Endothelin and its inhibitors: [with 17 tables]
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2001
|
| Series: | Handbook of experimental pharmacology
152 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXIV, 532 S. Ill., graph. Darst. |
| ISBN: | 3540679855 |
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| adam_text | Contents
CHAPTER 1
Historical Perspective and Introduction
to the Endothelin Family of Peptides
T. Masaki. With 1 Figure 1
References 7
CHAPTER 2
Sarafotoxins and Their Relationship
to the Endothelin Family of Peptides
M. Sokolovsky and Z. Shraga Levine 11
A. Introduction 11
B. Structure 12
C. Organization of SRTX cDNA 13
D. Biosynthesis and Degradation 14
E. Receptors 15
I. Binding 15
II. ETB Receptors 17
III. ETA Receptors 19
IV. Atypical Receptors 20
F. Differences in Sensitivities to Antagonists 21
G. Similar and Opposing Responses Mediated by ETs/SRTXs 23
H. Signaling Differences Between ET and SRTX 26
I. Conclusions 28
References 29
CHAPTER 3
Identity of Endothelin Converting Enzyme and Other Targets for
the Therapeutic Regulation of Endothelin Biosynthesis
R. Corder. With 9 Figures 35
A. Biosynthesis of the Endothelins 35
I. Introduction 35
II. Tissue Expression and Localisation 35
III. Regulation of Prepro ET 1 Expression 37
1. Basal Synthesis 37
2. Ca2+ and Intracellular pH 38
3. Protein Kinase C 38
4. Cytokines 39
5. Thrombin 40
6. Stretch 40
IV. Physiological Functions of ET 1 Biosynthesis 41
1. Role of ET 1 in Development 41
2. ET 1 and Vascular Homeostasis 41
B. Inhibition of ET 1 Synthesis vs Endothelin
Receptor Antagonists 42
I. Lung 42
1. Pulmonary Hypertension 42
2. Airways Disease 43
II. Atherosclerosis 43
III. Renal Failure 44
C. Endothelin Converting Enzyme 45
I. Background to Endothelin Converting Enzyme 45
II. Evidence of a Secondary Structure for Big ET 1 47
III. Molecular Modelling of Big ET 1 48
IV Endothelin Converting Enzyme 1 50
1. Purification and Cloning of ECE 1 50
2. Expression and Localisation of ECE 1 51
3. Implications from ECE 1 Gene Deletion Studies 53
V. The Search for the Physiologically Relevant ECE 54
D. Alternative Strategies for Inhibiting ET 1 Synthesis 56
I. Inhibition of Intracellular Signalling Mechanisms 57
II. Anti Inflammatory Mediators which Suppress
ET 1 Synthesis 58
E. Summary 58
List of Abbrevations 58
References 59
CHAPTER 4
Endothelin Receptors
P.J. Henry and R.G. Goldie 69
A. Introduction 69
B. Pharmacological Classification of ET Receptors 69
I. General 69
II. ETA and ETB Receptor Selective Agonists and
Antagonists 70
III. Characterization of ETA and ETB Receptor
Populations 71
C. Molecular Biology of ET Receptors 73
I. Cloning of ET Receptor Genes 73
II. Mutations of ET Receptor Genes 74
D. Subclassification of ETA and ETB Receptors 75
I. ETA Receptor Subtypes 75
II. ETB Receptor Subtypes 76
III. ETC and Other Putative Subtypes 78
IV. Splice Variants of ET Receptors 79
E. ET Receptor Structure 80
I. Structure 80
II. Post Translational Modification of ET Receptors 81
1. Glycosylation 81
2. Palmitoylation 81
III. Binding Characteristics of ET Receptors 82
1. Differences Between Membranes and Intact Cells 85
F. ET Receptor Coupling 85
G. Alterations in ET Receptor Expression and Density 86
I. Desensitization and Internalization 86
II. Drugs 88
1. Glucocorticoids 88
2. Cyclosporine 88
3. Phosphoramidon 89
III. Cytokines and Other Peptides 89
IV. Cell and Tissue Culture 90
V. Development 91
VI. Pregnancy/Menstrual Cycle 92
VII. Disease 92
H. Summary 98
References 99
CHAPTER 5
Cell Signaling by Endothelin Peptides
M.S. Simonson. With 3 Figures 115
A. Introduction and Overview 115
B. Contractile Signaling by ET 1 115
I. Activation of Phospholipase C by Endothelin 1 115
II. Ca2+ Signaling and ET 1 Induced Contraction 116
III. Ca2+ Channels and ET 1 117
IV. Unresolved Issues in ET 1 Ca2+ Signaling 119
V. PKC and ET 1 Induced Contraction 119
C. Genomic Signaling by ET: Cell Growth and Development 120
I. Mitogenic Signaling by ET 121
1. ET 1 and MAPK Cascades 123
2. ET and Non Receptor Protein Tyrosine Kinases in
Mitogenic Signaling 124
3. ET and Survival, Anti Apoptotic Signaling 129
II. ET Post Receptor Signals in Development and
Differentiation 130
D. Summary and Perspective 132
References 133
CHAPTER 6
Lessons from Gene Deletion of Endothelin Systems
H. Kurihara, Y. Kurihara and Y. Yazaki. With 1 Figure 141
A. Introduction 141
B. Developmental Defects in Endothelin Knockout Mice 141
I. Gene Knockout of ET 1/ET A Receptor Pathway 141
II. Gene Knockout of ET 3/ET B Receptor Pathway 142
III. Gene Knockout of Endothelin Converting Enzyme 143
C. Neural Crest and the Endothelin System 143
I.Outline of Neural Crest Development 143
II. Developmental Expression of the ET System 145
III. Involvement of the ET System in Neural Crest
Development 145
D. Endothelin Knockout Mice and Human Diseases 147
I. ET 3/ET B Receptor Knockout Mice and
Hirschsprung s Disease 147
II. ET 1/ET A Receptor Knockout Mice and
Craniofacial/Cardiovascular Disease 149
E. Perspectives 149
References 150
CHAPTER 7
Endothelin Converting Enzyme Inhibitors and their Effects
B. Battistini and A.Y. Jeng. With 6 Figures 155
A. Introduction 155
I. Mature ET Peptides and their Precursors 155
II. ECE: Cloning, Classification, and Cellular Localization .... 157
III. Alternative Pathways for ET Production and
Perspectives Provided by Gene Targeting Studies 160
1. Aspartyl Proteases 160
2. Thiol (Cysteine) Proteases 161
3. Serine Proteases 162
4. Gene Targeting 162
IV. Modulation of ECE Expression and Activity 163
V. ECE: Substrate Specificity and pH Dependence 163
B. Development of ECE Inhibitors: Chemical Identity,
Selectivity, Potency, and Oral Bioavailability 164
I. Chemical Identities of ECE Inhibitors 164
II. Non Specific ECE Inhibitors: Metal Chelators 171
III. Non Selective Dual NEP/ECE Inhibitors 173
1. More Potent Against NEP 173
a) Phosphoramidates 173
b) Aminophosphonic Acids 181
c) Carboxylic Acids 181
d) Sulfhydryl Containing Compounds 181
2. More Potent Against ECE 184
a) Phosphonamides 184
b) Aminophosphonic Acids 184
IV. Non Selective Triple ACE/NEP/ECE Inhibitors 184
1. Phosphinic Acids 184
2. Phosphonamides 184
3. Aminophosphonic Acid 185
4. Other Compounds 185
V. Selective ECE Inhibitors 185
1. Peptidic Compounds 185
2. Non Peptidic Compounds from Natural Products 185
3. Other Non Peptidic Compounds 186
VI. Other Compounds Presenting Some ECE Inhibitory
Activities 186
C. Effects of Protease Inhibitors, Chelating Agents and
Metal Ions on ECE Activities in Cultured Cells, Isolated Tissues,
Perfused Organs, and In Vivo 187
I. In Cultured Cells 187
1. In Endothelial Cells 187
2. In Airway Epithelial Cells 188
3. In Other Types of Cells 188
II. In Isolated Vascular and Non Vascular Preparations 188
1. Vascular Preparations 188
2. Non Vascular Preparations 188
III. In Isolated and Perfused Organs 189
IV. In Semi Purified and Purified Preparations 189
V. In Vivo Studies 189
D. Effect of ECE Inhibitors in Various Pre Clinical Animal Disease
Models and in Clinical Studies 190
I. Cerebral Vasospasm Following Subarachnoid
Hemorrhage 191
II. Conditions Associated with Vascular Remodeling 191
1. Hypertension 191
2. Congestive Heart Failure 191
3. Post Angioplastic Restenosis 192
III. Renal Failure 192
IV. Pulmonary Vascular Diseases 192
V. Pulmonary Respiratory Diseases 193
E. Conclusions and Perspectives 193
References 196
CHAPTER 8
Endothelin Converting Enzymes and Endothelin Receptor
Localisation in Human Tissues
A.P. Davenport and F.D. Russell. With 6 Figures 209
A. Introduction 209
B. Endothelin Converting Enzymes 209
I. ECE 1 209
1. Localisation of mRNA Encoding Isoforms of
ECE 1 210
2. Localisation of ECE 1 Using Immunocytochemistry .... 210
3. Quantification of ECE 1 Isoforms 210
II. ECE 2 211
C. ECE and ET Receptor Sub Types in
the Peripheral Vasculature 211
I. Ultrastructural Localisation of ECE 1 in Endothelial
Cells 211
II. Evidence for Smooth Muscle Cell ECE and
Upregulation in Cardiovascular Disease 213
III. ECE 2 216
IV. ET Receptor Sub Types 218
D. ECE and ET Receptor Sub Types in Organ Systems 220
I. Heart 220
II. Lungs 221
HI. Adrenal Gland 222
IV. Kidney 223
V. Central Nervous System 225
1. Cerebral Vasculature 225
2. Neurones 227
3. Astrocytes 227
4. Neural Receptors 228
E. Conclusions 228
List of Abbreviations 229
References 229
CHAPTER 9
Endothelin Receptor Antagonists
J.D. Elliott and J. N. Xiang. With 26 Figures 239
A. Peptide Endothelin Receptor Antagonists 239
I. ETA Selective Antagonists 239
II. ETB Selective Antagonists 242
III. ETA/ETB Balanced Antagonists 244
B. Non Peptide Endothelin Receptor Antagonists 245
I. ETA/ETB Balanced Antagonists 245
II. ETA Selective Antagonists 252
III. ETB Selective Antagonists 264
References 265
CHAPTER 10
Toxicology of Endothelin Antagonists
S.J. Morgan, P.K. Cusick, and B.A. Trela 271
A. Introduction 271
B. Cardiovascular System 271
C. Teratology 272
I. ETA Receptor 272
II. ETB Receptor 273
D. Clinical Trials 274
References 274
CHAPTER 11
Endothelins and the Release of Autacoids
P. D Orleans Juste, G. Bkaily, M. Duval, J. Labonte,
M. Plante, G. Cournoyer, and N. Berthiaume. With 5 Figures 277
A. Introduction 277
B. Endothelin Induced Release of Endothelial Derived Factors 279
I. Nitric Oxide 279
II. Eicosanoids 279
1. Receptors Involved in the Release of Eicosanoids 280
III. Cross Talk Between the Endothelin, Nitric Oxide and
Arachidonic Acid Pathways 282
IV. Intracellular Mechanisms Involved in the Nitric Oxide
or PGI2 Induced Downregulation of ET 1 Production 283
V. ET 1 Induced Release of Cytokines 284
C. Autacoid Mediators Generated by Endothelin 1 in
Non Vascular Cells 285
D. Endothelin Converting Enzyme Dependent Release of
Modulators 287
I. Eicosanoids 287
II. Big Endothelins and NO 289
E. Modulator Releasing Properties of Endothelins in Mice 291
I. Nitric Oxide 291
II. Eicosanoids 291
F. Conclusion 293
References 294
CHAPTER 12
The Roles of Endothelins in Proliferation, Apoptosis,
and Angiogenesis
J.R. Wu Wong and T.J. Opgenorth. With 5 Figures 299
A. Introduction 299
B. The Role of Endothelins in Cell Proliferation 300
I. The Mitogenic Effect of ETs 300
II. The Effects of ET 1 on the Migration and Proliferation
of Endothelial Cells 303
III. The Anti Proliferative Effect of ETs 306
C. The Role of Endothelin in Apoptosis 307
D. The Role of Endothelin in Angiogenesis 310
I. Is ET 1 an Angiogenic Factor? 310
II. Is ET 1 Found in Diseases with Angiogenesis? 311
III. Interaction Between ETs and Angiogenic Factors 312
E. Conclusion 314
List of Abbreviations 316
References 316
CHAPTER 13
The Involvement of Endothelins in
Cerebral Vasospasm and Stroke
O. Touzani and J. McCulloch. With 7 Figures 323
A. Introduction 323
B. Endothelins and Endothelin Receptors in the Brain and
Cerebral Circulation 324
I. Endothelins in the Brain and Cerebral Circulation 324
II. Endothelin Receptors in the Brain and
Cerebral Circulation 324
III. Function of Endothelins in the Brain 325
IV. Endothelins and the Cerebral Circulation 326
1. ETA Receptor Mediated Effects 326
2. ETB Receptor Mediated Effects 327
3. Role of Endothelins in the Regulation of
Cerebrovascular Tone 329
C. Pathophysiological Role of Endothelins in the Cerebral
Circulation 330
I. Subarachnoid Haemorrhage 330
1. Cerebrovascular Reactivity to Endothelins 331
2. Levels of Endothelins 332
3. Treatment with Endothelin Receptor Antagonists 334
II. Cerebral Ischaemia 340
1. Clinical Observations in Man 341
2. Induced Cerebral Ischaemia in Animals 342
a) Global Cerebral Ischaemia 342
b) Focal Cerebral Ischaemia 343
D. Concluding Remarks 346
References 346
CHAPTER 14
Involvement of the Endothelins in Airway Reactivity and Disease
R.G. Goldie and P.J. Henry. With 1 Figure 357
A. Introduction 357
B. The Endothelin System 358
I. Is There a Link to Asthma? 358
II. ET Structure, Synthesis and Degradation 358
1. Structure 358
2. Synthesis 358
3. Degradation 359
C. ET Receptors 360
D. ET and the Major Pathologies in Respiratory Diseases 360
I. Asthma 360
II. Allergic Rhinitis 361
III. Adult Respiratory Distress Syndrome (ARDS) 361
IV. Cryptogenic Fibrosing Alveolitis (CFA) 361
V. Pulmonary Fibrosis 362
VI. Pulmonary Tumours 362
E. ET 1 and the Standard Criteria for Mediator Status
in Asthma 362
I. Synthesis, Release and Degradation of the ETs in
the Lung 363
1. Synthesis 363
2. Release 363
3. Degradation 363
II. ET Receptor Distribution 364
1. Airway Smooth Muscle 364
2. Other Sites 364
III. ET Receptor Mediated Responses Relevant to Asthma .... 365
1. Altered Bronchial Tone 365
a) Direct Airway Smooth Muscle Contraction 366
b) Modulation of Neurotransmission 366
c) Bronchoconstriction In Vivo 367
2. Mitogenesis 368
a) Fibroblasts 368
b) Airway Smooth Muscle 369
c) Mucous Glands 369
3. Secretion of Mucus 370
4. Altered Microvascular Permeability 370
5. ET 1 as a Pro Inflammatory Mediator 370
a) ET 1 Induced Pro Inflammatory Mediator
Release 371
b) ET 1 Induced Inflammatory Cell Chemotaxis 371
c) Some Evidence Against a Major
Pro Inflammatory Role for ET 1 in the Airways 371
IV. Airway Inflammation, Increased ET Levels and Asthma ... 372
1. Evidence from Models In Vitro 372
2. Evidence from Animal Models Ex Vivo or In Vitro 372
3. Asthma Associated Airway Inflammation and
ET Levels 373
4. Respiratory Tract Viral Infection, Asthma and ETs 374
5. ET Levels and Asthma Symptoms 374
F. Conclusions 375
References 375
CHAPTER 15
Endothelin 1 and Pulmonary Hypertension
D.J. Stewart and YD. Zhao. With 3 Figures 389
A. Mechanisms of Pulmonary Hypertension 389
B. Endothelial Dysfunction and Pulmonary Hypertension 390
C. The Search for a Vasoconstrictor Factor in Pulmonary
Hypertension 390
D. ET 1 Homeostasis in the Pulmonary Vasculature in Health
and Disease 393
E. Role of ET Antagonists in Pulmonary Hypertension 397
References 400
CHAPTER 16
Vascular and Cardiac Effects of Endothelin
S.A. Douglas and E.H. Ohlstein 405
A. Endothelin Induced Vascular Smooth Muscle Contraction 405
B. Modulatory Role of the Endothelium on the Contractile
Actions of the Endothelin Isopeptides 406
C. Multiple Receptor Subtypes Mediating the Vascular Actions
of Endothelin 1 406
D. Cardiac Actions of Endothelin 1 408
E. Integrated Cardiovascular Actions of Endothelin 1 409
F. Functional Genomics 412
I. Endothelin Isopeptides 412
II. ETA and ETB Receptor 413
III. Endothelin Converting Enzyme 413
G. Hemodynamic Actions of ET 1 in Man 413
I. Endothelin Isopeptide Administration 414
II. Endothelin Receptor Antagonism 414
H. Endothelin 1 and the Central Control of Cardiovascular
Function 415
I. Endothelin 1 and Endothelium Derived Contracting Factor
(EDCF) 416
J. Endothelin 1 and the Control of Smooth Muscle and
Myocyte Structure 416
K. Hemostatic Actions of Endothelin 1 419
L. Endothelin and the Pathogenesis of
Cardiovascular Dysfunction 419
I. Congestive Heart Failure 419
II. Hypertension 422
III. Atherosclerosis and Vascular Restenosis 425
IV. Myocardial Ischemia 427
V. Cerebral Vasospasm, Stroke, and
Subarachnoid Hemorrhage 427
VI. Diabetes 428
VII. Endotoxic Shock 428
VIII. Migraine 429
IX. Reynaud s Phenomenon 429
M. Pharmacological Profile for the Treatment of
Cardiovascular Disease 429
N. Summary 430
References 430
CHAPTER 17
Endothelins Within the Liver and the Gastrointestinal System
B. Battistini 453
A. Introduction: The ET System in the Liver and the GI Tract 453
I. ETs and ET Receptors 453
II. In Situ and/or Immunocytochemical Distribution 454
III. Production, Release and Tissue Levels of ETs 454
IV. Metabolism 455
B. The Pharmacology of ETs in the Hepatopancreatic System 456
I. ET Induced Responses in the Liver and Pancreas 456
II. ET Induced Responses in Hepatic and Pancreatic
Cells 456
C. Responses of Isolated Smooth Muscle Preparations Related
to the GI System 457
I. The Esophagus 457
II. The Stomach and Gastric Cells 458
1. ET Induced Vascular Response of the Stomach 458
2. ET Induced Contraction of the Fundus 458
3. ET Induced Effects in Gastric Cells 459
III. The Gallbladder 459
IV. The Duodenum 460
V. The Jejunum 461
VI. The Ileum 461
VII. The Colon 462
D. Possible Roles of ETs in Gastrointestinal Diseases and
Clinical Relevance 463
I. Animal Models of GI Disorders: Modulation of
the ET System and Treatment with ET Antibodies,
ECE Inhibitors, or ET Receptor Antagonists 463
1. Portal Hypertension 463
2. Gastric/Duodenal Mucosal Injury and Ulceration 463
3. Chronic or Acute Pancreatitis 465
4. Inflammatory Bowel Disease 466
5. Intestinal Mucosal Acidosis 466
II. Human Subjects and Patients 467
1. Peptic Ulcer 467
2. Chronic Pancreatitis 467
3. Inflammatory Bowel Diseases: Crohn s Disease and
Ulcerative Colitis 467
E. Discussion and Conclusions 468
References 468
CHAPTER 18
Endothelin and the Kidney
D.M. Pollock 477
A. Introduction 477
B. Localization of ET 1, ECE, and Endothelin Receptors in
the Kidney 477
C. Hemodynamic Effects of Exogenous ET 1 in the Kidney 479
D. Tubular Actions of Endothelin 481
E. Role of Endothelin in Control of Excretory Function 482
F. Interaction Between Endothelial Factors in the Kidney 484
G. Role of Renal ET 1 in Hypertension 485
H. Role of ET 1 in Acute Renal Failure 487
I. Role of ET 1 in Chronic Renal Failure 490
J. Conclusion 492
References 492
CHAPTER 19
Endothelin Ligands and their Experimental Effects Within
the Human Circulation
S.J. Leslie and D.J. Webb 503
A. Introduction 503
B. Research Tools Used in Human Subjects 503
I. Local Study Techniques 503
II. Systemic Study Techniques 504
C. Endothelin Ligands Used in Human Studies 505
D. Endothelin Ligands and their Effects in Healthy Volunteers 506
I. Local Activation of the Endothelin System in
Healthy Volunteers 506
1. Resistance Vessels 506
2. Capacitance Vessels 507
3. Microcirculation 507
II. Local Inhibition of the Endothelin System in Healthy
Volunteers 508
1. Resistance Vessels 508
2. Microcirculation 508
III. Systemic Activation of the Endothelin System in
Healthy Volunteers 509
1. Cardiovascular Effects 509
2. Renovascular Effects 509
IV. Systemic Inhibition of the Endothelin System in
Healthy Volunteers 510
1. Cardiovascular Effects 510
a) Non Selective Inhibition 510
b) Selective Inhibition 510
2. Renovascular Effects 511
E. Endothelin Ligands and their Effects in Patients 511
I. Heart Disease 511
1. Congestive Heart Failure 511
2. Coronary Artery Disease (CAD) 513
3. Hypertension 513
II. Renal Disease 514
1. Chronic Renal Failure 514
2. Hepatorenal Failure 514
3. Contrast Nephropathy 515
F. Conclusion 515
References 515
Subject Index 521
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV013557699 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:47:57Z |
| institution | BVB |
| isbn | 3540679855 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009259089 |
| oclc_num | 45500382 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-188 DE-578 |
| physical | XXIV, 532 S. Ill., graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Endothelin and its inhibitors [with 17 tables] contributors B. Battistini ... Ed. Timothy D. Warner Berlin [u.a.] Springer 2001 XXIV, 532 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 152 Endothelins cabt Receptors cabt Physiology cabt Antagonists cabt Endothelinen gtt Endothelins Endothelins Antagonists Receptors, Endothelin antagonists & inhibitors Receptors, Endothelin physiology Antagonist (DE-588)4198647-7 gnd rswk-swf Endothelin (DE-588)4255702-1 gnd rswk-swf Pharmakologischer Antagonist (DE-588)4198682-9 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Inhibitor (DE-588)4027007-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Endothelin (DE-588)4255702-1 s Antagonist (DE-588)4198647-7 s DE-604 Rezeptor (DE-588)4049722-7 s Inhibitor (DE-588)4027007-5 s Pharmakologischer Antagonist (DE-588)4198682-9 s Warner, Timothy D. Sonstige oth Battistini, Bruno Sonstige oth Handbook of experimental pharmacology 152 (DE-604)BV002390716 152 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009259089&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Endothelin and its inhibitors [with 17 tables] Handbook of experimental pharmacology Endothelins cabt Receptors cabt Physiology cabt Antagonists cabt Endothelinen gtt Endothelins Endothelins Antagonists Receptors, Endothelin antagonists & inhibitors Receptors, Endothelin physiology Antagonist (DE-588)4198647-7 gnd Endothelin (DE-588)4255702-1 gnd Pharmakologischer Antagonist (DE-588)4198682-9 gnd Rezeptor (DE-588)4049722-7 gnd Inhibitor (DE-588)4027007-5 gnd |
| subject_GND | (DE-588)4198647-7 (DE-588)4255702-1 (DE-588)4198682-9 (DE-588)4049722-7 (DE-588)4027007-5 (DE-588)4143413-4 |
| title | Endothelin and its inhibitors [with 17 tables] |
| title_auth | Endothelin and its inhibitors [with 17 tables] |
| title_exact_search | Endothelin and its inhibitors [with 17 tables] |
| title_full | Endothelin and its inhibitors [with 17 tables] contributors B. Battistini ... Ed. Timothy D. Warner |
| title_fullStr | Endothelin and its inhibitors [with 17 tables] contributors B. Battistini ... Ed. Timothy D. Warner |
| title_full_unstemmed | Endothelin and its inhibitors [with 17 tables] contributors B. Battistini ... Ed. Timothy D. Warner |
| title_short | Endothelin and its inhibitors |
| title_sort | endothelin and its inhibitors with 17 tables |
| title_sub | [with 17 tables] |
| topic | Endothelins cabt Receptors cabt Physiology cabt Antagonists cabt Endothelinen gtt Endothelins Endothelins Antagonists Receptors, Endothelin antagonists & inhibitors Receptors, Endothelin physiology Antagonist (DE-588)4198647-7 gnd Endothelin (DE-588)4255702-1 gnd Pharmakologischer Antagonist (DE-588)4198682-9 gnd Rezeptor (DE-588)4049722-7 gnd Inhibitor (DE-588)4027007-5 gnd |
| topic_facet | Endothelins Receptors Physiology Antagonists Endothelinen Endothelins Antagonists Receptors, Endothelin antagonists & inhibitors Receptors, Endothelin physiology Antagonist Endothelin Pharmakologischer Antagonist Rezeptor Inhibitor Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009259089&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT warnertimothyd endothelinanditsinhibitorswith17tables AT battistinibruno endothelinanditsinhibitorswith17tables |