Microbial fundamentals of biotechnology: final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 365 S. Ill., graph. Darst. |
| ISBN: | 3527277293 3527306153 |
Internformat
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Datensatz im Suchindex
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| adam_text | DEUTSCHE FORSCHUNGSGEMEINSCHAFT MICROBIAL FUNDAMENTALS OF BIOTECHNOLOGY
FINAL REPORT OF THE COLLABORATIVE RESEARCH CENTRE 323, ,,MIKROBIELLE
GRUNDLAGEN DER BIOTECHNOLOGIE: STRUKTUR, BIOSYNTHESE UND WIRKUNG
MIKROBIELLER STOFFE , 1986- 1999 EDITED BY VOLKMAR BRAUN AND FRIEDRICH
GOTZ COLLABORATIVE RESEARCH CENTRES TECHNISCHE UNIVERSITAT DARMSTADT
FACHBEREJCH 10 * 3IOLOGIE **BIBLIOTHEK * SCHNITTSPAHNSTRABE 10 0-64287
DARMSTADT INV.-NR. )WILEY-VCH DFG CONTENTS ANTIBIOTICS AND OTHER
BIOLOGICALLY ACTIVE MICROBIAL METABOLITES 1 INTRODUCTION 3 VOLKMAR BRAUN
AND FRIEDRICH GOTZ ABSTRACT 3 1.1 ANTIBIOTIC RESEARCH 3 1.2 THE UNIQUE
FEATURES OF MICROBIAL IRON TRANSPORT 6 1.3 TRANSPORT OF BACTERIAL
PROTEINS 9 1.4 MEMBRANE COMPONENTS AND MEMBRANE POLARIZATION 10 1.5
CHEMISTRY OF MICROBIAL PEPTIDES AND PROTEINS 12 1.6 SUMMARY OF
SHORT-TERM PROJECTS OF THE COLLABORATIVE RESEARCH CENTRE 14 2 SCREENING
FOR NEW^SECONDARY METABOLITES FROM MICROORGANISMS 16 HANS-PETER FIEDLER
AND HANS ZAHNER 2. 1 INTRODUCTION . . . _ 16 2.2 SCREENING METHODS AND
NOVEL COMPOUNDS 18 2.3 INCREASING STRUCTURAL DIVERSITY BY DIRECTED
FERMENTATIONS 41 ACKNOWLEDGMENTS 45 REFERENCES . 47 3 BIOSYNTHESIS OF
THE LANTIBIOTICS EPIDERMIN AND GALLIDERMIN 52 FRIEDRICH GOTZ AND GUNTHER
JUNG 3.1 HISTORY OF LANTIBIOTICS AND LANTIBIOTIC RESEARCH IN TUBINGEN 52
3.2 PRIMARY STRUCTURE AND PROPOSED MATURATION OF EPIDERMIN IN
STAPHYLOCOCCI 55 3.3 GENETIC ORGANIZATION AND REGULATION OF THE
EPIDERMIN GENES 56 3.4 ISOLATION AND CHARACTERIZATION OF GENETICALLY
ENGINEERED GALLIDERMIN AND EPIDERMIN ANALOGUES 59 3.5 FUNCTION OF THE
EPIDERMIN IMMUNITY GENES EPIFEG 66 3.6 INACTIVATION AND CHARACTERIZATION
OF THE EPIDERMIN LEADER PEPTIDASE EPIP . 72 3.7 THE FLAVOENZYME EPID AND
FORMATION OF PEPTIDYL-AMINO- ENETHIOLATES 74 V CONTENTS 3.8
INCORPORATION OF D-ALANINE INTO S. AUREUS TEICHOIC ACIDS CONFERS
RESISTANCE TO DEFENSINS, PROTEGRINS, AND OTHER ANTIMICROBIAL PEPTIDES 83
3.9 CONCLUSIONS 86 REFERENCES 88 4 FERMENTATION OF LANTIBIOTICS
EPIDERMIN AND GALLIDERMIN 93 UWE THEOBALD 4.1 INTRODUCTION 93 4.2
STRAINS FOR GALLIDERMIN/EPIDERMIN PRODUCTION 94 4.3 DISADVANTAGES DURING
GALLIDERMIN PROCESS DEVELOPMENT 94 4.4 GALLIDERMIN - A LANTIBIOTIC AND
ITS WAY TOWARDS INDUSTRIAL PRODUCTION 95 4.5 CONCLUSION 99 REFERENCES
100 5 GENETICS OF NIKKOMYCIN PRODUCTION IN STREPTOMYCES TENDAETII 901
102 CHRISTIANE BORMANN 5.1 INTRODUCTION: NIKKOMYCINS 102 5.2 ISOLATION
OF NIKKOMYCIN BIOSYNTHETIC GENES 104 5.3 ISOLATION OF THE NIKKOMYCIN
GENE CLUSTER AND EXPRESSION IN STREPTOMYCES LIVIDANS 108 5.4
ORGANIZATION OF THE NIKKOMYCIN GENE CLUSTER 109 5.5 ROLES OF THE NIK
GENES 110 5.6 TRANSCRIPTIONAL ORGANIZATION AND REGULATION OF THE NIK
CLUSTER 120 REFERENCES 121 6 GLYCOSYLATED ANTIBIOTICS: STUDIES,ON GENES
INVOLVED IN DEOXY- SUGAR FORMATION, MODIFICATION AND ATTACHMENT, AND
THEIR USE IN COMBINATORIAL BIOSYNTHESIS 124 ANDREAS BECHTHOLD 6.1
INTRODUCTION 124 6.2 CLONING OF THE AVILAMYCIN, LANDOMYCIN, URDAMYCIN,
AND GRANATICIN BIOSYNTHETIC GENE CLUSTERS 127 6.3 ORGANIZATION OF
AVILAMYCIN, LANDOMYCIN, URDAMYCIN, AND GRANATICIN BIOSYNTHETIC GENES 128
6.4 NEW GENETICALLY ENGINEERED NATURAL COMPOUNDS 132 REFERENCES 136 7
ANALYSIS OF THE BIOSYNTHESIS OF GLYCOPEPTIDE ANTIBIOTICS: BASIS FOR
CREATING NEW STRUCTURES BY COMBINATORIAL BIOSYNTHESIS 139 STEFAN PELZER
AND WOLFGANG WOHLLEBEN 7.1 INTRODUCTION 139 7.2 RESULTS 141 7.3 OUTLOOK
149 REFERENCES 149 VI CONTENTS 8 HOMOLOGOUS RECOMBINATION AND THE
INDUCTION OF THE SOS-RESPONSE IN ANTIBIOTIC PRODUCING STREPTOMYCETES 151
GIINTHER MUTH AND WOLFGANG WOHLLEBEN 8.1 INTRODUCTION 151 8.2 MUTATIONAL
ANALYSIS OF THE S. LIVIDANS RECA GENE 152 8.3 REGULATION OF RECA
ACTIVITY 156 REFERENCES 160 MEMBRANE PROCESSES 9 REGULATED TRANSPORT AND
SIGNAL TRANSFER CHANNELS INVOLVED IN BACTERIAL IRON SUPPLY 163 VOLKMAR
BRAUN AND HELMUT KILLMANN 9.1 INTRODUCTION 163 9.2 THE FHU PROTEINS
CATALYZE ACTIVE TRANSPORT OF FERRICHROME AND THE ANTIBIOTIC ALBOMYCIN
ACROSS THE OUTER MEMBRANE AND THE CYTO- PLASMIC MEMBRANE OF E. COLI 165
9.3 TRANSDUCTION OF ENERGY FROM THE CYTOPLASMIC MEMBRANE INTO THE OUTER
MEMBRANE 4 OR THE ACTIVATION OF FHUA AS A TRANSPORTER AND PHAGE RECEPTOR
175 9.4 TRANSPORT OF FERRICHROME ACROSS THE CYTOPLASMIC MEMBRANE 178 9.5
FERRIC-CARBOXYLATE TRANSPORT SYSTEM OF MORGANELLA MORGANII VOLKMAR BRAUN
181 9.6 TRANSPORT OF FERRIC IRON IONS BY THE SFU SYSTEM OF SERRATIA
MARCESCENS VOLKMAR BRAUN 182 ACKNOWLEDGMENTS 183 REFERENCES -. 183 10
IRON TRANSPORT IN GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA .... 188
KLAUS HANTKE 10.1 FERRIC IRON TRANSPORT IN BACTERIA 188 10.2
FERROUS-IRON TRANSPORT SYSTEMS (FEO) OF E. COLI 194 10.3 REGULATION OF
IRON TRANSPORT AND METABOLISM 195 10.4 AN [2FE-2S] PROTEIN IS INVOLVED
IN FERRIOXAMINE B UTILIZATION 198 REFERENCES . . 201 11 REGULATION OF
THE FERRIC-CITRATE TRANSPORT SYSTEM BY A NOVEL TRANSMEMBRANE
TRANSCRIPTION CONTROL 205 VOLKMAR BRAUN AND SABINE ENZ 11.1 INTRODUCTION
205 11.2 TRANSPORT OF FE 3+ IS MEDIATED BY CITRATE 205 11.3,
TRANSCRIPTION INITIATION BY A SIGNALING CASCADE FROM THE CELL SURFACE
INTO THE CYTOPLASM 207 11.4 IRON REGULATION OF FECIR AND FECABCDE
TRANSCRIPTION 209 VII CONTENTS 5 ACKNOWLEDGMENTS 209 REFERENCES 211 12
STRUCTURE, FUNCTION, IMPORT, AND IMMUNITY OF COLICINS 212 VOLKMAR BRAUN
AND HELMUT PILSL 12.1* INTRODUCTION 212 12.2 COLICIN M INHIBITS MUREIN
BIOSYNTHESIS AND THUS DISPLAYS A UNIQUE ACTIVITY AMONG THE COLICINS 213
12.3 COLICINS 5 AND 10 ARE TAKEN UP BY A NOVEL MECHANISM 214 12.4
COLICINS EVOLVED BY THE EXCHANGE OF DNA FRAGMENTS WHICH PRECISELY
DEFINED FUNCTIONAL DOMAINS 215 12.5 PORE-FORMING COLICINS ARE
INACTIVATED BY THE COGNATE IMMUNITY PROTEINS SHORTLY BEFORE THE
FORMATION OF THE TRANSMEMBRANE PORES . 217 12.6 PESTICIN IS A MURAMIDASE
WHICH IS INACTIVATED BY THE IMMUNITY PROTEIN IN THE PERIPLASM 218
ACKNOWLEDGMENTS 220 REFERENCES 220 13 STRUCTURE, ACTIVITY, ACTIVATION,
AND SECRETION OF THE SERRATIA MARCESCENS HEMOLYSIN/CYTOLYSIN 222 VOLKMAR
BRAUN AND RALF HERTLE ( 13.1 INTRODUCTION 222 13.2 CHARACTERIZATION OF
THE S. MARCESCENS HEMOLYSIN (SHLA) 224 13.3 PATHOGENICITY OF S.
MARCESCENS HEMOLYSIN/CYTOLYSIN 231 REFERENCES *! 235 14 STAPHYLOCOCCAL
LIPASES: MOLECULAR CHARACTERIZATION AND USE AS AN EXPRESSION AND
SECRETION SYSTEM 238 FRIEDRICH GOTZ AND RALF ROSENSTEIN 14.1
INTRODUCTION 238 14.2 MOLECULAR ORGANIZATION OF STAPHYLOCOCCAL LIPASES
239 14.3 BIOCHEMICAL CHARACTERIZATION OF STAPHYLOCOCCAL LIPASES 241 14.4
ROLE OF THE PRO-PEPTIDE REGION 244 14.5 THE USE OF SHYL AS EXPRESSION
AND SECRETION SYSTEM 244 14.6 CONCLUDING REMARKS 246 REFERENCES 246 15 A
MULTIENZYME COMPLEX INVOLVED IN MUREIN SYNTHESIS OF ESCHERICHIA COLI 249
MORITZ VON RECHENBERG, WALDEMAR VOLLMER, AND JOACHIM-VOLKER HOLTJE 15.1
THE MUREIN SACCULUS, A GROWING MOLECULE 249 15.2 MUREIN GROWTH IS
ACCOMPANIED BY MASSIVE TURNOVER 252 15.3 ENLARGEMENT AND DIVISION OF A
STRESS BEARING STRUCTURE . 253 15.4 INTERACTION OF MUREIN HYDROLASES AND
SYNTHASES AS INDICATED BY AFFINITY CHROMATOGRAPHY 254 VIII CONTENTS 15.5
DIMERIZATION OF THE BIFUNCTIONAL TRANSPEPTIDASE/TRANSGLYCOSYLASE PBP1B
255 15.6 RECONSTITUTION OF THE CORE PARTICLE OF A MUREIN SYNTHESIZING
MACHINERY 256 15.7 PROPOSED STRUCTURE OF A HYPOTHETICAL HOLOENZYME OF
MUREIN SYNTHESIS 256 15.8 RECENT INSIGHTS IN THE MECHANISM OF GROWTH OF
THE MUREIN SACCULUS REVEAL NOVEL TARGETS FOR ANTIBIOTICS 259 REFERENCES
260 16 THE CHANGING PATH OF HOPANOID RESEARCH: FROM CONDENSING LIPIDS TO
NEW MEMBRANE ENZYMES 263 KARL PORALLA 16.1 INTRODUCTION 263 16.2 THE
CYCLIZATION REACTION 265 16.3 PURIFICATION OF SQUALENE CYCLASES 266 16.4
PROPERTIES OF PURIFIED CYCLASES 267 16.5 CLONING OF SQUALENE-HOPENE
CYCLASES 270 16.6 PROPERTIES OF SHC SEQUENCES 271 16.7 THE STRUCTURE OF
SQUALENE-HOPENE CYCLASE 272 16.8 SITE DIRECTED MUTAGENESIS OF
SQUALENE-HOPENE CYCLASE 274 16.9 HOPANOID BIOSYNTHESIS GENE CLUSTERS 278
16.10 MISCELLANEOUS RESULTS 279 16.11 OUTLOOK 280 ACKNOWLEDGMENTS 280
REFERENCES 281 17 GENETIC AND BIOCHEMICAL ANALYSIS OF THE BIOSYNTHESIS
OF THE ORANGE CAROTENOID STAPHYLOXANTHIN OF STAPHYLOCOCCUS AUREUS . .
284 FRIEDRICH GOTZ 17.1 INTRODUCTION 284 17.2 CLONING OF THE CAROTENOID
BIOSYNTHETIC GENES FROM S. AUREUS NEWMAN IN S. CARNOSUS AND E. COLI 285
17.3 FUNCTION OF CRTM AND CRTN 286 17.4 IDENTIFICATION OF CAROTENOIDS IN
S. CARNOSUS (POC21), E. COLI (PUGL), AND S. AUREUS NEWMAN 287 17.5
IDENTIFICATION OF DEHYDROSQUALENE IN E. COLI (PUGL) AND E. COLI (UG9)
287 17.6 SQUALENE IS VERY LIKELY NO SUBSTRATE FOR CRTN, THE PROPOSED
DEHYDROSQUALENE DESATURASE 288 17.7 THE CRT OPERON 288 17.8 HOMOLOGY OF
CRTO, CRTP, AND CRTQ 289 17.9 CONSTRUCTION OF CRTM MUTANTS OF S. AUREUS
STRAIN NEWMAN 289 17.10 CJ B -REGULATED PROMOTER OF THE CRT OPERON FROM
S. AUREUS STRAIN NEWMAN 290 IX CONTENTS 17.11 THE CAROTENOID
BIOSYNTHESIS GENES 290 17.12 FUNCTION OF THE PIGMENTS IN S. AUREUS
STRAIN NEWMAN 292 17.13 DISTRIBUTION OF PIGMENT BIOSYNTHESIS GENES AMONG
STAPHYLOCOCCAL SPECIES 292 .- REFERENCES 293 18 SECOND MESSENGER SYSTEMS
IN PARAMECIUM 295 JOACHIM E. SCHULTZ AND JIIRGEN HINDER 18.1
INTRODUCTION .- 295 18.2 IDENTIFICATION AND CHARACTERIZATION OF CGMP
AND CAMP SECOND MESSENGER SIGNALING SYSTEMS IN PARAMECIUM 296 18.3
BIOCHEMICAL PROPERTIES OF AN ADENYLYL CYCLASE 300 18.4 A GUANYLYL
CYCLASE DISGUISED AS AN ADENYLYL CYCLASE 302 18.5 ON THE WAY TO AN
ADENYLYL CYCLASE WITH AN INTRINSIC ION CONDUC- TANCE 306 18.6 DOWNSTREAM
OF SECOND MESSENGERS 308 18.7 IN VIVO SCREENING OF BACTERIAL SECONDARY
METABOLITES . .- 311 ACKNOWLEDGMENTS , 312 REFERENCES 312 CHEMICAL
SYNTHESIS AND STRUCTURE ELUCIDATION 19 STRUCTURE ELUCIDATION AND
CHEMICAL SYNTHESIS OF MICROBIAL METABOLITES 319 RODERICH D. SIIBMUTH,
JORG METZGER, AND GIINTHER JUNG 19.1 INTRODUCTION 319 19.2 DEVELOPMENT
OF METHODS 320 19.3 STRUCTURE ELUCIDATION 325 19.4 SUMMARY 337
REFERENCES 339 DOCUMENTATION 20 DOCUMENTATION OF THE COLLABORATIVE
RESEARCH CENTRE 323 345 20.1 LIST OF INSTITUTES INVOLVED 345 20.2 LIST
OF SUPPORTED PROJECT AREAS 345 20.3 PROMOTION OF MEMBERS OF THE
COLLABORATIVE RESEARCH CENTRE 348 20.4 RECRUITMENT OF NEW PROJECT
LEADERS 349 20.5 ALPHABETICAL LIST OF MEMBERS AND PARTICIPANTS 349 20.6
SUPPORT OF YOUNG SCIENTISTS ~. 355 20.7 ALPHABETICAL LIST OF GUESTS 364
20.8 INTERNATIONAL COOPERATION 364 20.9 INTERNATIONAL CONFERENCES 365
20.10 FUNDING 365 X
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| id | DE-604.BV013969525 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:55:20Z |
| institution | BVB |
| institution_GND | (DE-588)10026178-4 |
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| physical | XII, 365 S. Ill., graph. Darst. |
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| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 Deutsche Forschungsgemeinschaft. Ed. by Volkmar Braun ... Weinheim Wiley-VCH 2001 XII, 365 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Anti-Bacterial Agents biosynthesis Biological Transport Membrane Transport Proteins Microbial biotechnology Microbial metabolites Biotechnologie (DE-588)4069491-4 gnd rswk-swf Mikrobiologie (DE-588)4316357-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Biotechnologie (DE-588)4069491-4 s Mikrobiologie (DE-588)4316357-9 s DE-604 Braun, Volkmar Sonstige oth Sonderforschungsbereich Mikrobielle Grundlagen der Biotechnologie, Struktur, Biosynthese und Wirkung Mikrobieller Stoffe Sonstige (DE-588)10026178-4 oth HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009562012&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 Anti-Bacterial Agents biosynthesis Biological Transport Membrane Transport Proteins Microbial biotechnology Microbial metabolites Biotechnologie (DE-588)4069491-4 gnd Mikrobiologie (DE-588)4316357-9 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)4316357-9 (DE-588)4143413-4 |
| title | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 |
| title_auth | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 |
| title_exact_search | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 |
| title_full | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 Deutsche Forschungsgemeinschaft. Ed. by Volkmar Braun ... |
| title_fullStr | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 Deutsche Forschungsgemeinschaft. Ed. by Volkmar Braun ... |
| title_full_unstemmed | Microbial fundamentals of biotechnology final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 Deutsche Forschungsgemeinschaft. Ed. by Volkmar Braun ... |
| title_short | Microbial fundamentals of biotechnology |
| title_sort | microbial fundamentals of biotechnology final report of the collaborative research centre 323 mikrobielle grundlagen der biotechnologie struktur biosynthese und wirkung mikrobieller stoffe 1986 1999 |
| title_sub | final report of the Collaborative Research Centre 323, "Mikrobielle Grundlagen der Biotechnologie: Struktur, Biosynthese und Wirkung Mikrobieller Stoffe", 1986 - 1999 |
| topic | Anti-Bacterial Agents biosynthesis Biological Transport Membrane Transport Proteins Microbial biotechnology Microbial metabolites Biotechnologie (DE-588)4069491-4 gnd Mikrobiologie (DE-588)4316357-9 gnd |
| topic_facet | Anti-Bacterial Agents biosynthesis Biological Transport Membrane Transport Proteins Microbial biotechnology Microbial metabolites Biotechnologie Mikrobiologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009562012&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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