Cutaneous biometrics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Kluwer Acad. / Plenum
2000
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 358 S. graph. Darst. |
| ISBN: | 0306461595 |
Internformat
MARC
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| 650 | 4 | |a Mathematik | |
| 650 | 4 | |a Biometry | |
| 650 | 4 | |a Biometry |x methods | |
| 650 | 4 | |a Dermatology |x Mathematics | |
| 650 | 4 | |a Dermatology, Experimental | |
| 650 | 4 | |a Research Design | |
| 650 | 4 | |a Skin Diseases | |
| 650 | 4 | |a Skin |x Research |x Methodology | |
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Datensatz im Suchindex
| _version_ | 1804128484402921472 |
|---|---|
| adam_text | Contents
I. Basic Concepts
7. Statistics in Clinical Research
Volker W. Rahlfs
1. Introduction 3
2. The Meaning of the P Value 4
3. The Appropriate Statistical Test 5
3.1. Parallel Groups 6
3.2. Correlated Samples 8
4. Effect Size Measures and Confidence Intervals 9
4.1. Effect Size Measures 9
4.2. The Confidence Interval 10
5. Multiple Testing and the Control of a 11
6. Tests for Difference and Equivalence 14
7. Two Examples and Their Interpretation 15
8. Conclusions 19
References 20
2. The Case Control Study
Cornelius Kennedy, Helen J. Heacock, and Jason K. Rivers
1. Introduction 23
2. Reasons for Selecting a Case Control Design 24
3. Planning and Carrying Out a Case Control Study 25
3.1. Developing a Study Protocol 26
3.2. Data Collection 30
3.3. Data Analysis and Interpretation of Results 31
4. Criteria Use to Judge Causality 34
5. Conclusion 34
References 35
xi
xii CONTENTS
3. Principles for the Conduct of Nondrug Clinical Studies
Gerhard J. Schmitt
1. Introduction 37
2. World Medical Association Declaration of Helsinki 38
3. Nondrug vs. Drug Studies 38
4. Skin Care Products 39
5. Protection of Trial Subjects: Written Informed Consent 39
6. Study Protocol 39
7. Safety Documentation for Test Products 40
8. Data Handling and Documentation 40
9. Statistics 41
10. Final Report 41
11. Summary 41
References 42
4. Questionnaire Design in Skin Disease Epidemiology
Paivikki Susitaival
1. Questionnaire Methods Used in Skin Disease Epidemiology 43 •
1.1. Some Epidemiological Concepts 43
1.2. Hand Dermatitis and Other Dermatoses 44
1.3. Atopy 46
1.4. Skin Cancer 47
1.5. Concluding Remarks 47
2. Designing a Questionnaire 48
2.1. Introduction 48 ,
2.2. The Art of Asking Questions 49
2.3. Answer Categories 50
2.4. Final Tasks 50
3. The Tuohilampi Questionnaire 51 :
References 52
//. Non invasive Evaluation of Skin Properties
5. Scale Development for Clinical Assessment
Gerhard J. Schmitt
1. Assessment Criteria and Scales 57
2. Case Report Forms 59
3. Validation and Calibration of Investigators 62
4. Relevance of Biophysical and Biochemical Parameters 63
i
CONTENTS xiii
6. Evaluation of Cosmetics by Sensory Assessment
Peter Busch and Thomas Gassenmeier
1. Introduction 65
2. The Relationship between Effect and Perception 65
3. Reasons for Sensory Vagueness in Assessing Cosmetic Effects 66
4. The Significance of Language 67
4.1. Correlation of Experience and Language 67
4.2. Generation of Verbal Terms 68
5. Quantitative Testing 71
5.1. Principles of Quantification of Subjective Tests 71
5.2. Comparison Test vs. Defined References 72
5.3. Mathematical Aspects 77
5.4. Structuring of Sensory Profiles 80
6. Areas of Application for Sensory Assessment in the Cosmetic Field ... 80
References 80
7. Cutaneous Bioengineering
Dimiter Iliev, Peter Eisner, and Howard I. Maibach
1. Introduction 81
2. Barrier Function of Stratum Corneum as Measured by Transepidermal
Water Loss 81
3. Skin Moisture 82
4. Acid Mantle of the Skin 83
5. Skin Color 83
6. Skin Blood Flow 86
7. Skin Roughness as Measured by Visiometry 86
8. Skin Thickness 87
9. Other Methods and Relations among Different Measurements 87
References 88
///. Skin Diseases and Therapy
8. Atopic Dermatitis: Severity Scoring
Alain Ta i eb and Jean Francois Stalder
1. Introduction 93
2. Historical Perspective 94
3. Defining Extent 94
4. Choosing/Defining Severity/Intensity Terms 95
5. Interobserver Variability 96
5.1. Physician Profile 96
5.2. Intensity Items 96
5.3. Extent 98
x/V CONTENTS
6. Subjective Items and Quality of Life 98
7. Assessment of Outcome with a Cumulative Compound Index: The
SCORAD Index 99
8. Severity and Time Course of the Disease 101
9. Quality Control and Routine Scoring of Atopic Dermatitis 101
10. Scoring with SCORAD for Special Purposes 102
10.1. Localized Assessment 102
10.2. Inclusion Criteria for Clinical Trials 102
10.3. Epidemiological Studies 103
11. Biophysical and Biochemical Evaluation of Severity 103
12. Training 103
Appendix 1. EFFAD Recommendations and Definitions for Grading
Intensity Items 103
Appendix 2. A Proposal for Severity Grading of Atopic Dermatitis .... 105
References 105
9. A Review of the Use of Essential Fatty Acid Supplementation
in Atopic Dermatitis with Emphasis on the Methodology of
Trial Design
John Berth Jones and Robin A. C. Graham Brown
1. Introduction 109 ;
2. Rationale for Essential Fatty Acid Supplementation in Atopic Dermatitis . 110
3. Evidence for Efficacy 110
3.1. The n6 Series EFA Supplementation Ill
3.2. The n3 Series EFA Supplementation 112
3.3. The n6 and Combined w6 and n3 Series EFA Supplementation ... H2
4. Observations on the Methodology of Clinical Trials in Atopic Dermatitis . 114
5. Conclusions 115
References 116
10. Severity Scoring of Atopic Dermatitis
Aline B. Sprikkelman and Wim M. C. van Aalderen
1. Introduction 119
2. Atopic Dermatitis Severity Scoring Systems 120
2.1. Severity Scoring Systems for Clinical Practice 120 .
2.2. Severity Scoring Systems for Clinical Research 121
3. Conclusions and Recommendations 126
References 127
CONTENTS xv
11. A Metric for Acneiform Eruptions of the Face
Jonathan K. Wilkin
1. Introduction 129
2. Materials and Methods 131
3. Results 137
4. Comment 139
References 147
12. Toward a New Psoriasis Severity Scoring Using Bioengineering
Techniques
Doris A. Schwindt and Howard I. Maibach
1. Introduction 149
2. The Psoriasis Area and Severity Index 149
3. Assessing Severity with Bioengineering Techniques 151
3.1. Infiltration 152
3.2. Erythema 153
3.3. Desquamation 154
4. Summary 155
References 156
13. Epidemic of Melanoma: How Real Is It?
Tsu Yi Chuang
1. The Epidemic of Melanoma 159
2. An Analysis of the Epidemic 160
2.1. Clinical Diagnosis 160
2.2. Tumor Registry 160
2.3. Shifting Pathological Diagnostic Criteria 160
2.4. The Methods of Case Finding and Documentation 161
2.5. Early Detection and Thin Melanoma 162
2.6. Increase of Incidence Only in Certain Areas 162
2.7. Increase of Incidence Only in Certain Types of Melanoma 162
2.8. Birth Cohort Effect 162
2.9. The Paradox of Increasing Incidence and Decreasing Mortality ... 162
3. The Experience of an Epidemic in Kauai, Hawaii, 1981 1990 163
3.1. Kauai and Its Residents 163
3.2. Study Design 163
3.3. Results 164
4. Check the Reality 165
References 166
xvi CONTENTS
14. Prognostic Models in Melanoma
Ranjini Natarajan and Martin A. Weinstock
1. Introduction 167
2. A Brief Review of Current Methods 168
3. A Mixed Effects Survival Model 168
3.1. The Model 169
3.2. Assessing Significance of the Model 170
3.3. Reporting Results from a Mixed Model 171
4. Future Directions 171
References 172
15. Photoaging
William J. Cunningham
1. Introduction 173
2. Background 173
3. Rationale for Biometrics 174
4. Application of Biometrics 174
4.1. Clinical Aspects 174
4.2. Instrumentation 178
4.3. Histologic Assessments 180
5. Summary 181
References 181
16. Measurement in Scleroderma Clinical Trials
Janet E. Pope
1. Introduction 183
2. Statistics and Clinical Trial Guidelines 184
3. Diagnosis of Scleroderma 184
4. Skin Outcome Measurements 187
4.1. Functional Assessment 191
4.2. Global Assessments 192
4.3. Physical Performance Assessments 192 ,
4.4. Visceral Assessments 193
5. Raynaud s Phenomenon in Scleroderma 194
6. Discussion 195
References 198
17. Quantification of Wound Healing
Laura Bolton, Ann Jeanette Vasko, and Karyn Monte
1. Why Measure Healing? 205
2. Overall Healing Measures 206
CONTENTS xvii
3. Quantifying the Stages of Healing 206
3.1. Hemostasis 206
3.2. Inflammation 209
3.3. Granulation 211
3.4. Epithelization 211
3.5. Maturation and Complications 211
4. Conclusion 215
References 215
18. Design of Clinical Trials to Evaluate Antimycotic Agents in the
Treatment of Dermatophyte Infections
Beatrice B. Abrams and Dennis E. Babel
1. Introduction 221
2. General Trial Design 222
3. Elucidation of the Pathogenic Organism 223
3.1. Specimen Procurement 223
3.2. KOH Examination 224
3.3. Culture 225
4. Clinical Assessments 227
5. Alternative Designs 230
6. Conclusions 230
References 231
19. Sites of Contact Dermatitis in Relationship to Particular Allergens:
A Follow Up Study
Bjorn Edman
1. Introduction 233
2. Material and Methods 233
3. Statistics 234
4. Results 237
5. Discussion 237
References 241
20. Evaluating Surveillance Systems in Contact Dermatitis
Axel Schnuch
1. Introduction 243
2. Epidemiologic Methods 244
3. Measures of Frequency: The Time Factor 244
4. Data Generation: Active or Passive 245
5. Study Population (Problem: Selection Bias) 245
6. Diagnostic Procedure (Problem: Information Bias) 246
7. General Aspects of Evaluating a Surveillance System 247
xviii CONTENTS
8. Discussion of Several Methods 248
8.1. Active Data Generation 248
8.2. Passive Data Generation 249
9. Conclusions 251
Appendix: Proposal to Establish Guidelines for Evaluating Surveillance
Systems in Contact Dermatitis 252
References 253
21. Sodium Lauryl Sulfate: Water Soluble Irritant Contact Dermatitis
Model
Cheol Heon Lee and Howard I. Maibach
1. Sodium Lauryl Sulfate 257
2. Application Methods 257
2.1. Purity and Carbon Length of SLS 258
2.2. Quantity and Concentration of the Test Solution 258
2.3. Evaporation and Temperature of the Test Solution 259
2.4. Time of Evaluation 259
3. Biologic Endpoints 259
4. Host Related Factors 261
4.1. Age 261
4.2. Sex 261
4.3. Anatomic Region 262
4.4. Skin Color 262
4.5. Skin Hydration 262
4.6. Sensitive Skin 263
4.7. Hyperirritable Skin (Excited Skin Syndrome) 263
4.8. Atopic Dermatitis 263
4.9. Hand Eczema 264
4.10. Seborrheic Dermatitis 264
5. Conclusion 264
References 264
22. Quaternium 18 Bentonite in the Prevention of Allergic Contact
Dermatitis
Robert L. Rietschel
1. Introduction 269
2. Time of Occlusion 269
3. When to Read Patch Tests 270
4. What to Grade When Reading Patch Tests 270
References 272
CONTENTS xix
23. Personal Cleansers: Irritation and Moisturization
Keith D. Ertel
1. Introduction 273
2. Irritancy of Personal Cleansing Products 274
2.1. Surfactant Interactions with Skin 274
2.2. Estimating Personal Cleanser Irritation Potential 277
3. Moisturization from Personal Cleansing Products 281
3.1. Aspects of Moisturization from Personal Cleansers 282
3.2. Protocol Considerations for Demonstrating Moisturization from
Personal Cleansers 282
3.3. Examples of Moisturizing from Personal Cleansing Products .... 284
References 284
IV. Pharmacologic Assays
24. Small Plaque Assay
Antti Lauerma and Howard I. Maibach
1. Introduction 289
2. Small Plaque Assay 289
2.1. Why Perform Small Plaque Assay 289
2.2. Selection of Patients, Washout Period, and Pretreatment 290
2.3. Treatment Period 290
2.4. Follow Up 290
3. Small Plaque Assay Efficacy Parameters 290
3.1. Clinical Scoring 291
3.2. Chromametry 291
3.3. Surface Roughness Assessment 291
3.4. Transepidermal Water Loss 291
3.5. Skin Ultrasound 291
3.6. Histopathology 292
4. Alternative Small Plaque Assay Methods 292
5. Conclusions 292
References 292
25. Application of the Minolta Chromameter to the Assessment of
Corticosteroid lnduced Skin Blanching
Roderick B. Walker, John M. Haigh, and Eric W. Smith
1. Introduction 295
2. Methodology 296
2.1. Materials 296
2.2. Methods 296
xx CONTENTS
3. Results 299
3.1. Assessment of Visual Blanching Profiles 299
3.2. Assessment of Chromameter Blanching Profiles 299
4. Conclusions 303
References 303
26. Assaying for Bioavailability in Acne
Otto H. Mills, Jr., Caroline W. Cardin, and Mitchell Wortzman
1. Introduction 307
2. Pilot Studies of Benzoyl Peroxide and Topically Applied Erythromycin . 308
3. Comparative Study of Salicylic Acid Levels 310
3.1. Clinical Applications and Sampling Schedule 310
3.2. Analytical Method for Salicylic Acid Analysis (Isocratic HPLC
Using UV Detection) 311
4. Conclusion 313
References 314
27. In Vitro/In Vivo Correlations
Eric Beyssac, J. M. Cardot, and C. Bonnabry
1. Introduction 315
2. Topical Availability or Bioavailability 316
3. In Vitro and In Vivo Methods for Studying Drug Release: Diffusion and
Permeation of Drugs from Dermatological Preparations 317
3.1. In Vitro Methods 317
3.2. In Vivo Methods 322
4. In Vivo/In Vitro Correlations or Relationships 324
4.1. Relationships between In Vitro Release and Diffusion and In Vivo
Penetration 325
4.2. Relationship between In Vitro Release and Systemic Occurrence of
the Product 326
5. Conclusion 327
References 328
V. Pharmacoeconomics
28. Pharmacoeconomics and Outcomes Research
Rukmini Rajagopalan
1. Introduction 333
2. Audience for Economic Evaluation and Economic Messages 333
3. Evaluation Methodology 334
3.1. Cost Benefit Analysis 334
CONTENTS xxi
3.2. Cost Utility Analysis 334
3.3. Cost Effectiveness Analysis 336
3.4. Cost Minimization Analysis 336
4. Benefits of Outcomes Research Studies 337
5. Examples of Cost Effectiveness Studies 337
5.1. An Economic Analysis of Oral Therapies for Onychomycosis . . . . 337
5.2. An Economic Evaluation of Patch Testing in Diagnosis and
Management of Allergic Contact Dermatitis 337
5.3. Systematic Analysis of Components of Compounds and Outcomes
Data 340
5.4. A Comparison of Outcomes between the Standard Treatment and the
Treatment Based on Iterative Feedback and Simulation Modeling . . 342
6. Conclusion 342
References 342
29. The Cost ofAtopic Eczema to Society: An International
Perspective
Rukmini Rajagopalan
1. Introduction 343
2. Clinical Definition 343
3. Prevalence 344
4. International Scenes 346
4.1. United States 346
4.2. United Kingdom 348
4.3. Australia 349
5. Discussion 351
6. Conclusion 351
References 352
Index 353
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| indexdate | 2024-07-09T18:49:59Z |
| institution | BVB |
| isbn | 0306461595 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009342089 |
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| owner_facet | DE-355 DE-BY-UBR DE-29 |
| physical | XXI, 358 S. graph. Darst. |
| publishDate | 2000 |
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| publisher | Kluwer Acad. / Plenum |
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| spelling | Cutaneous biometrics ed. by Doris A. Schwindt ... New York [u.a.] Kluwer Acad. / Plenum 2000 XXI, 358 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Mathematik Biometry Biometry methods Dermatology Mathematics Dermatology, Experimental Research Design Skin Diseases Skin Research Methodology Dermatologie (DE-588)4135648-2 gnd rswk-swf Biostatistik (DE-588)4729990-3 gnd rswk-swf Dermatologie (DE-588)4135648-2 s Biostatistik (DE-588)4729990-3 s DE-604 Schwindt, Doris A. 1967- Sonstige (DE-588)121603741 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009342089&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cutaneous biometrics Mathematik Biometry Biometry methods Dermatology Mathematics Dermatology, Experimental Research Design Skin Diseases Skin Research Methodology Dermatologie (DE-588)4135648-2 gnd Biostatistik (DE-588)4729990-3 gnd |
| subject_GND | (DE-588)4135648-2 (DE-588)4729990-3 |
| title | Cutaneous biometrics |
| title_auth | Cutaneous biometrics |
| title_exact_search | Cutaneous biometrics |
| title_full | Cutaneous biometrics ed. by Doris A. Schwindt ... |
| title_fullStr | Cutaneous biometrics ed. by Doris A. Schwindt ... |
| title_full_unstemmed | Cutaneous biometrics ed. by Doris A. Schwindt ... |
| title_short | Cutaneous biometrics |
| title_sort | cutaneous biometrics |
| topic | Mathematik Biometry Biometry methods Dermatology Mathematics Dermatology, Experimental Research Design Skin Diseases Skin Research Methodology Dermatologie (DE-588)4135648-2 gnd Biostatistik (DE-588)4729990-3 gnd |
| topic_facet | Mathematik Biometry Biometry methods Dermatology Mathematics Dermatology, Experimental Research Design Skin Diseases Skin Research Methodology Dermatologie Biostatistik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009342089&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schwindtdorisa cutaneousbiometrics |