Advances in isotope methods for the analysis of trace elements in man:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Pr.
2001
|
| Schriftenreihe: | CRC series in modern nutrition
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 223 S. Ill., graph. Darst. |
| ISBN: | 0849387302 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Chapter 1 Advances in Stable isotope Methodology
Leslie R. Woodhouse and Steven A. Abrams
1.1 History 1
1.1.1 First Use of Stable Isotopes with Humans —
Deuterium and 15N 2
1.1.2 Use of Mass Spectrometry for Mineral Stable isotope Research... 2
1.2 Using Stable Isotopes to Study Trace element Metabolism 3
1.2.1 Advantages and Disadvantages 3
1.2.2 Stable isotope Elements Available for Research 4
1.2.3 Instrumentation for Mineral Stable isotope Research 8
1.2.3.1 Neutron Activation Analysis (NAA) 9
1.2.3.2 Gas Chromatography Mass Spectrometry (GC MS) 9
1.2.3.3 Thermal Ionization Mass Spectrometry (TIMS) 9
1.2.3.4 Inductively Coupled Plasma Mass Spectrometry
(ICP MS) 10
1.2.3.5 Fast Atom Bombardment Mass Spectrometry
(FAB MS) 11
1.3 Stable isotope Dosage, Preparation, and Administration 12
1.4 Practical Strategies for Conducting Stable isotope Tracer Studies 14
1.4.1 Zinc 14
1.4.2 Iron 17
1.5 Appendix — Stable isotope Suppliers 18
References 19
Chapter 2 Advances in Radioisotope Methodology
Marianne Hansen, Mats Isaksson, and Brittmarie Sandstmm
2.1 Introduction 23
2.2 Radioisotopes 24
2.3 Whole body Counting Techniques 28
2.3.1 Whole body Counting 28
2.3.2 Whole body Counting Applications 29
2.3.2.1 Metabolism and Biological Turnover Rate 29
2.3.2.2 Absorption Studies 30
2.3.3 Equipment and Technological Development 31
2.4 Body Imaging Techniques 34
2.5 Indirect Measurements of Absorption or Metabolism 35
2.5.1 Tissue Retention 35
2.5.2 Urinary Excretion 36
2.5.3 Fecal Monitoring 38
2.5.4 Equipment and Technological Development 38
2.6 Conclusion 39
References 39
Chapter 3 Tracer to tracee Ratio for Compartmental Modelling of
Stable isotope Tracer Data
Gianna Toffolo, David M. Shames, Alessandro Stevanato, and Claudio Cobelli
3.1 Introduction 43
3.2 Single pool Tracer Kinetics and Measurement 44
3.3 Tracer to tracee Ratio from Mass Spectrometry Measurements 47
3.4 Multi pool Tracer Kinetics and Measurement 50
3.5 The Multiple Tracer Case 52
3.6 A Test of the Endogenous constant, Steady state Assumption 54
3.7 Software Tool: TTRM 54
3.8 Conclusion 56
References 56
Chapter 4 Methods for Analysis of Trace element Absorption
S.J. Fairweather Tait, T.E. Fox, L.J. Harvey, B. Teucher, and }. Dainty
4.1 General Introduction 60
4.1.1 Use of Isotopes 60
4.1.2 Methods 60
4.1.3 Definition of Absorption 61
4.2 Iron 62
4.2.1 Introduction 62
4.2.2 Normalization of Iron Absorption Data 62
4.2.3 Hemoglobin Incorporation 63
4.2.4 Whole body Counting 64
4.2.5 Fecal Monitoring 64
4.2.6 Plasma Appearance/Disappearance 65
4.2.7 In vitro (Caco 2 Cells) 65
4.2.8 Conclusion 66
4.3 Copper 66
4.3.1 Introduction 66
4.3.2 Fecal Monitoring 66
4.3.3 Plasma Appearance 67
4.3.4 Whole body Counting 67
4.3.5 Conclusion 68
4.4 Zinc 68
4.4.1 Introduction 68
4.4.2 Whole body Counting.: 68
4.4.3 Fecal Monitoring 69
4.4.4 Urinary Monitoring 70
4.4.5 Plasma Appearance/Disappearance 70
4.4.6 Use of Simulation to Predict Absorption 71
4.4.7 Whole gut Lavage Technique 71
4.4.8 In vitro (Caco 2 Cells) 72
4.4.9 Conclusion 72
4.5 Selenium 72
4.5.1 Introduction 72
4.5.2 Fecal Monitoring 74
4.5.3 Plasma Appearance/Disappearance 74
4.5.4 Whole body Counting 75
4.5.5 Urinary Monitoring 75
4.5.6 Conclusion 76
References 76
Chapter 5 Kinetic Studies of Whole body Trace element Metabolism
Nicola M. Lowe and Malcolm }. Jackson
5.1 Introduction 81
5.2 General Considerations in Study Design 82
5.2.1 Isotope Dose 82
5.2.2 Sampling Strategy 82
5.2.3 Free Living or Metabolic Unit 83
5.3 Compartmental Modelling 83
5.3.1 General Assumptions 84
5.4 Specific Examples of Isotope Turnover Studies 85
5.4.1 Zinc 85
5.4.2 Copper 86
5.4.3 Selenium 88
5.5 Conclusion 89
References 90
Chapter 6 Stable isotope Methods for the Investigation of
Iron Metabolism in Man
Morteza Janghorbani
6.1 Introduction 93
6.2 Iron Metabolism in Relation to the Design of Stable isotope Protocols... 94
6.3 Feasibility Issues 95
6.4 Analytical Methods 99
6.4.1 Neutron Activation Analysis 99
6.4.2 Mass Spectrometry 100
6.4.3 Summary of Current Analytical Capabilities 101
6.5 Selected Applications 102
6.5.1 Relationship between Mucosal Absorption and
Hemoglobin Incorporation of Dietary Iron 102
6.5.2 Issues of Dietary Availability of Iron 103
6.6 Conclusion 104
References 105
Chapter 7 Use of Isotopes in the Assessment of Zinc Status
Malcolm J. Jackson and Nicola M. Lowe
7.1 Introduction 109
7.2 Isotopic Techniques Ill
7.2.1 Short term Two compartment Model 112
7.2.2 Simplified Techniques to Measure the Exchangeable Zinc Pool... 113
7.3 Conclusion 113
References 114
Chapter 8 Copper Status and Metabolism Studied with
Isotopic Tracers
Judith R. Turnlund
8.1 Introduction 117
8.2 Background 118
8.3 Copper Status 118
8.4 Isotopic Tracers 119
8.4.1 Radioactive Tracers 119
8.4.2 Stable isotope Tracers 120
8.4.2.1 Methods of Stable isotope Analysis 120
8.4.2.1.1 Neuron Activation Analysis 120
8.4.2.1.2 Electron Impact Mass Spectrometry and
Gas Chromatography Mass Spectrometry.. 120
8.4.2.1.3 Thermal Ionization Mass Spectrometry.... 121
8.4.2.1.4 Inductively Coupled Plasma Mass
Spectrometry 121
8.4.2.2 Multiple Stable isotope Labelling 121
8.4.2.3 Studies Using Isotopic Tracers of Copper 122
8.5 Conclusion 123
References 123
Chapter 9 Use of Stable Isotopes of Selenium to Investigate
Selenium Status
Helen M. Crews
9.1 Introduction 130
9.2 Dietary Selenium and Its Metabolism 130
9.2.1 Sources and Daily Intakes 130
9.2.2 Chemical Form and Bioavailability 131
9.2.3 Metabolism of Selenium 132
9.3 The Role of Selenium in the Body 133
9.3.1 Selenium and Disease 133
9.3.1.1 Selenium Deficiency and Disease 133
9.3.1.2 Selenium and Cancer 134
9.3.2 Selenoproteins 134
9.3.2.1 Intracellular Glutathione Peroxidases (EC 1.11.1.9.).. 135
9.3.2.1.1 Cellular (Cystolic) GSHpx 135
i
9.3.2.1.2 Phospholipid Hydroperoxide GSHpx 135
9.3.2.1.3 Gastrointestinal GSHpx 136
9.3.2.2 Extracellular GSHpx 136
9.3.2.2.1 Plasma GSHpx 136
9.3.2.3 Iodothyronine Deiodinases (EC 3.8.1.4.) 136
9.3.2.4 Thioredoxin Reductase (EC 1.6.4.5.) 136
9.3.2.5 Selenium binding Protein 137
9.3.2.6 Others 137
9.4 Assessment of Selenium Status and Use of Stable Isotopes 137
9.4.1 Status Assays 137
9.4.2 Analytical Aspects 138
9.4.2.1 Assays for GSHpx Activity 138
9.4.2.2 Measurement of Selenium Isotopes 139
9.4.3 Modelling of Selenium Body Pools 140
9.4.4 Stable isotope Studies with Low to medium Selenium Intakes.. 143
9.4.5 Stable isotope Studies with High Selenium Intakes 144
9.5 Conclusion 145
References 146
Chapter 10 Use of Isotopes for Studies with Manganese, Chromium,
and Molybdenum
John W. Finley
10.1 Manganese 152
10.1.1 Introduction 152
10.1.2 Manganese Biochemistry 152
10.1.3 Radioactive Isotopes of Manganese and Studies of
Manganese Essentiality 153
10.1.3.1 Studies with Laboratory Animals and Cultured Cells.. 153
10.1.3.2 Distribution and Retention of Radioactive Manganese
in Humans 154
10.1.3.3 Radioactive Methods of Determining Apparent
Manganese Absorption in Humans 155
10.1.3.4 Radioactive Methods for Determining True
Manganese Absorption 156
10.1.3.5 The Use of Radioisotopes to Study
Manganese/Iron Interactions 158
10.2 Chromium 159
10.2.1 Introduction 159
10.2.2 Chemistry and Biochemistry 160
10.2.3 Radioactive Chromium in Human Studies 160
10.2.3.1 Nutritional Studies with 51Cr 160
10.2.3.2 Stable Isotopes of Chromium in Human Studies 161
10.3 Molybdenum 161
10.3.1 Chemistry and Biochemistry..... 161
10.3.2 Radioactive Isotopes of Molybdenum in Human Studies 161
10.3.3 Stable Isotopes of Molybdenum in Human Studies 162
10.4 Summary 162
References 163
Chapter 11 Trace element Studies in Infants and Pregnant or
Lactating Women
Lena Davidsson
11.1 Introduction 167
11.2 Iron 170
11.2.1 Methodology 170
11.2.2 Erythrocyte Incorporation and Iron Absorption 173
11.2.2.1 Studies in Premature Infants 173
11.2.2.2 Studies in Term Infants 174
11.2.2.2.1 Human Milk and Infant Formula 174
11.2.2.2.2 Complementary Foods 176
11.2.2.2.3 Iron Supplements 177
11.2.2.3 Studies in Pregnant Women 177
11.3 Zinc 178
11.4 Zinc and Copper 180
11.5 Selenium 181
11.6 Chromium 182
11.7 Conclusion 183
References 183
Chapter 12 Stable isotope Studies in the Elderly
Catherine LA. Jack, Nicola M. Lowe, and Malcolm J. Jackson
12.1 Introduction 187
12.2 Practicalities of Working with Elderly Subjects 188
12.3 Ethical Considerations 188
12.4 Examples of Stable isotope Studies in the Elderly 189
12.4.1 Zinc Homeostasis in the Elderly 189
12.4.2 Copper Homeostasis in the Elderly 189
12.5 Selenium Status of the Elderly 190
12.6 Conclusion 190
Acknowledgments 190
References 191
Chapter 13 Applications of Trace element Studies in
Developing Countries: Practical and Technical Aspects
R.S. Gibson and C. Hotz
13.1 Introduction 194
13.2 Applications of Isotope Studies in Developing Countries 195
13.2.1 Supplementation 195
13.2.2 Fortification 197
13.2.3 Dietary Strategies 198
13.3 Practical Aspects of Implementing Isotope Studies in
Developing Countries 199
13.3.1 Securing Support within the Country at the National and
Community Level 199
13.3.2 Selecting the Study Design 200
13.3.3 Assessing the Nutritional and Health Status of
the Study Participants 201
13.3.4 Assessing Levels of Trace Elements and Absorption
Modifiers in the Habitual Diets of Study Participants 203
13.3.4.1 Assessing Food Intakes 203
13.3.4.2 Compiling a Local Food Composition Table for
Use in a Developing Country 204
13.3.4.3 Assessing Intakes of Trace Elements and
Absorption Modifiers in Habitual Diets 204
13.3.4.4 Assessing Nutrient Intakes during the
Metabolic Study 205
13.4 Technical Aspects of Implementing Isotope Studies in
Developing Countries 206
13.4.1 Considerations When Selecting the Isotopic Technique 207
13.4.1.1 Fecal Monitoring 207
13.4.1.2 Urinary Monitoring 208
13.4.1.3 Tissue Retention 209
13.4.1.4 Plasma Tolerance Curves and Plasma Deconvolution..209
13.4.2 Collecting, Preparing, and Processing the Metabolic Samples
for Analysis of Native Trace Elements and Isotopic Enrichment ..210
13.4.2.1 Fecal Samples 210
13.4.2.2 Urine Samples 211
13.4.2.3 Blood Samples 211
13.5 Conclusion 212
References 212
Index 217
1
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| id | DE-604.BV013872300 |
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| indexdate | 2024-07-09T18:53:32Z |
| institution | BVB |
| isbn | 0849387302 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009489341 |
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| spelling | Advances in isotope methods for the analysis of trace elements in man ed. by Nicola Lowe ... Boca Raton [u.a.] CRC Pr. 2001 223 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier CRC series in modern nutrition Dieta Nutrición Isotopes Trace Elements analysis Trace Elements metabolism Trace elements in human nutrition Trace elements Analysis Trace elements Isotopes Isotop (DE-588)4027801-3 gnd rswk-swf Analytische Methode (DE-588)4142352-5 gnd rswk-swf Spurenelement (DE-588)4056595-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Isotop (DE-588)4027801-3 s Analytische Methode (DE-588)4142352-5 s Spurenelement (DE-588)4056595-6 s DE-604 Lowe, Nicola Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009489341&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Advances in isotope methods for the analysis of trace elements in man Dieta Nutrición Isotopes Trace Elements analysis Trace Elements metabolism Trace elements in human nutrition Trace elements Analysis Trace elements Isotopes Isotop (DE-588)4027801-3 gnd Analytische Methode (DE-588)4142352-5 gnd Spurenelement (DE-588)4056595-6 gnd |
| subject_GND | (DE-588)4027801-3 (DE-588)4142352-5 (DE-588)4056595-6 (DE-588)4143413-4 |
| title | Advances in isotope methods for the analysis of trace elements in man |
| title_auth | Advances in isotope methods for the analysis of trace elements in man |
| title_exact_search | Advances in isotope methods for the analysis of trace elements in man |
| title_full | Advances in isotope methods for the analysis of trace elements in man ed. by Nicola Lowe ... |
| title_fullStr | Advances in isotope methods for the analysis of trace elements in man ed. by Nicola Lowe ... |
| title_full_unstemmed | Advances in isotope methods for the analysis of trace elements in man ed. by Nicola Lowe ... |
| title_short | Advances in isotope methods for the analysis of trace elements in man |
| title_sort | advances in isotope methods for the analysis of trace elements in man |
| topic | Dieta Nutrición Isotopes Trace Elements analysis Trace Elements metabolism Trace elements in human nutrition Trace elements Analysis Trace elements Isotopes Isotop (DE-588)4027801-3 gnd Analytische Methode (DE-588)4142352-5 gnd Spurenelement (DE-588)4056595-6 gnd |
| topic_facet | Dieta Nutrición Isotopes Trace Elements analysis Trace Elements metabolism Trace elements in human nutrition Trace elements Analysis Trace elements Isotopes Isotop Analytische Methode Spurenelement Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009489341&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lowenicola advancesinisotopemethodsfortheanalysisoftraceelementsinman |