Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Göttingen
Cuvillier
2001
|
| Ausgabe: | 1. Aufl. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Zürich, Univ., Diss., 2001 |
| Beschreibung: | 228 S. graph. Darst. |
| ISBN: | 3898730743 |
Internformat
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| 246 | 1 | 3 | |a Evaluation of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome |
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Datensatz im Suchindex
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|---|---|
| adam_text | 1 Introduction 1
1.1 Clinical presentation 1
1.2 Definitions and Diagnosis 2
1.3 Epidemiology 4
1.4 Etiological models 6
1.4.1 CFS and infections 7
1.4.2 CFS and immune dysfunctions 9
1.4.2.1 T cell phenotype and function 9
1.4.2.2 Natural killer cell phenotype and function 10
1.4.2.3 Cytokines 11
1.4.2.4 CFS and immunity Conclusion 14
1.4.2 CFS and psychiatric disorders 14
1.4.3 CFS and psychological factors 22
1.4.3.1 Predisposing factors: CFS and personality 22
1.4.3.2 Precipitating factors: CFS and stress 24
1.4.3.3 Perpetuation factors: CFS and subjective illness models 26
1.4.3.4 CFS and the cognitive behavioral model 28
1.4.4 CFS and neuroendocrine dysregulations 30
1.4.4.1 The hypothalamic pituitary adrenal (HPA) axis 30
1.4.4.1.1 Hypothalamic control of the HPA axis: CRH and AVP 31
1.4.4.1.1.a Central stress circuits 31
1.4.4.1.1 ,b CRH and AVP release 36
1.4.4.1.2 ACTH 38
1.4.4.1.3 Cortisol: Biosynthesis and secretion 39
1.4.4.1.4 Regulation of activity and reactivity 42
1.4.4.1.4.a Basal activity and circadian rhythm 42
1.4.4.1.4.b Reactivity and feedback control 43
1.4.4.2 Effects and actions of HPA axis hormones 45
1.4.4.2.1 HPA axis and the immune system 45
1.4.4.2.1.a Direct effects of CRH on immune functions 46
1.4.4.2.1 .b Effects of glucocorticoids on immune functions 46
1.4.4.2.2 Metabolic effects of glucocorticoids 49
1.4.4.2.3 Cognitive effects of HPA axis hormones 50
1.4.4.2.3.a Behavioral effects olCRH au
1.4.4.2.3.a Glucocorticoid modulation of cognitive function 53
1.4.4.2.4 Modulation of HPA axis functioning M
1.4.4.2.4.a Early life events: postnatal handling 55
1.4.4.2.4.D. Early life events: maternal separation
1.4.4.2.4.C Early life events: Manipulated foraging demands 56
1.4.4.2.4.d Early life events: human studies 59
1.4.4.2.4.6 Chronic stress: Animal studies
1.4.4.2.4.f Chronic stress: Human studies
1.4.4.2.2.g Stress theoretical concepts
1.4.4.3.1 Basal HPA axis activity in CFS 71
1.4.4.3.2. HPA axis reactivity in CFS 72
1.4.4.3.3. Theoretical concepts 7
1.5. Conclusions 2. Empirical studies 7
79
2.1 Study rationale
2.2 Study 1: HPA axis reactivity in CFS and health under psychological, physiological and
80
pharmacological stress
2.2.1 Subjects and methods 81
2.2.1.1 Subjects 81
2.2.1.2 Test protocols ^
2.2.1.2.1 Trier Social Stress Test (TSST) B2
2.2.1.2.2 Incremental cycle ergometry test fl3
2.2.1.2.3 Insulin Tolerance Test (ITT) °
83
2.2.1.3 Sampling methods and biochemical analyses 83
2.2.1.3.1 Endocrine measures 2.2.1.3.2 Heart rate W
84
2.2.1.3.3 Psychometric assessment
2.2.1.4 Statistical ana lysis 84
2.2.2 Results 85
2.2.2.1 Patients and controls characteristics 85
2.2.2.2 TSST 85
2.2.2.3 ERGO 89
2.2.2.3 ITT 92
2.2.2.4 Comparisons of endocrine parameters between tests and groups 94
2.2.2.5 Associations between endocrine responses and patient characteristics 95
2.2.3 Discussion 95
2.3 Study 2: Enhanced Suppression of salivary free cortisol following the low dose dexamethasone
suppression test in chronic fatigue syndrome and health 99
2.3.1 Subjects and methods 100
2.3.1.1 Subjects 100
2.3.1.2 Cortisol assessment and biochemical analysis 101
2.3.1.3 Statistical analysis 102
2.3.2 Results 102
2.3.3 Discussion 107
3. General discussion 110
3.1 General results 110
3.1.1 Basal and responsive cortisol secretion 110
3.1.2 Adrenocortical cortisol secretion 111
3.1.3 ACTH secretion 112
3.1.4 Enhanced negative feedback 114
3.2 Possible confounders 116
3.2.1 Psychiatric comorbidity 116
3.2.2 Length of illness 117
3.3 Implications 118
3.3.1 Etiology of CFS 118
3.3.2 Treatment of CFS 122
3.4 Outlook 124
References 126
|
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| author | Gaab, Jens 1970- |
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| discipline | Psychologie Medizin |
| edition | 1. Aufl. |
| format | Book |
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| id | DE-604.BV013810571 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:52:23Z |
| institution | BVB |
| isbn | 3898730743 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009442722 |
| oclc_num | 48560526 |
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| physical | 228 S. graph. Darst. |
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| spelling | Gaab, Jens 1970- Verfasser (DE-588)12306564X aut Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome Jens Gaab Evaluation of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome 1. Aufl. Göttingen Cuvillier 2001 228 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: Zürich, Univ., Diss., 2001 Funktionsstörung (DE-588)4126507-5 gnd rswk-swf Neuroendokrinopathie (DE-588)4277112-2 gnd rswk-swf Neuroendokrines System (DE-588)4128912-2 gnd rswk-swf Chronisches Ermüdungssyndrom (DE-588)4265096-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Chronisches Ermüdungssyndrom (DE-588)4265096-3 s Neuroendokrines System (DE-588)4128912-2 s Funktionsstörung (DE-588)4126507-5 s DE-604 Neuroendokrinopathie (DE-588)4277112-2 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009442722&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gaab, Jens 1970- Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome Funktionsstörung (DE-588)4126507-5 gnd Neuroendokrinopathie (DE-588)4277112-2 gnd Neuroendokrines System (DE-588)4128912-2 gnd Chronisches Ermüdungssyndrom (DE-588)4265096-3 gnd |
| subject_GND | (DE-588)4126507-5 (DE-588)4277112-2 (DE-588)4128912-2 (DE-588)4265096-3 (DE-588)4113937-9 |
| title | Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome |
| title_alt | Evaluation of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome |
| title_auth | Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome |
| title_exact_search | Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome |
| title_full | Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome Jens Gaab |
| title_fullStr | Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome Jens Gaab |
| title_full_unstemmed | Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome Jens Gaab |
| title_short | Evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome |
| title_sort | evaluation of the hypothalamus pituitary adrenal axis in chronic fatigue syndrome |
| topic | Funktionsstörung (DE-588)4126507-5 gnd Neuroendokrinopathie (DE-588)4277112-2 gnd Neuroendokrines System (DE-588)4128912-2 gnd Chronisches Ermüdungssyndrom (DE-588)4265096-3 gnd |
| topic_facet | Funktionsstörung Neuroendokrinopathie Neuroendokrines System Chronisches Ermüdungssyndrom Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009442722&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gaabjens evaluationofthehypothalamuspituitaryadrenalaxisinchronicfatiguesyndrome |