Grauzone and completion of Meiosis during Drosophila oogenesis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boston [u.a.]
Kluwer
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 80 S. Ill., graph. Darst. |
| ISBN: | 0792373634 |
Internformat
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| 650 | 4 | |a Meiosis | |
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| 650 | 4 | |a Oogenesis | |
| 650 | 4 | |a Oogenesis |x physiology | |
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Datensatz im Suchindex
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|---|---|
| adam_text | GRAUZONE AND COMPLETION OF
MEIOSIS DURING DROSOPHILA
OOGENESIS
by
Bin Chen
Stanford University
KLUWER ACADEMIC PUBLISHERS
Boston / Dordrecht / London
Contents
LIST OF FIGURES XI
LIST OF TABLES XIII
PREFACE XV
ACKNOWLEDGEMENTS XIX
GENERAL INTRODUCTION 1
1 FEMALE MEIOTIC CELL CYCLE 1
2 GENESIS AND MEIOSIS IN DROSOPHILA FEMALES 4
3 CELL CYCLE REGULATION OF DROSOPHILA FEMALE MEIOSIS 5
4 MUTATIONS IN GRAUZONE (GRAU) AND CORTEX (CORT) BLOCK
PROGRESSION OF DROSOPHILA FEMALE MEIOSIS AND CAUSE OTHER
DEFECTS 6
5 GOALS AND SIGNIFICANCE OF THIS DISSERTATION RESEARCH 7
MAPPING OF DROSOPHILA MUTATIONS USING SITE-SPECIFIC
MALE RECOMBINATION 11
1 INTRODUCTION 11
2 MATERIALS AND METHODS 13
2 1 Drosophila stocks 13
2 2 Complementation tests of grau mutations with chromosomal
deficiencies and P element insertion lines 15
Vlll
23 Generating recombinants by P-element-induced male
recombination 15
2 4Fertility tests ofP element induced male recombinants 16
3 RESULTS 17
3 1 Scheme for mapping Drosophila mutations using P element induced
male recombination 17
3 2 Mapping the grau gene 19
3 3 Mapping the cort gene 22
4 DISCUSSION 27
COMPLETION OF MEIOSIS IN DROSOPHILA OOCYTES
REQUIRES TRANSCRIPTIONAL CONTROL BY GRAUZONE, A
NEW ZINC FINGER PROTEIN 31
1 INTRODUCTION 31
2 EXPERIMENTAL PROCEDURES 33
2 1 Fly stocks and mapping
2 2Genetic test between grau and cort 34
2 3 P-element-mediated transformation and rescue 35
2 4Molecular techniques 55
2 5 Grau-GFP construct 55
2 6 Microscopy 36
2 7 Construction and purification ofGST-Grau fusion protein 37
2 8Gel shift assay 37
3 RESULTS 38
3 1 Isolation of the grau gene 38
3 2 The Grau protein 42
3 3 Nature of the grau mutant alleles 44
3 4 Expression of the grau transcript during development 46
3 5 The Grau-GFP fusion protein is localized to the nucleus of both
nurse cells and follicle cells 46
3 6Interaction between grau and cort 47
3 7 Grau protein binds to the cort promoter 51
4 DISCUSSION 53
4 1 Mutations in the grau alleles affect the coding region of the protein53
4 2 Regulation of Grau function during oogenesis and at later
developmental stages 54
4 3 Control ofmeiotic divisions 55
4 4 Translational control, meiosis, and early development 57
5 ACKNOWLEDGEMENTS 59
CONCLUSIONS AND CONSIDERATIONS 61
1 DROSOPHILA AS A MODEL TO STUDY REGULATION OF FEMALE MEIOTIC
CELL CYCLE 61
IX
2 GRAU AND CORT ARE TWO MEMBERS OF A NEW PATHWAY THAT
REGULATES THE MEIOTIC CELL CYCLE MACHINERY IN DROSOPHILA
FEMALES 62
3 MALE RECOMBINATION MAPPING IS A GENERAL METHOD TO MAP
DROSOPHILA AUTOSOMAL MUTATIONS 66
REFERENCES 69
INDEX ; 77
|
| any_adam_object | 1 |
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| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.8/45 |
| dewey-search | 571.8/45 |
| dewey-sort | 3571.8 245 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:55:04Z |
| institution | BVB |
| isbn | 0792373634 |
| language | English |
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| spelling | Chen, Bin Verfasser aut Grauzone and completion of Meiosis during Drosophila oogenesis by Bin Chen Boston [u.a.] Kluwer 2001 XX, 80 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drosophila Drosophila cytology Meiosis Meiosis genetics Oogenesis Oogenesis physiology Zinc Fingers genetics Zinc-finger proteins Genregulation (DE-588)4122166-7 gnd rswk-swf Zink-Finger-Proteine (DE-588)4326267-3 gnd rswk-swf Zellzyklus (DE-588)4129960-7 gnd rswk-swf Drosophila (DE-588)4150708-3 gnd rswk-swf Drosophila (DE-588)4150708-3 s Zellzyklus (DE-588)4129960-7 s Genregulation (DE-588)4122166-7 s Zink-Finger-Proteine (DE-588)4326267-3 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009550931&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chen, Bin Grauzone and completion of Meiosis during Drosophila oogenesis Drosophila Drosophila cytology Meiosis Meiosis genetics Oogenesis Oogenesis physiology Zinc Fingers genetics Zinc-finger proteins Genregulation (DE-588)4122166-7 gnd Zink-Finger-Proteine (DE-588)4326267-3 gnd Zellzyklus (DE-588)4129960-7 gnd Drosophila (DE-588)4150708-3 gnd |
| subject_GND | (DE-588)4122166-7 (DE-588)4326267-3 (DE-588)4129960-7 (DE-588)4150708-3 |
| title | Grauzone and completion of Meiosis during Drosophila oogenesis |
| title_auth | Grauzone and completion of Meiosis during Drosophila oogenesis |
| title_exact_search | Grauzone and completion of Meiosis during Drosophila oogenesis |
| title_full | Grauzone and completion of Meiosis during Drosophila oogenesis by Bin Chen |
| title_fullStr | Grauzone and completion of Meiosis during Drosophila oogenesis by Bin Chen |
| title_full_unstemmed | Grauzone and completion of Meiosis during Drosophila oogenesis by Bin Chen |
| title_short | Grauzone and completion of Meiosis during Drosophila oogenesis |
| title_sort | grauzone and completion of meiosis during drosophila oogenesis |
| topic | Drosophila Drosophila cytology Meiosis Meiosis genetics Oogenesis Oogenesis physiology Zinc Fingers genetics Zinc-finger proteins Genregulation (DE-588)4122166-7 gnd Zink-Finger-Proteine (DE-588)4326267-3 gnd Zellzyklus (DE-588)4129960-7 gnd Drosophila (DE-588)4150708-3 gnd |
| topic_facet | Drosophila Drosophila cytology Meiosis Meiosis genetics Oogenesis Oogenesis physiology Zinc Fingers genetics Zinc-finger proteins Genregulation Zink-Finger-Proteine Zellzyklus |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009550931&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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