Severe asthma: pathogenesis and clinical management
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Dekker
2001
|
| Ausgabe: | 2. ed., rev. and expanded |
| Schriftenreihe: | Lung biology in health and disease
159 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 673 S. Ill., graph. Darst. |
| ISBN: | 0824705521 |
Internformat
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| 245 | 1 | 0 | |a Severe asthma |b pathogenesis and clinical management |c ed. by Stanley J. Szefler ... |
| 250 | |a 2. ed., rev. and expanded | ||
| 264 | 1 | |a New York [u.a.] |b Dekker |c 2001 | |
| 300 | |a XXIV, 673 S. |b Ill., graph. Darst. | ||
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| 650 | 2 | |a Asthme | |
| 650 | 7 | |a Asthme |2 ram | |
| 650 | 7 | |a Astma |2 gtt | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Asthma |x physiopathology | |
| 650 | 4 | |a Asthma |x therapy | |
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Datensatz im Suchindex
| _version_ | 1804128771016491008 |
|---|---|
| adam_text | CONTENTS
Series Introduction m
Preface v
Contributors be
Part One PATHOPHYSIOLOGY
1. Asthma as a Progressive Disease: Pulmonary and
Epidemiological Insights 1
Scott T. Weiss
I. Introduction 1
II. Relationship of Symptoms to Lung Function 2
III. Growth and Decline Curve 4
IV. Diagnosis of Asthma as a Function of Age 5
V. Relationship of Asthma to Chronic Obstructive
Pulmonary Disease 14
VI. Summary 16
References 16
xv
xw Contents
2. Genetic Influences on Asthma Severity 19
John W. Holloway, Steuart Rorke, Bianca Beghe, and Stephen
T. Holgate
I. Introduction 19
II. Phenotypes for Measuring Asthma Severity 20
III. Is Asthma Severity Heritable? 23
IV. Linkage and Association Studies of Asthma Severity 24
V. Genetic Influences on the Effectiveness of Therapy 31
VI. Conclusions 32
References 32
3. Pulmonary Physiology of Severe Asthma in Children
and Adults 39
Gary L. Larsen, Gwendolyn S. Kerby, and Charles G. Irvin
I. Introduction 39
II. Airway Responsiveness 40
III. Lung Mechanics 47
IV. Arterial Blood Gases 55
V. Conclusions 59
References 60
4. Inflammatory Mediators and Neural Mechanisms in Severe
Asthma 67
Peter J. Barnes
I. Introduction 67
II. Inflammatory Mediators 68
III. Cytokines 73
IV. Neural Mechanisms 77
V. Conclusions 80
References 81
5. Role of Airway Remodeling in Severe Asthma 89
Sophie Molet and Qutayba Hamid
I. Introduction 89
II. Somatic Components of Asthma 90
III. Effects of Treatment on Airway Remodeling 108
IV. Conclusion 108
References 109
Contents xva
Part Two CLINICAL PHARMACOLOGY
6. Pharmacological Management of Severe Asthma 125
Stanley J. Szefler
I. Introduction 125
II. What Are the Goals of Management for the Patient with
Severe Asthma? 125
III. What Do We Know? 126
IV. What Do We Need to Know? 143
V. How Do We Get the Answers? 146
VI. Conclusions 147
References 147
7. Leukotrienes and Antileukotriene Therapy in Severe
Asthma 153
Sally E. Wenzel
I. Introduction 153
II. The Leukotriene Pathway 153
III. Evidence for Leukotriene Involvement in Severe Asthma 155
IV. Usefulness of Antileukotriene Therapy in Severe Asthma 157
V. Antileukotriene Therapy and the Prevention of Disease
Progression 160
VI. Suggestions for the Use of Antileukotriene Therapy in
Patients with Severe Asthma 161
References 161
8. Molecular Mechanisms of Glucocorticoid Action 167
John W. Bloom
I. Introduction 167
II. Glucocorticoid Receptors 168
III. Glucocorticoid Targets in Asthma 176
IV. Repression of Gene Expression by Glucocorticoids 178
V. Summary and Perspectives 184
References 185
9. Nocturnal Asthma as a Component of Severe Asthma 195
E. Rand Sutherland and Richard J. Martin
I. Introduction 195
II. What Is Nocturnal Asthma? 195
III. Pathophysiology of Nocturnal Asthma 196
xviii Contents
IV. Inflammatory Mechanisms of Nocturnal Asthma 197
V. Physiologic Variations in Nocturnal Asthma 203
VI. Epidemiology of Nocturnal Asthma 207
VII. Morbidity and Mortality in Nocturnal Asthma 208
VIII. Therapeutic Considerations in Nocturnal Asthma 209
IX. Conclusion 216
References 216
10. Complementary and Alternative Therapies for Asthma 221
Esther L. Langmack
I. Introduction 221
II. CAM for Asthma 222
III. Botanicals 223
IV. Homeopathy 227
V. Acupuncture 228
VI. Yoga and Hypnosis 230
VII. Dietary Modifications 231
VIII. Conclusions 233
References 233
Part Three MANAGEMENT PRINCIPLES
11. Gastroesophageal Reflux in Severe Asthma 239
Donna L. Bratton and Philip D. Hanna
I. Introduction 239
II. GERD Prevalence in the Normal Population
and in Asthma 240
III. The Vicious Cycle of Asthma and GERD 243
IV. Diagnosis of GERD in the Patient with Severe Asthma 253
V. Asthma Outcomes with Treatment of GERD 254
VI. Conclusions 258
References 258
12. Application of Imaging Procedures in the Diagnosis and
Management of Severe Asthma 271
Steven P. Jensen, David A. Lynch, and John D. Newell, Jr.
I. Introduction 271
II. Medical Imaging Tools in the Assessment of Severe
Asthma 271
III. Indications for Imaging in Severe Asthma 274
Contents x{x
IV. Key Imaging Findings in Severe Asthma 277
V. Imaging the Complications of Asthma 286
VI. Detection of Conditions Which May Mimic Severe
Asthma 292
VII. Conclusion 296
References 297
13. Chronic Infection and Severe Asthma 303
David N. Pham and Monica Kraft
I. Introduction 303
II. Chlamydia pneumoniae 304
III. Mycoplasma pneumoniae 311
IV. Serologic, Culture, and Polymerase Chain Reaction
Testing 314
V. Role of Antibiotic Testing 316
VI. Conclusion 318
References 318
14. Sleep Disorders in Severe Asthma 323
Robert D. Ballard
I. Introduction 323
II. Sleep and Upper Airway Function 324
III. Obstructive Sleep Apnea and Awake Airway Function
in Patients Without Other Respiratory Disease 325
IV. Obstructive Sleep Apnea and Asthma 325
V. Sleep, Airflow Resistance, Lung Volume, and
Intrapulmonary Blood Volume in Asthmatics with
Nocturnal Worsening 328
VI. The Effect of Sleep and Circadian Rhythms on Rhinitis:
Implications for Asthmatic Patients 332
VII. Disturbed Sleep in Asthmatics 334
VIII. Conclusion 336
References 337
15. Allergen Specific Therapy for Severe Asthma 343
Tina K. Hatley, Judith A. Woodfolk, George A. Ward, and
Thomas A. E. Platts Mills
I. Introduction 343
II. Inhalant Allergens 346
xx Contents
III. Fungal Colonization and Sensitization as a Complication
of (or Cause of) Severe Asthma 350
IV. Sinusitis 352
V. Immunotherapy 353
VI. Diet 354
VII. Conclusion 354
References 355
16. Aspirin, Nonsteroidal Anti Inflammatory Drugs, and
Preservatives as Causes for Severe Asthma 361
Donald D. Stevenson
I. Introduction 361
II. Concept and Clinical Features of Aspirin Sensitive
Respiratory Disease 362
III. Pathogenesis 364
IV. Detection of Aspirin Sensitive Respiratory Disease 366
V. Prevalence of Aspirin Sensitive Respiratory Disease 368
VI. Reactions and Cross Reactions Between ASA and
NSAIDS 369
VII. Pathogenesis of ASA and NSAID Induced Respiratory
Reactions 370
VIII. Cross Reactions with Aspirin 370
IX. Lack of Cross Reactions with Aspirin 372
X. Aspirin Desensitization 376
XI. Mechanisms of Aspirin Densensitization 376
XII. Treatment 377
References 382
17. Occupational Asthma: Spectrum of Severity and
Implications for Management 389
Ron Balkissoon
I. Introduction 389
II. Work Related Asthma: Definitions and Classifications 390
III. Reports of Severe and Fatal Asthma Attacks in the
Work Environment 390
IV. Epidemiological Aspects of Occupational Asthma 392
V. Host Risk Factors 393
VI. Socioeconomic Consequences of Occupational Asthma 394
VII. Etiological Agents of Occupational Asthma 395
VIII. Pathophysiology 398
IX. Clinical Assessment 399
Contents xxi
X. Management 407
XI. Prognosis 408
XII. Prevention 408
XIII. Workers Compensation 409
XIV. Impairment and Disability Evaluations 409
XV. Conclusions 410
References 411
18. Clinical Significance of Rhinosinusitis in Severe Asthma
and Its Management 419
Daniel L. Hamilos
I. Introduction 419
II. Definition of Rhinosinusitis 419
III. Spectrum and Prevalence of Rhinosinusitis and Asthma 420
IV. Inflammatory Mechanisms in Chronic Rhinosinusitis 422
V. Mechanisms of Association 426
VI. Nasobronchial or Sinobronchial Reflexes in
Bronchospasm 426
VII. Postnasal Drainage (Pulmonary Aspiration of Sinonasal
Secretions) 427
VIII. Pharyngobronchial Reflexes 428
IX. Shared Pathogenesis or Common Mucosal
Susceptibility 429
X. Systemic Amplification 433
XL Therapeutic Interventions in Rhinosinusitis and Their
Impact on Severe Asthma 436
XII. Management of Rhinosinusitis in Severe Asthma 439
XIII. The Special Case of Allergic Fungal Sinusitis and
Associated Asthma 441
XIV. The Special Case of Aspirin Sensitivity/Nasal Polyposis
and Asthma 443
XV. Summary and Conclusions 443
References 444
19, Monitoring Activity of Severe Asthma 453
Richard Leigh, Margaret M. Kelly, and Frederick E. Hargreave
I. Introduction 453
II. Principles in the Monitoring of Severe Asthma 455
III. Symptoms 456
IV. Spirometry 457
V. Peak Expiratory Flow 457
xxii Contents
VI. Airway Hyperresponsiveness 459
VII. Measurement of Airway Inflammation 460
VIII. Conclusions 465
References 465
20. Psychosocial Aspects of Severe Asthma in Children 471
Marianne Z. Wamboldt and Frederick S. Wamboldt
I. Introduction 471
II. Genetic and Environmental Interplay in the Onset and
Course of Asthma 473
III. The Role of Individual Psychological Factors in Asthma
Outcome 476
IV. The Success of Treatment in Severely 111 Asthmatic
Children Is Related to Family Functioning 480
V. Treatment Adherence Is the Likely Mediator Between
Psychosocial Factors and Asthma Treatment Outcome 484
VI. Evaluation and Management Issues 488
VII. Conclusion 495
References 495
21. Growth Impairment Related to Severe Asthma 505
David B. Allen
I. Introduction 505
II. Normal Growth 506
III. Chronic Diseases and Growth: General Pathophysiology 507
IV. Effects of Severe Asthma on Growth 509
V. Effects of Glucocorticoids on Growth 512
VI. Growth of Asthmatic Children Treated with Oral
Glucocorticoids 515
VII. Growth of Asthmatic Children Treated with Inhaled
Glucocorticoids 516
VIII. Summary 526
References 527
22. Steroid Induced Osteoporosis: Prevention and Management 533
Dennis K. Ledford
I. Introduction 533
II. Definitions 533
III. Epidemiology 535
IV. Pathophysiology of Corticosteroid Related Osteoporosis 540
Contents xxiu
V. Diagnosis and Assessment 541
VI. Epidemiology of Systemic Corticosteroid Therapy
and Osteoporosis 547
VII. Epidemiology of Inhaled Corticosteroid Therapy
and Osteoporosis 548
VIII. Treatment of Osteoporosis 551
IX. Risk Stratification of Subjects with Asthma 560
X. Summary 564
References 565
23. Management of Severe Asthma 575
Antonio M. Vignola, Pascal Chanez, and Jean Bousquet
I. Introduction 575
II. Reasons for Asthma Treatment Failure 576
III. Therapeutic Options for Severe Asthma 577
IV. Churg Strauss Syndrome 585
V. Management of Patients with Severe Asthma 585
VI. Conclusions 587
References 587
24. Steroid Resistant Asthma: New Insights and Implications
for Management 597
Donald Y. M. Leung, Joseph D. Spahn, and Stanley J. Szefler
I. Introduction 597
II. Definition of Steroid Resistant Asthma 598
III. Immune Responses in Steroid Resistant Asthma 599
IV. Mechanisms of Corticosteroid Action 601
V. Glucocorticoid Receptor Abnormalities in Steroid
Resistant Asthma 601
VI. Molecular Mechanisms of Steroid Resistant Asthma 603
VII. Factors Contributing to Corticosteroid Resistance 604
VIII. Management of Steroid Resistant Asthma 610
References 615
25. Prevention of Severe Asthma: Promising Opportunities 621
Stanley J. Szelfer and Donald Y. M. Leung
I. Introduction 621
II. Can We Reverse the Course of Severe Asthma Once It
Is Established? 622
xxxv Contents
III. Can We Interrupt the Course of Severe Asthma to Halt
Progression to Increasing Severity? 626
IV. Summary 633
References 633
Author Index 637
Subject Index 659
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| language | English |
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| spelling | Severe asthma pathogenesis and clinical management ed. by Stanley J. Szefler ... 2. ed., rev. and expanded New York [u.a.] Dekker 2001 XXIV, 673 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 159 Asthme Asthme ram Astma gtt Asthma Asthma physiopathology Asthma therapy Bronchialasthma (DE-588)4069674-1 gnd rswk-swf Bronchialasthma (DE-588)4069674-1 s DE-604 Szefler, Stanley J. 1948- Sonstige (DE-588)132844338 oth Lung biology in health and disease 159 (DE-604)BV000008326 159 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009529620&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Severe asthma pathogenesis and clinical management Lung biology in health and disease Asthme Asthme ram Astma gtt Asthma Asthma physiopathology Asthma therapy Bronchialasthma (DE-588)4069674-1 gnd |
| subject_GND | (DE-588)4069674-1 |
| title | Severe asthma pathogenesis and clinical management |
| title_auth | Severe asthma pathogenesis and clinical management |
| title_exact_search | Severe asthma pathogenesis and clinical management |
| title_full | Severe asthma pathogenesis and clinical management ed. by Stanley J. Szefler ... |
| title_fullStr | Severe asthma pathogenesis and clinical management ed. by Stanley J. Szefler ... |
| title_full_unstemmed | Severe asthma pathogenesis and clinical management ed. by Stanley J. Szefler ... |
| title_short | Severe asthma |
| title_sort | severe asthma pathogenesis and clinical management |
| title_sub | pathogenesis and clinical management |
| topic | Asthme Asthme ram Astma gtt Asthma Asthma physiopathology Asthma therapy Bronchialasthma (DE-588)4069674-1 gnd |
| topic_facet | Asthme Astma Asthma Asthma physiopathology Asthma therapy Bronchialasthma |
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