Pharmacokinetic principles of dosing adjustments: understanding the basics
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press
2001
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 258 S. Ill. |
| ISBN: | 1566768993 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | Table of Contents
Preface xi
I. BASIC CONCEPTS
1. PHARMACOKINETIC PROCESSES 3
Introduction 3
Overview of Pharmacokinetic Processes 3
Study Guide for Chapter I 14
2. KINETIC PROCESSES APPLIED
TO THE WHOLE BODY 17
Introduction 17
Classical Pharmacokinetic Models 21
Justification for Application of a One Compartment
Model 25
Study Guide for Chapter 2 27
3. DISPOSITION PARAMETERS OF
THE ONE COMPARTMENT MODEL 29
Introduction 29
Elimination Rate Constant 30
Half Life 34
Volume of Distribution 36
Area Under the Plasma Concentration Time Curve 41
Systemic Clearance 44
Study Guide for Chapter 3 46
vii
viii Table of Contents
4. PARAMETERS USED IN ADJUSTING DOSES 49
Therapeutic Drug Monitoring and the Retrospective
Approach 49
Prospective Approach 51
Urine Measurements of Drugs and Renal
Clearance 56
Dosage Adjustment in Renal Failure 60
Hepatic Elimination and Dosing Adjustments 67
Study Guide for Chapter 4 68
II. PARENTERAL DOSING ADJUSTMENTS
5. INFUSION 73
Introduction 73
Basic Infusion Principles 74
Bolus Dose Plus Constant Rate Infusion 79
Rapid Infusion Followed by Slow Infusion 82
Intermittent Infusion 84
Study Guide for Chapter 5 90
III. ORAL DOSING
6. IMPORTANT PARAMETERS 95
Introduction 95
Fraction Absorbed (F) 98
Absorption Rate Constant 100
Factors Affecting the Absorption of Drugs 103
Study Guide for Chapter 6 120
7. BIOAVAILABILITY/BIOEQUIVALENCE 123
Introduction 123
Definitions 124
Bioavailability Measurements 125
B ioequivalence 127
Generic Substitution 131
Study Guide for Chapter 7 134
Table of Contents ix
8. MULTIPLE DOSING REGIMENS 137
Introduction 137
Superposition Principle and Multiple Dosing 138
Multiple Dosing Factor 138
Multiple Dosing Equations 143
Accumulation 145
Missed Dose 154
Study Guide for Chapter 8 157
IV. ADVANCED CONSIDERATIONS
9. TWO COMPARTMENT MODEL 163
Introduction 163
Volumes of Distribution 171
IV Infusion: Two Compartment Model 175
Dosing Strategies 180
Advanced Considerations 187
Study Guide for Chapter 9 191
10. AN INTRODUCTION TO NONLINEAR
PHARMACOKINETICS 193
Introduction 193
Application to Phenytoin Dosing Regimens 197
Single Point Method 201
Bayesian Approach 203
Study Guide for Chapter 10 205
APPENDIX. STUDY GUIDE SOLUTIONS 207
Index 255
|
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| indexdate | 2024-07-09T18:51:45Z |
| institution | BVB |
| isbn | 1566768993 |
| language | English |
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| spelling | Schoenwald, Ronald D. Verfasser aut Pharmacokinetic principles of dosing adjustments understanding the basics Ronald D. Schoenwald Boca Raton [u.a.] CRC Press 2001 258 S. Ill. txt rdacontent n rdamedia nc rdacarrier Farmacokinetica gtt Hoeveelheid gtt Drugs Dosage Pharmacokinetics Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009416598&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schoenwald, Ronald D. Pharmacokinetic principles of dosing adjustments understanding the basics Farmacokinetica gtt Hoeveelheid gtt Drugs Dosage Pharmacokinetics Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4115557-9 |
| title | Pharmacokinetic principles of dosing adjustments understanding the basics |
| title_auth | Pharmacokinetic principles of dosing adjustments understanding the basics |
| title_exact_search | Pharmacokinetic principles of dosing adjustments understanding the basics |
| title_full | Pharmacokinetic principles of dosing adjustments understanding the basics Ronald D. Schoenwald |
| title_fullStr | Pharmacokinetic principles of dosing adjustments understanding the basics Ronald D. Schoenwald |
| title_full_unstemmed | Pharmacokinetic principles of dosing adjustments understanding the basics Ronald D. Schoenwald |
| title_short | Pharmacokinetic principles of dosing adjustments |
| title_sort | pharmacokinetic principles of dosing adjustments understanding the basics |
| title_sub | understanding the basics |
| topic | Farmacokinetica gtt Hoeveelheid gtt Drugs Dosage Pharmacokinetics Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Farmacokinetica Hoeveelheid Drugs Dosage Pharmacokinetics Pharmakokinetik |
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