiology Genetics Mutation Mutation (Biology) Gen (DE-588)4128987-0 gnd Mutation (DE-588)4170883-0 gnd Umwelttoxizität (DE-588)4577864-4 gnd Umweltbelastung (DE-588)4061619-8 gnd Epigenetik (DE-588)7566079-9 gnd |
| topic_facet | Genen Milieuverontreiniging Moleculaire biologie DNA Damage DNA Repair DNA damage DNA repair Environmental Pollutants adverse effects Gene Expression Regulation physiology Genetics Mutation Mutation (Biology) Gen Umwelttoxizität Umweltbelastung Epigenetik |
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