Protein adaptations and signal transduction:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2001
|
| Schriftenreihe: | Cell and molecular responses to stress
2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 291 S. Ill., graph. Darst. |
| ISBN: | 0444507590 |
Internformat
MARC
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| 245 | 1 | 0 | |a Protein adaptations and signal transduction |c ed. by K. B. Storey ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2001 | |
| 300 | |a XVII, 291 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Cell and molecular responses to stress |v 2 | |
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| 650 | 7 | |a Protéines de choc thermique |2 ram | |
| 650 | 7 | |a Résistance au stress |2 ram | |
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Datensatz im Suchindex
| _version_ | 1804128778944774144 |
|---|---|
| adam_text | xi
Contents
Preface v
List of Contributors vii
Chapter 1. Signal Transduction and Gene Expression in the Regulation of Natural Freezing Survival
Kenneth B. Storey and Janet M. Storey 1
1. Strategies of winter survival in animals 1
2. Freeze induced gene expression 3
2.1. Freeze induced gene expression in wood frogs 4
2.2. Freeze induced gene expression in hatchling turtles and mitochondrial gene expression 7
3. Freeze tolerance, glucose metabolism and signal transduction 8
3.1 Unique glucose metabolism of freeze tolerant frogs 8
3.2. Structural modification of insulin in wood frogs II
3.3. Adrenergic control of freeze induced glucose production 12
3.4. Protein kinase A 12
3.5. Protein phosphatase 1 13
3.6. PKG, PKC and MAPKs 14
4. Conclusions and future directions 16
Acknowledgements 16
References 16
Chapter 2. Drosophila as a Model Organism for the Transgenic Expression of Antifreeze Proteins
Bernard P. Duncker, Derrick E. Rancourt, Michael G. Tyshenko, Peter L. Davies and Virginia K. Walker. 21
1. Introduction 21
2. Properties of AFPs 21
3. Drosophila as a model system for fish AFP expression 22
3.1. Poor expression in transgenic type I AFP flies 23
3.2. Antifreeze activity in flies expressing type II AFP 24
3.3. Improved thermal hysteresis in flies expressing type III AFP 25
4. Prospects for the transgenic expression of other AFPs 26
5. Cautions and conclusions 27
Acknowledgements 27
References 27
Chapter 3. Cold adapted Enzymes: An Unachieved Symphony Salvino D Amico, Paule Claverie, Tony Collins.
Georges Feller, Daphne Georlette, Emmanuelle Gratia, Anne Hoyoux, Marie Alice Meuwis. Laurent
Zecchinon and Charles Gerday 31
1. Introduction 31
2. The low temperature challenge 31
3. Structural basis of adaptation to cold 32
3.1. Achievements 32
3.2. Active sites structural organization—the flexibility requirement 33
3.3. Structural factors implicated in cold adaptation 34
xii Contents
4. The activity stability flexibility trilogy 35
4.1. The current hypothesis 35
4.2. Random mutagenesis, the perfect tool? 35
4.3. Natural evolution vs. directed evolution 37
4.4. Differential scanning calorimetry 37
5. Conclusion and perspectives 39
Acknowledgements 39
References 40
Chapter 4. The Role of Cold shock Proteins in Low temperature Adaptation Jeroen A. Wouters, Frank M. Rombouts,
Oscar P. Kuipers, Willem M. de Vos, and T. Abee 43
1. Low temperature adaptation and sensing 43
1.1. Low temperature adaptation 43
1.2. Low temperature sensing 44
1.3. Production of non 7 kDa cold induced proteins 46
1.4. Protein synthesis at low temperature and the role of ribosomes in cold adaptation 46
2. Cold shock proteins and their role in cold and general stress adaptation 47
2.1. CSPs as transcriptional activators 47
2.2. CSPs as RNA chaperones 49
2.3. CSPs and freeze protection 49
2.4. Role of CSPs in general stress response 49
3. Regulatory elements involved in CSP synthesis 50
3.1. Transcriptional regulation and mRNA stability 50
3.2. Translational regulation involving ris acting elements 52
3.3. Protein stability 52
4. Perspectives 53
Acknowledgements 53
References 53
Chapter 5. Hibernation: Protein Adaptations Alexander M. Rubtsov 57
1. Introduction 57
2. Adjustment of energy metabolism for needs of hibernators 58
3. Molecular mechanisms of excitation contraction coupling in heart and skeletal muscles of mammals 61
4. Changes in the properties of enzyme systems responsible for the functional activity of heart and skeletal muscles
during hibernation 62
4.1. Ca channels of plasma membrane 62
4.2. Sarcoplasmic reticulum proteins 63
4.3. Contractile proteins 68
5. Concluding remarks 69
References 69
Chapter 6. Aquaporins and water stress Alfred N. Van Hoek, Yan Huang and Pingke Fang 73
1. Rationale 73
2. Introduction 73
2.1. Identification of Aquaporins 73
3. Osmosis, diffusion and functional properties of aquaporins 75
3.1. Physiological relevance of solvent drag 76
3.2. Measurement of/5,, Ps and a 77
4. Uphill flow of water 78
5. Desert kangaroo rat and aquaporin distributions 79
6. Physiology of AQP3 and AQP4 81
7. Water transport in liver and stomach 81
Contents xiii
8. Adaptation 83
9. Concluding remarks 83
Acknowledgements 83
References 83
Chapter 7. Gene Expression Associated with Muscle Adaptation in Response to Physical Signals —
Geoff Goldspink and Shi Yu Yang 87
1. Introduction 87
2. Mechanical factors that influence myosin heavy chain gene expression in mammalian muscle 88
3. Metabolic adaptation in relation to activity 89
4. Switches in myosin gene expression in response to environmental temperature in fish muscle 90
5. Molecular motor switching in response to muscle activity 91
6. Local control of muscle mass and phenotype 91
7. Action of MGF in inducing muscle hypertrophy 93
8. Binding protein and local action of growth factors 94
9. Mechanotransduction mechanisms 94
10. Summary and conclusions 94
References 95
Chapter 8. Early Responses to Mechanical Stress: From Signals at the Cell Surface to Altered Gene Expression
Matthias Chiquet and Martin Fliick 97
1. Introduction 97
2. Mechanical stress and tissue homeostasis 97
3. Mechanosensation at the cell surface 98
3.1. Force transduction between the extracellular matrix and the cytoskeleton 98
3.2. Stretch activated ion channels 99
3.3. Integrins as mechanosensory molecules 99
4. Early generation of chemical signals at the cell surface 100
4.1. Calcium influx through stretch activated cation channels 100
4.2. Secretion of autocrine/paracrine mediators 100
4.3. Integrin dependent events at the focal adhesion complex 101
4.5. Generation of intracellular reactive oxygen species 102
5. Triggering of intracellular signalling cascades 103
5.1. Mitogen activated protein kinase (MAPK) pathways 103
5.2. Nuclear factor kappa B (NF kB) pathway 104
5.3. Protein kinase C 104
6. Transcriptional activation of mechano responsive genes: examples 104
6.1. A transcription factor: Egr 1 (early growth response 1) 105
6.2. A growth factor: PDGF (platelet derived growth factor) 105
6.3. An extracellular matrix protein: Tenascin C 106
7. Conclusions and perspectives 106
Acknowledgements 107
References 107
Chapter 9. Fasting and Refeeding: Models of Changes in Metabolic Efficiency Stephen P.J. Brooks Ill
1. Introduction Ill
2. Biochemical and physiological changes associated with fasting and energy restriction 112
2.1. The biochemical controls on fasting gluconeogenesis: demands on muscle protein 112
2.2. Lipid metabolism in starving animals 114
3. Biochemical changes associated with refeeding 116
4. Metabolic depression and metabolic efficiency 117
4.1. Refeeding fasted and energy restricted animals 119
xiv Contents
4.2. Factors affecting metabolic efficiency 121
4.3. Relevance to humans 121
References 123
Chapter 10. Nutritional Regulation of Hepatic Gene Expression — Howard C. Towle 129
1. Introduction—energy homeostasis 129
2. Role of the liver in energy homeostasis 129
3. Fatty acid oxidation and the peroxisome proliferator activated receptor 130
3.1. The hepatic response to fasting 130
3.2. Role of PPARa in the hepatic response to fasting 131
3.2. Role of PPARy in adipogenesis 132
4. Lipogenesis and the induction of lipogenic enzyme genes 133
5. Lipogenesis and the sterol regulatory element binding protein 134
5.1. SREBP in the regulation of cholesterol homeostasis 134
5.2. SREBP in regulation of lipogenesis 135
6. Lipogenesis and the carbohydrate responsive transcription factor 136
6.1. Glucose metabolism generates an intracellular signal for inducing lipogenic enzyme genes 136
6.2. The carbohydrate response element 137
6.3. The carbohydrate responsive transcription factor 138
7. Model for lipogenic enzyme gene regulation 139
8. Conclusions 140
References 141
Chapter 11. The AMP activated/SNFl Protein Kinases: Key Players in the Response of Eukaryotic Cells to
Metabolic Stress D. Grahame Hardie 145
1. Introduction 145
2. Early studies of the AMPK/SNF1 protein kinases 145
2.1. Mammalian AMP activated protein kinase 145
2.2. The yeast SNF1 protein kinase 146
2.3. The higher plant SNF1 related protein kinases 146
3. Structure of the AMPK/SNF1 kinases 147
3.1. Structure of mammalian AMP activated and yeast SNF1 protein kinases 147
3.2. Structure of higher plant SNF1 related protein kinases 148
4. Regulation of the AMPK/SNF1 kinases 149
4.1. Regulation of mammalian AMP activated protein kinase 149
4.2. Regulation of yeast SNF1 protein kinase 150
4.3. Regulation of higher plant SNF1 related protein kinases 151
5. Cellular stresses that switch on the AMPK/SNF1 systems 151
5.1. Activation of AMPK in intact cells and in vivo 151
5.2. Regulation of yeast SNF1 and plant SnRKl kinases in vivo 152
6. Target pathways and proteins for AMPK/SNF1 systems 152
6.1. Recognition of targets by the AMPK/SNF1 protein kinase family 152
6.2. Targets for mammalian AMPK 153
6.3. Targets for the yeast SNF1 complex 156
6.4. Targets for the plant SnRKl complexes 157
7. Future perspectives 157
Acknowledgements 157
References 158
Chapter 12. Cellular Regulation of Protein Kinase C Alexandra C. Newton and Alex Toker 163
1. Protein kinase C: a central role in signaling 163
2. Structure, function, and regulation of protein kinase C 163
Contents xv
2.1. Protein kinase C family members 163
2.2. Membrane binding modules regulate the function of protein kinase C 164
2.3. Phosphorylation 164
2.4. Regulation of PDK 1, the upstream kinase for protein kinase C 165
2.5. Protein kinase C anchoring proteins 166
2.6. Summary 166
3. Protein kinase C in cell survival and programmed cell death 167
3.1. Conventional protein kinase Cs 167
3.2. Novel protein kinase Cs 168
3.3. Atypical protein kinase Cs 169
4. Perspectives 170
References 170
Chapter 13. Mitogen activated protein kinases and stress Klaus P. Hoeflich and James R. Woodgett 175
1. Introduction 175
2. The SAPK family 176
3. Dual specificity protein kinases of the SAPK pathway 179
4. Regulation of SAPK by MAPKKKs 181
5. The p38 MAPK family 184
6. Genetic analysis of p38a in mice 185
7. Concluding remarks 188
Acknowledgements 189
References 189
Chapter 14. How to Activate Intrinsic Stress Resistance Mechanisms to Obtain Therapeutic Benefit — Prasanta K. Ray,
Tanya Das and Gaurisankar Sa 195
1. General introduction 195
2. Body s defense against different forms of stress 195
2.1. Immune defense 195
2.2. Detoxification process 196
2.3. Cell regeneration and replenishment 197
2.4. DNA repair 197
2.5. Growth factors/cytokines/hormones/chaperones 198
3. Failure of the intrinsic defense 198
4. Possible avenues for reversal of stress injury 199
5. Future directions 200
Acknowledgements 200
References 200
Chapter 15. Regulation of Ion Channel Function and Expression by Hypoxia — Chris Peers 203
1 Cellular responses to acute hypoxia 203
2. The carotid body 203
3. O, sensitive K* channels in other tissues 205
4. O, sensitive Ca2* channels 206
5. Other O, sensitive ion channels 206
6. Mechanisms of O, sensing 206
7. Chronic hypoxia 208
8. Conclusions 210
Acknowledgements 210
References 210
xvi Contents
Chapter 16. Ca* Dynamics Under Oxidant Stress in the Cardiovascular System Tapati Chakxaborti, Sudip Das,
Malay Mandal, Amritlal Mandal and Sajal Chakraborti 213
1. Introduction 213
2. Ca2* influx from extracellular to intracellular space 213
2.1. ATP independent Ca2* binding 213
2.2. Ca:* channels 214
2.3. f} Adrenergic receptors 215
2.4. NaVCa2* and NaTH* exchange, and NaVK* ATPase activities 216
2.5. Ischemic preconditioning and K* Channels 217
3. Ca* extrusion from intracellular space to extracellular space 217
3.1. NaVCa* exchange 217
3.2. Ca2* ATPase of sarcolemmal membrane 218
3.3. Effect of ROS on sulfhydryl groups 218
3.4. Effect of ROS on protein fragmentation 219
4. Ca2* translocating processes of sarcoplasmic reticulum 219
5. Protein bound Ca2* 220
6. Mitochondrial Ca2* dynamics 220
7. Consequences of oxidant induced increase in [Ca2*]i 222
7.1. AP 1 transcription factors 222
7.2. NF kB transcription factors 222
8. Future prospects 223
Acknowledgements 224
References 224
Chapter 17. Role ofNF E2 Related Factors in Oxidative Stress David Bloom, Saravanakumar Dhakshinamoorthy,
Wei Wang, Claudia M. Celli and Anil K. Jaiswal 229
1. Oxidative stress 229
2. Oxidative stress activated defensive mechanisms 229
3. Transcription factor NF kB 230
4. NF E2 Related factors 231
5. Role of NF E2 related factors in protection against oxidative stress 232
6. Nrf 1 and Nrf2 associated factors 233
7. Mechanism of Nrf signaling and activation of ARE mediated expression and coordinated induction of
defensive genes 234
Acknowledgements 235
References 235
Chapter 18. Signal Transduction Cascades Responsive to Oxidative Stress in the Vasculature Zheng Gen Jin
and Bradford C. Berk 239
1. Introduction: Oxidative stress is implicated in the pathogenesis of vascular diseases 239
2. Cellular sensors of oxidative stress 240
2.1. Receptor tyrosine kinases (RTKs) 240
2.2. G protein coupled receptors and G proteins 241
2.3. Non receptor protein tyrosine kinases (PTKs) 241
2.4. Integrin signaling 242
2.5. Ion channels 242
3. Redox regulation of phospholipid dependent signaling 243
3.1. Phospholipase and oxidative stress 244
3.2. Calcium signaling and oxidative stress 244
3.3. Protein kinase C (PKC) and oxidative stress 244
4. Mitogen activated protein kinases as the primary redox sensitive signal mediators 244
4.1. Small G proteins as intermediates from PTKs to MAPK signaling in response to oxidative stress 245
4.2. MAPK pathways in redox sensitive signal transduction 245
Contents xvii
5. Regulation of gene expression and protein secretion by oxidative stress 247
5.1. Redox regulation of transcription factor activity and gene expression 247
5.2. Protein secretion in response to oxidative stress 248
6. Conclusion 248
References 249
Chapter 19. Oxidative Stress Signaling Hasem Habelhah and Ze ev Ronai 253
1. Introduction 253
2. Key Sources of ROS generation 253
3. ROS as second messengers in mitogenic signaling 254
4. Role of ROS in signal transduction 255
5. Transcriptional regulation by ROS 257
6. ROS regulation of NF kB 258
7. ROS in apoptosis 259
References 259
Chapter 20. Antioxidant Defenses and Animal Adaptation to Oxygen Availability During Environmental Stress
Marcelo Hermes Lima, Janet M. Storey and Kenneth B. Storey 263
1. Free radicals, antioxidant enzymes and oxidative stress 263
2. Natural anoxia tolerance and adaptations to oxidative stress 265
2.1. Antioxidants and garter snakes under anoxia exposure 266
2.2. Antioxidants and leopard frogs under anoxia and reoxygenation 267
2.3. Antioxidants and goldfish under anoxia and reoxygenation 268
2.4. Antioxidants and turtles under anoxia and reoxygenation 269
2.5. Lipid peroxidation, xanthine oxidase, and post anoxic reoxygenation in vertebrates 272
2.6. Oxidative stress and anoxia tolerance in a marine gastropod 273
3. Oxidative stress and natural freeze tolerance in vertebrates 274
3.1. Antioxidants and freeze tolerance in garter snakes 275
3.2. Oxidative stress and freeze tolerance in wood frogs 275
4. Oxidative stress and dehydration tolerance in leopard frogs 277
5. Estivation and oxidative stress in land snails and toads 278
5.1. Estivation in land snails and oxidative stress 278
5.2. Oxidative stress and estivation in a desert toad 280
6. Conclusions, speculations and perspectives 282
Acknowledgements 284
References 284
Index 289
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| id | DE-604.BV013933031 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:54:39Z |
| institution | BVB |
| isbn | 0444507590 |
| language | English |
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| series | Cell and molecular responses to stress |
| series2 | Cell and molecular responses to stress |
| spelling | Protein adaptations and signal transduction ed. by K. B. Storey ... Amsterdam [u.a.] Elsevier 2001 XVII, 291 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell and molecular responses to stress 2 Protéines antigel ram Protéines de choc thermique ram Résistance au stress ram Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Stressreaktion (DE-588)4138565-2 gnd rswk-swf Proteine (DE-588)4076388-2 gnd rswk-swf Stressreaktion (DE-588)4138565-2 s Proteine (DE-588)4076388-2 s Signaltransduktion (DE-588)4318717-1 s DE-604 Storey, Kenneth B. Sonstige oth Cell and molecular responses to stress 2 (DE-604)BV013987873 2 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009534527&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Protein adaptations and signal transduction Cell and molecular responses to stress Protéines antigel ram Protéines de choc thermique ram Résistance au stress ram Signaltransduktion (DE-588)4318717-1 gnd Stressreaktion (DE-588)4138565-2 gnd Proteine (DE-588)4076388-2 gnd |
| subject_GND | (DE-588)4318717-1 (DE-588)4138565-2 (DE-588)4076388-2 |
| title | Protein adaptations and signal transduction |
| title_auth | Protein adaptations and signal transduction |
| title_exact_search | Protein adaptations and signal transduction |
| title_full | Protein adaptations and signal transduction ed. by K. B. Storey ... |
| title_fullStr | Protein adaptations and signal transduction ed. by K. B. Storey ... |
| title_full_unstemmed | Protein adaptations and signal transduction ed. by K. B. Storey ... |
| title_short | Protein adaptations and signal transduction |
| title_sort | protein adaptations and signal transduction |
| topic | Protéines antigel ram Protéines de choc thermique ram Résistance au stress ram Signaltransduktion (DE-588)4318717-1 gnd Stressreaktion (DE-588)4138565-2 gnd Proteine (DE-588)4076388-2 gnd |
| topic_facet | Protéines antigel Protéines de choc thermique Résistance au stress Signaltransduktion Stressreaktion Proteine |
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