Molecular genetic epidemiology: a laboratory perspective ;
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2002
|
| Schriftenreihe: | Principles and practice
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 214 S. Ill., graph. Darst. |
| ISBN: | 354041388X 3540413871 |
Internformat
MARC
| LEADER | 00000nam a22000008c 4500 | ||
|---|---|---|---|
| 001 | BV013926473 | ||
| 003 | DE-604 | ||
| 005 | 20011114 | ||
| 007 | t | ||
| 008 | 010918s2002 gw ad|| |||| 00||| eng d | ||
| 016 | 7 | |a 961235331 |2 DE-101 | |
| 020 | |a 354041388X |9 3-540-41388-X | ||
| 020 | |a 3540413871 |9 3-540-41387-1 | ||
| 035 | |a (OCoLC)46785310 | ||
| 035 | |a (DE-599)BVBBV013926473 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c DE | ||
| 049 | |a DE-355 |a DE-20 | ||
| 050 | 0 | |a RA652 | |
| 082 | 0 | |a 614.4 |2 21 | |
| 084 | |a WC 4460 |0 (DE-625)148102: |2 rvk | ||
| 084 | |a XF 4119 |0 (DE-625)152771:12925 |2 rvk | ||
| 245 | 1 | 0 | |a Molecular genetic epidemiology |b a laboratory perspective ; |c Ian N. M. Day (ed.) |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2002 | |
| 300 | |a XII, 214 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Principles and practice | |
| 650 | 7 | |a Epidemiologia |2 larpcal | |
| 650 | 7 | |a Epidemiologie |2 gtt | |
| 650 | 7 | |a Genetica |2 gtt | |
| 650 | 7 | |a Saúde pública |2 larpcal | |
| 650 | 4 | |a Épidémiologie génétique - Manuels de laboratoire | |
| 650 | 4 | |a Épidémiologie moléculaire - Manuels de laboratoire | |
| 650 | 4 | |a DNA Probes |x diagnostic use | |
| 650 | 4 | |a Genetic Techniques |x trends | |
| 650 | 4 | |a Genetic epidemiology |v Laboratory manuals | |
| 650 | 4 | |a Molecular Biology |x methods | |
| 650 | 4 | |a Molecular Epidemiology |x methods | |
| 650 | 4 | |a Molecular epidemiology |v Laboratory manuals | |
| 650 | 4 | |a Oligonucleotide Probes |x diagnostic use | |
| 650 | 4 | |a Polymorphism, Genetic | |
| 650 | 0 | 7 | |a Labormedizin |0 (DE-588)4073931-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Epidemiologie |0 (DE-588)4015016-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekulargenetik |0 (DE-588)4039987-4 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Epidemiologie |0 (DE-588)4015016-1 |D s |
| 689 | 0 | 1 | |a Molekulargenetik |0 (DE-588)4039987-4 |D s |
| 689 | 0 | 2 | |a Labormedizin |0 (DE-588)4073931-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Day, Ian N. M. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009530172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-009530172 | ||
Datensatz im Suchindex
| _version_ | 1804128771821797376 |
|---|---|
| adam_text | Contents
1 Mapping Genes for Common Diseases:
Statistical Planning, Power, Efficiency and Informatics
Andy Collins
1.1 Introduction 1
1.2 Power and Sampling Considerations 2
1.3 Models of Locus Action 6
1.4 Maximum Likelihood Estimation 7
1.5 Allelic Association 12
1.6 The Malecot Model for Association 14
1.7 Candidate Genes for Allelic Association 17
1.8 Significance Levels 17
1.9 Meta Analysis 18
1.10 Informatics 20
1.11 Summary 24
References 24
2 Human DNA Sampling and Banking
Emmanuel Spanakis
2.1 Introduction 27
2.2 A Brief History of DNA Research 27
2.3 Goals and Needs of Human Population Genetics 29
2.4 Selection of the Source Tissue 33
2.5 A Fundamental Change in Sampling Methodology 36
2.6 DNA Isolation and Purification 38
2.7 Sample Storing 42
2.8 Sample Banking 44
References 46
3 Microsatellite Genotyping
Cheni Kwok and Karin Schmitt
3.1 Introduction 55
3.2 Microsatellite Markers 57
3.3 The Genotyping Process Experimental Considerations 60
3.4 Data Analysis 62
VIII Contents
3.5 Data Management 68
3.6 Hardware 70
3.7 Future Developments 76
3.8 Applications 79
References 80
4 Minisatellite and Microsatellite DNA Fingerprinting
Paul G. Debenham
4.1 Introduction 87
4.2 Blood Grouping 87
4.3 DNA Fingerprinting The Discovery 88
4.4 DNA Fingerprinting The Applications 90
4.5 An Explosion of DNA Fingerprinting Sequences 92
4.6 Shortcomings of Multilocus Probes 93
4.7 Single Locus Probes DNA Profiling 94
4.8 Europe and the USA Disagree 96
4.9 Lessons from the Castro Case 96
4.10 Impact of PCR 98
4.11 Digital DNA Typing 101
4.12 Short Tandem Repeat Profiling 101
4.13 The UK National DNA Database 103
4.14 STR Profiling Applications 103
4.15 The Future 104
References 105
5 Multiplex Polymerase Chain Reaction and Immobilized Probes:
Application to Cardiovascular Disease
Suzanne Cheng
5.1 Introduction 107
5.2 Multiplex Polymerase Chain Reaction (PCR) Methodology 108
5.3 Sequence Specific Oligonucleotide Probe (SSOP)
Methodology 116
5.4 Example: Candidate Markers of CVD Risk 120
5.5 Summary 127
References 127
6 The Special Case of HLA Genes: Detection and Resolution
of Multiple Polymorphic Sites in a Single Gene
W. Martin Howell and Katherine L. Poole
6.1 Introduction 131
6.2 The HLA System 132
6.3 Requirement for HLA Genotyping: Historical Perspectives 134
6.4 PCR based Approaches to HLA Genotyping 136
Contents IX
6.5 A PCR SSOP Based Strategy for HLA Class II Typing Using
DNA Derived from Archival Tissue Banks 147
6.6 Concluding Remarks 152
References 152
7 Microplate Array Diagonal Gel Electrophoresis (MADGE)
Methodologies: The First Five Years
Ian N.M. Day, Emmanuel Spanakis, Lesley J. Hinks,
Anca Voropanov, Xaio he Chen, and Sandra D. O Dell
7.1 Introduction 157
7.2 Microplate Array Diagonal Gel Electrophoresis (MADGE) 161
7.3 CpG PCR 163
7.4 Temporal Thermal Ramp MADGE Electrophoresis
(Melt MADGE) 165
7.5 Software Applications (Applies to All MADGE Not Just
Melt MADGE) 170
7.6 Future Developments 172
References 179
8 The Use of Sequence Analysis for Homozygote
and Heterozygote Base Variation Discovery
Hans Ulrich Thomann, Michael FitzGerald,
Heidi Giese, and Kristen Wall
8.1 Introduction 183
8.2 Sequence Analysis: a Polymorphism Discovery Method 183
8.3 Key Advancements in Sequencing Technologies:
Chemistries, Hardware, and Software 184
8.4 Heterozygote and Homozygote Polymorphism Base Calling .... 191
8.5 Strategies for Sequencing Based Polymorphism Detection 194
8.6 Summary and Outlook: To Sequence or Not To Sequence
This Is Not in Question 203
References 207
Subject Index 211
k
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV013926473 |
| callnumber-first | R - Medicine |
| callnumber-label | RA652 |
| callnumber-raw | RA652 |
| callnumber-search | RA652 |
| callnumber-sort | RA 3652 |
| callnumber-subject | RA - Public Medicine |
| classification_rvk | WC 4460 XF 4119 |
| ctrlnum | (OCoLC)46785310 (DE-599)BVBBV013926473 |
| dewey-full | 614.4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 614 - Forensic medicine; incidence of disease |
| dewey-raw | 614.4 |
| dewey-search | 614.4 |
| dewey-sort | 3614.4 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02383nam a22006258c 4500</leader><controlfield tag="001">BV013926473</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20011114 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">010918s2002 gw ad|| |||| 00||| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">961235331</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">354041388X</subfield><subfield code="9">3-540-41388-X</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540413871</subfield><subfield code="9">3-540-41387-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)46785310</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV013926473</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-20</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA652</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">614.4</subfield><subfield code="2">21</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WC 4460</subfield><subfield code="0">(DE-625)148102:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XF 4119</subfield><subfield code="0">(DE-625)152771:12925</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Molecular genetic epidemiology</subfield><subfield code="b">a laboratory perspective ;</subfield><subfield code="c">Ian N. M. Day (ed.)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2002</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XII, 214 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Principles and practice</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Epidemiologia</subfield><subfield code="2">larpcal</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Epidemiologie</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Genetica</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Saúde pública</subfield><subfield code="2">larpcal</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Épidémiologie génétique - Manuels de laboratoire</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Épidémiologie moléculaire - Manuels de laboratoire</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA Probes</subfield><subfield code="x">diagnostic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetic Techniques</subfield><subfield code="x">trends</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetic epidemiology</subfield><subfield code="v">Laboratory manuals</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular Biology</subfield><subfield code="x">methods</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular Epidemiology</subfield><subfield code="x">methods</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular epidemiology</subfield><subfield code="v">Laboratory manuals</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oligonucleotide Probes</subfield><subfield code="x">diagnostic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polymorphism, Genetic</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Labormedizin</subfield><subfield code="0">(DE-588)4073931-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Epidemiologie</subfield><subfield code="0">(DE-588)4015016-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Molekulargenetik</subfield><subfield code="0">(DE-588)4039987-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Epidemiologie</subfield><subfield code="0">(DE-588)4015016-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Molekulargenetik</subfield><subfield code="0">(DE-588)4039987-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Labormedizin</subfield><subfield code="0">(DE-588)4073931-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Day, Ian N. M.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009530172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-009530172</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV013926473 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:54:33Z |
| institution | BVB |
| isbn | 354041388X 3540413871 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009530172 |
| oclc_num | 46785310 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-20 |
| owner_facet | DE-355 DE-BY-UBR DE-20 |
| physical | XII, 214 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Springer |
| record_format | marc |
| series2 | Principles and practice |
| spelling | Molecular genetic epidemiology a laboratory perspective ; Ian N. M. Day (ed.) Berlin [u.a.] Springer 2002 XII, 214 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Principles and practice Epidemiologia larpcal Epidemiologie gtt Genetica gtt Saúde pública larpcal Épidémiologie génétique - Manuels de laboratoire Épidémiologie moléculaire - Manuels de laboratoire DNA Probes diagnostic use Genetic Techniques trends Genetic epidemiology Laboratory manuals Molecular Biology methods Molecular Epidemiology methods Molecular epidemiology Laboratory manuals Oligonucleotide Probes diagnostic use Polymorphism, Genetic Labormedizin (DE-588)4073931-4 gnd rswk-swf Epidemiologie (DE-588)4015016-1 gnd rswk-swf Molekulargenetik (DE-588)4039987-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Epidemiologie (DE-588)4015016-1 s Molekulargenetik (DE-588)4039987-4 s Labormedizin (DE-588)4073931-4 s DE-604 Day, Ian N. M. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009530172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular genetic epidemiology a laboratory perspective ; Epidemiologia larpcal Epidemiologie gtt Genetica gtt Saúde pública larpcal Épidémiologie génétique - Manuels de laboratoire Épidémiologie moléculaire - Manuels de laboratoire DNA Probes diagnostic use Genetic Techniques trends Genetic epidemiology Laboratory manuals Molecular Biology methods Molecular Epidemiology methods Molecular epidemiology Laboratory manuals Oligonucleotide Probes diagnostic use Polymorphism, Genetic Labormedizin (DE-588)4073931-4 gnd Epidemiologie (DE-588)4015016-1 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| subject_GND | (DE-588)4073931-4 (DE-588)4015016-1 (DE-588)4039987-4 (DE-588)4143413-4 |
| title | Molecular genetic epidemiology a laboratory perspective ; |
| title_auth | Molecular genetic epidemiology a laboratory perspective ; |
| title_exact_search | Molecular genetic epidemiology a laboratory perspective ; |
| title_full | Molecular genetic epidemiology a laboratory perspective ; Ian N. M. Day (ed.) |
| title_fullStr | Molecular genetic epidemiology a laboratory perspective ; Ian N. M. Day (ed.) |
| title_full_unstemmed | Molecular genetic epidemiology a laboratory perspective ; Ian N. M. Day (ed.) |
| title_short | Molecular genetic epidemiology |
| title_sort | molecular genetic epidemiology a laboratory perspective |
| title_sub | a laboratory perspective ; |
| topic | Epidemiologia larpcal Epidemiologie gtt Genetica gtt Saúde pública larpcal Épidémiologie génétique - Manuels de laboratoire Épidémiologie moléculaire - Manuels de laboratoire DNA Probes diagnostic use Genetic Techniques trends Genetic epidemiology Laboratory manuals Molecular Biology methods Molecular Epidemiology methods Molecular epidemiology Laboratory manuals Oligonucleotide Probes diagnostic use Polymorphism, Genetic Labormedizin (DE-588)4073931-4 gnd Epidemiologie (DE-588)4015016-1 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| topic_facet | Epidemiologia Epidemiologie Genetica Saúde pública Épidémiologie génétique - Manuels de laboratoire Épidémiologie moléculaire - Manuels de laboratoire DNA Probes diagnostic use Genetic Techniques trends Genetic epidemiology Laboratory manuals Molecular Biology methods Molecular Epidemiology methods Molecular epidemiology Laboratory manuals Oligonucleotide Probes diagnostic use Polymorphism, Genetic Labormedizin Molekulargenetik Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009530172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT dayiannm moleculargeneticepidemiologyalaboratoryperspective |