Environmental toxicants: human exposures and their health effects
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Wiley Interscience
2000
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 987 S. graph. Darst. |
| ISBN: | 0471292982 |
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Datensatz im Suchindex
| _version_ | 1804128811737939968 |
|---|---|
| adam_text | CONTENTS
Preface xiii
Contributors yv
1 Introduction and Background 1
Morton Lippmann, Ph.D.
Characterization of Chemical Contaminants 2
Human Exposures and Dosimetry 7
Chemical Exposures and Dose to Target Tissues 7
Concentration of Toxic Chemicals in Human Microenvironments 8
Inhalation Exposures and Respiratory Tract Effects 11
Ingestion Exposures and GI Tract Effects 18
Skin Exposure and Dermal Effects 19
Absorption through Membranes and Systemic Circulation 20
Accumulation in Target Tissues and Dosimetric Models 21
Indirect Measures of Past Exposures 21
Characterization of Health 23
Exposure Response Relationships 24
References 27
2 Ambient Particulate Matter 31
Morton Lippmann, Ph.D.
Sources and Pathways for Human Exposure 32
Ambient Air PM Concentrations 36
Extent of Population Exposures to Ambient Air PM 38
Nature of the Evidence for Human Health Effects of Ambient Air PM 41
Epidemiological Evidence for Human Health Effects of Ambient Air PM 41
Discussion and Current Knowledge on the Health Effects of PM 57
Standards and Exposure Guidelines 59
References 60
3 Asbestos and Other Mineral and Vitreous Fibers 65
Morton Lippmann, Ph.D.
Important Special Properties of Fibers 65
Exposures to Fibers 68
Fiber Deposition in the Respiratory Tract 71
Fiber Retention, Dissolution, and Translocation 73
Properties of Mineral and Vitreous Fibers Relevant to Disease 81
vi CONTENTS
Asbestos Related Diseases 81
Review of Biological Effects of Size Classified Fibers in Animals
and Humans 83
Critical Fiber Parameters Affecting Disease Pathogenesis 86
Exposure—Response for Asbestos Related Lung Cancer and Mesothelioma:
Human Experience 95
Risk Assessment Issues: Asbestos 100
Review of Epidemiological Evidence for Health Effects in Workers
Exposed to MMMFs 103
Risk Assessment Issues: Man made Mineral Fibers 106
Key Factors Affecting Fiber Uptake and Toxicity: Recapitulation ;
and Synthesis 108
Acronyms 109
References 110
4 Benzene 121
Bernard D. Goldstein, M.D., and Gisela Witz, Ph.D.
Benzene Exposure 122
Uptake 124
Metabolism and Disposition 124
Mechanisms of Toxicity 131
Risk Assessment 138
References 141
5 Carbon Monoxide 151
Michael T. Kleinman, Ph.D.
CO Exposure and Dosimetry 151
Mechanisms of CO Toxicity 152
Populations at Risk of Health Effects due to CO Exposure 153
Regulatory Background 154
Health Effects of CO 155
Summary and Conclusions 165
References 166
6 Chromium 173
Mitchell D. Cohen, Ph.D., and Max Costa, Ph.D.
Essentiality 173
Environmental Sources and Standards 174
Exposure Scenarios 176
Uptake and Distribution 178
Toxicological Effects 179
Immunotoxicity 180
Carcinogenicity and Teratogenic Effects 182
Genotoxicity and Mutagenicity 183
References 185
CONTENTS vii
7 Diesel Exhaust 193
Joe L. Mauderly, D. V.M.
Historical Overview 193
Exposures to Diesel Exhaust 194
Health Effects 199
Current Issues and Research Needs 230
References 232
8 Dioxins and Dioxin like Chemicals 243
Michael J. De Vito, Ph.D., and Michael A. Gallo, Ph.D.
Sources 243
Toxicological Effects and Mechanism of Action 249
Mechanism of Action 252
References 258
9 Drinking Water Disinfection 267
Richard J. Bull, Ph.D.
Chemical Methods of Disinfection 268
Chemical Nature and Occurrence of Disinfectant By products 269
Associations of Human Disease with Drinking Water Disinfection 276
Toxicology of Disinfectants 279
Summary and Conclusions 298
References 303
10 Environmental Tobacco Smoke 319
Jonathan M. Samet, M.D., M.S., and Sophia S. Wang, Ph.D.
Exposure to Environmental Tobacco Smoke (ETS) 320
Health Effects of Involuntary Smoking in Children 331
Health Effects of Involuntary Smoking in Adults 345
Respiratory Symptoms and Illnesses in Adults 359
Summary 363
References 363
11 Food Constituents, Additives, and Contaminants 377
Joseph V Rodricks, Ph.D.
Food Related Health Risks 377
Legal and Regulatory Framework 380
Toxicity Test Requirements and Safety Criteria 381
Substances Intentionally Added to Food 387
Food Contaminants of Industrial Origin 395
Constituents and Contaminants of Natural Origin 397
Summary and Conclusions 404
Acronyms 405
References 405
viii CONTENTS
12 Formaldehyde and Other Aldehydes 409
George D. Leikauf, Ph.D.
Background 409
Single Exposure Health Effects 417
Effects of Multiple Exposures 426
References 434
13 Indoor Bioaerosol Contaminants 449
Mary Kay O Rourke, Ph.D., and Michael D. Lebowitz, Ph.D.
Sources 449
Biological Factors 450
Exposure 453
Morbidity Effects 457
Hazard Assessment 461
Controls 468
Summary and Conclusions 470
References 471
14 Lead and Compounds 481
Kathryn R. Mahaffey, Ph.D., James McKinney, Ph.D., and
J. Routt Reigart, M.D.
Physical / Chemical Properties and Behavior of Lead and Its Compounds 482
Lead in the Environment and Human Exposure 484
Absorption 486
Distribution 491
Kinetics 493
Health Effects 500
Biomarkers 502
Some Chemical /Molecular Considerations in Lead Neurotoxicity 506
Treatment of Lead Toxicity 509
Conclusions 511
References 513
15 Human made Ionizing Radiation and Radioactivity:
Sources, Levels, and Effects 523
John J. Mauro, Ph.D., and Norman Cohen, Ph.D.
Source Documents 523
Special Units 524
Sources of Human made Radioactivity and Radiation 525
Nuclear Fuel Cycle 526
Nuclear Weapons Complex 537
Local, Tropospheric, and Global Fallout 542
Medical Exposures 544
Industrial Uses (Other Than Nuclear Fuel) 546
CONTENTS ix
Consumer Products 548
Exposures to Diffuse, Enhanced Sources of Naturally Occurring
Radioactive Material (NORM) and Radiation 548
Overview of Potential Health Impacts of Natural and Human made Sources
of Radioactivity 549
References 556
16 Mercury 563
Jesper Bo Nielsen, Ph.D., and Philippe Grandjean, Ph.D.
Chemistry 563
Sources 563
Environmental Exposures 565
Occupational Exposures 567
Kinetics and Metabolism 566
Health Effects 570
References 573
17 Microwaves and Electromagnetic Fields 577
David H. Sliney, Ph.D., and Francis Colville
Background 578
Philosophical Approaches 579
Standards Development 581
Current OELs and EELs for RF Radiation 582
Lowest Frequencies 585
U.S. Government Activities 586
Alternatives to OELs: Do They Exist? 586
Epidemiological Studies 586
Protective Measures 587
Engineering/Installation/Design Controls 587
Range Controls 588
Conclusions 589
Glossary 590
References 590
18 Nitrogen Oxides 595
Richard B. Schlesinger, Ph.D.
Sources of NOx 595
Nitrogen Dioxide 596
Nitric Oxide 612
Nitric/Nitrous Acid 614
Inorganic Nitrates 615
Mixtures of Nitrogen Oxides 616
Summary and Conclusions 621
References 623
x CONTENTS
19 Noise: Its Effects and Control 639
Daniel L Johnson, Ph.D.
Human Auditory System 639
Measurement of Sound 642
Direct Physical Effects 643
General Effects of Noise 645
Control of Noise 649
Summary 652
References 653
20 Ozone 655
Morton Lippmann, Ph.D.
Background 661
Effects of Single Exposures to Ozone 668
Effects of Multiple Day and Ambient Episode Exposures 698
Summary and Conclusions 707
References 710
21 Pesticides 725
Philip J. Landrigan, M.D., M.Sc, Luz Claudio, Ph.D.,
and Rob McConnell, M.D.
Evolving Patterns of Pesticide Use 726
Exposure 726
Epidemiology of Acute Pesticide Poisoning 728
Toxicity of Pesticides 729
Fumigants and Nematocides 733
Other Pesticides 734
Inert Ingredients 734
Pesticides and Endocrine / Reproductive Toxicity 735
Conclusion: Issues for the Future 736
References 738
22 Radon and Daughters 741
Naomi H. Harley, Ph.D.
Effects of Radon Exposure 741
Units of Radon Exposure 742
Outdoor Radon 743
Indoor Radon 745
Underground Mine Radon Epidemiology 751
Environmental Epidemiology 752
Lung Dosimetry 754
Lung Cancer Models for Humans 757
NIH Model 760
Childhood Exposure 764
Animal Studies 764
CONTENTS xi
Smoking and Radon 765
Summary 766
References 766
23 Sulfur Oxides: Acidic Aerosols and SO2 771
Morton Lippmann, Ph.D.
Sources and Exposures 772
Health Effects 776
References 803
24 Trace Elements: Aluminum, Arsenic, Cadmium, and Nickel 811
Max Costa, Ph.D.
Aluminum 811
Arsenic 817
Cadmium 824
Nickel 829
References 837
25 Ultraviolet Radiation 851
Colin M. H. Driscoll, Ph.D., and Nigel A. Cridland, D.Phil.
Radiation Emissions 851
Pathways to Human Exposure 853
Biological Mechanisms Leading to Health Effects 854
Populations at Special Risk 865
Applicable Standards and Exposure Guidelines 867
Risk Assessment and Education Policy 877
Summary 882
References 883
26 Volatile Organic Compounds and the Sick Building Syndrome 889
Lars Mfiylave, M.D.
Toxic Effects 889
Prevalence of Exposures to Volatile Organic Compounds 889
Health and Volatile Organic Compounds 892
Prevalence of the Sick Building Syndrome 894
Dose Response for Health Effects Caused by Low Level VOC Exposure 896
Guidelines for Volatile Organic Compounds in Nonindustrial Indoor
Environments 898
References 901
27 Perspectives on Individual and Community Risks 905
Arthur C. Upton, M.D.
Nature of Risk 905
Identification and Quantification of Risks 906
xii CONTENTS
Risk Communication 911
Risk Reduction 914
References 918
28 Reducing Risks: An Environmental Engineering Perspective 921
Raymond C. Loehr, Ph.D.
Historical Perspective 921
Pollution Control Process 923
Environmental Risk Assessment and Management 923
Applications and Use 929
Conclusions 922
References 943
29 Clinical Perspective on Respiratory Toxicology 945
Mark J. Utell, M.D., and Jonathan M. Samet, M.D.
Concepts of Exposure 946
Tools for Studying Animals 947
Tools for Studying Populations 955
Limitations of Clinical and Epidemiological Assessments of the
Effects of Inhaled Agents 960
Advice and Counseling of Patients 961
Summary 963
References 964
30 Industrial Perspectives: Translating the Knowledge Base
into Corporate Policies, Programs, and Practices for Health
Protection 969
Fred D. Hoerger, Ph.D., Larry W. Rampy, Ph.D., Douglas
A. Rausch, Ph.D., and James S. Bus, Ph.D.
Life Cycle of a Chemical 969
Knowledge Base for the Identification of Hazard Control Strategies 970
Industrial Hygiene and Occupational Health Programs 972
Product Stewardship 975
Responsible Care 978
Concluding Perspective 980
Index 981
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| spellingShingle | Environmental toxicants human exposures and their health effects Gesundheitsgefährdung (DE-588)4071808-6 gnd Umweltverschmutzung (DE-588)4186812-2 gnd Umweltgift (DE-588)4186801-8 gnd Toxikologie (DE-588)4060538-3 gnd Gesundheit (DE-588)4020754-7 gnd |
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| title | Environmental toxicants human exposures and their health effects |
| title_auth | Environmental toxicants human exposures and their health effects |
| title_exact_search | Environmental toxicants human exposures and their health effects |
| title_full | Environmental toxicants human exposures and their health effects ed. by Morton Lippmann |
| title_fullStr | Environmental toxicants human exposures and their health effects ed. by Morton Lippmann |
| title_full_unstemmed | Environmental toxicants human exposures and their health effects ed. by Morton Lippmann |
| title_short | Environmental toxicants |
| title_sort | environmental toxicants human exposures and their health effects |
| title_sub | human exposures and their health effects |
| topic | Gesundheitsgefährdung (DE-588)4071808-6 gnd Umweltverschmutzung (DE-588)4186812-2 gnd Umweltgift (DE-588)4186801-8 gnd Toxikologie (DE-588)4060538-3 gnd Gesundheit (DE-588)4020754-7 gnd |
| topic_facet | Gesundheitsgefährdung Umweltverschmutzung Umweltgift Toxikologie Gesundheit Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009555559&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lippmannmorton environmentaltoxicantshumanexposuresandtheirhealtheffects |