Natural and artificial antisense RNA: a study of inhibition of gene expression
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Uppsala
Swedish Univ. of Agricultural Sciences
2000
|
| Schriftenreihe: | Sveriges Lantbruksuniversitet <Uppsala u.a.>: [Acta Universitatis Agriculturae Sueciae / Agraria]
237 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Uppsala, Sveriges Lantbruksuniv., Diss., 2000 |
| Beschreibung: | Getr. Zählung Ill., graph. Darst. |
| ISBN: | 915765784X |
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Datensatz im Suchindex
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| adam_text | Titel: Natural and artificial antisense RNA
Autor: Engdahl, Hilde Merete
Jahr: 2000
Contents
Introduction 13
The plasticity of RNA 13
Antisense RNA - historical perspectives 13
Control of gene expression by natural antisense RNAs 14
Plasmids and antisense RNA control 15
Control of plasmid replication by antisense RNA 15
IncFII-like plasmids: indirect inhibition of translation 16
ColEl-relatives: inhibition of primer maturation 19
IncB andlncla plasmids: antisense RNA-mediated inhibition of RNA
pseudoknot formation 20
Plasmid pIPSOl andpT181: induced termination of transcription 21
Plasmid maintenance functions and antisense RNA control 22
Conjugation control 22
Post-segregational host killing 22
DNA transposition control by antisense RNA 23
Antisense RNA control of bacterial and phage gene expression 23
Regulation of eukaryotic gene expression by antisense RNA 24
Gene silencing by nucleic acids 25
Oligodeoxyribonucleotides 25
Peptide nucleic acids 26
Antisense RNAs 27
RNA interference andpost-transcriptional gene silencing 28
Antisense ribozymes 29
Present investigation 30
Antisense RNA control of plasmid Rl replication 30
An inhibitory structure prevents RepA translation (I) 30
The mechanism by which CopA antisense RNA inhibits RepA
translation (I and H) 32
Inhibition of gene expression by intermolecular or intramolecular
structures (II) 33
Implications of a stepwise CopA-CopT binding pathway (M) 33
Rational design of bifunctional antisense RNAs as gene silencers (IV) 35
The inhibitory unit 37
The prokaryotic test system 3 7
Introduction of multiple stem-loop units (V) 39
Introduction of an RNA stabilizer helix (V) 39
Irrational design: in vitro selection for identification of acessible
target sites (unpublished) 40
Summary of results 42
Discussion 42
General considerations about the features of natural antisense RNA
systems 43
General considerations about the design of bifunctional antisense
RNAs 45
Post-transcriptionai gene silencing in eukaryotes 47
Irrational design 49
In vivo screening 50
Concluding remarks and future prospects 50
References 51
Acknowledgements 61
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| indexdate | 2024-07-09T18:51:47Z |
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| spelling | Engdahl, Hilde Merete Verfasser aut Natural and artificial antisense RNA a study of inhibition of gene expression Hilde Merete Engdahl Uppsala Swedish Univ. of Agricultural Sciences 2000 Getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Sveriges Lantbruksuniversitet <Uppsala u.a.>: [Acta Universitatis Agriculturae Sueciae / Agraria] 237 Zugl.: Uppsala, Sveriges Lantbruksuniv., Diss., 2000 Antisense RNA Bacterial genetics Antisense-RNS (DE-588)4324981-4 gnd rswk-swf Genexpression (DE-588)4020136-3 gnd rswk-swf Inhibition (DE-588)4273127-6 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Antisense-RNS (DE-588)4324981-4 s Inhibition (DE-588)4273127-6 s Genexpression (DE-588)4020136-3 s DE-604 Genregulation (DE-588)4122166-7 s Agraria] Sveriges Lantbruksuniversitet <Uppsala u.a.>: [Acta Universitatis Agriculturae Sueciae 237 (DE-604)BV010948960 237 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009417620&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Engdahl, Hilde Merete Natural and artificial antisense RNA a study of inhibition of gene expression Antisense RNA Bacterial genetics Antisense-RNS (DE-588)4324981-4 gnd Genexpression (DE-588)4020136-3 gnd Inhibition (DE-588)4273127-6 gnd Genregulation (DE-588)4122166-7 gnd |
| subject_GND | (DE-588)4324981-4 (DE-588)4020136-3 (DE-588)4273127-6 (DE-588)4122166-7 (DE-588)4113937-9 |
| title | Natural and artificial antisense RNA a study of inhibition of gene expression |
| title_auth | Natural and artificial antisense RNA a study of inhibition of gene expression |
| title_exact_search | Natural and artificial antisense RNA a study of inhibition of gene expression |
| title_full | Natural and artificial antisense RNA a study of inhibition of gene expression Hilde Merete Engdahl |
| title_fullStr | Natural and artificial antisense RNA a study of inhibition of gene expression Hilde Merete Engdahl |
| title_full_unstemmed | Natural and artificial antisense RNA a study of inhibition of gene expression Hilde Merete Engdahl |
| title_short | Natural and artificial antisense RNA |
| title_sort | natural and artificial antisense rna a study of inhibition of gene expression |
| title_sub | a study of inhibition of gene expression |
| topic | Antisense RNA Bacterial genetics Antisense-RNS (DE-588)4324981-4 gnd Genexpression (DE-588)4020136-3 gnd Inhibition (DE-588)4273127-6 gnd Genregulation (DE-588)4122166-7 gnd |
| topic_facet | Antisense RNA Bacterial genetics Antisense-RNS Genexpression Inhibition Genregulation Hochschulschrift |
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