Genetically engineered viruses: development and applications
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | Undetermined |
| Veröffentlicht: |
New York, NY
Springer
2001
|
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | X, 279 S. Ill., graph. Darst., Kt. |
| ISBN: | 0387916113 |
Internformat
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| 245 | 1 | 0 | |a Genetically engineered viruses |b development and applications |c ed. by Christopher J.A. Ring ... |
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Datensatz im Suchindex
| _version_ | 1804128713575497728 |
|---|---|
| adam_text | Contents
Contributors vii
Abbreviations viii
Preface xi
1 Introduction: Viruses as vehicles and expressors of genetic material. 1
C.J.A. Ring and E.D. Blair
2 Prokaryotic viruses. M.D. Jones 5
Introduction 5
Bacteriophage A. vectors 6
Filamentous bacteriophage vectors 11
Phage display systems 21
Phage gene delivery vectors 31
Bacteriophages as antibiotics 34
Conclusion 35
References 35
3 Insect viruses. I.M. Jones 43
Introduction 43
The baculovirus expression system 45
References 54
4 Plant viruses. C. Lacomme, G.P. Pogue, T.M.A. Wilson, S. Santa Cruz 59
Introduction 59
General properties of plant viruses 60
Development of plant virus based vectors 64
Applications of plant virus based vectors in basic research 76
Commercial applications of plant virus based vectors 88
Conclusions 98
References 99
5 Mammalian expression systems and vaccination. 107
M.W. Carroll, G.W.G. Wilkinson, K. Lundstrom
Introduction 107
Recombinant poxvirus expression vectors 108
Recombinant adenovirus expression vectors 120
Recombinant alphavirus expression vectors 133
Conclusions 141
References 142
vi Prelims
6 Genetic engineering of animal DNA viruses in order to study and 159
modify pathogenesis. D.A. Leib
Introduction 159
Reverse genetics and animal models 160
Herpes simplex virus 161
Regulation of HSV gene expression and pathogenesis 166
Immune evasion and pathogenesis 170
Conclusions 177
References 178
7 Genetic engineering of animal RNA viruses in order to study and 187
modify pathogenesis. W.S. Barclay, D.J. Evans
Introduction 187
The positive strand RNA viruses 188
The negative strand RNA viruses 198
Concluding remarks 206
References 207
8 Therapeutic applications of viral vectors. 215
P. Lowenstein, D. Stone, A. David, A. Melcher, R. Vile, C. Thomas,
D. Bataille, M. Castro
Viruses as vectors: what s new? 215
Retroviral vectors 220
HSV 1 vectors 226
Adenoviruses as vectors for gene therapy 233
Adeno associated virus (AAV) vectors 239
References 243
9 The safety of work with genetically modified viruses. S.R. Warne 255
Introduction 255
Physical containment 256
Experimental design and risk assessment 260
Competency of staff and safety management issues 265
The regulatory framework and ethical issues 268
Discussion and conclusions 269
References 272
Index 275
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:53:37Z |
| institution | BVB |
| isbn | 0387916113 |
| language | Undetermined |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009492884 |
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| owner | DE-Aug7 |
| owner_facet | DE-Aug7 |
| physical | X, 279 S. Ill., graph. Darst., Kt. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Springer |
| record_format | marc |
| spelling | Genetically engineered viruses development and applications ed. by Christopher J.A. Ring ... New York, NY Springer 2001 X, 279 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Ring, Christopher J. A. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009492884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genetically engineered viruses development and applications |
| title | Genetically engineered viruses development and applications |
| title_auth | Genetically engineered viruses development and applications |
| title_exact_search | Genetically engineered viruses development and applications |
| title_full | Genetically engineered viruses development and applications ed. by Christopher J.A. Ring ... |
| title_fullStr | Genetically engineered viruses development and applications ed. by Christopher J.A. Ring ... |
| title_full_unstemmed | Genetically engineered viruses development and applications ed. by Christopher J.A. Ring ... |
| title_short | Genetically engineered viruses |
| title_sort | genetically engineered viruses development and applications |
| title_sub | development and applications |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009492884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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