Breast cancer: a practical guide
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam ; Lausanne ; New York ; Oxford ; Shannon ; Singapore ; Tokyo
Elsevier
2000
|
| Ausgabe: | Second edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | viii, 518 Seiten Illustrationen, Diagramme |
| ISBN: | 0444505652 |
Internformat
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| 245 | 1 | 0 | |a Breast cancer |b a practical guide |c Orlando E. Silva, M.D., Stefano Zurrida, M.D., [editors] |
| 250 | |a Second edition | ||
| 264 | 1 | |a Amsterdam ; Lausanne ; New York ; Oxford ; Shannon ; Singapore ; Tokyo |b Elsevier |c 2000 | |
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Datensatz im Suchindex
| _version_ | 1804128659613679616 |
|---|---|
| adam_text | Table of Contents
I. BENIGN BREAST DISEASE 1
Cysts 1
Fibrocystic changes 2
Epithelial hyperplasia 2
Atypical hyperplasia 2
Adenomas 3
Fibroadenoma 3
Mammary duct ectasia 4
Mammary duct fistula 5
Papillomas 5
Puerperal (lactational) Mastitis 6
Periareolar sepsis 7
Fat necrosis 8
Mondor disease 9
Granular cell tumors 9
Lipomas 9
Hamartomas 9
Sarcoid 10
BREAST CARCINOMA 11
II. HISTORY OF BREAST CANCER 13
III. EPIDEMIOLOGY 15
IV. RISK FACTORS 18
Factors that increase risk 18
Hereditary Breast Cancer 21
Genetic testing 26
Current recommendations for high risk patients. . . 27
Potential risk factors 29
Factors that decrease risk 30
Estimating risk factors 33
V. SCREENING 35
Self examination 38
Screening Mammography 39
Diagnostic Mammography 39
i
VI. IMAGING STUDIES 47
Ultrasound 47
MRI 47
Bone scan 48
Sestamibi scan 48
PET scan 49
Liver scan 50
VII. EVALUATION OF A PALPABLE BREAST MASS
AND NIPPLE DISCHARGE 51
History and physical examination 51
Needle aspiration 52
Mammography 53
Ultrasound 54
CT/MRI 54
FNA/Core Needle Biopsy/Open Biopsy 55
VIII. BREAST PATHOLOGY 56
Histologic (tissue) grade 56
Nuclear grade 56
Mitoses 56
Multifocality 57
Multicentricity 57
Bilaterality 57
Non invasive breast cancer 58
Ductal Carcinoma In Situ (DCIS) 58
Lobular Carcinoma In Situ (LCIS) 60
Microinvasive breast cancer 60
Invasive breast cancer 62
Paget disease 64
Inflammatory breast cancer 64
IX. STAGING 66
TNM system 66
Clinical staging 67
Survival 69
X. PROGNOSTIC FACTORS 71
Primary prognostic factors 71
The Nottingham Prognostic Index (NPI) 74
New Prognostic Factors 74
ii
NON INVASIVE CANCER 87
CARCINOMA IN SITU 87
XI. DCIS 89
Local excision alone 91
Multicentricity 93
Radiation Therapy 93
Rationale for radiation 97
XII. LCIS (Lobular Carcinoma In Situ) 103
Treatment 104
INVASIVE CANCER 105
XIII. SURGICAL TREATMENT 107
Stage I/II operable breast cancer 107
Lumpectomy 107
Quadrantectomy 107
Mastectomy 107
XIV. POST MASTECTOMY RADIOTHERAPY 122
1987 Meta analysis 123
Cause specific mortalities 123
Early Breast Cancer Trialists Collaborative
Group (1995 Meta analysis) 123
The Danish Breast Cancer Cooperative
Group 82b Trial 124
British Columbia Trial 125
The Danish Breast Cancer Cooperative
Group 82c Trial 126
XV. AXILLARY LYMPH NODE DISSECTION (ALND) . 130
DCIS 131
Microinvasive carcinoma 132
Tla lesions 132
Complications of axillary LN dissection 134
Sentinel lymph node localization
(lymphatic mapping) 134
iii
XVI. AXILLARY LYMPH NODE IRRADIATION 141
XVII. BREAST RECONSTRUCTION AFTER
MASTECTOMY 144
Timing of breast reconstruction 144
Choice of reconstructive technique 145
Breast reconstruction and oncology 158
XVIII. GENERAL FACTS ABOUT BREAST CANCER
AND CHEMO HORMONAL THERAPY 160
XIX. PRIMARY CHEMOTHERAPY 162
XX. STAGE III DISEASE 172
Combined systemic approach 174
Inflammatory breast cancer 177
Intra arterial cytotoxic chemotherapy 178
XXI. ADJUVANT CHEMOTHERAPY IN
PREMENOPAUSAL BREAST CANCER 179
Adjuvant chemotherapy 184
Chemotherapy dose intensity 190
Sequencing of adjuvant chemotherapy and
radiation therapy 198
Timing of adjuvant chemotherapy 200
Duration of adjuvant chemotherapy 201
Future, ongoing, and recently closed trials in the
adjuvant setting 206
Side effects of chemotherapy 210
XXII. ADJUVANT ENDOCRINE THERAPY IN PRE
and POST MENOPAUSAL 211
Adjuvant tamoxifen in premenopausal 211
Conclusions of above studies 217
Long term tamoxifen follow up 217
Other adjuvant endocrine therapy 218
Adjuvant chemohormonal therapy 221
Adjuvant immunotherapy 222
iv
XXIII. ADJUVANT CHEMOTHERAPY IN
POSTMENOPAUSAL BREAST CANCER 223
Side effects of Chemotherapy 225
Chemotherapy + Tamoxifen 225
XXIV. LOCAL BREAST RECURRENCE 229
Local Breast recurrence after breast conservation
therapy (BCT) 229
Local breast recurrence after mastectomy 235
Treatment modalities for local recurrence
after mastectomy 236
XXV. CHARGES RELATED TO BREAST CANCER
TREATMENT IN THE US EUROPE 240
XXVI. METASTATIC BREAST CANCER 242
Loco Regional Disease 245
Bone Only 248
Visceral Disease 254
Visceral Crises 264
XXVII. ENDOCRINE THERAPY FOR METASTATIC BREAST
CANCER 269
Antiestrogens 271
Selective aromatase inhibitors 277
Non selective aromatase inhibitors 284
Progestational agents 285
GnRH analogs (Gonadotropin hormone releasing
analogs) 285
Oophorectomy 288
Phase III Clinical Trials in Premenopausal 288
XXVIII. STANDARD CHEMOTHERAPY FOR
METASTATIC BREAST CANCER 289
Duration of chemotherapy in the metastatic setting 289
Factors that predict response to chemotherapy . . . 289
Chemotherapy regimens 290
Biologic agents with and without chemotherapy. . . 315
v
XXIX. SIDE EFFECTS OF CHEMOTHERAPY 320
XXX. INVESTIGATIONS. AGENTS 325
XXXI. HIGH DOSE THERAPY 334
U.S. Bone Marrow Transplant Regimens 335
High Dose Therapy in Europe 341
Preliminary results of randomized high dose
chemotherapy trials in the adjuvant setting .... 344
Preliminary results of randomized high dose
chemotherapy trials in the metastatic setting ... 347
Side Effects of High Dose Therapy 349
XXXII. PSYCHOSOCIAL SEQUELAE OF BREAST
CANCER 355
Prominent affective responses 355
Specific responses to diagnosis 356
Specific responses to treatment 357
Specific responses to end of treatment 358
Specific responses to recurrence 358
Psychosocial responses are not universal 359
End of life issues 360
XXXIII. BREAST CANCER AND DEPRESSION 361
Classification of depressive disorders 361
Diagnosis of depression in cancer patients 362
XXXIV. FOLLOWING BREAST CANCER PATIENTS 369
Localized disease 369
Current recommendations for mammography
after breast cancer treatment 369
Metastatic disease 369
Tumor markers 370
XXXV. HORMONE REPLACEMENT THERAPY (HRT)
IN BREAST CANCER SURVIVORS 373
Menopausal symptoms 375
XXXVI. UNUSUAL PRESENTATIONS 382
Paget disease 382
vi
Breast cancer and pregnancy 383
Occult breast cancer presenting as solitary
axillary mass 385
Phyllodes tumor 385
XXXVII. MALE BREAST 387
Sclerosing adenosis 387
Phyllodes tumor 387
Male Breast Cancer 387
XXXVIII. CHEMOPREVENTION 390
Tamoxifen chemoprevention trials 390
Raloxifene chemoprevention trials 390
Retinoids chemoprevention trials 397
XXXIX. CARE OF THE DYING PATIENT 399
Palliative Medicine 399
Hospice care 399
Symptoms 400
Communication 401
Management strategies 401
Religion 409
Existential suffering 410
Family 410
Bereavement 411
XL. ISSUES IN BREAST CANCER LIABILITY 412
Introduction 412
The standard of care 412
The standard of care for physicians treating breast
cancer patients 413
Defenses to a breast cancer related claim 414
Areas of breast cancer liability 416
Failure to screen individuals for breast cancer. ... 416
Failure to elicit information 418
Failures to diagnose breast cancer 419
Causation in failure to diagnose cases 421
Damages in failure to diagnose cases 422
Misreading mammograms 423
Failure to order biopsies 424
vii
Negligent performance of needle aspirations 425
Negligent ordering and performing mastectomies. . 426
Negligent post operative treatment 427
Issues in breast reconstruction 428
HMO and insurance company liability 428
APPENDICES 431
APPENDIX I. Expanded Table of Contents with Citations.... 433
APPENDIX II. National Breast Cancer Support Organizations. . 475
APPENDIX III. Breast Cancer Local Support Groups in the US . 483
APPENDIX IV. Pharmaceuticals: Generic names, Trade
names Manufacturers 497
INDEX 501
viii
|
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| discipline | Medizin |
| edition | Second edition |
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| title | Breast cancer a practical guide |
| title_auth | Breast cancer a practical guide |
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| title_full | Breast cancer a practical guide Orlando E. Silva, M.D., Stefano Zurrida, M.D., [editors] |
| title_fullStr | Breast cancer a practical guide Orlando E. Silva, M.D., Stefano Zurrida, M.D., [editors] |
| title_full_unstemmed | Breast cancer a practical guide Orlando E. Silva, M.D., Stefano Zurrida, M.D., [editors] |
| title_short | Breast cancer |
| title_sort | breast cancer a practical guide |
| title_sub | a practical guide |
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