Nuclear transport:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Berlin ; Heidelberg ; New York ; Barcelona ; Hong Kong ; London
Springer
2001
|
Schriftenreihe: | Results and problems in cell differentiation
35 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XIII, 197 S. Ill., graph. Darst. |
ISBN: | 3540423680 |
Internformat
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245 | 1 | 0 | |a Nuclear transport |c Karsten Weis (ed.) |
264 | 1 | |a Berlin ; Heidelberg ; New York ; Barcelona ; Hong Kong ; London |b Springer |c 2001 | |
300 | |a XIII, 197 S. |b Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
490 | 1 | |a Results and problems in cell differentiation |v 35 | |
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adam_text |
CONTENTS
THE
STRUCTURE
AND
COMPOSITION
OF
THE
YEAST
NPC
CATERINA
STRAMBIO-DE-CASTILLIA
AND
MICHAEL
P.
ROUT
1
INTRODUCTION
.
1
2
OVERVIEW
OF
THE
YEAST
NPC
STRUCTURE
.
2
3
YEAST
NUCLEOPORINS:
WHAT
'
S
NUP,
WHAT
'
S
NOT
.
4
3.1
GENERAL
CHARACTERISTICS
OF
YEAST
NUCLEOPORINS
.
4
3.1.1
FG
NUCLEOPORINS
.
5
3.1.2
NON-FG
NUCLEOPORINS
.
6
3.1.3
PORE
MEMBRANE
PROTEINS
.
7
3.2
OTHER
CONSERVED
DOMAINS
AMONG
YEAST
NUCLEOPORINS
.
7
4
THE
YEAST
NPC
AS
A
DYNAMIC
STRUCTURE
.
8
4.1
ALTERATIONS
OF
NPC
STRUCTURE
DURING
NUCLEOCYTOPLASMIC
TRANSPORT
.
8
4.2
NPC
BIOGENESIS
.
8
4.3
MOVEMENT
OF
YEAST
NPCS
IN
THE
NE
.
10
4.4
REGULATION
OF
NUCLEOCYTOPLASMIC
TRANSPORT
DURING
THE
CELL
CYCLE
.
10
5
PUTTING
IT
ALL
TOGETHER:
THE
INTERNAL
ORGANIZATION
OF
THE
YEAST
NPC
.
10
5.1
ARCHITECTURAL
ORGANIZATION
OF
NUCLEOPORINS
.
10
5.2
INTERACTIONS
BETWEEN
NUCLEOPORINS
.
12
6
FUNCTIONAL
ENVIRONMENT
OF
THE
YEAST
NPC:
THE
INTERACTIONS
WITH
ITS
NEIGHBORS
.
14
7
MECHANISM
OF
NUCLEOCYTOPLASMIC
TRANSPORT
.
16
REFERENCES
.
17
THE
VERTEBRATE
NUCLEAR
PORE
COMPLEX:
FROM
STRUCTURE
TO
FUNCTION
BIRTHE
FAHRENKROG
AND
UELI
AEBI
1
INTRODUCTION
.
25
2
TOWARD
THE
THREE-DIMENSIONAL
ARCHITECTURE
OF
THE
NUCLEAR
PORE
COMPLEX
.
.'
26
3
MOLECULAR
CONSTITUENTS
OF
THE
NUCLEAR
PORE
COMPLEX:
THE
NUCLEOPORINS
.
29
4
WHAT
IS
THE
FUNCTIONAL
SIGNIFICANCE
OF
THE
MULTIPLE
LOCATIONS
OF
NUCLEOPORINS?
.
35
X
CONTENTS
5
FROM
NUCLEAR
PORE
COMPLEX
STRUCTURE
TO
NUCLEOCYTOPLASMIC
TRANSPORT
.
37
6
CONCLUDING
REMARKS
.
42
REFERENCES
.
43
HOW
RAN
IS
REGULATED
F.
RALF
BISCHOFF,
KLAUS
SCHEFFZEK,
AND
HERWIG
PONSTINGL
1
RAN
BELONGS
TO
THE
SUPERFAMILY
OF
RAS-RELATED
PROTEINS
.
49
2
RAN
.
50
3
STIMULATION
OF
GUANINE
NUCLEOTIDE
EXCHANGE
BY
RANGEF
.
52
4
INDUCTION
OF
THE
RAN
GTPASE
BY
RANGAP
.
53
5
ROLE
OF
RAN
IN
PROTEIN
IMPORT
.
54
6
EFFECTS
OF
IMPORTIN-P-RELATED
PROTEINS
ON
THE
ACTIVITIES
OF
RAN
.
55
7
RECYCLING
OF
EXPORTED
IMPORT
FACTORS
BY
RANBPL/RANBP2
.
56
8
EXPORT
OF
MACROMOLECULES
FROM
THE
NUCLEUS
.
58
9
ROLE
OF
RANBP3
IN
EXPORTIN
1
-MEDIATED
EXPORT
.
59
10
IMPORT
OF
RAN
INTO
THE
NUCLEUS
.
60
11
MOGI
INDUCES
RELEASE
OF
GTP
FROM
RAN
.
60
12
RANGTP
IN
MITOSIS
.
61
REFERENCES
.
61
EXPORTIN-MEDIATED
NUCLEAR
EXPORT
OF
PROTEINS
AND
RIBONUCLEOPROTEINS
MAARTEN
FORNEROD
AND
MUTSUHITO
OHNO
1
INTRODUCTION
.
67
2
RAN
IS
KING
.
68
3
EXPORTINS
.
68
4
CRML/EXPORTIN-1
.
70
4.1
LEPTOMYCIN
B
AND
CRM1
.
70
4.2
LEUCINE-RICH
NUCLEAR
EXPORT
SIGNALS
.
72
4.3
REGULATION
OF
LEUCINE-RICH
NUCLEAR
EXPORT
SIGNALS
.
72
4.4
THREE-DIMENSIONAL
STRUCTURE
OF
THE
NUCLEAR
EXPORT
SIGNAL
.
74
4.5
NON-CONSENSUS
NUCLEAR
EXPORT
SIGNALS
.
74
4.6
EXPORT
OF
RANBPL
AND
RANGAP
.
75
4.7
NES
AND
RANGTP
INTERACTION
DOMAINS
IN
CRM1
.
76
4.8
ADDITIONAL
SOLUBLE
FACTORS
THAT
MAY
BE
REQUIRED
FOR
NES
EXPORT
.
77
5
EXPORTIN-MEDIATED
EXPORT
OF
RIBONUCLEOPROTEINS
.
77
5.1
NUCLEAR
EXPORT
OF
U
SNRNAS
.
78
5.2
NUCLEAR
EXPORT
OF
5S
RRNA
.
80
5.3
IS
CRM1
AN
EXPORT
FACTOR
FOR
MRNAS?
.
80
6
EXPORTIN-4
.
81
CONTENTS
XI
7
MSN5/EXPORTIN-5
.
81
8
INTERACTION
OF
EXPORTINS
WITH
THE
NUCLEAR
PORE
COMPLEX
.
82
9
PERSPECTIVES
.
84
REFERENCES
.
85
STRUCTURES
OF
IMPORTINS
ELENA
CONTI
1
INTRODUCTION
.
93
2
NLS
RECOGNITION:
ASSOCIATION
WITH
A
.
95
3
CARGO
BINDING
TO
THE
RECEPTOR:
IMPORTIN-P-BINDING
ASSOCIATION
WITH
0
.
100
4
CARGO
RELEASE:
RANGTP
BINDING
TO
P
AND
P2
.
103
5
NUCLEAR
PORE
COMPLEX
DOCKING
.
108
6
FROM
STATIC
SNAPSHOTS
TO
A
DYNAMIC
PICTURE
.
110
ADDENDUM
.
ILL
REFERENCES
.
ILL
NUCLEAR
EXPORT
OF
TRNA
GEORGE
SIMOS,
HELGE
GROFIHANS,
AND
ED
HURT
1
INTRODUCTION
.
115
2
TRNA
PROCESSING:
PREPARATION
TO
EXIT
THE
NUCLEUS?
.
117
3
A
DISTINCT
PATHWAY
FOR
THE
NUCLEAR
EXPORT
OF
MATURE
TRNA
.
118
4
IDENTIFICATION
OF
LOSLP/XPO-T
AS
A
NUCLEAR
EXPORT
RECEPTOR
FOR
TRNA
.
119
5
STRUCTURAL
REQUIREMENTS
FOR
THE
XPO-T/TRNA
INTERACTION:
A
PROOFREADING
MECHANISM?
.
122
6
AN
ALTERNATIVE
NUCLEAR
TRNA
EXPORT
PATHWAY
AND
THE
ROLE
OF
AMINOACYLATION
.
123
7
NUCLEAR
TRNA
EXPORT
AS
A
REGULATORY
MECHANISM?
.
126
8
CONCLUDING
REMARKS
.
127
REFERENCES
.
128
NUCLEAR
EXPORT
OF
MESSENGER
RNA
ELISA
IZAURRALDE
1
INTRODUCTION
.
133
2
RAE1/GLE2P
AND
TAP/MEX67P
MAY
FUNCTION
AS
NUCLEAR
EXPORT
RECEPTORS
FOR
MRNA
.
134
2.1
ROLE
OF
HRAEL/GLE2P
IN
MRNP
NUCLEAR
EXPORT
.
135
2.2
TAP
AND
MEX67P
BELONG
TO
THE
CONSERVED
FAMILY
OF
NUCLEAR
EXPORT
FACTOR
PROTEINS
.
136
2.2.1
NXF
PROTEINS
ACT
AS
HETERODIMERS
.
137
XII
CONTENTS
2.2.2
INTERACTION
OF
NXF
PROTEINS
WITH
THE
NPC
.
138
2.2.3
BINDING
OF
NXF
PROTEINS
TO
RNRNPS
.
139
3
ROLE
OF
HNRNP-LIKE
PROTEINS
IN
MRNA
EXPORT
.
141
3.1
HNRNP-LIKE
PROTEINS
MAY
RECRUIT
NXFS
TO
MRNP
COMPLEXES
.
141
4
EXPORT
OF
SPLICED
AND
UNSPLICED
MRNAS
.
142
5
DISASSEMBLY
OF
EXPORT
COMPLEXES
AND
RECYCLING
OF
EXPORT
FACTORS:
THE
ROLE
OF
DBP5
.
143
5.1
THE
TERMINAL
STEP
OF
THE
MRNP
EXPORT
PROCESS
MAY
OCCUR
AT
THE
CYTOPLASMIC
FIBRILS
OF
THE
NPC
.
144
6
PERSPECTIVES
.
145
REFERENCES
.
146
USING
RETROVIRUSES
TO
STUDY
THE
NUCLEAR
EXPORT
OF
MRNA
BRYAN
R.
CULLEN
1
NUCLEAR
MRNA
EXPORT
AND
THE
RETROVIRAL
LIFE
CYCLE
.
151
2
CRML-DEPENDENT
RETROVIRAL
MRNA
EXPORT
.
152
2.1
THE
HUMAN
IMMUNODEFICIENCY
VIRUS
REV
PROTEIN
.
152
2.2
THE
HUMAN
T-CELL
LEUKEMIA
VIRUS
REX
PROTEIN
.
158
2.3
THE
HUMAN
ENDOGENOUS
RETROVIRUS
K
K-REV
PROTEIN
.
159
3
TAP-DEPENDENT
RETROVIRAL
MRNA
EXPORT
.
160
4
OTHER
RETROVIRUSES,
OTHER
PATHWAYS?
.
163
REFERENCES
.
164
REGULATED
NUCLEAR
TRANSPORT
CHRISTOPH
SCHULLER
AND
HELMUT
RUIS
1
INTRODUCTION
.
169
2
PROTEIN
KINASES
.
170
2.1
MAP
KINASES:
CONTROL
OF
NUCLEAR
CONCENTRATION
BY
DUAL
PHOSPHORYLATION,
BY
NUCLEAR
RETENTION
AND
BY
REGULATED
EXPORT
.
171
2.1.1
MAP
KINASES
REQUIRE
DUAL
PHOSPHORYLATION
FOR
NUCLEAR
ACCUMULATION
.
171
2.1.2
MAPK
NUCLEAR
IMPORT
AND
EXPORT
ARE
ACTIVE
PROCESSES
.
172
2.1.3
NUCLEAR
EXPORT
REQUIRES
MAPK
ACTIVITY
AND
IS
CORRELATED
WITH
MAPK
DEPHOSPHORYLATION
.
173
2.1.4
RETENTION
CONTRIBUTES
TO
NUCLEAR
ACCUMULATION
.
173
2.1.5
SUMMARY
.
174
2.2
PROTEIN
KINASE
A
.
174
2.2.1
MAMMALIAN
PKA:
EXTRANUCLEAR
ANCHORING,
DIFFUSION
TO
THE
NUCLEUS,
AND
ACTIVE
NUCLEAR
EXPORT
.
174
2.2.2
BUDDING
YEAST
PKA:
NUCLEAR
IN
RAPIDLY
GROWING
CELLS,
NUCLEOCYTOPLASMIC
IN
SLOWLY
OR
NON-GROWING
CELLS
.
175
CONTENTS
XIII
3
TRANSCRIPTION
FACTORS
.
176
3.1
SWI5:
REGULATED
NUCLEAR
IMPORT
AND
NUCLEAR
DEGRADATION
.
176
3.2
PHO4:
SWITCH-LIKE
REGULATION
OF
A
SHUTTLING
PROTEIN
BY
PHOSPHORYLATION
.
177
3.3
MIGL
AND
MSN2/4:
VARIATIONS
OF
THE
PHO4
THEME?
.
178
3.4
NF
K
B:
CONTROL
BY
NLS
MASKING
AND
PIGGYBACK
NUCLEAR
EXPORT
.
179
3.5
P53:
NES
MASKING
BY
HOMOTETRAMERIZATION
VERSUS
SYNERGISTIC
EFFECTS
ON
EXPORT
BY
HETERODIMER
FORMATION?
.
179
3.6
NF-AT:
NLS
MASKING
BY
PHOSPHORYLATION
AND
NUCLEAR
EXPORT
CONTROL
BY
EXPORTIN-PHOSPHATASE
COMPETITION
.
180
3.7
YAPL:
MODIFICATION
BY
OXIDATION
AS
AN
ALTERNATIVE
TO
PHOSPHORYLATION?
.
181
3.8
HIF1:
HYPOXIA
CONTROL
OF
AN
NLS
AND
OF
AN
OVERLAPPING
ACTIVATION
DOMAIN
.
181
3.9
CYCLIN
BL:
PIGGYBACK
NUCLEAR
UPTAKE
AND
AN
NES
OVERLAPPING
WITH
A
CYTOPLASMIC
RETENTION
SIGNAL
.
182
3.10
WNT
SIGNALING
TO
THE
NUCLEUS
BY
PREVENTING
(3-CATENIN
DEGRADATION
.
182
3.11
NOTCH:
RELEASE
OF
A
SOLUBLE
TRANSCRIPTION
FACTOR
BY
PROTEOLYTIC
CLEAVAGE
OF
A
TRANSMEMBRANE
PROTEIN
.
183
3.12
LIGHT
REGULATION
IN
PLANTS:
LIGHT-INDUCED
NUCLEAR
LOCALIZATION
OF
A
PHOTORECEPTOR
AND
LIGHT
ACTIVATED
NUCLEAR
EXPORT
OF
A
REPRESSOR
.
183
3.13
GLUCOCORTICOID
RECEPTOR
(GR):
CONTROL
OF
NUCLEAR
IMPORT
BY
DISSOCIATION
OF
A
COMPLEX
WITH
HSP
-
OR
SHUTTLING
OF
A
GR-HSP
COMPLEX?
.
184
4
STRESS
REGULATION
OF
NUCLEAR
MRNA
EXPORT
.
184
5
SOME
GENERAL
CONCLUSIONS
.
184
REFERENCES
.
185
SUBJECT
INDEX
.
191 |
any_adam_object | 1 |
building | Verbundindex |
bvnumber | BV013909809 |
classification_rvk | WE 5400 |
classification_tum | BIO 180f BIO 200f BIO 220f |
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discipline | Biologie |
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genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
genre_facet | Aufsatzsammlung |
id | DE-604.BV013909809 |
illustrated | Illustrated |
indexdate | 2024-08-24T00:41:47Z |
institution | BVB |
isbn | 3540423680 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009517415 |
oclc_num | 248017661 |
open_access_boolean | |
owner | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-12 DE-20 |
owner_facet | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-12 DE-20 |
physical | XIII, 197 S. Ill., graph. Darst. |
publishDate | 2001 |
publishDateSearch | 2001 |
publishDateSort | 2001 |
publisher | Springer |
record_format | marc |
series | Results and problems in cell differentiation |
series2 | Results and problems in cell differentiation |
spelling | Nuclear transport Karsten Weis (ed.) Berlin ; Heidelberg ; New York ; Barcelona ; Hong Kong ; London Springer 2001 XIII, 197 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Results and problems in cell differentiation 35 Stofftransport Biologie (DE-588)4443397-9 gnd rswk-swf Zellkern (DE-588)4067544-0 gnd rswk-swf Proteintransport (DE-588)4273577-4 gnd rswk-swf RNS (DE-588)4076759-0 gnd rswk-swf Eukaryontische Zelle (DE-588)4153142-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Eukaryontische Zelle (DE-588)4153142-5 s Zellkern (DE-588)4067544-0 s Proteintransport (DE-588)4273577-4 s DE-604 RNS (DE-588)4076759-0 s Stofftransport Biologie (DE-588)4443397-9 s Weis, Karsten Sonstige oth Results and problems in cell differentiation 35 (DE-604)BV000022913 35 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009517415&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Nuclear transport Results and problems in cell differentiation Stofftransport Biologie (DE-588)4443397-9 gnd Zellkern (DE-588)4067544-0 gnd Proteintransport (DE-588)4273577-4 gnd RNS (DE-588)4076759-0 gnd Eukaryontische Zelle (DE-588)4153142-5 gnd |
subject_GND | (DE-588)4443397-9 (DE-588)4067544-0 (DE-588)4273577-4 (DE-588)4076759-0 (DE-588)4153142-5 (DE-588)4143413-4 |
title | Nuclear transport |
title_auth | Nuclear transport |
title_exact_search | Nuclear transport |
title_full | Nuclear transport Karsten Weis (ed.) |
title_fullStr | Nuclear transport Karsten Weis (ed.) |
title_full_unstemmed | Nuclear transport Karsten Weis (ed.) |
title_short | Nuclear transport |
title_sort | nuclear transport |
topic | Stofftransport Biologie (DE-588)4443397-9 gnd Zellkern (DE-588)4067544-0 gnd Proteintransport (DE-588)4273577-4 gnd RNS (DE-588)4076759-0 gnd Eukaryontische Zelle (DE-588)4153142-5 gnd |
topic_facet | Stofftransport Biologie Zellkern Proteintransport RNS Eukaryontische Zelle Aufsatzsammlung |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009517415&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV000022913 |
work_keys_str_mv | AT weiskarsten nucleartransport |