The molecular basis of dementia:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
New York Acad. of Sciences
2000
|
| Schriftenreihe: | New York Academy of Sciences: Annals of the New York Academy of Sciences
920 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 339 S. Ill., graph. Darst. |
| ISBN: | 1573312835 1573312843 |
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Datensatz im Suchindex
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 920
December 2000
THE MOLECULAR BASIS OF
DEMENTIA
Editors and Conference Organizers
John H. Growdon, Richard J. Wurtman, Suzanne Corkin,
and Roger M. Nitsch
[These papers were presented at the ninth meeting of the International Study Group on the
Pharmacology of Memory Disorders Associated with Aging, held on February 18 20, 2000
in Zurich, Switzerland.]
CONTENTS
Preface. By John H. Growdon, Richard J. Wurtman, Suzanne Corkin,
and Roger M. Nitsch xi
Part I. a Synuclein in Neurodegenerative Disease
Clinical Lewy Body Syndromes. By I.G. McKeith 1
Clinical and Neuropathological Correlates of Dementia with Lewy Bodies. By
E. G6MEZ TORTOSA, M.C. IRIZARRY, T. G6MEZ ISLA, AND
B.T. Hyman 9
The a Synucleinopathies: Parkinson s Disease, Dementia with Lewy Bodies,
and Multiple System Atrophy. By Maria Grazia Spillantini and
Michel Goedert 16
Genetics of Parkinson s Disease. By Mihael H. Polymeropoulos 28
Physiology and Pathophysiology of a Synuclein: Cell Culture and Transgenic
Animal Models Based on a Parkinson s Disease associated Protein. By
Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, and
Christian Haass 33
Accelerated Oligomerization by Parkinson s Disease Linked a Synuclein
Mutants. By K.A. Conway, S. J. Lee, J. C. Rochet, T.T. Ding,
J.D. Harper, R.E. Williamson, and P.T. Lansbury, Jr 42
Part II. Novel Mutations in Dementia
Classification and Description of Frontotemporal Dementias. By D. Neary,
J.S. Snowden, and D.M.A. Mann 46
Progress in Hereditary Tauopathies: A Mutation in the Tau Gene (G389R)
Causes a Pick Disease like Syndrome. By Bernardino Ghetti,
Jill R. Murrell, Paolo Zolo, Maria Grazia Spillantini, and
Michel Goedert 52
Molecular Genetics of Chromosome 17 Tauopathies. By Michael Hutton . 63
Tau Gene Mutations in Frontotemporal Dementia and Parkinsonism Linked to
Chromosome 17 (FTDP 17): Their Relevance for Understanding the
Neurodegenerative Process. By MICHEL GOEDERT, BERNARDINO
Ghetti, and Maria Grazia Spillantini 74
Amyloidogenesis in Familial British Dementia Is Associated with a Genetic
Defect on Chromosome 13. By J. Ghiso, R. Vidal, A. Rostagno,
L. MlRAVALLE, J.L. HOLTON, S. MEAD, T. REVESZ, G. PLANT, AND
B. Frangione 84
Familial British Dementia: Expression and Metabolism of BRI. By
Seong Hun Kim, Rong Wang, David J. Gordon, Joseph Bass,
Donald F. Steiner, Gopal Thinakaran, David G. Lynn,
Stephen C. Meredith, and Sangram S. Sisodia 93
High Frequency of Mutations in Four Different Disease Genes in Early Onset
Dementia. By Ulrich Finckh, Tomas Muller Thomsen,
Ulrike Mann, Christian Eggers, Josef Marksteiner,
Wolfgang Meins, Giuliano Binetti, Antonella Alberici,
Peter Sonderegger, Christoph Hock, Roger M. Nitsch, and
Andreas Gal 100
Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and
Differential Neuronal Vulnerabilities. By Christel Mailliot,
Thierry Bussiere, Malika Hamdane, Nicolas Sergeant,
Marie Laure Caillet, Andre Delacourte, and Luc Buee 107
Coexistent Tau and Amyloid Pathology in Hereditary Frontotemporal Demen¬
tia with Tau Mutations. By S.M. Rosso, W. Kamphorst, R. Ravid,
and J.C. Van Swieten 115
The Clinical Spectrum of Guam ALS and Parkinson Dementia Complex:
1997 1999. By Douglas Galasko, David Salmon, Ulla Katrina
Craig, and Wigbert Wiederholt 120
Part III. Transgenic and Knockout Approaches to
Neurodegenerative Diseases
In Vivo Analysis of Wild type and FTDP 17 Tau Transgenic Mice. By
J. Gotz, R. Barmettler, A. Ferrari, M. Goedert, A. Probst, and
R.M. Nitsch 126
Pathogenic Mechanisms of Alzheimer s Disease Analyzed in the APP23
Transgenic Mouse Model. By Christine Sturchler Pierrat and
Matthias Staufenbiel 134
Prions: Pathogenesis and Reverse Genetics. By Adriano Aguzzi,
Michael A. Klein, Fabio Montrasio, Vladimir Pekarik,
Sebastian Brandner, Hisako Furukawa, Pascal Kaser,
Christiane Rockl, and Markus Glatzel 140
Presenilin Function in APP Processing. By Wim Annaert, Philippe
Cupers, Paul Saftig, and Bart de Strooper 158
Role of Presenilin 1 in Murine Neural Development. By Xudong YANG,
Melissa Handler, and Jie Shen 165
Modulation of Ap Deposition in APP Transgenic Mice by an Apolipoprotein
E Null Background. By M.C. Irizarry, G.W. Rebeck, B. Cheung, K.
Bales, S.M. Paul, D. Holzman, and B.T. Hyman 171
The Value of Transgenic Models for the Study of Neurodegenerative Diseases.
By Donald L. Price, Philip C. Wong, Alicja L. Markowska,
Michael K. Lee, Gopal Thinakaren, Donald W. Cleveland,
Sangram S. Sisodia, and David R. Borchelt 179
Part IV. Proteases in Alzheimer s Disease
Identifying Proteases That Cleave APP. By Martin Citron 192
Toward the Characterization and Identification of y Secretases Using
Transition state Analogue Inhibitors. By Chad L. Moore,
Thekla S. Diehl, Dennis J. Selkoe, and Michael S. Wolfe 197
Recent Advances in the Understanding of the Processing of APP to Beta Amy¬
loid Peptide. By S. Sinha, J. Anderson, V. John, L. McConlogue,
G. Basi, E. Thorsett, and D. Schenk 206
Presenilin 1: A Component of Synaptic and Endothelial Adherens Junctions.
By Anastasios Georgakopoulos, Philippe Marambaud, Victor
L. Friedrich, Jr., Junichi Shioi, Spiros Efthimiopoulos, and
NlKOLAOS K. ROBAKIS 209
cc Secretase Activity of the Disintegrin Metalloprotease ADAM 10:
Influences of Domain Structure. By Falk Fahrenholz, Sandra
Gilbert, Elzbieta Kojro, Sven Lammich, and Rolf Postina .... 215
Rapid Notchl Nuclear Translocation after Ligand Binding Depends on
Presenilin associated y Secretase Activity. By Oksana Berezovska,
Christine Jack, Pamela McLean, Jon C. Aster, Carol Hicks,
Weiming Xia, Michael S. Wolfe, Gerry Weinmaster,
Dennis J. Selkoe, and Bradley T. Hyman 223
GSK3p Forms a Tetrameric Complex with Endogenous PS1 CTF/NTF and
p Catenin: Effects of the D257/D385A and FAD linked Mutations. By
G. Tesco and R.E. Tanzi 227
An Empirical Model of y Secretase Activity. By M.P. Murphy, R. Wang,
P.E. Fraser, A. Fauq, and T.E. Golde 233
Overexpression of Presenilin 2 Enhances Apoptotic Death of Cultured Corti¬
cal Neurons. By W. Araki, K. Yuasa, S. Takeda, K. Shirotani,
K. Takahashi, and T. Tabira 241
al Antichymotrypsin Inhibits A0 Degradation in Vitro and in Vivo. By
Carmela R. Abraham, Walker T. McGraw, Franchot Slot,
and Rina Yamin 245
Activated Mitogenic Signaling Induces a Process of Dedifferentiation in
Alzheimer s Disease That Eventually Results in Cell Death. By
Thomas Arendt, Max Holzer, Andrea Stobe, Ulrich Gartner,
Hans Joachim Luth, Martina K. Bruckner, and Uwe Ueberham 249
Inhibition of the Neuronal Insulin Receptor: An in Vivo Model for Sporadic
Alzheimer Disease? By Siegfried Hoyer, Sae Kyung Lee, Thomas
LOFFLER, AND REINHARD SCHLIEBS 256
Cytoplasmic Presenilin Aggregates in Proteasome Inhibitor treated Cells. By
L.A. Mackenzie Ingano, K.M. Lentini, I. Kovacs, R.E. Tanzi,
and D.M. Kovacs 259
Part V. Therapies for Alzheimer s Disease beyond AChE Inhibitors
Regulation of APP Synthesis and Secretion by Neuroimmunophilin Ligands
and Cyclooxygenase Inhibitors. By Robert K.K. Lee and Richard J.
Wurtman 261
A(J Modulation: The Next Generation of AD Therapeutics. By KEVIN M.
Felsenstein 269
Prevention and Reduction of AD type Pathology in DPAPP Mice Immunized
with Ap]^2 By Dora Games, Frederique Bard, Henry Grajeda,
Terry Guido, Karen Khan, Ferdie Soriano, Nicki Vasquez,
Nancy Wehner, Kelly Johnson Wood, Ted Yednock, Peter
Seubert, and Dale Schenk 274
Treatment with the Selective Muscarinic Agonist Talsaclidine Decreases
Cerebrospinal Fluid Levels of Total Amyloid p Peptide in Patients with
Alzheimer s Disease. By C. Hock, A. Maddalena, I. Heuser,
D. Naber, W. Oertel, H. von der Kammer, M. Wienrich,
A. Raschig, M. Deng, J.H. Growdon, and R.M. Nitsch 285
Metal Chelation as a Potential Therapy for Alzheimer s Disease. By Math P.
Cuajungco, Kyle y. Faget, Xudong Huang, Rudolph E. Tanzi,
and Ashley I. Bush 292
Regulation of Gene Expression by Muscarinic Acetylcholine Receptors: A
Comprehensive Approach for the Identification of Regulated Genes. By
Heinz von der Kammer, Manuel Mayhaus, Claudia Albrecht,
Barbara Andresen, Jaroslav Klaudiny, Cuneyt Demiralay,
and Roger M. Nitsch 305
Cholinergic Modulation of Amyloid Processing and Dementia in Animal
Models of Alzheimer s Disease. By O. Isacson and L. Lin 309
Ml Muscarinic Agonists as Potential Disease Modifying Agents in
Alzheimer s Disease: Rationale and Perspectives. By A. Fisher,
D.M. Michaelson, R. Brandeis, R. Haring, S. Chapman, and
Z. PITTEL 315
Cholinesterase Inhibitors Stabilize Alzheimer s Disease. By Ezio Giacobini 321
Nasal AP Treatment Induces Anti Ap Antibody Production and Decreases
Cerebral Amyloid Burden in PD APP Mice. By C.A. Lemere,
R. Maron, E.T. Spooner, T.J. Grenfell, C. Mori, R. Desai,
W.W. Hancock, H.L. Weiner, and D.J. Selkoe 328
Cytidine (5 )Diphosphocholine Modulates Dopamine K+ evoked Release in
Striatum Measured by Microdialysis. By J. AGUT, J. A. Ortiz, and
RJ. Wurtman 332
Index of Contributors 337
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| spellingShingle | The molecular basis of dementia New York Academy of Sciences: Annals of the New York Academy of Sciences Dementie gtt Démence - Aspect moléculaire - Congrès Moleculaire biologie gtt Ziekte van Alzheimer gtt Dementia Molecular aspects Dementia drug therapy Congresses Dementia genetics Congresses Dementia physiopathology Congresses Molekularpathologie (DE-588)4170396-0 gnd Demenz (DE-588)4011404-1 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4170396-0 (DE-588)4011404-1 (DE-588)4039983-7 (DE-588)1071861417 |
| title | The molecular basis of dementia |
| title_auth | The molecular basis of dementia |
| title_exact_search | The molecular basis of dementia |
| title_full | The molecular basis of dementia ed. by John H. Growdon ... |
| title_fullStr | The molecular basis of dementia ed. by John H. Growdon ... |
| title_full_unstemmed | The molecular basis of dementia ed. by John H. Growdon ... |
| title_short | The molecular basis of dementia |
| title_sort | the molecular basis of dementia |
| topic | Dementie gtt Démence - Aspect moléculaire - Congrès Moleculaire biologie gtt Ziekte van Alzheimer gtt Dementia Molecular aspects Dementia drug therapy Congresses Dementia genetics Congresses Dementia physiopathology Congresses Molekularpathologie (DE-588)4170396-0 gnd Demenz (DE-588)4011404-1 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Dementie Démence - Aspect moléculaire - Congrès Moleculaire biologie Ziekte van Alzheimer Dementia Molecular aspects Dementia drug therapy Congresses Dementia genetics Congresses Dementia physiopathology Congresses Molekularpathologie Demenz Molekularbiologie Konferenzschrift 2000 Zürich |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009306898&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT growdonjohnh themolecularbasisofdementia |