Nuclear receptors and genetic disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 419 S. Ill., graph. Darst. |
| ISBN: | 0121461602 |
Internformat
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| 245 | 1 | 0 | |a Nuclear receptors and genetic disease |c ed. by Thomas P. Burris ... |
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 2001 | |
| 300 | |a XII, 419 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 650 | 4 | |a Genetic Diseases, Inborn |x physiopathology | |
| 650 | 4 | |a Genetic disorders | |
| 650 | 4 | |a Hormones |x physiology | |
| 650 | 4 | |a Nuclear receptors (Biochemistry) | |
| 650 | 4 | |a Pathology, Molecular | |
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| 650 | 4 | |a Transcription Factors |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804128575534661632 |
|---|---|
| adam_text | Contents
List of Contributors ix
Preface xi
1 The Nuclear Receptor Superfamily 1
Thomas P. Burris
Introduction and historical perspective I
Nuclear receptor structure 6
Nuclear receptor function 16
Nuclear receptors and human disease 34
References 35
2 Thyroid Hormone Receptors 59
Uwe Dressel and Aria Baniahmad
Introduction and historical perspective 59
Physiology 60
Structure and mechanism of action of thyroid hormone receptors 62
Genetics 64
Pathophysiology 84
Diagnosis 85
Pharmacology 86
References 87
3 Estrogen and Progesterone Receptors 97
George F. Allan
Introduction and historical perspective 97
Physiology 98
Structure and mechanism of action of estrogen and progesterone receptors 106
Genetics 111
Pharmacology 117
References 123
4 The Androgen Receptor 137
Guido Jenster, Jan Trapman and Albert O. Brinkmann
Introduction 137
Physiology 138
Androgen receptor structure and function 139
Androgen receptor and disease 144
Summary and conclusions 160
References 162
5 DAX 1 and Related Orphan Receptors 179
Eric Vilain and Edward R. B. McCabe
Introduction and historical perspective 179
Vi CONTENTS
Physiology 183
Structure and mechanism of action 185
Genetics 187
Pathophysiology 188
Diagnosis 190
Pharmacology 190
References 191
6 The Vitamin D Receptor 197
Paul N. MacDonald, Dennis M. Kraichely and Alex J. Brown
Introduction and historical perspective 197
Physiology 198
Structure and mechanism of action of the VDR 209
Genetics 220
Pathophysiology and diagnosis 226
Pharmacology 226
References 227
7 Retinoid Receptors 245
Arthur C. K. Chung and Austin J. Cooney
Introduction and historical perspective 245
Physiology 246
Structure and mechanism of action of retinoid receptors 248
Genetics 261
Pathophysiology 263
Diagnosis 269
Pharmacology 270
Summary 273
References 274
8 Mineralocorticoid and Glucocorticoid Receptors 297
Tomoshige Kino, Alessandra Vottero and George P. Chrousos
Introduction 297
Structure and actions of the mineralocorticoid and glucocorticoid receptors 298
Pathophysiology and clinical presentation 300
Diagnostic evaluation and therapy 304
References 305
9 Hepatocyte Nuclear Factor 4a 309
Frances M. Sladek and Shawn D. Seidel
Introduction and historical perspective 309
Physiology 314
Structure and mechanism of action of HNF4oc 328
Genetics 333
Pathophysiology 338
Diagnosis 346
Pharmacology 347
Conclusion 348
References 348
CONTENTS vii
10 Peroxisome Proliferator Activated Receptors 363
Alex Elbrecht, Alan Adams and David E. Moller
Introduction and historical perspectives 363
Physiology 365
Structure and mechanism of action 367
Genetics 371
Pathophysiology 373
Pharmacology 375
Conclusion 379
References 380
11 Coactivators and Corepressors 389
David M. Lonard and Zafar Nawaz
Introduction 389
Historical perspective 389
The SRC coactivator family 391
SRC family misexpression and cancer 393
Coactivators involved in ubiquitin proteasome mediated protein
degradation 395
Mutations to the E6 AP gene and Angelman syndrome 396
Cointegrators: CBP and p300 397
Mutations of CBP and Rubinstein Taybi syndrome 398
Androgen receptor specific coactivators: possible involvement in prostate
cancer 399
TRIP 230, a coactivator associated with the retinoblastoma gene product 399
Corepressors 399
Corepressors modulate responses to receptor antagonists 400
Corepressors and resistance to thyroid hormone 401
Corepressors and acute promyelocytic leukemia 401
Conclusions 402
References 403
Index 409
Plate section appears between pages 52 and 53
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:51:25Z |
| institution | BVB |
| isbn | 0121461602 |
| language | English |
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| physical | XII, 419 S. Ill., graph. Darst. |
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| spelling | Nuclear receptors and genetic disease ed. by Thomas P. Burris ... San Diego [u.a.] Acad. Press 2001 XII, 419 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetic Diseases, Inborn genetics Genetic Diseases, Inborn physiopathology Genetic disorders Hormones physiology Nuclear receptors (Biochemistry) Pathology, Molecular Receptors, Cytoplasmic and Nuclear chemistry Receptors, Cytoplasmic and Nuclear physiology Transcription Factors physiology Burris, Thomas P. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009403140&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nuclear receptors and genetic disease Genetic Diseases, Inborn genetics Genetic Diseases, Inborn physiopathology Genetic disorders Hormones physiology Nuclear receptors (Biochemistry) Pathology, Molecular Receptors, Cytoplasmic and Nuclear chemistry Receptors, Cytoplasmic and Nuclear physiology Transcription Factors physiology |
| title | Nuclear receptors and genetic disease |
| title_auth | Nuclear receptors and genetic disease |
| title_exact_search | Nuclear receptors and genetic disease |
| title_full | Nuclear receptors and genetic disease ed. by Thomas P. Burris ... |
| title_fullStr | Nuclear receptors and genetic disease ed. by Thomas P. Burris ... |
| title_full_unstemmed | Nuclear receptors and genetic disease ed. by Thomas P. Burris ... |
| title_short | Nuclear receptors and genetic disease |
| title_sort | nuclear receptors and genetic disease |
| topic | Genetic Diseases, Inborn genetics Genetic Diseases, Inborn physiopathology Genetic disorders Hormones physiology Nuclear receptors (Biochemistry) Pathology, Molecular Receptors, Cytoplasmic and Nuclear chemistry Receptors, Cytoplasmic and Nuclear physiology Transcription Factors physiology |
| topic_facet | Genetic Diseases, Inborn genetics Genetic Diseases, Inborn physiopathology Genetic disorders Hormones physiology Nuclear receptors (Biochemistry) Pathology, Molecular Receptors, Cytoplasmic and Nuclear chemistry Receptors, Cytoplasmic and Nuclear physiology Transcription Factors physiology |
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