Adjunct treatment modalities for skull base tumors:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2000
|
| Schriftenreihe: | Neurosurgery clinics of North America
11,4 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X S., S. 575 - 751 Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Adjunct treatment modalities for skull base tumors |c Joung H. Lee, guest ed. |
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| 490 | 1 | |a Neurosurgery clinics of North America |v 11,4 | |
| 650 | 2 | |a Base du crâne - Chirurgie | |
| 650 | 2 | |a Radiochirurgie | |
| 650 | 2 | |a Tumeurs de la base du crâne - Traitement médicamenteux | |
| 650 | 4 | |a Radiosurgery | |
| 650 | 4 | |a Skull Base Neoplasms |x drug therapy | |
| 650 | 4 | |a Skull Base Neoplasms |x radiotherapy | |
| 650 | 4 | |a Skull Base |x surgery | |
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Datensatz im Suchindex
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| adam_text | ADJUNCT TREATMENT MODALITIES FOR SKULL BASE TUMORS
CONTENTS
Preface xiii
Joung H. Lee
PART I: RADIATION THERAPY: General Overview
Conventional Radiation Therapy for Skull Base Tumors:
An Overview 575
John H. Suh and Jerrold P. Saxton
Radiation therapy is an important treatment option for patients with skull
base tumors. It may he used as a primary treatment, adjunctive treatment,
or as therapy for recurrence. The use of conventional radiation therapy for
skull base tumors has resulted in good to excellent control of these lesions.
This article discusses the radiobiology, physics, and outcomes of conven¬
tional radiation therapy in managing skull base tumors.
Recent Advances in the Treatment of Skull Base Tumors
Using Radiation 587
Gene H. Barnett, John H. Suh, and Richard L. Crownover
The evolution of technology has led to dramatic advances in the ability to
treat tumors of the skull base, and the future of new devices seems bright.
Only with time, however, will we be certain of their true role in management
of tumors of the skull base.
Acute and Long Term Complications of Therapeutic Radiation
for Skull Base Tumors 597
Keith J. Stelzer
Acute toxicity from radiation of skull base tumors typically resolves sponta¬
neously within days to weeks after completion of therapy. Long term com¬
plications have a latency of months to years after radiation and are usually
NEUROSURGERY CLINICS OF NORTH AMERICA
VOLUME 11 • NUMBER 4 • OCTOBER 2000 vjj
reversible. Use of conformal radiation techniques with image guidance may
result in improved tumor control by allowing delivery of higher radiation
doses to the tumor, while maintaining an acceptable level of risk for chronic
toxicity. Symptoms resulting from chronic radiation toxicity are indistin¬
guishable from symptoms caused by tumor progression. Diagnosis of late
term radiation complication must be made only after verifying that the
tumor has not progressed.
PART II: RADIATION THERAPY: Specific Applications
Conventional Radiation Therapy for Skull Base Meningiomas 605
Brian J. Goldsmith and David A. Larson
Indications, techniques, and results for skull base meningioma radiotherapy
are reviewed. Prognostic factors in the setting of adjuvant radiotherapy
are summarized.
Conventional Radiotherapy for Pituitary Tumors 617
Edward R. Laws, Jr and Mary Lee Vance
Radiation therapy as an adjunct for the management of pituitary tumors
has a long and continually evolving history. Primary indications for the use
of radiation therapy are for control of hyperactive endocrine systems as
seen in acromelagy and Cushing s disease and for the management of
aggressive, recurrent pituitary tumors. Many lesions are suitable for ste
reotactic radiosurgery, and this modality is proving to be effective and
safe.
Proton Radiation Therapy for Chordomas and Chondrosarcomas
of the Skull Base 627
Eugen B. Hug and Jerry D. Slater
More than 500 patients with chordomas and low grade chondrosarcomas
of the skull base have undergone fractionated proton radiation therapy
since 1975. Maximum surgical resection followed by high dose irradiation
resulted in durable tumor control and superior results in the majority of
patients, compared with conventional x ray treatment. Some complications
have been observed, but the rate of serious toxicities appears to be acceptable.
Patients with chondrosarcomas fare better than patients with chordomas.
Small tumor size and prior surgical decompression of dose limiting struc¬
tures are also associated with improved tumor control.
Interstitial Brachytherapy for Skull Base Tumors 639
Pradeep P. Kumar and Angelo A. Patil
Over the past decade, great advances have been made in the development
of technology and the techniques in the treatment of skull base tumors;
however, because of the complexity of skull base anatomy, the morbidity,
mortality, and recurrence rate following surgery for these tumors is high.
Interstitial brachytherapy with 1 125 permanent implants is a viable al¬
ternative as a primary and second line treatment for these difficult tu¬
mors.
Viii CONTENTS
PART III: RADIOSURGERY
Gamma Knife Radiosurgery for Vestibular Schwannomas 651
Douglas Kondziolka, L. Dade Lunsford, and John C. Flickinger
Stereotactic radiosurgery using the Gamma Knife has become one of the
most common procedures performed for patients with newly diagnosed,
residual, or recurrent acoustic tumors (vestibular schwannomas). In this
article, clinical and imaging outcomes are provided for patients with solitary
tumors and patients with neurofibromatosis type 2.
Gamma Knife Radiosurgery for Skull Base Meningiomas 659
Bruce E. Pollock, Scott L. Stafford, and Michael J. Link
Complete resection of many skull base meningiomas is not possible without
acceptable morbidity. As an alternative to resection, stereotactic radiosur¬
gery has been used as an adjunct for residual and recurrent meningiomas
after prior tumor removal or as a primary management strategy. Magnetic
resonance imaging and improved dose planning software has made radio¬
surgery of skull base tumors safer and more effective. Contemporary skull
base meningioma radiosurgery has a greater than 90% chance of tumor
growth control with morbidity that is less than microsurgical resection for
most tumor locations.
Linear Accelerator Radiosurgery for Skull Base Tumors 667
William A. Friedman and Kelly D. Foote
The role of radiosurgery in the management of meningiomas is being de¬
fined. It seems to offer an attractive option for those patients in whom
complete surgical resection is attempted but unsuccessful or is considered
unattainable without acceptable morbidity.
PART IV: CHEMOTHERAPY
The Role of Chemotherapy for Skull Base Carcinomas
and Sarcomas 681
David J. Adelstein
The role of chemotherapy in the carcinomas and sarcomas that involve the
base of skull is reviewed in this article. An established role exists for cispla tin
based multimodality treatment in the definitive management of nasopharyn
geal carcinoma. Extrapolation from data generated for other head and neck
squamous cell cancers also suggests a role for concomitant chemotherapy
and radiation when these tumors involve the skull base. For the other
neoplasms in this region, including the nonsquamous cell cancers of salivary
gland and paranasal sinus, and the sarcomas and metastatie tumors, chemo¬
therapy remains a palliative tool with limited overall benefit.
Chemotherapy for Esthesioneuroblastomas 693
Jonas M. Sheehan, Jason P. Sheehan, John A. Jane, Sr,
and Richard S. Polin
Chemotherapy is being used more frequently for the treatment of esthesio¬
neuroblastomas. In this article, the literature is reviewed and the experience
of using chemotherapy for esthesioneuroblastomas at the University of
Virginia is presented.
CONTENTS ix
PART V: EMERGING TREATMENT MODALITIES
Gene Therapy for Skull Base Tumors 703
John A. Jane, Jr and Gregory A. Helm
Recent innovations in skull base approaches have permitted neurosurgeons
to remove tumors that were once thought unresectable. Nevertheless, sig¬
nificant numbers of patients develop disabling neurologic deficits postopera
tively. There remains ample opportunity for alternative treatments that are
minimally invasive, and yet reduce considerably or eradicate tumor burden.
Gene therapy offers such an alternative modality. Although clinical investi¬
gation has focussed primarily on malignant neoplasms, gene therapy tech¬
niques may prove effective in the treatment of benign tumors as well.
Current concepts in gene therapy are discussed with specific reference to
central nervous system neoplasia.
Future Treatment Modalities for Meningiomas: Targeting of
Neurofibromatosis Type 2 and Ras regulated Pathways 717
James J. Evans, Joung H. Lee, Yong Seok Park, Sin Soo Jeun,
Jyoti A. Harwalker, Hasan Safayhi, and Mladen Golubic
The loss of neurofibromatosis type 2 (NF2) tumor suppressor gene function
and enhanced proliferative signal transduction through the Ras pathway
are the hallmark of meningioma tumorigenesis. Although the exact mecha¬
nisms by which NF2 and Ras proteins contribute to meningioma tumorigen¬
esis remain to be elucidated, the present knowledge is sufficient to start
exploring exciting therapies that are directed at these molecular targets.
Gene therapy to restore the functions of inactivated NF2 tumor suppressor
protein and the use of several promising agents that target signal transduc¬
tion molecules of the Ras pathway are reviewed. An increased understand¬
ing of the biologic functions of the new therapeutic targets discussed in this
article will facilitate the development of meningioma treatments that are
minimally toxic, yet highly effective.
Cumulative Index 2000 735
Subscription Information Inside back cover
X CONTENTS
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| spelling | Adjunct treatment modalities for skull base tumors Joung H. Lee, guest ed. Philadelphia [u.a.] Saunders 2000 X S., S. 575 - 751 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neurosurgery clinics of North America 11,4 Base du crâne - Chirurgie Radiochirurgie Tumeurs de la base du crâne - Traitement médicamenteux Radiosurgery Skull Base Neoplasms drug therapy Skull Base Neoplasms radiotherapy Skull Base surgery Schädelbasis (DE-588)4051939-9 gnd rswk-swf Hirntumor (DE-588)4072521-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Schädelbasis (DE-588)4051939-9 s Hirntumor (DE-588)4072521-2 s DE-604 Lee, Joung H. Sonstige oth Neurosurgery clinics of North America 11,4 (DE-604)BV002758938 11,4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009258933&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Adjunct treatment modalities for skull base tumors Neurosurgery clinics of North America Base du crâne - Chirurgie Radiochirurgie Tumeurs de la base du crâne - Traitement médicamenteux Radiosurgery Skull Base Neoplasms drug therapy Skull Base Neoplasms radiotherapy Skull Base surgery Schädelbasis (DE-588)4051939-9 gnd Hirntumor (DE-588)4072521-2 gnd |
| subject_GND | (DE-588)4051939-9 (DE-588)4072521-2 (DE-588)4143413-4 |
| title | Adjunct treatment modalities for skull base tumors |
| title_auth | Adjunct treatment modalities for skull base tumors |
| title_exact_search | Adjunct treatment modalities for skull base tumors |
| title_full | Adjunct treatment modalities for skull base tumors Joung H. Lee, guest ed. |
| title_fullStr | Adjunct treatment modalities for skull base tumors Joung H. Lee, guest ed. |
| title_full_unstemmed | Adjunct treatment modalities for skull base tumors Joung H. Lee, guest ed. |
| title_short | Adjunct treatment modalities for skull base tumors |
| title_sort | adjunct treatment modalities for skull base tumors |
| topic | Base du crâne - Chirurgie Radiochirurgie Tumeurs de la base du crâne - Traitement médicamenteux Radiosurgery Skull Base Neoplasms drug therapy Skull Base Neoplasms radiotherapy Skull Base surgery Schädelbasis (DE-588)4051939-9 gnd Hirntumor (DE-588)4072521-2 gnd |
| topic_facet | Base du crâne - Chirurgie Radiochirurgie Tumeurs de la base du crâne - Traitement médicamenteux Radiosurgery Skull Base Neoplasms drug therapy Skull Base Neoplasms radiotherapy Skull Base surgery Schädelbasis Hirntumor Aufsatzsammlung |
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