Systemic dermatologic therapy:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2001
|
| Schriftenreihe: | Dermatologic clinics
19,1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 219 S. Ill. |
Internformat
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| 245 | 1 | 0 | |a Systemic dermatologic therapy |c Norman Levine, guest ed. |
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| adam_text | SYSTEMIC DERMATOLOGIC THERAPY • :
CONTENTS
Preface xiii
Norman Levine
Systemic Antibiotic Agents 1
Neil S, Sadick
This article presents an updated review of commonly used agents of
importance to the dermatologist in the treatment of bacterial infections of
the skin. It includes a detailed discussion of pharmacokinetics, dosage,
side effect profiles, and clinical indications that may be used by the clini¬
cian. It is intended to widen the scope of therapeutic alternatives that will
enable delivery of optimal care for treating cutaneous bacterial infectious
processes.
Antiviral Agents 23
Tricia J. Brown, Melody Vander Straten, and Stephen K. Tyring
More than 30 drugs are approved for the therapy of viral infections.
Although dermatologists do not routinely prescribe all of these drugs,
they will care for patients using these agents and, thus, need to be familiar
with them, and with their side effects and interactions. Most antiviral
drugs are viristatic, not viricidal; therefore it is especially important to
prevent viral diseases by public health measures and with vaccines.
Systemic Antifungal Therapy 35
Meena Moossavi, Bita Bagheri, and Richard K. Scher
There are five oral antifungal agents used in dermatology: griseofulvin,
ketoconazole, itraconazole, fluconazole, and terbinafine. These drugs are
used to treat superficial mycoses, such as tinea capitis and onychomycosis,
which do not respond to topical antifungals. Knowledge of pharmacology,
combined with clinical experience and the cost of therapy, are necessary
to select the proper drug. The search to identify new oral antifungal agents
should continue, because none of the five currently used drugs fulfill the
criteria of the ideal antifungal therapy.
VOLUME 19 • NUMBER 1 • JANUARY 2001 vii
Antihistamines 53
Malcolm W. Greaves
In the 1990s, major improvements occurred in the therapeutic index of
Hi antihistamines. The third generation compounds promise to be more
effective and nontoxic. Future major advances are likely to result from the
development and exploitation of non Hi receptor mediated antiallergenic
actions of these drugs.
Update on Systemic Glucocorticosteroids in Dermatology 63
Laura C. Williams and Lee T. Nesbitt, Jr
Glucocorticosteroids (GCSs) are the most important group of systemic
drugs in dermatology for managing inflammatory skin disorders. This
article reviews clinical usage guidelines, pharmacology, and mechanisms
of action of GCSs, with particular focus on adverse reactions to these
agents. The functioning of the hypothalamic pituitary adrenal axis also is
covered, with a discussion of ways to minimize its suppression when
GCSs are used. Recommendations are made for laboratory and radiologic
studies during therapy. Finally, essential nutritional and dietary preventive
therapy is outlined, along with possible necessary medication manage¬
ment, and appropriate medical or surgical subspecialty consultations.
Dapsone and Sulfapyridine 79
Uma Paniker and Norman Levine
Dapsone and sulfapyridine are structurally related compounds with anti¬
microbial and anti inflammatory effects. Dapsone remains the most im¬
portant drug for leprosy and is useful in the prophylaxis of Pneumocystis
pneumonia in patients with HIV disease. The medical treatment of choice
for dermatitis herpetiformis is dapsone; and sulfapyridine also can be
used for those patients who are intolerant of dapsone. Other neutrophilic
disorders also may respond to these drugs. Toxic side effects of both
dapsone and sulfapyridine are mediated through the hydroxylamine me¬
tabolite. These include hemolysis, methemoglobinemia, and agranulocyto
sis. Careful monitoring for possible adverse reactions includes frequently
performing complete blood counts and regular blood chemistry profile
determinations.
Thalidomide 87
Carrie L. Radomsky and Norman Levine
The recent US Food and Drug Administration approval of thalidomide for
use in erythema nodosum now permits its use in a variety of unrelated
dermatologic conditions. The drug s teratogenic and neuropathic effects
must be considered, however, before it is used. Strict regulatory guidelines
have been implemented to prevent another tragedy, as experienced in the
1960s. This article reviews thalidomide s pharmacology, adverse affects,
and regulatory constraints, and provides general therapeutic guidelines
for its use in various dermatologic conditions.
Antimetabolites and Cytotoxic Drugs 105
Nancy G. Silvis
Mycophenolic mofetil, azathioprine, thioguanine, methotrexate, and cy
clophosphamide were initially used for the treatment of malignancies.
Because of their immunosuppressive activity, the range of diseases respon¬
sive to these medications has expanded to include various autoimmune
CONTENTS
related diseases. Discussion includes a historical perspective of each medi¬
cation, recent updates on responsive dermatologic conditions, dosages,
monitoring guidelines, and medication expense.
Cyclosporine and Tacrolimus in Dermatology 119
Jennifer Clay Cather, William Abramovits, and Alan Menter
Immune modulators are being used with increasing frequency in dermatol¬
ogy. This article reviews two such agents, cyclosporine and tacrolimus.
Discussion emphasizes the pharmacology, side effects, and uses of these
two drugs in dermatologic disorders.
The Interf erons 139
Libby Edwards
The interferons are a group of naturally occurring biologic response mod¬
ifiers that exhibit antiviral, antiproliferative, differentiating, and immune
enhancing properties. This interesting group of compounds has been
found to be effective for the treatment of condylomata acuminata, skin
cancers, high risk melanoma, hepatitis C, mycosis fungoides, and keloid
scars. The advantages of these agents must be weighed against their
toxicities, the number of treatments, and cost.
Antimalarials 147
Marta J. Van Beek and Warren W. Piette
Antimalarial medications have become the parenteral drugs of choice for
treating the cutaneous manifestations of lupus erythematosus. The im¬
mune modulating activity of these agents makes them useful in a variety
of other dermatoses. With prudent dosage and monitoring, these agents
can be used safely and effectively in the treatment and management of
dermatologic disease.
Systemic Retinoid Therapy 161
John J. DiGiovanna
Systemic retinoids are widely used in dermatology. They are among the
most effective drugs available for several severe dermatoses. This article
reviews the systemic retinoids, with particular reference to their use in
dermatology. The history of their development and use, relevant com¬
pounds, their indications and toxicities, and how they are used in the
management of severe skin disorders are explained and discussed.
Hormonal Therapy in Dermatology 169
James C. Shaw
Hormonal therapy in dermatology is used primarily to reverse or diminish
the effect of androgens, which are responsible for causing acne, hirsutism,
and androgenetic alopecia. Although hormonal therapy is one of many
treatments for acne, it is the only medical therapy available for hirsutism,
and likely the only hope for the successful medical treatment of androgen¬
etic alopecia. This article addresses the pathophysiologic rationale for the
use of hormonal therapies in dermatology, the patients, the diseases for
which they are used, the drugs most used, and what pretreatment evalua¬
tion should be considered.
CONTENTS ix
Neurotropic and Psychotropic Drugs in Dermatology 179
Heath Tennyson and Norman Levine
Several psychotropic and neurotropic agents are useful in treating patients
with skin diseases such as obsessive compulsive skin manipulation, delu¬
sions of parasitosis, generalized pruritus, and post herpetic neuralgia. The
mechanism of action of these agents is based on their interaction with
central and peripheral neuronal receptors. The medications discussed in
this article include the tricyclic antidepressants, serotonin reuptake inhibi¬
tors, naltrexone, pimozide, and gabapentin. The pharmacology, mechanism
of action, adverse effects, drug interactions, and monitoring guidelines are
outlined for each of these drugs.
Current Therapy
Introduction to Facial Flaps 199
Joel Cook
The increasing evidence of facial nonmelanoma skin cancer requires that
the dermatologic surgeon be knowledgeable in the reconstruction of a
variety of facial defects. Regional approaches to facial reconstruction may
provide a template for operative success.
Index 213
Subscription information Inside back cover
CONTENTS
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| series | Dermatologic clinics |
| series2 | Dermatologic clinics |
| spelling | Systemic dermatologic therapy Norman Levine, guest ed. Philadelphia [u.a.] Saunders 2001 X, 219 S. Ill. txt rdacontent n rdamedia nc rdacarrier Dermatologic clinics 19,1 Face - Chirurgie Maladies de la peau - Traitement médicamenteux Produits dermatologiques Dermatologic Agents Face surgery Skin Diseases drug therapy Levine, Norman Sonstige oth Dermatologic clinics 19,1 (DE-604)BV000004924 19,1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009510331&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Systemic dermatologic therapy Dermatologic clinics Face - Chirurgie Maladies de la peau - Traitement médicamenteux Produits dermatologiques Dermatologic Agents Face surgery Skin Diseases drug therapy |
| title | Systemic dermatologic therapy |
| title_auth | Systemic dermatologic therapy |
| title_exact_search | Systemic dermatologic therapy |
| title_full | Systemic dermatologic therapy Norman Levine, guest ed. |
| title_fullStr | Systemic dermatologic therapy Norman Levine, guest ed. |
| title_full_unstemmed | Systemic dermatologic therapy Norman Levine, guest ed. |
| title_short | Systemic dermatologic therapy |
| title_sort | systemic dermatologic therapy |
| topic | Face - Chirurgie Maladies de la peau - Traitement médicamenteux Produits dermatologiques Dermatologic Agents Face surgery Skin Diseases drug therapy |
| topic_facet | Face - Chirurgie Maladies de la peau - Traitement médicamenteux Produits dermatologiques Dermatologic Agents Face surgery Skin Diseases drug therapy |
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