Neurotoxicity risk assessment for human health: principles and approaches
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
2001
|
| Schriftenreihe: | Environmental health criteria
223 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Mit einer Zsfassung in franz. und span. Sprache |
| Beschreibung: | XXI, 223 S. |
| ISBN: | 924157223X |
Internformat
MARC
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| 245 | 1 | 0 | |a Neurotoxicity risk assessment for human health |b principles and approaches |c first draft prep. by J. Harry ... |
| 264 | 1 | |a Geneva |b World Health Organization |c 2001 | |
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| 490 | 1 | |a Environmental health criteria |v 223 | |
| 500 | |a Mit einer Zsfassung in franz. und span. Sprache | ||
| 650 | 7 | |a Biologisch effect |2 gtt | |
| 650 | 7 | |a CHEMICAL SAFETY |2 unbist | |
| 650 | 7 | |a CHEMICALS |2 unbist | |
| 650 | 7 | |a ENVIRONMENTAL HEALTH |2 unbist | |
| 650 | 4 | |a Neurotoxicologie | |
| 650 | 4 | |a Neurotoxicologie - Aspect de l'environnement | |
| 650 | 7 | |a Neurotoxicologie |2 gtt | |
| 650 | 7 | |a Structuur-activiteit-relatie |2 gtt | |
| 650 | 7 | |a TOXIC SUBSTANCES |2 unbist | |
| 650 | 7 | |a Verbindingen (chemie) |2 gtt | |
| 650 | 4 | |a Écotoxicologie | |
| 650 | 4 | |a Évaluation du risque | |
| 650 | 4 | |a Umwelt | |
| 650 | 4 | |a Environmental Exposure | |
| 650 | 4 | |a Environmental Pollutants |x toxicity | |
| 650 | 4 | |a Environmental toxicology | |
| 650 | 4 | |a Nervous System |x drug effects | |
| 650 | 4 | |a Neurotoxicity Syndromes |x etiology | |
| 650 | 4 | |a Neurotoxicology | |
| 650 | 4 | |a Neurotoxicology |x Environmental aspects | |
| 650 | 4 | |a Risk Assessment |x methods | |
| 650 | 4 | |a Risk assessment | |
| 650 | 4 | |a Toxicology |x methods | |
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| 700 | 1 | |a Harry, J. |e Sonstige |4 oth | |
| 830 | 0 | |a Environmental health criteria |v 223 |w (DE-604)BV000011459 |9 223 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-009504845 | ||
Datensatz im Suchindex
| _version_ | 1804128732458254336 |
|---|---|
| adam_text | CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR
NEUROTOXICITY RISK ASSESSMENT FOR HUMAN
HEALTH: PRINCIPLES AND APPROACHES
PREAMBLE ix
ACRONYMS AND ABBREVIATIONS xix
1. SUMMARY AND RECOMMENDATIONS 1
1.1 Summary 1
1.2 Recommendations 4
2. INTRODUCTION 7
2.1 Purpose of the publication 7
2.2 General principles of neurotoxicity risk assessment 9
2.3 Examples of chemical induced neurotoxicity 10
2.4 Definitions and critical concepts in neurotoxicology 17
2.4.1 Neurotoxicity versus adverse effects 17
2.4.2 Direct versus indirect effects 18
2.4.3 Primary versus secondary effects 18
2.4.4 Transient versus persistent effects 19
2.4.5 Compensation 19
2.5 Assumptions in neurotoxicity risk assessment 20
2.6 Criteria for quality of data used in risk assessment 21
2.6.1 Sensitivity 22
2.6.2 Specificity 22
2.6.3 Reliability/validity 23
2.6.4 Dose response 23
3. BASIC PRINCIPLES FOR NEUROTOXICITY RISK
ASSESSMENT 25
3.1 Neurobiological principles 25
3.1.1 Structure of the nervous system 25
3.1.2 Transport processes 28
3.1.3 Ion channels 29
EHC 223: Neurotoxicity Risk Assessment for Human Health
3.1.4 Neurotransmission 3 0
3.1.5 Metabolism 32
3.1.6 Blood brain and blood nerve barriers 32
3.1.7 Regenerative ability 35
3.1.8 Neuroendocrine system 37
3.1.9 Integrative function of the nervous system 3 8
3.2 Toxicological principles 38
3.2.1 Neurotoxicity 38
3.2.2 Structure activity relationships 39
3.3 Susceptible populations 40
3.3.1 Developing nervous system 41
3.3.2 Aged nervous system 43
3.3.3 Genetic susceptibility 44
3.4 Types of effects on the nervous system 44
3.4.1 Neurotransmitter function 45
3.4.2 Morphological effects 45
3.4.3 Behaviour 46
3.5 Summary 47
4. HUMAN NEUROTOXICITY 49
4.1 Introduction 49
4.2 Methods for assessing human neurotoxicity 51
4.2.1 Clinical neurological evaluation 51
—~ 2TT2.2 Neuropsychological and neurobehavioural
Deutsche testing 52
Zentralbibliothek 4 2 21 Individual neuropsychological
... ,. .. . assessment 52
TurMeaizin 4222 Cognitivetestingbatteries 55
K°tn 4.2.2.3 Psychiatric and symptom
questionnaires 61
QQ IV/I 4.2.2.4 Behaviouralneurophysiological
*3O VI 1 tests 62
QCV ?B r 4 2 ^ Electrophysiological tests 65
4.2.4 Neuroimaging techniques 69
4.3 Types of human studies 70
4.3.1 Clinical case studies 70
4.3.2 Epidemiological studies 71
4.3.2.1 Assessment of exposure and dose 75
4.3.2.2 Causal inferences and confounding
factors 82
4.3.3 Human experimental exposure studies 85
4.3.4 Developmental human neurotoxicity studies 87
4.4 Ethical considerations in human studies 89
4.5 Summary 90
5. ANIMAL NEUROTOXICITY 92
5.1 Animal models 92
5.1.1 Role of animal models 92
5.1.2 Special considerations in animal models 93
5.1.2.1 Dosing scenario 93
5.1.2.2 Species differences 94
5.1.2.3 Other factors 95
5.1.2.4 Statistical considerations 96
5.1.2.5 Animal welfare issues 97
5.2 End points of neurotoxicity 98
5.2.1 Introduction 98
5.2.2 Behavioural end points 98
5.2.2.1 Observational batteries 101
5.2.2.2 Motor activity 104
5.2.2.3 Neuromotor function 106
5.2.2.4 Sensory function 107
5.2.2.5 Learning and memory 108
5.2.2.6 Attention 110
5.2.2.7 Schedule controlled behaviour 111
5.2.2.8 Pharmacological challenges 113
5.2.3 Neurophysiological end points 114
5.2.3.1 Peripheral nerve function studies 116
5.2.3.2 Sensory evoked potentials 117
5.2.3.3 Electroencephalography 119
5.2.3.4 Seizure activity 119
5.2.3.5 Electromyography 120
5.2.3.6 Spinal reflex excitability . 120
5.2.3.7 Ion channel function and synaptic
transmission 121
5.2.3.8 Hippocampal field potentials 121
5.2.4 Neurochemical end points 122
5.2.4.1 General biochemical measures 123
5.2.4.2 Cholinesterase inhibiting
compounds 124
5.2.4.3 Cellular protein markers 125
EHC 223: Neurotoxicity Risk Assessment for Human Health
5.2.5 Neuroendocrine end points 126
5.2.6 Structural end points 127
5.2.7 Axonal transport 135
5.3 Special issues in developmental neurotoxicity 137
5.4 In vitro methods 141
5.5 Testing strategies for neurotoxicity 144
5.6 Emerging issues 146
5.6.1 Genetic approaches to neurotoxicology 146
5.6.2 Neuroimmunotoxicology 147
5.6.3 Endocrine dysfunction/disruption 148
5.7 Summary 148
6. NEUROTOXICITY RISK ASSESSMENT 150
6.1 Introduction 150
6.2 Hazard identification 150
6.2.1 Human studies 151
6.2.2 Animal studies 151
6.2.3 Special issues 152
6.2.3.1 Animal to human extrapolation 152
6.2.3.2 Susceptible populations 152
6.2.3.3 Cumulative toxicity 152
6.2.3.4 Recovery of function 153
6.2.4 Characterization of the database and
classification schemes 154
6.3 Dose response assessment 160
6.4 Exposure assessment 166
6.5 Risk characterization 167
6.5.1 Introduction 167
6.5.2 Integration 168
6.5.3 Quality of the database 169
6.5.4 Descriptors of neurotoxicity risk 170
6.5.4.1 Estimation of the number of
individuals 170
6.5.4.2 Presentation of specific scenarios 170
6.5.4.3 Risk characterization for highly
exposed individuals 170
6.5.4.4 Risk characterization for highly
sensitive or susceptible
individuals 171
6.5.4.5 Other risk descriptors 172
6.6 Summary 173
REFERENCES 174
RESUME ET RECOMMANDATIONS 211
RESUMEN Y RECOMENDACIONES 218
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| id | DE-604.BV013891644 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T18:53:55Z |
| institution | BVB |
| isbn | 924157223X |
| language | English |
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| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spelling | Neurotoxicity risk assessment for human health principles and approaches first draft prep. by J. Harry ... Geneva World Health Organization 2001 XXI, 223 S. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 223 Mit einer Zsfassung in franz. und span. Sprache Biologisch effect gtt CHEMICAL SAFETY unbist CHEMICALS unbist ENVIRONMENTAL HEALTH unbist Neurotoxicologie Neurotoxicologie - Aspect de l'environnement Neurotoxicologie gtt Structuur-activiteit-relatie gtt TOXIC SUBSTANCES unbist Verbindingen (chemie) gtt Écotoxicologie Évaluation du risque Umwelt Environmental Exposure Environmental Pollutants toxicity Environmental toxicology Nervous System drug effects Neurotoxicity Syndromes etiology Neurotoxicology Neurotoxicology Environmental aspects Risk Assessment methods Risk assessment Toxicology methods Nervengift (DE-588)4171484-2 gnd rswk-swf Toxizitätstest (DE-588)4060540-1 gnd rswk-swf Toxikologische Bewertung (DE-588)4303356-8 gnd rswk-swf Nervengift (DE-588)4171484-2 s Toxikologische Bewertung (DE-588)4303356-8 s DE-604 Toxizitätstest (DE-588)4060540-1 s Harry, J. Sonstige oth Environmental health criteria 223 (DE-604)BV000011459 223 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009504845&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neurotoxicity risk assessment for human health principles and approaches Environmental health criteria Biologisch effect gtt CHEMICAL SAFETY unbist CHEMICALS unbist ENVIRONMENTAL HEALTH unbist Neurotoxicologie Neurotoxicologie - Aspect de l'environnement Neurotoxicologie gtt Structuur-activiteit-relatie gtt TOXIC SUBSTANCES unbist Verbindingen (chemie) gtt Écotoxicologie Évaluation du risque Umwelt Environmental Exposure Environmental Pollutants toxicity Environmental toxicology Nervous System drug effects Neurotoxicity Syndromes etiology Neurotoxicology Neurotoxicology Environmental aspects Risk Assessment methods Risk assessment Toxicology methods Nervengift (DE-588)4171484-2 gnd Toxizitätstest (DE-588)4060540-1 gnd Toxikologische Bewertung (DE-588)4303356-8 gnd |
| subject_GND | (DE-588)4171484-2 (DE-588)4060540-1 (DE-588)4303356-8 |
| title | Neurotoxicity risk assessment for human health principles and approaches |
| title_auth | Neurotoxicity risk assessment for human health principles and approaches |
| title_exact_search | Neurotoxicity risk assessment for human health principles and approaches |
| title_full | Neurotoxicity risk assessment for human health principles and approaches first draft prep. by J. Harry ... |
| title_fullStr | Neurotoxicity risk assessment for human health principles and approaches first draft prep. by J. Harry ... |
| title_full_unstemmed | Neurotoxicity risk assessment for human health principles and approaches first draft prep. by J. Harry ... |
| title_short | Neurotoxicity risk assessment for human health |
| title_sort | neurotoxicity risk assessment for human health principles and approaches |
| title_sub | principles and approaches |
| topic | Biologisch effect gtt CHEMICAL SAFETY unbist CHEMICALS unbist ENVIRONMENTAL HEALTH unbist Neurotoxicologie Neurotoxicologie - Aspect de l'environnement Neurotoxicologie gtt Structuur-activiteit-relatie gtt TOXIC SUBSTANCES unbist Verbindingen (chemie) gtt Écotoxicologie Évaluation du risque Umwelt Environmental Exposure Environmental Pollutants toxicity Environmental toxicology Nervous System drug effects Neurotoxicity Syndromes etiology Neurotoxicology Neurotoxicology Environmental aspects Risk Assessment methods Risk assessment Toxicology methods Nervengift (DE-588)4171484-2 gnd Toxizitätstest (DE-588)4060540-1 gnd Toxikologische Bewertung (DE-588)4303356-8 gnd |
| topic_facet | Biologisch effect CHEMICAL SAFETY CHEMICALS ENVIRONMENTAL HEALTH Neurotoxicologie Neurotoxicologie - Aspect de l'environnement Structuur-activiteit-relatie TOXIC SUBSTANCES Verbindingen (chemie) Écotoxicologie Évaluation du risque Umwelt Environmental Exposure Environmental Pollutants toxicity Environmental toxicology Nervous System drug effects Neurotoxicity Syndromes etiology Neurotoxicology Neurotoxicology Environmental aspects Risk Assessment methods Risk assessment Toxicology methods Nervengift Toxizitätstest Toxikologische Bewertung |
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