Airway remodeling:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Dekker
2001
|
| Schriftenreihe: | Lung biology in health and disease
155 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 293 S. Ill., graph. Darst. |
| ISBN: | 0824704487 |
Internformat
MARC
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|---|---|---|---|
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| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Lung biology in health and disease |v 155 | |
| 650 | 7 | |a Astma |2 gtt | |
| 650 | 7 | |a Farmacotherapie |2 gtt | |
| 650 | 7 | |a Luchtwegen (anatomie) |2 gtt | |
| 650 | 4 | |a Airway (Medicine) | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Asthma |x physiopathology | |
| 650 | 4 | |a Respiratory System | |
| 650 | 0 | 7 | |a Bronchus |0 (DE-588)4259659-2 |2 gnd |9 rswk-swf |
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| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
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| 689 | 2 | 2 | |a Plastizität |g Physiologie |0 (DE-588)4174847-5 |D s |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-009266261 | ||
Datensatz im Suchindex
| _version_ | 1804128368124231680 |
|---|---|
| adam_text | CONTENTS
Introduction Claude Lenfant Hi
Preface v
Contributors ix
1. What Does Airway Remodeling Mean? Its Relevance
to Asthma 1
Jean Bousquet and Antonio Maurizio Vignola
References 3
2. How Can We Assess Airway Remodeling Using
Imaging? 5
Dany Jaffuel, Fabrice Jean Paganin, and Jean Bousquet
I. Introduction 5
II. Imaging Techniques and Airway Remodeling 6
xiii
x[v Contents
III. Importance of HRCT Scan in the Diagnosis of
Emphysema 7
IV. Importance of HRCT Scan in the Diagnosis of
Bronchiectasis 8
V. Demonstration of Irreversible Abnormalities Using
HRCT Scan in Asthma 9
VI. HRCT Scan Abnormalities and Asthma Severity 21
VII. Conclusion 22
References 23
3. The Use of Morphometry to Assess Airway Wall
Remodeling in Asthma 27
Neil G. Carroll and Alan Lloyd James
I. Introduction 27
II. Epithelium 29
III. Smooth Muscle 29
IV. Mucous Glands 31
V. Cartilage 34
VI. Sub basement Membrane Connective Tissue and
Extracellular Matrix 34
VII. Blood Vessels 36
VIII. Inner Wall Area 37
IX. Outer Wall Area 37
X. Total Wall Area 38
XI. Methodological Issues 38
References 42
4. Physiological Consequences of Lung Remodeling in
Asthma 45
Bjorn Jonson
I. Introduction 45
II. Relationship Between Lung Elastic Recoil and
Bronchial Dimensions 46
III. The Flow Regulator Method 47
IV. A Study of Bronchial and Parenchymal Physiology
in Chronic Asthma 47
V. Material 48
VI. Results 49
Contents xv
VII. Discussion 52
References 54
5. Consequences of Airway Remodeling to the Patient 57
Tari Haahtela
I. Introduction 57
II. From Individuals to Populations 58
III. Delayed Diagnosis 62
IV. Anti inflammatory Treatment Is Late 63
V. Long Term Effect of Treatment May Depend on
Timing of Intervention 64
VI. Treatment Guidelines 67
VII. Association of Treatment and Use of Health Care
Services 69
VIII. Finnish Experience 71
References 73
6. Signaling Mechanisms That Regulate Airway Smooth
Muscle Cell Function and Growth 79
Aili L. Lazaar and Reynold A. Panettieri, Jr.
I. Introduction 79
II. Airway Smooth Muscle Cell Growth 80
III. Cytokines Modulate Calcium Homeostasis and Cell
Adhesion Molecule Expression in Airway Smooth
Muscle Cells 87
IV. Cytokines Induce Cell Adhesion Molecule
Expression in Airway Smooth Muscle Cells 92
V. Summary 97
References 98
7. The Bronchial Vessels in Airway Remodeling 113
John W. Wilson and Xun Li
I. Introduction 113
IL. Quantitation of Bronchial Vasculature in Asthma 116
HI. Airway Inflammation and Increased Vascularity 120
IV. Angiogenesis 122
V. Microvascular Leakage 123
xvi Contents
VI. Airflow and Bronchial Vasculature 125
References 129
8. The Extracellular Matrix of the Airways and
Bronchial Asthma 137
William R. Roche
References 145
9. Role of the Airway Nervous System in Airway
Remodeling 147
Tony R. Bai and Darryl A. Knight
I. Introduction 147
II. Airway Innervation 149
III. Tachykinins and Sensory Neurons in the Lung 149
IV. Neurotrophic Cytokines 154
V. Experimental Animal Models 157
VI. Conclusions 159
References 159
10. The Influence of Pharmacological Therapy on Airway
Remodeling in Asthma 167
Peter H. Howarth
I. Introduction 167
II. Rate of Decline in Lung Function and Airflow
Obstruction 169
III. Bronchial Hyperresponsiveness 173
IV. Endobronchial Biopsy and Lavage Studies 177
V. Conclusions 181
References 182
11. The Human Eosinophil and Its Role in Airway
Remodeling 189
Per Venge
I. Introduction 189
II. Biochemistry and Function of the Human
Eosinophil 190
III. The Interaction Between Eosinophils and
Fibroblasts In Vivo 192
Contents xvii
IV. The Interaction Between Eosinophils and
Fibroblasts In Vitro 193
V. The Role of Eosinophils in Airway Remodeling:
Conclusion and Hypothesis 195
VI. Targets for Future Therapy 196
References 197
12. Role of Macrophages in Airway Remodeling in
Asthma: Future Therapeutic Target 201
Antonio Maurizio Vignola, Pascal Chanez, Liboria Siena,
Rosalia Gagliardo, Gisele Mautino, Giovanni Bonsignore,
Philippe Godard, and Jean Bousquet
I. Introduction 201
II. Function of Macrophages in Health and Disease 202
III. Macrophages in Airway Inflammation in Asthma 203
IV. Role of Macrophages in Airway Remodeling in
Asthma 203
V. Pharmacological Control of Airway Remodeling 209
References 209
13. Airway Smooth Muscle as a Target for Novel
Antiasthma Drugs Acting on Airway Wall Remodeling 217
Alastair G. Stewart
I. Introduction 217
II. Why Does Asthmatic Airway Smooth Muscle
Grow Excessively? 219
III. Synthetic Activities of Airway Smooth Muscle 225
IV. How Do Existing Antiasthma Drugs Influence
Airway Smooth Muscle Proliferation? 226
V. Potential Drug Targets 229
VI. Conclusions 234
References 235
14. Growth Factor Extracellular Matrix Interactions in
Bronchial Tissue in Asthma 245
Janis K. Shute
I. Introduction 245
II. Growth Factor Binding Molecules 246
xviii Contents
III. Mechanisms for Release and Activation of Matrix
Bound Growth Factors 251
IV. Growth Factors and Regulatory Mechanisms in the
Asthmatic Airways 255
References 257
15. Is There an Animal Model of Airway Remodeling? 261
Johan C. Kips, Els Palmans, Nele Vanacker, and Romain
A. Pauwels
I. Introduction 261
II. Rat Models of Airway Remodeling 263
III. Other Animal Models of Airway Remodeling 265
References 267
16. Future Directions in Airway Remodeling 271
John W. Wilson and Peter H. Howarth
I. Introduction 271
II. Noninvasive Physiological Measurement of Airway
Distensibility 272
III. Protease Activated Receptor 2 (PAR 2) in the
Activation of Airway Fibroblasts and Smooth
Muscle Cells 275
IV. Fibrogenic Factors and Metalloproteinases in
Airway Remodeling 280
V. The Regulatory Effect of Eosinophils on
Fibroblasts and Collagen Synthesis 283
VI. Animal Models of Airway Remodeling 284
VII. Intracellular Pathways Through Which Smooth
Muscle Remodeling May Occur 286
VIII. Microvascular Remodeling and Plasma Leakage 287
References 289
Index 291
|
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| dewey-search | 616.2/38 |
| dewey-sort | 3616.2 238 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV013567102 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:48:08Z |
| institution | BVB |
| isbn | 0824704487 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009266261 |
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| physical | XVIII, 293 S. Ill., graph. Darst. |
| publishDate | 2001 |
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| publisher | Dekker |
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| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Airway remodeling ed. by Peter H. Howarth ... New York [u.a.] Dekker 2001 XVIII, 293 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 155 Astma gtt Farmacotherapie gtt Luchtwegen (anatomie) gtt Airway (Medicine) Asthma Asthma physiopathology Respiratory System Bronchus (DE-588)4259659-2 gnd rswk-swf Hyperplasie (DE-588)4161084-2 gnd rswk-swf Wiederherstellung (DE-588)4352570-2 gnd rswk-swf Plastizität Physiologie (DE-588)4174847-5 gnd rswk-swf Bronchialschleimhaut (DE-588)4200265-5 gnd rswk-swf Bronchialasthma (DE-588)4069674-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bronchialasthma (DE-588)4069674-1 s Bronchus (DE-588)4259659-2 s Wiederherstellung (DE-588)4352570-2 s DE-604 Bronchialschleimhaut (DE-588)4200265-5 s Hyperplasie (DE-588)4161084-2 s Plastizität Physiologie (DE-588)4174847-5 s Howarth, Peter H. Sonstige oth Lung biology in health and disease 155 (DE-604)BV000008326 155 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009266261&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Airway remodeling Lung biology in health and disease Astma gtt Farmacotherapie gtt Luchtwegen (anatomie) gtt Airway (Medicine) Asthma Asthma physiopathology Respiratory System Bronchus (DE-588)4259659-2 gnd Hyperplasie (DE-588)4161084-2 gnd Wiederherstellung (DE-588)4352570-2 gnd Plastizität Physiologie (DE-588)4174847-5 gnd Bronchialschleimhaut (DE-588)4200265-5 gnd Bronchialasthma (DE-588)4069674-1 gnd |
| subject_GND | (DE-588)4259659-2 (DE-588)4161084-2 (DE-588)4352570-2 (DE-588)4174847-5 (DE-588)4200265-5 (DE-588)4069674-1 (DE-588)4143413-4 |
| title | Airway remodeling |
| title_auth | Airway remodeling |
| title_exact_search | Airway remodeling |
| title_full | Airway remodeling ed. by Peter H. Howarth ... |
| title_fullStr | Airway remodeling ed. by Peter H. Howarth ... |
| title_full_unstemmed | Airway remodeling ed. by Peter H. Howarth ... |
| title_short | Airway remodeling |
| title_sort | airway remodeling |
| topic | Astma gtt Farmacotherapie gtt Luchtwegen (anatomie) gtt Airway (Medicine) Asthma Asthma physiopathology Respiratory System Bronchus (DE-588)4259659-2 gnd Hyperplasie (DE-588)4161084-2 gnd Wiederherstellung (DE-588)4352570-2 gnd Plastizität Physiologie (DE-588)4174847-5 gnd Bronchialschleimhaut (DE-588)4200265-5 gnd Bronchialasthma (DE-588)4069674-1 gnd |
| topic_facet | Astma Farmacotherapie Luchtwegen (anatomie) Airway (Medicine) Asthma Asthma physiopathology Respiratory System Bronchus Hyperplasie Wiederherstellung Plastizität Physiologie Bronchialschleimhaut Bronchialasthma Aufsatzsammlung |
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