A primer of population genetics:
Gespeichert in:
| Späterer Titel: | Hartl, Daniel L. A primer of population genetics and genomics |
|---|---|
| 1. Verfasser: | |
| Format: | Buch |
| Sprache: | German English |
| Veröffentlicht: |
Sunderland, Mass.
Sinauer
2000
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 219 S. Ill., graph. Darst. |
| ISBN: | 0878933042 9780878933044 |
Internformat
MARC
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| 100 | 1 | |a Hartl, Daniel L. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a A primer of population genetics |c Daniel L. Hartl |
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| 264 | 1 | |a Sunderland, Mass. |b Sinauer |c 2000 | |
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| 785 | 0 | 0 | |i Gefolgt von |a Hartl, Daniel L. |t A primer of population genetics and genomics |b Fourth edition |d Oxford : Oxford University Press, 2020 |z 978-0-19-886230-7 |z 978-0-19-886229-1 |w (DE-604)BV046694707 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Preface xi
Acronyms and Abbreviations xv
Chapter 1 Genetic Variation 1
Genetic and Molecular Essentials 2
Genotype and Phenotype 2
Gene Expression 3
DNA Cleavage, Manipulation, and Amplification 5
Types of Polymorphisms 11
DNA Polymorphisms 11
Uses of DNA Polymorphisms 18
Protein Polymorphisms 18
Gene and Genotype Frequencies 20
Organization of Genetic Variation 23
Populations 24
Models 24
Random Mating 26
The Hardy Weinberg Principle 26
Implications of Random Mating 29
Chi square Test for HWE 29
Recessive Alleles Hidden in Heterozygotes 32
Multiple Alleles and X Linked Genes 33
Multiple Loci: Linkage and Linkage Disequilibrium 36
Inbreeding 41
Genotype Frequencies with Inbreeding 41
The Inbreeding Coefficient 44
Inbeeding Depression 46
Calculation of the Inbreeding Coefficient from Pedigrees 49
Regular Systems of Mating 52
Further Readings 53 • Problems 54
Chapter 2 The Causes of Evolution 59
Mutation 59
Forward Mutation 60
Reversible Mutation 61
Remote Inbreeding in a Finite Population 63
Equilibrium Heterozygosity with Mutation 65
Migration 66
The Island Model of Migration 67
How Migration Limits Genetic Divergence 68
Wahlund s Principle 70
Hierarchical Population Structure 72
Natural Selection 74
Haploid Selection 74
Diploid Selection 77
Time Required for Changes in Gene Frequency 80
Overdominance and Under dominance 83
Mutation Selection Balance 86
More Complex Modes of Selection 87
Random Genetic Drift 88
Diffusion Approximations 88
Probability of Fixation and Time to Fixation 94
Effective Population Number 96
Further Readings 98 • Problems 100
Chapter 3 Molecular Population Genetics 105
Molecular Polymorphisms glO6
The Information Content of Molecular Sequences 106
The Coalescent 108
Nucleotide Polymorphism 110
Nucleotide Diversity 111
Tajima s D Statistic 112
Patterns of Change in Nucleotide and Amino Acid Sequences 113
Synonymous and Nonsynonymous Substitutions 114
Codon Usage Bias 116
Selection for Optimal Codons and Amino Acids 117
Selective Sweeps versus Background Selection 120
Polymorphism and Divergence 122
The Hudson Kreitman Aguade (HKA) Test 123
The McDonald Kreitman Test 126
Polymorphism and Divergence in a Poisson Random Field 128
Convergence to Adaptation 130
Molecular Phylogenetics 132
The Multiple Hit Problem 134
Phylogenetic Inference 136
Molecular Clocks 138
Transposable Elements 141
Insertion Sequences and Transposons in Bacteria 142
Transposable Elements in Eukaryotes 143
Further Readings 144 • Problems 145
Chapter 4 The Genetic Architecture of Complex Traits 151
Types of Complex Traits 151
Phenotypic Variation 152
Genetics and Environment 156
Genotypic Variance and Environmental Variance 156
Broad Sense HeritabMty 158
Genotype Environment and Other Interactions 158
Genetic Effects on Complex Traits 160
Components ofGenotypic Variation 160
Artificial Selection 163
Prediction Equation for Individual Selection 165
Genetic Basis of Complex Traits 167
Change in Allele Frequency 169
Change in Mean Phenotype 170
Correlation between Relatives 172
Parent Offspring Correlation 173
HeritabHity Estimates from Resemblance between Relatives 174
Offspring on Parent Regression 176
Quantitative Genetics of Natural Populations 177
Directional Selection with Mutation Selection Drift 178
Stabilizing Selection with Mutation Selection Drift 179
Antagonistic Pleiotropy 180
Complex Traits with Discrete Expression 181
Threshold Traits: Genes as Risk Factors 181
Heritability of liability 182
Applications to Human Disease 185
Linkage Analysis and hod Scores 186
Quantitative Trait Loci (QTLs) 189
Number of Genes 189
QTL Mapping 190
Candidate Genes 194
Further Readings 195 • Problems 196
Literature Cited 203
Index 213
|
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| genre | Matériel didactique |
| genre_facet | Matériel didactique |
| id | DE-604.BV013743085 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:51:13Z |
| institution | BVB |
| isbn | 0878933042 9780878933044 |
| language | German English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009394281 |
| oclc_num | 299852897 |
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| owner | DE-355 DE-BY-UBR DE-634 |
| owner_facet | DE-355 DE-BY-UBR DE-634 |
| physical | XVII, 219 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Sinauer |
| record_format | marc |
| spelling | Hartl, Daniel L. Verfasser aut A primer of population genetics Daniel L. Hartl 3. ed. Sunderland, Mass. Sinauer 2000 XVII, 219 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Génétique des populations ram Génétique quantitative ram Quantitative Methode (DE-588)4232139-6 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Populationsgenetik (DE-588)4046804-5 gnd rswk-swf Matériel didactique Genetik (DE-588)4071711-2 s Quantitative Methode (DE-588)4232139-6 s DE-604 Populationsgenetik (DE-588)4046804-5 s Gefolgt von Hartl, Daniel L. A primer of population genetics and genomics Fourth edition Oxford : Oxford University Press, 2020 978-0-19-886230-7 978-0-19-886229-1 (DE-604)BV046694707 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009394281&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hartl, Daniel L. A primer of population genetics Génétique des populations ram Génétique quantitative ram Quantitative Methode (DE-588)4232139-6 gnd Genetik (DE-588)4071711-2 gnd Populationsgenetik (DE-588)4046804-5 gnd |
| subject_GND | (DE-588)4232139-6 (DE-588)4071711-2 (DE-588)4046804-5 |
| title | A primer of population genetics |
| title_auth | A primer of population genetics |
| title_exact_search | A primer of population genetics |
| title_full | A primer of population genetics Daniel L. Hartl |
| title_fullStr | A primer of population genetics Daniel L. Hartl |
| title_full_unstemmed | A primer of population genetics Daniel L. Hartl |
| title_new | Hartl, Daniel L. A primer of population genetics and genomics |
| title_short | A primer of population genetics |
| title_sort | a primer of population genetics |
| topic | Génétique des populations ram Génétique quantitative ram Quantitative Methode (DE-588)4232139-6 gnd Genetik (DE-588)4071711-2 gnd Populationsgenetik (DE-588)4046804-5 gnd |
| topic_facet | Génétique des populations Génétique quantitative Quantitative Methode Genetik Populationsgenetik Matériel didactique |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009394281&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hartldaniell aprimerofpopulationgenetics |