Cancer: principles & practice of oncology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Lippincott Williams & Wilkins
2001
|
| Ausgabe: | 6. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | LXXII, 3235, 164 S. zahlr. Ill., graph. Darst. |
| ISBN: | 0781722292 |
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Datensatz im Suchindex
| _version_ | 1804128364211994624 |
|---|---|
| adam_text | CONTENTS
PART 1
ESSENTIALS OF MODERN ONCOLOGIC SCIENCE
1
Essentials of Molecular Biology: Basic Principles 3
LANCE A. LIOTTA
EDISON T. LIU
Storage and Transmission of Genetic Information 3
Reading the Genetic Code and Production of Encoded Proteins 7
Protein Structure and Function 8
Subcellular Molecular Structure 9
Different Pathways to Cancer 12
Suggested Readings 15
2
Essentials of Molecular Biology: Genomics and Cancer 17
LANCE A. LIOTTA
EDISON T. LIU
Understanding Cancer at the Molecular Level: The New Frontier 17
Genetic Mechanisms of Cancer Progression: Cancer Is a Genetic Disease 17
Cancer Genes: Models of Action 18
Molecular Profiling: Prognosis and Treatment Tailored
to the Individual Patient 20
XXViii Contents
Postgenome Challenge for Molecular Medicine 21
cDNA Microarrays Are a New Tool to Analyze Gene Expression Patterns
in Human Cancer 22
Technology for Tissue Microdissection Brings Molecular Analysis
to the Tissue Cell Level 24
Tumor Tissue Arrays 25
Beyond Functional Genomics to Cancer Proteomics 25
3
Essentials of Signal Transduction 31
CHRISTOPHER L. CARPENTER
LEWIS C. CANTLEY
The Sensory Machinery: Ligands and Receptors 31
Propagation of Signals to the Cell Interior 34
Efficiency and Specificity: Formation of Multiprotein Signaling Complexes 38
Regulation of Protein Levels: Transcription, Translation,
and Proteolysis 39
4
Essentials of Immunology 43
NICHOLAS P. RESTIFO
JOHN R. WUNDERLICH
T Cells and Cellular Immunity 43
Antigen Presentation to T Cells 44
Specialized Antigen Presenting Cells 50
T Cell Recognition of Antigens 51
T Cell Maturation 53
Activation of Mature T Cells 55
States of Mature T Cells 59
Functions of Mature T Cells 60
Cytotoxic Effector Cell Mechanisms 61
B Cells and Humoral Immunity 64
Summary 67
partJI
PRINCIPLES OF ONCOLOGY
5
Molecular Biology of Cancer: Cytogenetics 77
MAZIN B. QUMSIYEH
PEINTNG LI
History of Cancer Cytogenetics 77
Chromosome Structure and Function 77
Contents XXIX
Cytogenetic Methods 79
International System of Cytogenetic Nomenclature 82
Mechanisms and Implications of Chromosomal Abnormalities in Cancer 82
Cautions to Exercise in Interpreting Chromosomal Abnormalities Seen
in Cancer Studies 86
Clonal Evolution and Chromosome Evolution 87
Constitutional Chromosomal Abnormalities Predisposing
to Cancer Development 88
Data Mining in Cancer Cytogenetics 89
Glossary 89
6
Molecular Biology of Cancer: The Cell Cycle 91
MICHAEL B. KASTAN
STEPHEN X.SKAPEK
Mechanics of the Cell Division Cycle 91
Control of the Cell Division Cycle 99
Implications for Cancer 102
7
Molecular Biology of Cancer: Apoptosis Ill
STANLEY J. KORSMEYER
SANDRA S. ZINKEL
Apoptosis 111
Genetics of Cell Death 112
Death Receptors 113
Caspases 113
The Bcl 2 Family 114
Bcl 2 Family Members Play Critical Roles in Tissue Homeostasis 117
Role of Mitochondria 118
Cell Proliferation and Apoptosis 118
Possibilities for Therapeutic Intervention 118
Conclusions 119
8
Molecular Biology of Cancer: Invasion and Metastases 123
WILLIAM G. STETLER STEVENSON
DAVID E. KLEINER, JR
The Metastatic Cascade 123
Oncogenesis: Metastasis and Tumorigenesis Are under Separate Genetic Control 125
Angiogenesis: Balance of Positive and Negative Effectors 126
Tumor Heterogeneity and Clonal Dominance 126
Defining the Invasive Phenotype 126
Cell Cell Adhesion Suppresses or Facilitates Metastasis Formation 127
Cell Extracellular Matrix Interactions in Tumor Progression 129
Intravasation, Extravasation, and Orthotopic Effect 134
XXX Contents
9
Biology of Cancer: Angiogenesis 137
ISAIAH J.FIDLER
ROBERT S. KERBEL
LEE M. ELLIS
Neoplastic Angiogenesis: The Balance of Proangiogenic and
Antiangiogenic Molecules 137
Lymphoid Cell Mediated Angiogenesis 140
Regulation of Angiogenic Factor Expression in Tumors 140
Endogenous Inhibitors of Angiogenesis 140
Clinical Utility of Angiogenesis 141
Antiangiogenic Therapy: Issues and Expectations 143
Antiangiogenic Therapy as a Component of Other Antineoplastic
Regimens 144
Conclusions 144
10
Etiology of Cancer: Viruses 149
section 1 RNA Viruses 149
ERIC M. POESCHLA
GARY L. BUCHSCHACHER, JR
FLOSSIE WONG STAAL
Retroviral Genetics: Selective Access to the Growth Control Genes of the Cell 149
Mechanisms of Retroviral Oncogenesis 150
Human T Cell Leukemia Virus Type I 152
Human T Cell Leukemia Virus Type II 154
Human Immunodeficiency Virus 154
Hepatitis C Virus 155
section 2 DNA Viruses 158
PETER M.HOWLEY
DON GANEM
ELLIOTT KIEEF
Hepadnaviruses and Hepatocellular Carcinoma 158
Papillomaviruses and Human Cancer 161
Epstein Barr Virus 168
Kaposi s Sarcoma Associated Herpesvirus (Human Herpesvirus 8) 171
11
Etiology of Cancer: Chemical Factors 179
STUART H. YUSPA
PETER G. SHIELDS
The Nature of Chemical Carcinogens: Chemistry and Metabolism 180
Animal Model Systems and Multistage Carcinogenesis 181
Protection against Chemical Carcinogens: DNA Repair, Tumor Suppressor Genes,
and Transforming Growth Factor {3 184
Genetic Susceptibility to Chemical Carcinogenesis in Experimental Models 184
Contents XXXl
Determination of Chemical Carcinogens for Humans and Population Based
Risk Assessment 185
Molecular Epidemiology of Cancer Risk from Chemicals 186
Mutational Spectrum of Human Cancers 190
Tobacco Smoking and Cancer Risk 190
12
Etiology of Cancer: Physical Factors 195
ROBERT L. ULLRICH
Interactions of Radiation with Cells and Tissues 195
Ionizing Radiation and Cancer 197
Ultraviolet Light 202
Asbestos 204
13
Etiology of Cancer: Cancer Genetics 207
ALLEN E. BALE
SUZANNE J. BROWN
Cancer as a Genetic Disease 207
Mechanisms of Cancer Predisposition 207
Gatekeepers, Caretakers, and Landscapers 211
Clinical Characteristics of Cancer Families 211
Multisystem Genetic Syndromes with a High Risk of Cancer 212
Nonsyndromic Hereditary Cancer 215
14
Epidemiology of Cancer 219
section 1 Epidemiologic Methods 219
MARGARET A. TUCKER
Observational Studies 219
Descriptive Studies 221
Analytic Studies 221
Intervention Studies 226
Future Directions 227
section 2 Descriptive Epidemiology: Cancer Statistics 228
PHILIP COLE
BRAD RODU
Descriptive Epidemiology 228
Perspectives 238
section 3 Analytic Epidemiology: Cancer Causes 241
PHILIP COLE
BRAD RODU
Evaluating Carcinogenicity 241
Causes of Cancer 242
Perspectives 249
XXXii Contents
15
Principles of Cancer Management: Surgical Oncology 253
STEVEN A. ROSENBERG
Historical Perspective 253
Anesthesia for Oncologic Surgery 254
Determination of Operative Risk 256
Roles for Surgery 259
The Surgical Oncologist 262
16
Principles of Cancer Management: Radiation Therapy 265
SAMUEL HELLMAN
Physical Considerations 265
Biologic Considerations 270
Clinical Considerations 282
17
Principles of Cancer Management: Chemotherapy 289
EDWARD CHU
VINCENT T. DEVITA, JR
History 289
Chemotherapy as Part of the Initial Treatment of Cancer 290
Clinical End Points in Evaluating Response to Chemotherapy 291
Principles Governing the Use of Combination Chemotherapy 292
Effect of the Biology of Tumor Growth on Response to Chemotherapy 294
Apoptosis, Cell Cycle Control, and Resistance to Chemotherapy 295
Concept of Dose Intensity 300
In Vitro Drug Response Assays 302
Principles of Cancer Management: Biologic Therapy 307
STEVEN A. ROSENBERG
Basic Principles of Tumor Immunology 307
Cells of the Immune System 308
Immune Effector Mechanisms Resulting in Cell Destruction 308
Cytokines 308
Tumor Antigens 320
Immunotherapy 324
Interferons 326
Contents XXXiii
19
Pharmacology of Cancer Chemotherapy 335
section 1 Pharmacokinetics and Pharmacodynamics 335
MARKJ.RATAIN
Pharmacokinetics: Fundamental Principles 335
Pharmacokinetics: What s Important to the Clinician? 338
Basic Methodology of Pharmacokinetic Studies 339
Pharmacodynamics 340
Rational Use of Pharmacokinetic and Pharmacodynamic Data
in Clinical Oncology 340
section 2 Cancer Drug Development 345
Section 2.1 Identification and Screening of New Agents 345
EDWARD CHU
MICHAEL R.GREVER
BRUCE A. CHABNER
Drug Discovery 345
Drug Development 352
Conclusion 354
Section 2.2 Combinatorial Chemistry 356
DAVID J.AUSTIN
Principles of Combinatorial Chemistry 356
The History of Combinatorial Chemistry 357
The Practice of Combinatorial Chemistry 359
Combinatorial Chemistry in Pharmaceutical Drug Development 360
The Future of Chemical Diversity in Drug Development 362
section 3 Antitumor Alkylating Agents 363
OLIVER MICHAEL COLVIN
History of the Alkylating Agents 363
Chemistry and Cytotoxicity of Alkylating Agents 363
Classes of Alkylating Agents and Their Properties 363
Mechanisms of Toxicity and Drug Resistance 369
Common Toxicities 311
section 4 Cisplatin and Its Analogues 376
STEVEN W.JOHNSON
JAMES P. STEVENSON
PETER J.O DWYER
Platinum Chemistry 376
Evolution of Novel Platinum Complexes 377
Mechanism of Action 378
Mechanisms of Resistance 380
Clinical Pharmacology 383
XXXIV Contents
section 5 Antimetabolites 388
EDWARD CHU
AUGUSTO C. MOTA
MIKLOS C. FOGARASI
Methotrexate 388
New Antif olates 393
Other Antif olates 393
Strategies to Permit Oral Administration of
Fluoropyrimidines 398
section 6 Topoisomerase Interactive Agents 415
CLINTON F. STEWART
MARKJ.RATAIN
Mechanism of Action of Topoisomerase Interactive
Agents 416
Epipodophyllotoxins 418
Camptothecin Analogues 422
Anthracyclines and Related Compounds 425
Mitoxantrone and Losoxantrone 421
Dactinomycin (Actinomycin D) 428
section 7 Antimicrotubule Agents 431
ERIC K. ROWINSKY
ANTHONY W. TOLCHER
Microtubules 431
Microtubule Associated Proteins and Microtubule Motors 432
Vinca Alkaloids 432
The Taxanes 437
Estramustine Phosphate 445
Novel Compounds Targeting Microtubules 447
section 8 Miscellaneous Chemotherapeutic Agents 452
BRUCE D. CHESON
Homoharringtonine 452
Suramin 453
Bleomycin 453
L Asparaginase 454
Amifostine 455
20
Pharmacology of Cancer Biotherapeutics 461
section 1 Interferons 461
JOHN M. KIRKWOOD
Rationale for Investigation of Interferons: Direct Regulation
of Cell Growth, Differentiation, Antigen Expression; Indirect
Effects Mediated through Modulation of the Host Immune
Response 461
Clinical Evaluation 464
Contents XXXV
section 2 Interleukin 2 471
JAMES W. MIER
MICHAEL B. ATKINS
Isolation, Characterization, and Cloning of Interleukin 2 471
Interleukin 2 Receptor 472
Interleukin 2 Activated Signaling Pathways 472
In Vitro Effects of Interleukin 2 473
Preclinical Studies with Interleukin 2 in Tumor Bearing Mice 473
Clinical Applications of Interleukin 2 473
Biology and Pharmacokinetics of Interleukin 2 475
Attempts to Improve Activity of Interleukin 2 Based
Therapy 476
section 3 Hormonal Therapies 478
CHARLES ERLICHMAN
CHARLES L. LOPRINZI
Selective Estrogen Receptor Modulators 478
Medroxyprogesterone and Megestrol 481
Aromatase Inhibitors 482
Gonadotropin Releasing Hormone Analogues 483
Antiandrogens 484
Fluoxymesterone 485
Diethylstilbestrol and Estradiol (Estrace) 485
Octreotide 486
section 4 Differentiation Agents 489
RAYMOND P. WARRELL, JR
Retinoids 489
Arsenic Trioxide 491
Histone Deacetylase Inhibitors 491
Vitamin D 493
Cytokines and Other Proteins 493
section 5 Therapeutic Monoclonal Antibodies: General Principles 495
LOUIS M. WEINER
GREGORY P. ADAMS
MARGARET VON MEHREN
Immunoglobulin Structure: Structural and Functional
Domains 495
Factors Regulating Antibody Based Tumor Targeting 495
Unconjugated Antibodies 497
Immunoconjugates 500
Therapeutic Applications 501
Future Directions 505
section 6 Antiangiogenesis Agents 509
JUD AH FOLKM AN
Guidelines to the Biologic Basis of Antiangiogenic Therapy 509
Clinical Trials of Angiogenesis Inhibitors 517
XXXVi Contents
Clinical Trials in Cancer 521
section 1 Design and Analysis of Clinical Trials 521
RICHARD SIMON
Phase I Clinical Trials 521
Phase II Clinical Trials 523
Design of Phase III Clinical Trials 526
Analysis of Phase III Clinical Trials 531
Epidemiology of Clinical Trials 537
Metaanalysis 537
section 2 Research Data Management 539
DOUGLAS HAGEMAN
DIANNE M. REEVES
Protocol Development 539
Protocol Implementation 540
Information Technology 543
Data Classification 544
U.S. Food and Drug Administration Recommendations 544
Data Validation 544
Direct Data Capture 545
Security 545
Summary 545
PART S
PRACTICE OF ONCOLOGY
22
Cancer Prevention: Preventing Tobacco Related Cancers 549
HOWARD K. KOH
CHRISTINE KANNLER
ALAN C. GELLER
Tobacco and Nicotine Addiction 549
Health Effects 550
Smoking Rates and Trends 550
Cigarette Product Modification 552
Spit Tobacco 552
Cigars 552
Environmental Tobacco Smoke 552
Tobacco Industry Advertising Strategies 553
Strategies for Tobacco Control 553
Community Level and State Interventions 555
Tobacco Taxes That Fund Dedicated, Comprehensive Statewide
Tobacco Control Programs 556
Contents XXXVii
Mass Media and Counter Advertising 557
Tobacco Litigation and Tobacco Settlement 557
Proposed U.S. Food and Drug Administration Regulation 558
Conclusion 558
23
Cancer Prevention: Diet and Chemopreventive Agents 561
section 1 Fat 561
WALTER C. WILLETT
Fat and Breast Cancer 562
Fat and Colon Cancer 564
Fat and Prostate Cancer 565
Other Cancers 565
Summary 565
section 2 Dietary Fibers 568
PETER GREENWALD
Sources and Types of Dietary Fiber 568
Dietary Fiber and Colorectal Cancer 568
Dietary Fiber and Breast Cancer 572
Dietary Fiber and Other Cancers 573
Public Health Implications 573
section 3 Retinoids, Carotenoids, and Micronutrients 575
SUSAN TAYLOR M AYNE
SCOTT M.LIPPMAN
Historical Perspective 575
Retinoid Biology and Pharmacology 576
Carotenoid Biology and Actions 577
Clinical Trials 577
Translational and Intermediate End Point Studies
in Retinoid Chemoprevention 586
New Retinoids and Carotenoids 587
Conclusions 588
section 4 Naturally Occurring Dietary Anticarcinogens 590
PETER GREENWALD
Carotenoids 590
Phytoestrogens 591
Organosulfur and Organoselenium Compounds 591
Phenolic Compounds 592
Monoterpenes 593
Isothiocyanates and Indoles 593
Protease Inhibitors 594
Implications for Cancer Prevention 594
XXXViH Contents
section 5 Dietary Carcinogens 595
PETER GREENWALD
Naturally Occurring Dietary Carcinogens 596
Products of Food Preparation and Processing 597
Synthetic Carcinogens in the Diet 599
Future Research Needs 599
section 6 Aspirin and Other Nonsteroidal Antiinflammatory Drugs
and the Risk of Cancer Development 601
MICHAEL J.THUN
CHARLES H. HENNEKENS
Pharmacology and Toxicity of Nonsteroidal Antiinflammatory
Drugs 601
Historical Evolution of the Hypothesis That Nonsteroidal
Antiinflammatory Drugs Inhibit Cancer 602
Cellular Mediators of Tumor Inhibition 606
Nonsteroidal Antiinflammatory Drugs and Cancers Other
Than Colorectal Cancer 607
Dose and Duration Issues in Chemoprevention 607
section 7 Physical Activity and Body Weight 610
GRAHAM A. COLDITZ
Colon Cancer 610
Breast Cancer 612
Obesity 613
Relationship between Obesity and Carcinoma 614
Conclusions 614
24
Cancer Prevention: Role of Surgery in Cancer Prevention 617
RICHARD M. SHERRY
Multiple Endocrine Neoplasia 2 and Familial Medullary
Thyroid Carcinoma 617
Barrett s Esophagus and Esophageal Cancer 618
Breast Cancer 620
Ovarian Cancer 621
Colorectal Cancer 622
Testicular Cancer and Cryptorchidism 624
25
Cancer Screening 627
BARBARA K. RIMER
JOELLEN SCHILDKRAUT
ROBERT A. HIATT
What Is Cancer Screening? 627
Evaluation of a Screening Test 628
Breast Cancer Screening 629
Contents XXXIX
Cervical Cancer Screening 634
Skin Cancer Screening 634
Prostate Cancer Screening 634
Colorectal Cancer Screening 635
Lung Cancer Screening 637
The Future of Screening 637
26
Cancer Diagnosis: Molecular Pathology 641
JOSE COSTA
CARLOS CORDON CARDO
Role of Molecular Pathology in Clinical Oncology and Translational Research 641
Use of Human Tissue Samples for Molecular Analyses 642
Overview of the Technological Approaches to Molecular Diagnostics 643
Applications of Molecular Markers: Diagnostic Molecular Pathology 651
Considerations for the Future 655
27
Cancer Diagnosis: Imaging 659
section 1 Computed Tomography 659
ELLIOT K. FISHMAN
BRUCE A. URBAN
Liver 659
Pancreas 660
Kidney 661
Adrenal Gland 662
Small Bowel and Colon 663
Esophagus and Stomach 665
Lungs and Mediastinum 665
Musculoskeletal System 668
Central Nervous System 668
Summary 668
section 2 Magnetic Resonance Imaging 669
ARTHUR E.LI
DAVIDA.BLUEMKE
Basic Principles 669
Brain 671
Spine 672
Head and Neck 672
Breast 673
Liver 673
Adrenal Glands 674
Kidney 675
Uterus 675
Cervix 675
Ovary 676
xl Contents
Prostate 676
Bladder 677
Musculoskeletal System 677
section 3 Functional and Metabolic Imaging 679
MARTIN G. POMPER
Techniques for Functional and Metabolic Imaging 679
New Functional and Metabolic Imaging Modalities 687
Summary 687
section 4 Interventional Radiology 690
JEAN FRANCOIS H. GESCHWIND
Diagnostic Procedures 690
Therapeutic Interventions 692
section 5 Ultrasound 708
ULRIKE M. HAMPER
Ultrasonography Applications 708
Urologic Oncology 705
Gynecologic Oncology 709
Medical Oncology 710
Ultrasonographically Guided Interventional
Procedures 712
Summary 713
section 6 Radionuclide Imaging 714
E. EDMUND KIM
Indirect Radionuclide Tumor Imaging 714
Direct Radionuclide Tumor Imaging 716
28
Cancer Diagnosis: Endoscopy. 721
ROBERT C. KURTZ
ROBERT J. GINSBERG
Upper Gastrointestinal Endoscopy 721
Endoscopic Ultrasonography 722
Sigmoidoscopy 724
Colonoscopy 725
Laparoscopy 726
Endoscopic Retrograde Cholangiopancreatography 727
Small Intestinal Endoscopy: Enteroscopy 729
Percutaneous Endoscopic Gastrostomy 729
Bronchoscopy 729
Mediastinoscopy 733
Thoracoscopy 734
Contents xli
29
Specialized Techniques in Cancer Management 739
section 1 Laparoscopy 739
ALANT.LEFOR
Laparoscopic Physiology 740
Port Site Metastases 741
Laparoscopy in the Diagnosis of Malignancy 742
Laparoscopy in the Staging of Malignancy 743
Laparoscopy in the Treatment of Malignancy 750
Laparoscopy in the Palliation of Malignancy 756
The Future of Laparoscopy in the Care of the Patient
with Cancer 757
section 2 Vascular Access and Specialized Techniques
of Drug Delivery 760
STEVEN K. LIBUTTI
MCDONALD K. HORNE III
Catheter Types 760
Insertion Technique 762
Selecting the Appropriate Catheter 764
Catheter Related Complications 765
section 3 Isolation Perfusion 769
H. RICHARD ALEXANDER
Principles of Isolation Perfusion 769
Results of Isolation Perfusion 771
Conclusions 775
section 4 Intensity Modulated Radiation Therapy 777
C.CLIFTON LING
CHEN CHUI
THOMAS LOSASSO
CHANDRA BURMAN
MARGIE HUNT
GIGAS MAGERAS
HOWARD IRA AMOLS
MICHAEL J. ZELEFSKY
ZVIY.FUKS
STEVEN A. LEIBEL
Process of Intensity Modulated Radiotherapy 777
Clinical Experience 783
Consideration of Treatment Uncertainties 785
Development and Research Issues 785
Xlli Contents
30
Cancer of the Head and Neck 789
section 1 Molecular Biology of Head and Neck Tumors 789
DAVID SIDRANSKY
Genetic Susceptibility 789
Cytogenetic Alterations 790
Protooncogenes 790
Suppressive Growth Regulation 790
Tumor Suppressor Genes 791
Field Cancerization 792
Molecular Epidemiology 793
Human Papillomavirus 793
Diagnostics 793
section 2 Tumors of the Nasal Cavity and Paranasal Sinuses,
Nasopharynx, Oral Cavity, and Oropharynx 797
STIMSON P. SCHANTZ
LOUIS B. HARRISON
ARLENE A. FORASTIERE
Anatomy 797
Pathology 797
Staging and Screening 797
Treatment 800
Principles of Chemotherapy: Recurrent and Metastatic Disease 804
Biologic Targeted Therapies 811
Principles of Chemotherapy: Previously Untreated Disease 811
Postoperative Adjuvant Treatment 813
Principles of Chemoprevention 817
Posttreatment Rehabilitation 819
Nasal Cavity and Paranasal Sinuses 819
Nasopharynx 824
Oral Cavity 832
Lip 833
Alveolar Ridge and Retromolar Trigone 834
Floor of Mouth 836
Tongue 839
Hard Palate 841
Buccal Mucosa 841
Rehabilitation of the Oral Cancer Patient 842
Oropharynx 842
Base of Tongue 843
Tonsil, Tonsillar Pillar, and Soft Palate 846
Pharyngeal Wall 850
section 3 Tumors of the Larynx and Hypopharynx 861
ROY B. SESSIONS
LOUIS B. HARRISON
ARLENE A. FORASTIERE
Larynx 861
Hypopharynx 878
Contents xliii
section 4 Tumors of the Salivary Glands and Paragangliomas 886
ROY B. SESSIONS
LOUIS B. HARRISON
ARLENE A. FORASTIERE
Major Salivary Gland Tumors 886
Minor Salivary Gland Tumors 897
Paragangliomas 900
section 5 Rehabilitation after Treatment for Head and Neck Cancer 907
SUSAN D. MILLER
ROY B. SESSIONS
Pretreatment Assessment 907
Diagnostic Evaluation 907
Posttreatment Intervention 908
Volunteer and Support Organizations 914
31
Cancer of the Lung 917
section 1 Molecular Biology of Lung Cancer 917
YOSHITAKA SEKIDO
KWUN M. FONG
JOHN D.MINNA
Genetic and Epigenetic Alterations in Lung Cancers 917
Protooncogenes and Growth Stimulation 918
Tumor Suppressor Genes and Growth Suppression 920
Other Biologic Abnormalities for Lung Cancer Development 922
Molecular Tools in the Lung Cancer Clinic 924
section 2 Non Small Cell Lung Cancer 925
ROBERT J.GINSBERG
EVERETT E.VOKES
KENNETH ROSENZWEIG
Epidemiology 925
Pathology 927
Diagnosis and Staging 933
Pretreatment Prognostic Factors 939
Occult Disease 942
Chemoprevention 943
Overview of Invasive Lung Cancer Management: Treatment
Modalities 943
Specifics of Lung Cancer Management 951
section 3 Small Cell Lung Cancer 983
JOHNMURREN
ELI GLATSTEIN
HARVEY I. PASS
Epidemiology and Etiology 983
Pathology 984
XllV Contents
Clinical Presentation 985
Staging Evaluation and Prognostic Factors 986
Treatment 988
Combination Chemotherapy 990
Duration of Chemotherapy 992
General Approach to Patients with Limited Disease 992
General Approach to Patients with Extensive Disease 1000
Strategies to Optimize Chemotherapy Response 1001
Management of Small Cell Lung Cancer in the Elderly and Infirm 1006
Biologic Response Modifiers and Other Treatments 1007
Treatment at Relapse 1008
Treatment Outcome and Long Term Survival 1009
Extrapulmonary Small Cell Carcinoma 1010
32
Neoplasms of the Mediastinum 1019
ROBERT B. CAMERON
PATRICK J. LOEHRER
CHARLES R. THOMAS, JR
Anatomy 1019
Incidence and Pathology 1019
Diagnostic Considerations 1020
Thymic Neoplasms 1023
Germ Cell Tumors 1028
Mesenchymal Tumors 1030
Neurogenic Tumors 1031
Primary Cardiac Malignancies 1033
33
Cancers of the Gastrointestinal Tract 1037
section 1 Molecular Biology of Gastrointestinal Cancers 1037
ERIC R. FEARON
Colorectal Cancer as a Model System 1038
The Adenoma Carcinoma Sequence in the Colon 1038
Inherited Colorectal Cancer Syndromes 1038
Oncogene and Tumor Suppressor Gene Mutations in Colorectal
Tumor Progression 1043
Gene Defects in Pancreatic Carcinoma 1045
Gene Defects in Esophageal Adenocarcinoma 1046
Potential Clinical Applications of Molecular Advances 1047
section 2 Cancer of the Esophagus 1051
DAVID S. SCHRUMP
NASSER K. ALTORKI
ARLENE A. FORASTIERE
BRUCE D. MINSKY
Epidemiology 1051
Anatomy 1052
Contents xlv
Histology 1053
Predisposing Conditions 1054
Molecular Biology 1057
Clinical Presentation 1058
Treatment 1060
section 3 Cancer of the Stomach 1092
MARTIN S. KARPEH
DAVID P. KELSEN
JOEL E. TEPPER
Epidemiology 1092
Etiology and Pathogenesis 1093
Pathology and Tumor Biology 1095
Clinical Presentation 1097
Pretreatment Staging 1098
Pathologic Staging and Prognosis 1099
Treatment of Localized Disease 1101
Adjuvant Therapy 1106
Palliative Treatment of Gastric Cancer 1116
Predicting Response 1120
Chemotherapy versus Best Supportive Care 1121
Surgery for Palliation 1121
section 4 Cancer of the Pancreas 1126
DOUGLAS B. EVANS
JAMES L. ABBRUZZESE
CHRISTOPHER G. WILLETT
Epidemiology 1126
Etiologic Factors 1126
Pathology and Molecular Pathogenesis 1127
Clinical Signs and Symptoms 1129
Natural History and Patterns of Treatment Failure 1129
Clinical and Pathologic (Surgical) Staging 1131
Pretreatment Diagnostic Studies 1132
Treatment of Potentially Resectable Disease 1136
Palliative Methods of Biliary and Gastric Decompression 1143
Treatment of Locally Advanced Disease 1145
Treatment of Metastatic and Recurrent Disease 1148
section 3 Cancer of the Liver and Biliary Tree 1162
YUMANFONG
NANCY KEMENY
THEODORE S. LAWRENCE
Hepatocellular Carcinoma 1162
Other Primary Tumors of the Liver 1177
Cholangiocardnoma 1178
Tumors of the Gallbladder 1187
section 6 Cancer of the Small Intestine 1204
DANIEL G.COIT
History 1204
Incidence 1204
xM Contents
Etiology 1204
Anatomy 1205
Pathology 1205
Presentation 1205
Diagnosis 1206
Management 1207
section 7 Cancer of the Colon 1216
JOHNM.SKIBBER
BRUCE D. MINSKY
PAULO M. HOFF
Anatomy 1216
Epidemiology 1217
Etiology 1218
Primary Prevention 1219
Secondary Prevention 1220
Clinical Risk Factor: Age 1220
Genetic Risk Factors 1221
Predisposing Medical Conditions 1223
Screening 1224
Diagnosis 1227
Spread of Colorectal Cancer 1229
Staging and Prognostic Features 1230
Treatment of Precancerous Conditions 1238
Management of Potentially Curable Colon Cancer 1240
Treatment of Initially Advanced Colon Cancer 1254
Follow Up after Potentially Curative Treatment 1255
Chemotherapy for Metastatic Colorectal Cancer 1256
Miscellaneous Colorectal Tumors 1262
section 8 Cancer of the Rectum 1271
JOHNM.SKIBBER
PAULO M. HOFF
BRUCE D. MINSKY
Anatomy 1271
Diagnosis 1271
Clinical Staging System 1274
Treatment of Resectable Rectal Cancer 1275
Treatment of Invasive Cancer by Nonradical Approaches 1279
Results of Treatment of Rectal Cancer 1281
Radiation Therapy Alone for Resectable Rectal Cancer 1284
Adjuvant Therapy and Sphincter Saving Operations as an Alternative
to Abdominoperineal Resection 1285
Local Excision and Postoperative Radiation Therapy 1285
Preoperative Radiation Therapy Followed by Surgery 1288
Low Anterior Resection and Coloanal Anastomosis 1289
Adjuvant Radiation Therapy for Resectable Rectal Cancer 1291
Preoperative and Postoperative Radiation Therapy 1295
Selected Controversies in the Role of Preoperative Therapy 1295
Radical Surgery and Adjuvant Postoperative Combined Modality Therapy
for Resectable Rectal Cancer 1296
Contents Xlvii
Future of Adjuvant Therapy 1298
Complications of Pelvic Radiation Therapy 1299
Minimizing Toxicity of Radiation Therapy 1301
Treatment of Locally Advanced and Unresectable
Rectal Cancer 1305
Intraoperative or Postoperative Radiation Therapy
for Residual Disease 1309
Investigational Radiation Therapy Approaches 1311
Treatment of Patients with Synchronous Metastatic Disease 1312
Follow Up after Potentially Curative Treatment 1312
Treatment of Recurrence 1312
section 9 Cancer of the Anal Region 1319
BRUCE D. MINSKY
JOHN P. HOFFMAN
DAVID P. KELSEN
Epidemiology and Etiology 1319
Anal Cancer and Acquired Immunodeficiency
Syndrome 1320
Molecular and Chromosomal Abnormalities 1320
Other Associations 1320
Animal Studies 1321
Anatomy 1321
Pathology 1322
Precancerous Changes 1322
Squamous Cell Cancer 1323
Radiation Therapy Treatment Techniques 1334
Inguinal Node Involvement 1336
Residual or Recurrent Cancer 1336
Metastatic Disease 1337
Follow Up 1338
Anorectal Melanoma 1338
Adenocarcinoma 1339
Sarcoma 1339
Treatment of the Human Immunodeficiency
Virus Positive Patient 1339
Future Directions 1339
34
Cancers of the Genitourinary System 1343
section 1 Molecular Biology of Genitourinary Cancers 1343
W. MARSTON LINEHAN
BERTONZBAR
FREDRICK LEACH
CARLOS CORDON CARDO
WILLIAM ISAACS
Kidney Cancer 1343
Prostate Cancer 1348
Bladder Cancer 1352
Xlviii Contents
section 2 Cancer of the Kidney and Ureter 1362
W. MARSTON LINEHAN
BERTON ZBAR
SUSAN E. BATES
MICHAEL J. ZELEFSKY
JAMES C. YANG
Renal Carcinoma 1362
Carcinoma of the Renal Pelvis and Ureter 1384
section 3 Cancer of the Bladder 1396
HARRY W. HERR
WILLIAM U. SHIPLEY
DEAN F. BAJORIN
Epidemiology 1396
Clinical Presentation and Diagnosis 1397
Pathogenesis 1399
Treatment 1400
Summary 1414
section 4 Cancer of the Prostate 1418
PETER R. CARROLL
KEITH L. LEE
ZVIY.FUKS
PHILIP W.KANTOFF
Normal Prostate Anatomy and Histology 1418
Pathology and Patterns of Progression of Prostate
Cancer 1420
Premalignant Lesions (Prostatic Intraepithelial
Neoplasia) 1422
Staging 1423
Epidemiology 1424
Chemoprevention and Diet 1425
Prostate Cancer Early Detection 1427
Initial Cancer Staging and Risk Assessment 1431
Treatment Selection for Nonmetastatic (T1 T3N0M0)
Disease 1435
Treatment Selection for Advanced Disease: Metastatic
and Local Regional Disease 1459
Future Therapies: Novel Targets 1467
section 5 Cancer of the Urethra and Penis 1480
HARRY W. HERR
GUIDO DALBAGNI
DEAN F. BAJORIN
WILLIAM U. SHIPLEY
Carcinoma of the Male Urethra 1480
Carcinoma of the Female Urethra 1483
Cancer of the Penis 1484
Contents xlix
35
Cancer of the Testis 1491
GEORGE J. BOSL
DEAN F. BAJORIN
JOEL SHEINFELD
ROBERT J.MOTZER
R. S. K. CHAGANTI
Background: Incidence 1491
Epidemiology 1491
Initial Presentation and Management 1492
Histology 1492
Staging 1496
Management of Clinical Stage I Disease 1500
Management of Clinical Stage II (Low Tumor Burden) 1504
Management of Stage II and Stage III Disease (High Tumor Burden) 1505
Management of Relapse after Chemotherapy 1510
Treatment Sequelae 1511
Midline Tumors of Uncertain Histogenesis 1512
Other Testicular Tumors 1513
36
Gynecologic Cancers 1519
section 1 Molecular Biology of Gynecologic Cancers 1519
SETSUKO KUKI CHAMBERS
Endometrial Cancer 1519
Ovarian Cancer 1520
Cervical and Vulvar Cancer 1522
section 2 Cancer of the Cervix, Vagina, and Vulva 1526
PATRICIA J.EIFEL
JONATHAN S.BEREK
JAMES T. THIGPEN
Carcinoma of the Cervix 1526
Carcinoma of the Cervical Stump 1549
Carcinoma of the Vagina 1550
Carcinoma of the Vulva 1556
section 3 Cancers of the Uterine Body 1573
THOMAS W. BURKE
PATRICIA J.EIFEL
FRANCO M.MUGGIA
Endometrial Carcinoma 1573
Uterine Sarcomas 1586
section 4 Gestational Trophoblastic Diseases 1594
FRANCO M. MUGGIA
PATRICIA J.EIFEL
THOMAS W. BURKE
Epidemiology 1594
Pathology and Biology 1594
1 Contents
Clinical Diagnosis and Human Chorionic Gonadotropin 1594
Choriocarcinoma 1595
section 5 Ovarian Cancer, Fallopian Tube Carcinoma,
and Peritoneal Carcinoma 1597
ROBERT F. OZOLS
PETER E. SCHWARTZ
PATRICIA J.EIFEL
Ovarian Cancer 1597
Borderline Tumors 1624
Sex Cord Stromal Tumors 1624
Extraovarian Peritoneal Carcinoma 1625
Germ Cell Tumors of the Ovary 1626
Nondysgerminomatous Germ Cell Tumors 1627
Fallopian Tube Cancer 1628
37
Cancer of the Breast 1633
section 1 Molecular Biology of Breast Cancer 1633
ROBERT B.DICKSON
MARC E. LIPPMAN
Genetics 1633
Steroid and Growth Factor Pathways of Cellular Regulation 1635
The Cell Cycle and Cell Death 1641
Process of Malignant Progression 1643
Implications of Molecular Biology for Tumor Prevention,
Early Detection, Prognosis, and Response to Therapy 1645
section 2 Malignant Tumors of the Breast 1651
ERIC P. WINER
MONICA MORROW
C.KENTOSBORNE
JAY R. HARRIS
Risk Factors for Breast Cancer 1652
Management of the High Risk Patient 1655
Breast Cancer Prevention 1656
Biopsy Techniques for Suspicious Breast Lesions 1657
Ductal Carcinoma In Situ 1659
Lobular Carcinoma In Situ 1663
Staging of Breast Cancer 1664
Local Management of Invasive Breast Cancer 1667
Local Recurrence 1680
Breast Reconstruction 1682
Special Therapeutic Problems 1683
Prognostic and Predictive Factors 1687
Adjuvant Drug (Systemic) Therapy 1688
Adjuvant Chemotherapy 1692
Therapy of Locally Advanced and Inflammatory Breast Cancer 1697
Follow Up after Primary Treatment 1698
Management of Patients with Metastatic Breast Cancer 1699
Contents li
section 3 Rehabilitation after Treatment for Cancer of the Breast 1717
JOSEPH J. DISA
JEANNE A. PETREK
Delayed versus Immediate Reconstruction 1717
Prosthetic Reconstruction 1718
Autologous Tissue Reconstruction 1719
Postmastectomy after Breast Irradiation 1721
Skin Sparing Mastectomy with Immediate Reconstruction 1721
Lymphedema 1722
38
Cancer of the Endocrine System 1727
section I Molecular Biology of Endocrine Tumors 1727
TERRY C. LAIRMORE
SAMUEL A. WELLS, JR
JEFFREY F. MOLEY
Multiple Endocrine Neoplasia Syndromes 1727
Molecular Pathogenesis of Sporadic Thyroid Neoplasms 1733
Genetic Abnormalities in Parathyroid Neoplasms 1735
Other Genetic Loci Implicated in Familial Hypercalcemic
Syndromes 1736
Parathyroid Carcinoma 1737
Genetic Abnormalities in Adrenal Neoplasms 1737
Summary 1737
section 2 Thyroid Tumors 1740
DOUGLAS L. FRAKER
MONICA SKARULIS
VIRGINIA LIVOLSI
Thyroid Nodules 1741
Well Differentiated Thyroid Carcinoma 1742
Anaplastic Thyroid Cancer 1755
Medullary Thyroid Cancer 1756
Thyroid Lymphoma 1759
Secondary Thyroid Malignancy 1759
section 3 Parathyroid Tumors 1763
DOUGLAS L. FRAKER
Primary Hyperparathyroidism 1763
section 4 Adrenal Tumors 1770
JEFFREY A. NORTON
HOP N. LE
Pathology of the Adrenal Cortex 1770
Adrenal Cortical Adenoma 1770
Adrenal Cortical Carcinoma 1770
Clinical Presentations of Adrenal Cortical Neoplasms 1771
Treatment of Adrenal Cortical Neoplasms 1777
Hi Contents
Ectopic Adrenocorticotropic Hormone Syndrome 1780
Pheochromocytoma 1780
section 5 Pancreatic Endocrine Tumors 1788
H. RICHARD ALEXANDER
ROBERT T. JENSEN
Introduction 1788
Pathogenesis, Pathologic Features, and Tumor Biology 1788
Clinical Presentation and Diagnosis 1792
Imaging and Localization of Pancreatic Endocrine Tumors 1796
Treatment of Resectable Disease 1798
Treatment of Metastatic Disease 1806
section 6 Carcinoid Tumors and the Carcinoid Syndrome 1813
ROBERT T. JENSEN
GERARD M. DOHERTY
Pathology and Tumor Histology 1813
Molecular Pathogenesis 1816
Clinical Features 1816
Carcinoid Syndrome 1817
Treatment of the Carcinoid Tumor 1826
section 7 Multiple Endocrine Neoplasias 1834
GERARD M. DOHERTY
ROBERT T. JENSEN
Multiple Endocrine Neoplasia Type 1 1834
Familial Medullary Thyroid Carcinoma and Multiple Endocrine
Neoplasia Types 2A and 2B 1836
39
Sarcomas of the Soft Tissue and Bone 1841
section 1 Soft Tissue Sarcoma 1841
MURRAY F. BRENNAN
KALED M. ALEKTIAR
ROBERT G. MAKI
Incidence 1841
Etiology and Genetics 1841
Distribution 1843
Pathologic Classification 1844
Grading of Sarcoma 1847
Differential Diagnosis 1848
Clinicopathologic Features of Specific Types of Benign
and Malignant Soft Tissue Tumors 1848
Clinical Presentation 1855
Differential Diagnosis 1856
Management of Extremity and Superficial Truncal Soft
Tissue Sarcoma 1860
Radiation Therapy 1861
Special Considerations 1864
Contents liii
Definitive Radiation 1865
Adjuvant Chemotherapy 1865
Preoperative Chemotherapy 1870
Intraarterial Chemotherapy 1870
Hyperthermia and Limb Perfusion 1871
Special Features of the Management of Sarcomas of Nonextremity Sites 1871
Management of Head and Neck Sarcoma 1873
Management of Breast Sarcoma 1873
Serious Complications of Primary Treatment 1874
Prognostic Factors for Outcome 1874
Quality of Life and Functional Outcome 1875
Treatment of Local Recurrence 1875
Management of Advanced Disease 1876
Systemic Therapy for Advanced Disease 1876
Response by Histologic Subtype and Site 1880
Recommendations for Patients with Advanced Disease 1883
Future Directions 1883
section 2 Sarcomas of Bone 1891
MARTIN M. MALAWER
MICHAEL P. LINK
SARAH S. DONALDSON
Classification and Types of Bone Tumors 1891
Radiographic Evaluation and Diagnosis 1892
Natural History 1893
Staging Bone Tumors 1894
Preoperative Evaluation 1895
Biopsy Technique and Timing 1896
Restaging after Preoperative Chemotherapy 1896
Surgical Management of Skeletal Tumors 1898
Principles and Techniques of Limb Sparing Surgery 1898
Amputations 1900
Cryosurgery 1901
Chemotherapy for Bone Sarcomas 1901
Radiotherapy for Bone Tumors 1907
Benign Bone Tumors 1908
Malignant Bone Tumors 1910
40
Benign and Malignant Mesothelioma 1937
section 1 Molecular Biology of Mesothelioma 1937
JOSEPH R. TESTA
HARVEY I. PASS
MICHELE CARBONE
Mechanism of Asbestos Induced Oncogenesis 1937
Cytogenetic Assessment of Malignant Mesotheliomas 1938
Deletion Mapping 1938
Alterations of Tumor Suppressor Genes in Mesothelioma 1939
Simian Virus 40 1939
liv Contents
Conclusions 1941
Summary 1942
section 2 Management of Mesothelioma 1943
KAREN H. ANTMAN
HARVEY I. PASS
PETER B. SCHIFF
Epidemiology 1943
Biology of Mesothelioma: Ploidy Studies 1945
Diagnosis of Mesothelioma 1945
Malignant Pleural Mesothelioma 1947
Multimodality Treatment 1959
Malignant Peritoneal Mesothelioma 1961
Malignant Mesothelioma of the Tunica Vaginalis Testis 1963
Malignant Mesothelioma of the Pericardium 1964
Benign Mesothelioma 1964
41
Cancer of the Skin 1971
section 1 Molecular Biology of Skin Cancer 1971
DOUGLAS E. BRASH
ALLEN E. BALE
Skin Carcinogens 1971
Genetic Events 1972
Cellular Events 1973
Therapeutics 1974
section 2 Management of Skin Cancer 1976
DAVID J.LEFFELL
JOHNA.CARUCCI
Diagnosis 1976
General Approach to Management of Skin Cancer 1976
Nonmelanoma Skin Cancer and Precancerous
Lesions 1979
Carcinoma Metastatic to Skin 1998
Conclusion 1998
42
Melanoma 2003
section 1 Molecular Biology of Cutaneous Melanoma 2003
MEENHARD HERLYN
KAPAETTU SATYAMOORTHY
Etiology of Melanoma 2003
Genetics of Melanoma 2004
Functional Significance of Specific Gene Mutations
in Melanoma 2005
Contents lv
Biology of Melanoma Development and Progression 2007
Biologic Basis of Melanoma Progression 2008
section 2 Cutaneous Melanoma 2012
MICHAEL T. LOTZE
RAMSEY M. DALLAL
JOHN M. KIRKWOOD
JOHN C. FLICKINGER
Epidemiology 2012
Risk Factors, Prevention, and Screening 2015
Staging of Melanoma 2022
Imaging of Malignant Melanoma 2028
Radiobiology of Melanoma 2028
Stage I and II Disease: Management of Primary
Melanoma 2029
Stage I and II Disease: Examination of the Lymph
Node Basin 2032
Stage III Disease: Management of the Clinically Positive
Nodal Basin 2037
Stage III Disease: Management of In Transit Disease 2039
Adjuvant Medical Therapy 2044
Treatment of Stage IV Disease 2048
Cytotoxic Chemotherapy 2051
Immunotherapy of Metastatic Disease 2053
Management of Melanoma in the Pregnant Patient 2056
Future Prospects for the Biologic Therapy of Patients
with Melanoma 2056
section 3 Intraocular Melanoma 2070
JOSE A. SAHEL
ARTHUR S. POLANS
MINESH P. MEHTA
RICHARD M. AUCHTER
DANIEL M. ALBERT
Epidemiology 2070
Etiology and Histogenesis of Ocular Melanomas 2071
Histopathology, Prognostic Parameters, and Natural History 2072
Diagnosis of Uveal Melanomas: Choroidal and Ciliary Body Melanomas 2075
Management 2078
Future Directions for Research 2085
43
Neoplasms of the Central Nervous System 2091
section 1 Molecular Biology of Central Nervous System Neoplasms 2091
DAVID N.LOUIS
WEBSTER K. CAVENEE
Diffuse, Fibrillary Astrocytomas 2091
Other Gliomas 2093
Medulloblastomas 2096
M Contents
Meningiomas 2096
Peripheral Nerve Tumors 2097
Miscellaneous Tumors 2097
Neurologic Tumor Syndromes 2098
Summary 2098
section 2 Neoplasms of the Central Nervous System 2100
VICTOR A. LEVIN
STEVEN A. LEIBEL
PHILIP H. GUTIN
Incidence and Classification 2100
Genetic, Molecular, Environmental, Viral, and Other Factors
Associated with Central Nervous System Neoplasia 2101
Anatomic and Clinical Considerations 2102
Neurodiagnostic Tests 2108
Surgery 2112
Radiation Therapy 2114
Chemotherapy 2119
Cerebral Astrocytomas 2120
Brain Stem Gliomas 2127
Cerebellar Astrocytomas 2129
Optic, Chiasmal, and Hypothalamic Gliomas 2130
Oligodendrogliomas 2131
Ependymoma 2133
Meningiomas 2135
Primitive Neuroepithelial Tumors 2138
Medulloblastoma 2139
Pineal Region Tumors 2142
Pituitary Adenomas 2145
Craniopharyngiomas 2146
Cerebellopontine Vestibular Schwannomas 2147
Glomus Jugulare Tumors 2148
Chordomas 2149
Hemangioblastomas and Hemangiomas 2150
Choroid Plexus Papilloma and Carcinoma 2151
Spinal Axis Tumors 2152
44
Cancers of Childhood 2161
section 1 Molecular Biology of Childhood Cancers 2161
LEEJ.HELMAN
DAVID MALKIN
Tumor Suppressor Genes 2162
Retinoblastoma: The Paradigm 2162
Wilms Tumor: Three Distinct Loci 2163
Neurofibromatoses 2164
Neuroblastoma 2164
Ewing s Sarcoma Family of Tumors 2165
Rhabdomyosarcoma 2165
Contents Mi
Hereditary Syndromes Associated with Tumors
of Childhood 2166
Predictive Testing for Germline Mutations and
Childhood Cancers 2167
section 2 Solid Tumors of Childhood 2169
DAVID H. EBB
DANIEL M. GREEN
ROBERT C. SHAMBERGER
NANCY J.TARBELL
Epidemiology 2169
Management of Childhood Cancer 2170
Wilms Tumor 2171
Favorable Histology Wilms Tumor 2176
Neuroblastoma 2177
Retinoblastoma 2182
Treatment 2183
Advanced Unilateral Disease 2184
Limited Unilateral or Limited Bilateral Disease 2184
Bilateral Disease 2184
Chemotherapy 2185
Rhabdomyosarcoma 2185
Ewing s Sarcoma and Peripheral Primitive
Neuroectodermal Tumor 2193
Primary Hepatic Tumors 2197
Germ Cell Tumors 2200
Clinical Presentation and Treatment by Anatomic Site 2202
45
Lymphomas 2215
section 1 Molecular Biology of Lymphomas 2215
RICCARDO DALLA FAVERA
GIANLUC A G AIDANO
Histogenetic Pathways of Lymphoma 2215
General Mechanisms of Genetic Lesions in Lymphoma 2217
Molecular Pathogenesis of B Cell Non Hodgkin s
Lymphoma 2220
Molecular Pathogenesis of T Cell Non Hodgkin s
Lymphoma 2228
Molecular Pathogenesis of Hodgkin s Lymphoma 2230
Genetic Lesions as Clinical Tools in the Management
of Lymphoma 2230
section 2 Leukemias and Lymphomas of Childhood 2235
HOWARD J. WEINSTEIN
NANCY J.TARBELL
Leukemias 2235
Non Hodgkin s Lymphoma 2245
Hodgkin s Disease 2250
Mil Contents
section 3 Non Hodgkiris Lymphomas 2256
JAMES O. ARMITAGE
PETER M.MAUCH
NANCY LEE HARRIS
PHILIP BIERMAN
Epidemiology 2256
Etiology 2258
Principles of Management of Non Hodgkin s Lymphoma 2273
Specific Disease Entities 2276
Special Clinical Situations 2298
section 4 Cutaneous T Cell Lymphomas 2316
LYNN D. WILSON
GLENN W.JONES
BARRY M. KACINSKI
RICHARD L. EDELSON
PETER W.HEALD
Pathobiology 2316
Epidemiology 2317
Etiology 2317
Clinical Presentation 2317
Approach to Patients with Mycosis Fungoides 2318
Patient Evaluation 2320
Principles of Therapy 2321
section 5 Primary Central Nervous System Lymphoma 2330
LISA M. DEANGELIS
JOACHIM YAHALOM
Clinical Features 2330
Diagnostic Tests 2331
Pathology 2332
Management 2332
section 6 Hodgkin s Disease 2339
VOLKERDIEHL
PETER M.MAUCH
NANCY LEE HARRIS
History 2339
Etiology and Epidemiology 2339
Biology and Cell of Origin 2341
Pathology 2344
Diagnosis and Staging 2350
Clinical Presentation 2352
Treatment Methods 2353
Choice of Treatment 2355
Clinical Features 2374
Treatment Results 2375
Transformation to Non Hodgkin s Lymphoma 2375
Consequences for Future Treatment 2375
Hodgkin s Disease in the Elderly Patient 2375
Hodgkin s Disease During Pregnancy 2376
Contents X
Hodgkin s Disease in Human Immunodeficiency
Virus Positive Patients 2376
Sequelae 2377
Quality of Life 2379
New Drugs in Hodgkin s Disease 2379
Immunotherapy 2380
46
Leukemias 2389
section 1 Molecular Biology of Leukemias 2389
CLARA D. BLOOMFIELD
MICHAEL A. CALIGIURI
Gene Fusions in Leukemia 2392
Gene Activation in Leukemia 2399
Tumor Suppressor Genes in Leukemia 2400
Molecular Monitoring of Leukemia 2401
section 2 Acute Leukemias 2404
DAVID A. SCHEINBERG
PETER MASLAK
MARK WEISS
Epidemiology and Etiology 2405
Biology of Acute Leukemias 2407
Diagnosis and Classification of Acute Leukemias 2408
Treatment of Relapsed Acute Myelogenous Leukemias 2420
Acute Promyelocytic Leukemia 2422
Conclusions 2428
section 3 Chronic Leukemias 2433
Section 3.1 Chronic Myelogenous Leukemia 2433
HAGOP M. KANTARJIAN
STEFAN FADERL
MOSHE TALPAZ
Epidemiology 2433
Etiology and Pathogenesis 2434
Diagnosis and Clinical Course 2435
Treatment 2436
Conclusions 2445
Section 3.2 The Chronic Lymphocytic Leukemias 2447
BRUCE D. CHESON
Cell of Origin 2447
Immune Function and Autoimmunity in Chronic
Lymphocytic Leukemia 2448
Cytogenetics 2448
Molecular Biology and Genetics 2448
Diagnosis 2448
Clinical Features 2451
lx Contents
Staging and Prognostic Factors 2452
Therapy 2453
Related B Cell Leukemias 2458
section 4 Plasma Cell Neoplasms 2465
NIKHIL C. MUNSHI
GUIDO TRICOT
BARTBARLOGIE
History 2466
Epidemiology 2466
Etiology 2467
Pathogenesis 2467
Clinical Manifestations 2471
Diagnosis 2473
Differential Diagnosis 2479
Prognostic Variables 2480
Treatment 2482
Waldenstrom s Macroglobulinemia 2491
Perspective 2493
section 5 Myelodysplastic Syndromes 2499
HAGOP M. KANTARJIAN
ELIHUESTEY
Incidence 2499
Etiology 2499
Classification and Risk Groups 2500
Biology and Pathophysiology 2501
Clinical Manifestations 2502
Laboratory Features 2502
Differential Diagnosis 2503
Significance of the 30% Blast Cutoff to Distinguish High Risk
Myelodysplastic Syndromes from Acute Myeloid Leukemia 2503
Specific Subtypes of Myelodysplastic Syndromes 2503
Therapy 2504
Summary 2507
47
Paraneoplastic Syndromes 2511
SUSANNE M. ARNOLD
ROYPATCHELL
ANDREW M.LOWY
KENNETH A. FOON
Endocrinologic Manifestations of Cancer 2511
Hematologic Manifestations of Cancer 2516
Gastrointestinal Manifestations of Cancer 2518
Renal Manifestations of Nonrenal Cancer 2520
Cutaneous Paraneoplastic Syndromes 2521
Neurologic Manifestations of Cancer 2525
Miscellaneous Paraneoplastic Syndromes 2531
Contents M
48
Cancer of Unknown Primary Site 2537
FRANK A. GRECO
JOHN D. HAINSWORTH
Poorly Differentiated Neoplasms of Unknown Primary Site 2538
Adenocarcinoma of Unknown Primary Site 2540
Squamous Carcinoma of Unknown Primary Site 2545
Poorly Differentiated Carcinoma (with or without Features
of Adenocarcinoma) of Unknown Primary Site 2546
Neuroendocrine Carcinoma of Unknown Primary Site 2552
Special Issues 2554
Conclusion: Future Trends 2556
49
Peritoneal Carcinomatosis 2561
DAVID L. BARTLETT
Pathophysiology 2561
Diagnosis 2562
Histologic Subtypes 2563
Treatment 2561
50
Immunosuppression Related Malignancies 2575
section 1 AIDS Related Malignancies 2575
ROBERT YARCHOAN
RICHARD F. LITTLE
Kaposi s Sarcoma 2576
Acquired Immunodeficiency Syndrome Associated
Lymphomas 2581
Primary Central Nervous System Lymphoma in Acquired
Immunodeficiency Syndrome 2587
Effect of Antiretroviral Therapy on Primary Central Nervous System
Lymphoma Incidence 2588
Hodgkin s Disease 2588
Anogenital Cancers in Human Immunodeficiency Virus
Infection 2589
Future Directions 2591
section 2 Transplantation Related Malignancies 2597
STANLEY R. RIDDELL
Immune Surveillance and Tumor Development 2597
Hematopoietic Stem Cell Transplant Recipients 2597
Organ Transplant Recipients 2602
Mi Contents
51
Oncologic Emergencies 2609
section 1 Superior Vena Cava Syndrome 2609
JOACHIM YAHALOM
Anatomy and Pathophysiology 2609
Etiology and Natural History 2609
Diagnostic Procedures 2611
Management 2612
Treatment 2613
Recommendations 2615
section 2 Spinal Cord Compression 2617
BRIAN G. FULLER
JOHN D. HEISS
EDWARD H. OLDFIELD
Epidemiology 2617
Pathophysiology 2617
Clinical Presentation 2622
Diagnostic Evaluation 2623
Treatment 2624
Pediatric Spinal Cord Compression 2630
Conclusion 2630
section 3 Metabolic Emergencies 2633
RAYMOND P. WARRELL, JR
Hypercalcemia 2633
Treatment of Cancer Related Hypercalcemia 2635
General Approach to Treatment of
Hypercalcemia 2638
Hyperuricemia 2639
Tumor Lysis Syndrome 2640
Lactic Acidosis 2640
Hypoglycemia 2641
Adrenal Failure 2642
section 4 Urologic Emergencies 2645
McCLELLAN M. WALTHER
Urinary Tract Infection 2645
Cystitis 2645
Bladder Hemorrhage 2648
Urinary Obstruction 2649
Priapism 2650
Paraphimosis 2651
Contents MM
52
treatment ofMetastatic Cancer 2655
section 1 Metastatic Brain Cancer 2655
PATRICK Y. WEN
PETER MCLAREN BLACK
JAY S. LOEFFLER
Incidence and Epidemiology 2655
Method of Spread and Distribution 2655
Clinical Manifestations 2656
Diagnosis 2656
Brain Metastases without a Known Primary Tumor 2657
Management 2657
Prognosis 2667
section 2 Metastatic Cancer to the Lung 2670
JOE B. PUTNAM, JR.
Historical Perspective 2670
Identification of Pulmonary Metastases 2670
Selection of Patients for Surgery 2672
Preparation of the Patient for Metastasectomy 2673
Surgical Incisions 2673
Resection of Pulmonary Metastases 2674
Survival Analysis 2674
Results of Resection of Sarcomatous Pulmonary
Metastases 2675
Colorectal Neoplasms 2677
Breast Carcinoma 2678
Testicular Neoplasms 2679
Gynecologic Neoplasms 2679
Renal Cell Carcinoma 2680
Melanoma 2680
Squamous Cell Carcinoma 2680
Wilms Tumor 2680
Metastasis or Primary Bronchogenic Carcinoma? 2681
Recurrent Pulmonary Metastases 2681
Extended Resection of Pulmonary Metastases 2681
Prognostic Indicators 2683
Resectability 2685
Multivariate Analysis of Prognostic Indicators 2656
Novel Treatment Strategies 2686
section 3 Metastatic Cancer to the Liver 2690
H. RICHARD ALEXANDER
CARMEN J.ALLEGRA
THEODORE S. LAWRENCE
Natural History of Liver Metastases 2690
Imaging of Hepatic Metastases 2691
Resection of Hepatic Metastases 2692
Infusional Therapy for Hepatic Metastases 2697
Mv Contents
Local Ablative Therapy 2702
Conclusions 2709
section 4 Metastatic Cancer to the Bone 2713
HOLLY K. BROWN
JOHN H. HEALEY
Presentation 2713
Pathogenesis 2714
Diagnostic Evaluation 2714
Treatment Goals 2715
Imaging of Bone Lesions 2716
Therapeutic Modalities 2717
Specific Anatomic Sites 2724
section 5 Malignant Pleural and Pericardial Effusions 2729
DAVID S. SCHRUMP
DAO M. NGUYEN
Malignant Pleural Effusion 2729
Malignant Pericardial Effusion 2736
section 6 Malignant Ascites 2745
FRANCESCO M. MARINCOLA
DOUGLAS J. SCHWARTZENTRUBER
Diagnosis and Workup 2745
Treatment of Malignant Ascites 2746
53
Hematopoietic Therapy. 2753
section 1 Transfusion Therapy 2753
PETER L. PERROTTA
EDWARD L. SNYDER
Blood Component Therapy 2754
Transfusion Reactions and Complications 2759
Transfusion Transmitted Disease 2762
Use of Special Blood Products in Oncology
Patients 2763
Apheresis 2764
Conclusions 2765
section 2 Autologous Stem Cell Transplantation 2767
DENNIS L. COOPER
STUART SEROPI AN
History 2767
Stem Cell Mobilization 2768
Inadequate Mobilization of Stem Cells 2770
Tumor Contamination 2771
Practical Considerations for the Potential High Dose Therapy
and Autologous Stem Cell Rescue Patient 2772
Contents lxv
High Dose Therapy Regimens: New Directions 2773
Late Toxicity: Myelodysplasia 2775
Future Directions 2775
section 3 Allogeneic Stem Cell Transplantation 2779
RICHARD W.CHILDS
Historical Perspective 2779
Allogeneic Hematopoietic Stem Cell Transplantation
for Hematologic Malignancies 2779
Allogeneic Hematopoietic Stem Cell Transplantation
for Nonmalignant Disorders 2779
Preparative Regimens 2780
Graft versus Leukemia Effect 2780
Mechanisms 2782
Complications of Allogeneic Hematopoietic Stem Cell
Transplantation 2782
Sources of Allogeneic Hematopoietic Stem Cells 2786
Nonmyeloablative Allogeneic Stem Cell
Transplantation 2788
Results of Conventional Allogeneic Transplantation
for Hematologic Malignancies 2791
Future Prospects 2792
section 4 Hematopoietic Growth Factors 2798
JAMES D. GRIFFIN
Overview of Hematopoietic Growth Factors 2798
Biologic Features of the Major Hematopoietic Growth Factors
in Clinical Use 2800
Clinical Applications of Hematopoietic Growth Factors
in Cancer Therapy 2802
Long Term Effects of Growth Factor Administration 2809
Conclusions 2809
54
Infections in the Cancer Patient 2815
BRAHM H. SEGAL
THOMAS J.WALSH
STEVEN M. HOLLAND
Factors Predisposing to Infection in Patients
with Cancer 2815
Bacterial Pathogens in Cancer Patients 2820
Fungal Infections 2825
Viral Infections 2833
Parasitic Infections 2839
Evaluation and Management of Febrile Neutropenia 2841
Manifestations and Therapy of Infections 2848
Immune Augmentation Strategies 2858
lxvi Contents
55
Adverse Effects of Treatment 2869
section 1 Nausea and Vomiting 2869
ANN M. BERGER
REBECCA A. CLARK SNOW
Nature of the Problem 2869
Pathophysiology of Nausea and Vomiting 2869
Emetic Syndromes 2871
Control of Emesis and Patient Characteristics 2872
Antiemetic Agents 2873
Delayed Emesis 2875
Anticipatory Nausea and Vomiting 2875
Radiation Induced Nausea and Vomiting 2876
Nausea and Vomiting Secondary to Comorbid
Conditions 2877
Cost and Benefit of Antiemetic Therapy 2877
section 2 Oral Complications 2881
ANN M. BERGER
THOMAS J. KILROY
Direct Stomatotoxidty 2881
Pathophysiology of Mucositis 2882
Risk Factors 2882
Assessment of the Oral Mucosa 2883
Remedies for the Prevention and Treatment
of Mucositis 2883
Oral Complications in Radiotherapy 2889
Conclusion 2892
section 3 Pulmonary Toxicity 2894
DIANE E. STOVER
ROBERT J.KANER
Radiation Induced Pulmonary Toxicity 2894
Radiation Related Bronchiolitis Obliterans
with Organizing Pneumonia 2896
Chemotherapy Induced Pulmonary Toxicity 2897
section 4 Cardiac Toxicity 2904
LAUREL J. STEINHERZ
JOACHIM YAHALOM
Chemotherapy 2904
Radiation Induced Heart Disease 2912
Conclusion 2916
section 5 Hair Loss 2922
CLAUDIA A. SEIPP
Head Covering 2922
Prevention of Alopecia 2923
Contents lXVH
section 6 Gonadal Dysfunction 2923
MARVIN L. MEISTRICH
RENA VASSILOPOULOU SELLIN
LARRY I. LIPSHULTZ
Effects of Cytotoxic Agents on Adult Men 2924
Effects of Cytotoxic Agents on Adult Women 2926
Effects of Cytotoxic Agents on Children 2930
Gonadal Dysfunction after Cranial Irradiation 2930
Preservation of Fertility, Hormone Levels, and Sexual Function 2931
Genetic Concerns 2934
Counseling 2935
section 7 Second Cancers 2939
FLORA E. VAN LEEUWEN
LOIS B. TRAVIS
Methods to Assess Second Cancer Risk 2940
Carcinogenicity of Individual Treatment Modalities 2941
Risk of Second Malignancy in Patients with Selected
Primary Cancers 2944
Conclusion 2960
section 8 Miscellaneous Toxicities 2964
RAYMOND B. WEISS
Neurotoxicity 2964
Nephrotoxicity 2968
Hepatotoxidty 2970
Hypersensitivity Reactions 2972
Vascular Toxicity 2973
56
Supportive Care and Quality of Life 2977
section 1 Management of Cancer Pain 2977
KATHLEEN M. FOLEY
Epidemiology 2977
Definition and Types of Cancer Pain 2979
Types of Pain 2980
Temporal Aspects of Pain 2980
Intensity of Pain 2981
Measurement of Pain 2981
Classification of Patients with Cancer Pain 2984
Group I: Acute Cancer Related Pain 2984
Group II: Chronic Cancer Related Pain 2984
Group III: Preexisting Chronic Pain and Cancer Related Pain 2985
Group IV: Patients with a History of Drug Addiction and Pain 2985
Group V: Dying Patients with Pain 2986
Common Pain Syndromes 2986
Clinical Assessment of Pain 2986
Management of Cancer Pain 2989
lXVlii Contents
Analgesic Drug Therapy 2990
Classes of Drugs 2991
Principles of Opioid Drug Therapy 2994
Psychological Approaches 3001
Anesthetic and Neurosurgical Approaches 3002
Neurosurgical Approaches 3004
Physiatric Approaches 3007
Sedation in the Imminently Dying 3007
Algorithm for Cancer Pain Management 3009
Future Directions 3009
section 2 Nutritional Support 3012
J. STANLEY SMITH
WILEY W. SOUBA
Clinical Manifestations of Cancer Cachexia 3012
Causes and Consequences of Cancer Cachexia 3013
Nutritional Support of the Cancer Patient 3017
Techniques of Providing Nutritional Support 3028
Nutrition Support for Cancer Patients and Health
Care Reform 3030
section 3 Sexual Problems 3032
PATRICIA A. GANZ
MARK S. LITWIN
BETH E. MEYEROWITZ
Sexual Health and Physiology 3032
Sexual Problems and Their Prevalence among
the General Population 3034
Impact of Cancer and Its Treatment on Sexual Health 3035
Sexual Problems Associated with Specific Cancers 3040
Strategies for Assessment and Intervention 3044
Conclusions 3046
section 4 Genetic Counseling 3049
ELLEN T. MATLOFF
ALLEN E. BALE
Who Is a Candidate for Cancer Genetic Counseling? 3050
Components of the Cancer Genetic Counseling Session 3051
Issues in Cancer Genetic Counseling 3054
Future Directions 3056
section 5 Psychological Issues 3058
MARY JANE MASSIE
LISA CHERTKOV
ANDREW J. ROTH
Psychiatric Disorders in Cancer Patients 3058
Psychiatric Symptoms in Cancer Patients with Pain 3063
Unconventional Cancer Treatments 3063
Psychotherapeutic Interventions with Cancer Patients 3064
Survivor Issues 3064
Contents lxix
section 6 Community Resources 3066
BONNIE A. INDECK
PHYLLIS M. SMITH
Initial Diagnosis of Cancer 3066
Social Support Network 3066
Emotional Support 3066
Informational Support 3068
Internet 3068
Computer Groups 3069
Instrumental Support 3069
Trends Affecting Demand for Community Services 3071
Survivorship 3072
Appendix: Common Resources 3072
Emotional Support 3074
Financial Assistance 3074
Home Health Care 3075
section 7 Specialized Care of the Terminally III 3077
FREDERICK A. FLATOW
SCOTT LONG
Overview of Hospice Care 3077
Symptom Management 3079
Conclusion 3086
57
Rehabilitation of the Cancer Patient 3089
LYNN GERBER
JEANNE HICKS
JAY SHAH
Cancer Rehabilitation Team 3090
Functional Assessment 3091
Common Functional Impairments in Oncology 3091
Tumor Associated Myopathy 3093
Bone Replacement by Tumor 3094
Neuropathies and Plexopathies 3097
Lymphedema and Deep Venous Thrombosis 3098
Bowel and Bladder Disorders 3099
Psychosocial Aspects of Cancer Rehabilitation 3100
Rehabilitation and Management of Specific Tumors 3100
Conclusion 3109
58
Advanced Practice Nurses and Physician Assistants in Oncology Care 3111
M.TTSHKNOBF
SUSAN ANDERSON
Physician Assistants 3111
Advanced Practice in Oncology Nursing 3112
lXX Contents
59
Ethical Issues in Oncology and Clinical Trials 3119
CHRISTOPHER DAUGHERTY
MARKSIEGLER
Ethical Issues in Cancer Clinical Care 3119
Ethical Issues in Cancer Clinical Trials 3126
Conclusions 3131
60
Information Systems in Oncology 3135
SUSAN MOLLOY HUBBARD
National Cancer Institute s Information Services 3140
Conclusion 3146
61
Complementary, Alternative, and Unproven Methods of Cancer Treatment 3147
JEFFREY D. WHITE
Definitions 3147
Phenomenology of Complementary and Alternative Medicine
in Cancer 3147
Reasons for Cancer Patient Use of Complementary and Alternative
Medicine Modalities 3148
Complementary and Alternative Medicine Therapies 3150
Supportive Care (Complementary Medicine) 3153
Complementary and Alternative Medicine Cancer Research 3154
Practical Issues in the Interface of Oncology and Complementary
and Alternative Medicine 3154
PARTrK
NEWER APPROACHES IN CANCER TREATMENT
62
Genetic Therapy 3161
section 1 Gene Therapy 3161
PATRICK HWU
Methods of Gene Transfer 3161
Gene Marking Studies 3167
Genetic Modification of the Immune Response 3168
Modification of Tumors with Genes That Have Direct
Antitumor Effects 3173
Contents lxxi
Selective Replication of Virus in Tumors 3175
Introduction of Genes into Hematopoietic Stem Cells
to Decrease Toxicity from Chemotherapy 3175
Antiangiogenic Gene Therapy 3176
section 2 Molecular Therapy 3180
ALBERT B. DEISSEROTH
AMANDA PSYRRI
DAVID J.AUSTIN
Strategies of New Drug Design 3181
Approaches to Drug Design 3182
Summary and Future Directions 3187
63
Cancer Vaccines 3189
section 1 Preventive Cancer Vaccines 3189
DOUGLAS R. LOWY
JOHN T. SCHILLER
Infectious Agents and Cancer 3189
Prophylactic Versus Therapeutic Vaccination 3191
Hepatitis B Virus 3192
Human Papillomavirus 3193
section 2 Therapeutic Cancer Vaccines 3195
NICHOLAS P. RESTIFO
MARIO SZNOL
WILLEM W. OVERWIJK
Immune Mechanisms Underlying Vaccine Function 3196
Monitoring of Cancer Vaccine Trials 3198
Anticancer Vaccine Approaches Derived from Autologous
and Allogeneic Tumor Cells 3199
Approaches Using Recombinant and Synthetic Anticancer
Vaccines 3201
Enhancing Vaccine Induced Immune Responses 3210
Future Challenges: Tumor Escape from Immune Recognition 3211
Conclusion 3212
64
Image Guided Surgery 3219
NICK BRYAN
STEVEN K. LIBUTTI
Medical Imaging Techniques 3219
Image Guidance 3221
Specific Applications of Image Guided Surgery 3222
Conclusions 3226
Ixxii Contents
65
Proton Beam Radiation Therapy 3229
IRAJ.SPIRO
ALFRED R. SMITH
ANTHONY LOMAX
JAY S. LOEFFLER
Physical Aspects of Protons 3229
Proton Beam Radiation Treatment: Historical Note 3230
Clinical Results 3230
Design of Clinical Trials Using Proton Beams 3233
Conclusions and Future Directions 3234
|
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| dewey-full | 616.994 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.994 |
| dewey-search | 616.994 |
| dewey-sort | 3616.994 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 6. ed. |
| format | Book |
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| id | DE-604.BV013564221 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:48:04Z |
| institution | BVB |
| isbn | 0781722292 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009263678 |
| oclc_num | 248556140 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-29 |
| owner_facet | DE-91 DE-BY-TUM DE-29 |
| physical | LXXII, 3235, 164 S. zahlr. Ill., graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Lippincott Williams & Wilkins |
| record_format | marc |
| spelling | Cancer principles & practice of oncology ed. by Vincent T. DeVita ... 6. ed. Philadelphia [u.a.] Lippincott Williams & Wilkins 2001 LXXII, 3235, 164 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Cancer Krebs <Medizin> Neoplasms Krebs <Medizin> swd Onkologie - Handbuch idszbz Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Krebsforschung (DE-588)4165564-3 gnd rswk-swf Onkologie (DE-588)4075658-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s DE-604 Onkologie (DE-588)4075658-0 s Krebsforschung (DE-588)4165564-3 s 1\p DE-604 DeVita, Vincent T. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009263678&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Cancer principles & practice of oncology Cancer Krebs <Medizin> Neoplasms Krebs <Medizin> swd Onkologie - Handbuch idszbz Krebs Medizin (DE-588)4073781-0 gnd Krebsforschung (DE-588)4165564-3 gnd Onkologie (DE-588)4075658-0 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4165564-3 (DE-588)4075658-0 |
| title | Cancer principles & practice of oncology |
| title_auth | Cancer principles & practice of oncology |
| title_exact_search | Cancer principles & practice of oncology |
| title_full | Cancer principles & practice of oncology ed. by Vincent T. DeVita ... |
| title_fullStr | Cancer principles & practice of oncology ed. by Vincent T. DeVita ... |
| title_full_unstemmed | Cancer principles & practice of oncology ed. by Vincent T. DeVita ... |
| title_short | Cancer |
| title_sort | cancer principles practice of oncology |
| title_sub | principles & practice of oncology |
| topic | Cancer Krebs <Medizin> Neoplasms Krebs <Medizin> swd Onkologie - Handbuch idszbz Krebs Medizin (DE-588)4073781-0 gnd Krebsforschung (DE-588)4165564-3 gnd Onkologie (DE-588)4075658-0 gnd |
| topic_facet | Cancer Krebs <Medizin> Neoplasms Onkologie - Handbuch Krebs Medizin Krebsforschung Onkologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009263678&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT devitavincentt cancerprinciplespracticeofoncology |