Prader-Willi-Syndrome: effects of human growth hormone treatment ; 11 tables
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Basel [u.a.]
Karger
2001
|
| Schriftenreihe: | Endocrine development
3 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII,118 S. Ill., graph Darst. : 25 cm |
| ISBN: | 3805572565 |
Internformat
MARC
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| 245 | 1 | 0 | |a Prader-Willi-Syndrome |b effects of human growth hormone treatment ; 11 tables |c Urs Eiholzer |
| 246 | 1 | 3 | |a Prader-Willi syndrome |
| 264 | 1 | |a Basel [u.a.] |b Karger |c 2001 | |
| 300 | |a XII,118 S. |b Ill., graph Darst. : 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Endocrine development |v 3 | |
| 650 | 0 | 7 | |a Prader-Willi-Syndrom |0 (DE-588)4201277-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Somatotropin |0 (DE-588)4137446-0 |2 gnd |9 rswk-swf |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-009353190 | |
Datensatz im Suchindex
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CONTENTS
FOREWORD
BY
M.O.
SAVAGE
.
VII
FOREWORD
BY
A.
BACHLI
.
VIII
PREFACE
.
IX
ACKNOWLEDGEMENTS
.
XI
1
FUNDAMENTAL
ISSUES
.
1
1.1
FIRST
DESCRIPTION
BY
ANDREA
PRADER,
ALEXIS
LABHART
AND
HEINRICH
WILLI
IN
1956
IN
ZURICH
.
.
.
1
1.2
AGE-DEPENDENT
CLINICAL
CHARACTERISTICS
.
.
2
1.2.1
INFANT
PHASE
.
R.
.
2
1.2.2
CHILDHOOD
PHASE
.
3
1.2.3
ADOLESCENCE
.
4
1.3
GROWTH
AND
PUBERTAL
DEVELOPMENT
.
6
1.4
GENETIC
ISSUES
.
9
1.5
THE
HYPOTHALAMUS
.
10
2
FUNCTION
OF
THE
HYPOTHALAMO-PITUITARY
AXES
IN
PWS
.
12
2.1
THE
GROWTH
HORMONE
AXIS
.
12
2.2
THE
GONADAL
AXIS
.
14
2.3
THE
THYROID
AXIS
.
16
2.4
THE
ADRENAL
AXIS
.
17
3
METABOLISM
IN
PWS
.
18
3.1
CARBOHYDRATE
METABOLISM
.
18
3.2
LIPID
METABOLISM
.
19
3.3
ENERGY
BALANCE
IN
PWS
.
19
4
INFLUENCE
OF
GROWTH
HORMONE
ON
PHENOTYPE
.
20
4.1
INTRODUCTION
.
20
4.1.1
EARLY
EXPERIENCES
WITH
GROWTH
HORMONE
TREATMENT
IN
PWS
.
20
4.1.2
PATHOGENETIC
EXPLANATIONS
AT
THE
BEGINNING
OF
THE
1
990S
.
20
4.1.3
OUR
AIMS
IN
PWS
RESEARCH
.
21
4.1.4
DESIGN
OF
OUR
STUDY
.
23
4.2
RESULTS
OF
THE
DIFFERENT
GROWTH
HORMONE
STUDIES
.
25
4.2.1
GROWTH
.
25
4.2.2
WEIGHT
AND
BODY
COMPOSITION
.
32
4.2.3
IGF-I
SYSTEM
.
38
4.2.4
LEPTIN
.
42
4.2.5
CARBOHYDRATE
METABOLISM
.
43
4.2.6
LIPID
METABOLISM
.
49
4.2.7
NUTRITIONAND
VARIABLES
INFLUENCING
BODY
WEIGHT
.
51
4.2.8
PSYCHOMOTOR
DEVELOPMENT
AND
PHYSICAL
CAPABILITY
.
55
5
PHOTOGRAPHIC
DOCUMENTATION
OF
SELECTED
PATIENTS
.
57
6
DISCUSSION
.
76
6.1
DO
SPONTANEOUS
GROWTH
AND
WEIGHT
GAIN
IN
SWISS
CHILDREN
WITH
PWS
DIFFER
FROM
THOSE
IN
OTHER
REGIONS?
.
77
6.2
IS
ABNORMAL
GROWTH
CAUSED
BY
GHD
AND
CAN
IT
BE
NORMALIZED
BY
GROWTH
HORMONE
THERAPY?
.
78
6.2.1
DIAGNOSTICS
TO
ASCERTAIN
GHD
IN
PWS
.
78
6.2.2
SPONTANEOUS
GROWTH
PATTERN
.
79
6.2.3
CATCH-UP
GROWTH
DURING
GH
THERAPY
.
79
6.3
IS
BODY
COMPOSITION
RELATED
TO
POTENTIAL
GROWTH
HORMONE
DEFICIENCY?
.
81
6.3.1
ALTERED
BODY
COMPOSITION
BEFORE
TREATMENT
.
81
6.3.2
BODY
COMPOSITION
DURING
GH
TREATMENT
.
81
6.4
DOES
GROWTH
HORMONE
THERAPY
IMPROVE
PSYCHOMOTOR
DEVELOPMENT,
PHYSICAL
CAPABILITY
AND
GENERAL
WELL-BEING?
.
83
6.5
HOW
ARE
WEIGHT
AND
ENERGY
BALANCE
INFLUENCED
BY
EDUCATIONAL
BEHAVIOR
OR
GENETIC
DISPOSITION?
.
84
6.6
HOW
ARE
LIPID
AND
CARBOHYDRATE
METABOLISM
AND
INSULIN
SECRETION
REGULATED?
.
85
6.7
IS
THERE
A
DYSFUNCTION
OF
THE
LEPTIN
SYSTEM?
.
86
6.8
HOW
TO
DIAGNOSE
GHD
IN
PWS
EFFICIENTLY,
AND
HOW
TO
ASSESS
THE
SUCCESS
OF
GH
THERAPY
WITHIN
A
FRAMEWORK
OF
COMPREHENSIVE
CARE
.
87
7
CONCLUSION
.
89
8
APPENDICES
.
92
APPENDIX
I:
CLINICAL
DIAGNOSTIC
CRITERIA
FOR
PRADER-WILLI
SYNDROME
.
92
APPENDIX
II:
CONSENSUS
STATEMENT
-
PRADER-WILLI
SYNDROME:
GROWTH
HORMONE
(GH)/INSULIN-LIKE
GROWTH
FACTOR
AXIS
DEFICIENCY
AND
GH
TREATMENT
.
93
APPENDIX
III:
RECOMMENDATIONS
FOR
MANAGEMENT
OF
CHILDREN
WITH
PRADER-WILLI
SYNDROME
UNDER
GROWTH
HORMONE
TREATMENT
.
98
9
REFERENCES
.
101
SUBJECT
INDEX
.
116 |
| any_adam_object | 1 |
| author | Eiholzer, Urs 1951- |
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| author_facet | Eiholzer, Urs 1951- |
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| author_sort | Eiholzer, Urs 1951- |
| author_variant | u e ue |
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| discipline | Medizin |
| format | Book |
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| id | DE-604.BV013686989 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T01:00:58Z |
| institution | BVB |
| isbn | 3805572565 |
| language | English |
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| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | XII,118 S. Ill., graph Darst. : 25 cm |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Karger |
| record_format | marc |
| series | Endocrine development |
| series2 | Endocrine development |
| spelling | Eiholzer, Urs 1951- Verfasser (DE-588)114999163 aut Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables Urs Eiholzer Prader-Willi syndrome Basel [u.a.] Karger 2001 XII,118 S. Ill., graph Darst. : 25 cm txt rdacontent n rdamedia nc rdacarrier Endocrine development 3 Prader-Willi-Syndrom (DE-588)4201277-6 gnd rswk-swf Somatotropin (DE-588)4137446-0 gnd rswk-swf Prader-Willi-Syndrom (DE-588)4201277-6 s Somatotropin (DE-588)4137446-0 s DE-604 Endocrine development 3 (DE-604)BV012382038 3 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009353190&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Eiholzer, Urs 1951- Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables Endocrine development Prader-Willi-Syndrom (DE-588)4201277-6 gnd Somatotropin (DE-588)4137446-0 gnd |
| subject_GND | (DE-588)4201277-6 (DE-588)4137446-0 |
| title | Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables |
| title_alt | Prader-Willi syndrome |
| title_auth | Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables |
| title_exact_search | Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables |
| title_full | Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables Urs Eiholzer |
| title_fullStr | Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables Urs Eiholzer |
| title_full_unstemmed | Prader-Willi-Syndrome effects of human growth hormone treatment ; 11 tables Urs Eiholzer |
| title_short | Prader-Willi-Syndrome |
| title_sort | prader willi syndrome effects of human growth hormone treatment 11 tables |
| title_sub | effects of human growth hormone treatment ; 11 tables |
| topic | Prader-Willi-Syndrom (DE-588)4201277-6 gnd Somatotropin (DE-588)4137446-0 gnd |
| topic_facet | Prader-Willi-Syndrom Somatotropin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009353190&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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