Verfügbarkeit: Biochemical and physiological aspects of human nutrition

Biochemical and physiological aspects of human nutrition:

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Format:	Buch
Sprache:	English
Veröffentlicht:	Philadelphia [u.a.] Saunders 2000
Schlagworte:	Biochemie Ernährung Ernährungsphysiologie Lehrbuch
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XXX, 1007 S. Ill., graph. Darst.
ISBN:	072164452X

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Datensatz im Suchindex

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adam_text	Contents ?????????????????????????????? UNIT I Structure and Properties of the Macronutrients 1 Structure and Properties of Carbohydrates 3 Betty A. Lewis, Ph.D. Classification, Structures, and Nomenclature of the Monosaccharides 4 Chemical Reactivity of the Monosaccharides 8 Other Classes of Carbohydrates 10 Disaccharides and Oligosaccharides and Their Properties 12 Polysaccharides of Nutritional Importance 14 Glycoconjugates of Physiological Interest 18 2 Structure and Properties of Proteins and Amino Acids 23 Robert B. Rucker, Ph.D., and Taru Kosonen, Ph.D. Amino Acids 24 Peptides 31 Proteins 31 Nutritional Influences on Protein Structure and Assembly Function 36 3 Structure and Properties of Lipids 43 Donald M. Small, M.D. Lipids and Their Functions 44 The Chemical Classes of Lipids 47 The General Properties of Lipids 55 Properties of Dietary Fats and Oils and Their Products: Diacylglycerols, Monoacylglycerols, and Fatty Acids 62 XV xvi ? ? ? Contents UNIT II Digestion and Absorption of the Macronutrients 4 Overview of Digestion and Absorption 75 Patrick Tso, Ph.D., and Karen D. Crissinger, M.D., Ph.D. Digestion and Absorption in the Gastrointestinal Tract 76 The Mouth 76 The Stomach 77 The Small Intestine 78 Metabolism of Nutrients in the Enterocytes 85 Transport of Nutrients in the Circulation 85 Regulation of Digestion and Absorption 86 Developmental Aspects of Gastrointestinal Physiology 88 The Large Intestine and the Role of Colonic Bacteria 89 5 Digestion and Absorption of Carbohydrate 91 Gary M. Gray, M.D. Carbohydrate Components of the Human Diet 92 Sites and Mechanisms of Digestion of Carbohydrates 93 Absorption of Hexoses by the Enterocyte: Mechanisms and Regulation 97 Factors Influencing Carbohydrate Assimilation 101 6 Digestion and Absorption of Protein 107 Bruce R. Stevens, Ph.D. Digestion of Protein in the Gastrointestinal Tract 108 The Gastric Phase: Denaturation and Initial Hydrolysis of Proteins 108 Small Intestinal Luminal Phase: Activation and Action of Pancreatic Proteolytic Enyzmes 110 Small Intestinal Mucosal Phase: Brush Border and Cytosolic Peptidases 112 Absorption of Free Amino Acids and Small Peptides 113 Metabolism of Amino Acids in Intestinal Epithelial Cells 120 Use of Free Amino Acids and Peptides for Therapeutic Oral Rehydration 121 Uptake of Protein Macromolecules and Immune Response 121 Contents ? ? ? xvii 7 Digestion and Absorption of Lipids 125 Patrick Tso, Ph.D., and Karen D. Crissinger, M.D., Ph.D. Dietary Lipids 126 Luminal Digestion of Lipids 126 Uptake of Lipid Digestion Products by the Enterocytes 128 Intracellular Metabolism of Absorbed Lipids 130 Assembly of Intestinal Lipoproteins 133 Factors Affecting Formation and Secretion of Chylomicrons 135 Disorders of Intestinal Lipid Absorption 137 Intestinal Lipid Absorption and Mucosal Injury 138 Regional Differences in Intestinal Lipid Absorption 139 Portal Transport of Long Chain Fatty Acids 139 Satiety Effects of Fat Feeding 140 8 Dietary Fiber 143 Joanne Ft. Lupton, Ph.D., and Nancy D. Turner, Ph.D., C.N.S. Definition of Fiber 144 Major Physiological Effects of Fibers and Structure/Function Relationships 146 Recommendations for Fiber Intake 152 UNIT III Metabolism of the Macronutrients 9 Carbohydrate Metabolism—Synthesis and Oxidation 158 Mary M. McGrane, Ph.D. Overview of Carbohydrate Metabolism 159 Transport of Glucose Across Cell Membranes 160 Glycolysis 162 Gluconeogenesis 170 Regulation of Glycolysis and Gluconeogenesis 175 Regulation of the Expression of Glycolytic and Gluconeogenic Genes 183 Glycogen Metabolism 190 xviii ? ? ? Contents Regulation of Glycogenesis and Glycogenolysis 192 Pyruvate Dehydrogenase Complex and Citric Acid Cycle 198 Electron Transport and Oxidative Phosphorylation 202 Other Pathways of Carbohydrate Metabolism 205 10 Protein Synthesis and Degradation 211 Margaret A. McNurlan, Ph.D., and Peter J. Garlick, Ph.D. Essentiality of Protein 212 Dynamic Protein Metabolism 213 Measurement of Protein Synthesis and Degradation 215 Protein Turnover and Adaptation 219 Regulation of Protein Synthesis and Degradation at the Molecular Level 219 Regulation of Protein Metabolism 224 11 Amino Acid Metabolism 233 Martha H. Stipanuk, Ph.D., and Malcolm Watford, D.Phil. Overview of Amino acid Metabolism 234 Transport of Amino Acids 236 Reactions Involved in the Transfer, Release, and Incorporation of Nitrogen 237 Metabolism of the Carbon Chains of Amino Acids 240 Synthesis of Dispensable Amino Acids 245 Metabolism of Specific Amino Acids 245 Nitrogen Excretion 281 12 Protein and Amino Acid Requirements 287 Malcolm F. Fuller, Ph.D., Sc.D. The Physiological Basis of Protein and Amino Acid Requirements 288 Food Proteins and Protein Quality 291 Assessment of Requirements for Dietary Protein or Amino Acids 296 Factors that Affect Amino Acid Requirements 302 13 Lipid Metabolism—Synthesis and Oxidation 305 Alan G. Goodridge, Ph.D., and Hei Sook Sul, Ph.D. Biological Roles for Lipids 306 Contents ? ? ? xix Synthesis of Long Chain Fatty Acids from Acetyl CoA 306 Synthesis of Fatty Acids Other than Palmitate 311 Synthesis and Storage of Triacylglycerol 315 Mobilization of Stored Triacyglycerol 318 Oxidation of Fatty Acids 319 Formation of Ketone Bodies from Acetyl CoA in the Liver as a Fuel for Extrahepatic Tissues 330 Synthesis of Cholesterol from Acetyl CoA Units 333 Phosphatidate and Diacylglycerol as Precursors of Phospholipids 337 Sphingolipids as Structural and Signaling Molecules 346 14 Lipoprotein Synthesis, Transport, and Metabolism 351 Christopher J. Fielding, Ph.D. Classification of Plasma Lipoproteins 352 Synthesis and Secretion of Plasma Lipoproteins 354 Clearance of Triacylglycerol in Chylomicrons and VLDL by Lipoprotein Lipase 355 Role of HDL and Lecithin:Cholesterol Acyltransferase in Plasma Cholesterol Metabolism 356 Removal of Plasma Lipoproteins by Receptor Mediated Processes 358 Postprandial Lipoprotein Metabolism 358 Chronic Effects of Dietary Lipids on Plasma Lipoproteins and Lipid Metabolism 362 15 Lipid Metabolism: Essential Fatty Acids 365 Arthur A. Spector, M.D. Historical Perspective 366 Structure of Polyunsaturated Fatty Acids 366 Polyunsaturated Fatty Acid Synthesis in Mammalian Tissues 368 Essential Fatty Acids in Plasma 372 Essential Fatty Acid Deficiency 373 Polyunsaturated Fatty Acid Function 373 Lipid Peroxidation 379 Effects on Plasma Cholesterol and Lipoproteins 380 xx ? ? ? Contents Regulation of Gene Expression 381 16 Regulation of Fuel Utilization 384 Malcolm Watford, D.Phil., and Alan G. Goodridge, Ph.D. Fuels 385 The Metabolic Fate of Macronutrients 388 Hormonal Signals for Regulation of Fuel Utilization 395 Regulation and Control of Fuel Utilization 401 UNIT IV Energy 17 Cellular and Whole Animal Energetics 411 Adamandia D. Kriketos, Ph.D., John C. Peters, Ph.D., and James O. Hill, Ph.D. Metabolic Sources of Heat Production 412 Oxidative Phosphorylation 413 Oxidation of Fuel Molecules 414 Efficiency of Energy Conservation from Fuel Oxidation 416 Substrate Cycling 417 Measurement of Energy Expenditure 417 Components of Energy Expenditure 419 Determinants of Resting Metabolic Rate 421 18 Control of Energy Balance 425 John C. Peters, Ph.D., Adamandia D. Kriketos, Ph.D., and James O. Hill, Ph.D. Basic Concepts 426 Control of Energy Intake 430 Control of Energy Expenditure 434 Integration of Energy Intake and Expenditure 436 19 Disturbances of Energy Balance 439 James O. Hill, Ph.D., Adamandia D. Kriketos, Ph.D., and John C. Peters, Ph.D. Obesity Definition 440 Prevalence of Obesity 440 Health Consequences of Obesity 442 » Contents ? ? ? xxi Factors Involved in Development of Obesity 443 Obesity Management 44g Methods of Obesity Treatment 447 Why is it Difficult to Maintain a Reduced Body Weight? 449 Starvation Occurrence, Definition, and Historical Perspective 450 Effects on Energy Balance, Fuel Metabolism, and Body Composition 451 Adaptation to Prolonged Starvation 451 Protein Energy Malnutrition Effects on Energy Balance, Fuel Metabolism, and Body Composition 452 Adaptation to Chronic Undernutrition 452 Long Term Effects of Protein Energy Malnutrition 452 UNITV The Vitamins 20 Niacin, Riboflavin, and Thiamin 453 Donald B. McCormick, Ph.D. Niacin Niacin and Pyridine Nucleotide Coenzyme Structure and Nomenclature 4gg Sources, Digestion, and Absorption 4gg Transport and Conversion of Niacin to Coenzymes 463 Niacin Catabolism and Excretion 4g3 Functions of Pyridine Nucleotide Coenzymes in Metabolism 464 Noncoenzymic Functions of Niacin 4g6 Niacin Deficiency 4gg Biochemical Assessment of Niacin Nutriture 457 Niacin Requirements 4gg Riboflavin Riboflavin and Flavocoenzyme Structure and Nomenclature 468 Sources, Digestion, and Absorption 459 Transport and Conversion of Riboflavin to Coenzymes 471 xxii ? ? ? Contents Riboflavin Catabolism and Excretion 472 Functions of Flavocoenzymes in Metabolism 472 Riboflavin Deficiency 473 Biochemical Assessment of Riboflavin Nutriture 475 Riboflavin Requirements 475 Thiamin Thiamin and Thiamin Coenzyme Structure and Nomenclature 475 Sources, Digestion, and Absorption 476 Transport and Conversion of Thiamin to Coenzyme 476 Thiamin Catabolism and Excretion 477 Functions of Coenzymic Thiamin in Metabolism 477 Thiamin Deficiency 479 Biochemical Assessment of Thiamin Nutriture 480 Thiamin Requirements 480 21 Folic Acid, Vitamin B12, and Vitamin B6 483 Barry Shane, Ph.D. Folate Chemistry of Folate 484 Sources of Folate 485 Bioavailability and Absorption of Folate 485 Transport and Tissue Accumulation of Folate 486 Intracellular Metabolism and Turnover of Folate 487 Metabolic Functions of Folate 488 Folate Deficiency: Symptoms and Metabolic Bases 495 Folate Requirements 500 Folate Toxicity 500 Vitamin B12 Chemistry of Vitamin B12 501 Sources of Vitamin B12 501 Bioavailability and Absorption of Vitamin B12 502 . Contents ? ? ? xxiii Transport of Vitamin B12 503 Intracellular Metabolism of Vitamin B12 504 Metabolic Functions of Vitamin B12 504 Vitamin B12 Deficiency: Symptoms and Metabolic Bases 507 Vitamin B12 Requirements 510 Vitamin B12 Toxicity 511 Vitamin B6 Chemistry of Vitamin B6 511 Sources of Vitamin B6 511 Bioavailability and Absorption of Vitamin B6 511 Transport, Metabolism, and Tissue Accumulation of Vitamin B6 511 Metabolic Functions of Vitamin B6 513 Vitamin B6 Deficiency: Symptoms and Metabolic Bases 516 Vitamin B6 Requirements 517 Vitamin B6 Toxicity 517 22 Pantothenic Acid and Biotin 519 Lawrence Sweetman, Ph.D. Pantothenic Acid Microbial Synthesis and Structure of Pantothenic Acid 520 Absorption, Transport, and Excretion of Pantothenic Acid 520 Coenzyme A and ACYL Carrier Protein Synthesis and Degradation 522 Roles of Coenzyme A and ACYL Carrier Protein in Metabolism 524 Coenzyme A and Carnitine Interrelations 528 Dietary Sources, Recommended Intakes, and Deficiency Symptoms 528 Biotin Biotin Synthesis 529 Biotin Absorption, Transport, Excretion, and Degradation 530 Holocarboxylase Synthetase 531 Biotin Containing Carboxylases 531 Holocarboxylase Synthetase Deficiency 536 xxiv ? ? ? Contents Biotinidase Deficiency 536 Dietary Sources, Recommended Intakes, and Deficiency Symptoms 537 23 Vitamin C 541 Mark Levine, M.D., Steven C. Rumsey, Ph.D., Yaohui Wang, M.D., Jae B. Park, Ph.D., and Rushad Daruwala, Ph.D. Nomenclature, Structure, Formation, Chemical Characteristics, and Degradation of Vitamin C 542 Food Sources, Absorption, and Bioavailability of Vitamin C 544 Transport of Ascorbate into Cells 546 Enzymatic Functions of Ascorbate 548 Nonenzymatic Reductive Functions of Ascorbate 559 Ascorbate Function and Tissue Distribution 562 Ascorbate Deficiency 562 Toxicity and Adverse Effects of Vitamin C 563 Recommended Ingestion 563 24 Vitamin K 568 John W. Suttie, Ph.D. Vitamin K, An Antihemorrhagic Factor 569 Nomenclature of Vitamin K Active Compounds 569 Sources of Vitamin K 569 Absorption, Transport, and Metabolism of Vitamin K 571 Function of Vitamin K in the Synthesis of Specific Proteins 572 Physiological Roles of Vitamin K Dependent Proteins 577 Vitamin K Deficiency 580 Assessment oF Vitamin K Status 581 Recommendations for Vitamin K Intake 582 25 Vitamin E 584 Ching K. Chow, Ph.D. Nomenclature and Structure of Vitamin E 585 Absorption, Transport, and Metabolism of Vitamin E 586 Biological Functions of Vitamin E and Free Radical Induced Lipid Peroxidation 589 Functional Interactions of Vitamin E with other Nutrients 591 J Contents ? ? ? xxv Deficiency, Toxicity, and Health Effects of Vitamin E 592 Biopotency and Sources of Various Forms of Vitamin E 594 Requirement for Vitamin E and Assessment of Vitamin E Nutritional Status 596 26 Vitamin A 599 Noa Noy, Ph.D. Chemistry and Physical Properties of Vitamin A and Carotenoids 600 Physiological Functions of Vitamin A 602 Absorption, Transport, Storage, and Metabolism of Vitamin A and Carotenoids 607 Retinoid Binding Proteins and Transport of Retinoids 613 Nutritional Considerations of Vitamin A 618 27 Vitamin D 624 Michael F. Holick, Ph.D., M.D. Photobiology of Vitamin D 625 Food Sources of Vitamin D and the Recommended Dietary Allowances 629 Vitamin D in Bone Health 630 Vitamin D Metabolism and Function 632 Molecular Biology of Vitamin D 634 Biological Functions of 1,25(OH)2D in Noncalcemic Tissues 635 Recommendations for Satisfying the Vitamin D Requirement for Maximum Bone Health 636 UNIT VI The Minerals 28 Calcium and Phosphorus 643 Richard J. Wood, Ph.D. Chemical Properties of Calcium and Phosphorus 644 Physiological or Metabolic Functions of Calcium and Phosphorus 646 Hormonal Regulation of Calcium and Phosphate Metabolism 651 Calcium and Phosphate Homeostasis 654 Dietary Sources, Bioavailability, and Recommended Intakes for Calcium and Phosphorus 660 xxvi ? ? ? Contents Calcium and Phosphorus Deficiency and Assessment of Status 666 Clinical Disorders Involving Altered Calcium and Phosphorus Homeostasis 668 29 Magnesium 671 Robert K. Rude, M.D. Chemistry of Magnesium 672 Food Sources and Dietary Intake of Magnesium 672 Absorption and Excretion of Magnesium 672 Body Magnesium Content 675 Physiological Roles of Magnesium 676 Magnesium Requirements 680 Magnesium Depletion 680 Diagnosis of Magnesium Deficiency 683 Magnesium Toxicity 683 30 Sodium, Chloride, and Potassium 686 Hwai Ping Sheng, Ph.D. Functions of Sodium, Chloride, and Potassium 687 Sodium, Chloride, and Potassium Balance 694 Regulation of Sodium, Chloride, and Potassium Balance 697 Sodium and Chloride Imbalance and Its Consequences 704 Potassium Imbalance and Its Consequences 705 Nutritional Considerations 707 31 Iron 711 Roy D. Baynes, M.D., Ph.D., and Martha H. Stipanuk, Ph.D. Biological Functions of Iron 712 Proteins of Iron Transport and Iron Storage 715 Regulation of Concentrations of Proteins of Iron Transport and Storage 720 Body Iron Compartments 722 Internal Iron Exchange and Iron Delivery to Cells 722 External Iron Exchange and Iron Absorption 725 Recommended Dietary Intakes of Iron 731 Contents ? ? ? xxvii Assessment of Iron Status 732 Iron Deficiency 734 Iron Excess 736 32 Zinc, Copper, and Manganese 741 James C. Fleet Ph.D. The Role of Zinc, Copper, and Manganese in Enzyme Systems 742 Requirements and Food Sources of Zinc, Copper, and Manganese 744 Absorption, Transport, Storage, and Excretion of Zinc, Copper, and Manganese 746 Selected Functions of Zinc, Copper, and Manganese 752 Assessment of Zinc, Copper, and Manganese Status and Deficiency Symptoms 757 Toxicity of Zinc, Copper, and Manganese 758 33 Iodine 761 Hedley C. Freake, Ph.D. Uniqueness of Iodine 762 Production and Metabolism of Thyroid Hormones 762 Mechanism of Action of Thyroid Hormones 767 Physiological Functions of Thyroid Hormones 772 Iodine Deficiency 776 Iodine Requirements 780 34 Selenium 782 Roger A. Sunde, Ph.D. Chemistry of Selenium 783 Selenium Deficiency and Essentiality 783 Selenium Absorption, Distribution, and Excretion 785 Metabolic Pathways of Selenium 787 Selenium Incorporation into Selenoproteins 790 Mammalian Selenoproteins 794 Selenium Requirements 799 Mechanism and Function of Regulation of GPX1 Expression by Selenium 804 xxviii ? ? ? Contents Selenium and Vitamin E 805 Selenium Toxicity 806 Selenium and Cancer 806 35 Fluoride 810 GaryM. Whitford, Ph.D., D.M.D. Overview of Fluoride 811 Dental Fluorosis and Dental Caries 811 Fluoride Intake 813 Fluoride Physiology 817 Acute Fluoride Toxicity 821 Chronic Fluoride Toxicity 822 36 The Ultratrace Elements 825 Forrest H. Nielsen, Ph.D. Characteristics of Ultratrace Elements 826 Boron 826 Chromium 828 Molybdenum 831 Prospective Ultratrace Elements—Nickel, Vanadium, Silicon, Arsenic, and Fluorine 833 Abstruse Ultratrace Elements 840 UNIT VII Nutrition, Diet, and Health 37 Body Fluids and Water Balance 843 Hwai Ping Sheng, Ph.D. Body Water Compartments 844 Water Balance 850 Renal Excretion of Water 853 Regulation of Water Balance 858 Abnormal States of Osmolarities and Volumes 862 38 Diet and Oral Disease 866 Dominick P. DePaola, D.D.S., Ph.D., and Charles F. Schachtele, Ph.D. Perspectives on the Role of Carbohydrates in Oral Disease 867 ; Contents ? ? ? xxix Biological Basis for the Role of Carbohydrates in Oral Disease 869 Human Data Linking Carbohydrates to Oral Disease 873 The Role of Carbohydrates and Foods in Oral Disease Prevention 875 The Role of Carbohydrates in Other Oral Diseases 879 Prevention of Oral Disease 880 39 Fuel Utilization by Skeletal Muscle During Rest and During Exercise 882 Anton J. M. Wagenmakers, Ph.D. Skeletal Muscle Fuel Utilization During Rest 883 The Energy Cost of Movement 886 Fuels for Sprinting 887 Fuels for the Marathon 890 Skeletal Muscle Adaptations in Response to Training and the Consequences for Fuel Utilization and Performance 893 Fuels for Other Sporting Events 894 How Nutrition May Help Improve Performance 895 Protein and Amino Acid Metabolism in Skeletal Muscle During Rest and During Exercise 898 Skeletal Muscle Adaptations in Response to Disuse and Disease and the Consequences for Fuel Utilization and Weil Being During Normal Daily Life 898 40 Detoxification and Protective Functions of Nutrients 901 Dean P. Jones, Ph.D., and Mary J. DeLong, Ph.D. Defense Systems 902 Oxidative Processes 902 Detoxification of Xenobiotic Compounds 908 41 Nutrition, Lipids, and Cardiovascular Disease 917 Henry N. Ginsberg, M.D., and Wahida Karmally, M.S., Ft.D. Atherosclerotic Cardiovascular Disease 918 Effects of Diet on Plasma Lipids and Lipoproteins 927 Diet, Blood Lipids, and Atherosclerosis 936 Dietary Treatment of Hypercholesterolemia 938 xxx ? ? ? Contents 42 Translating Biochemical and Physiological Requirements into Practice 945 Christina M. Stark, M.S., R.D., C.N. Food as a Source of Nutrients 946 Recommended Dietary Allowances and Dietary Reference Intakes 946 Dietary Advice—Goals and Guidelines 951 Food Guides 952 Food Labels 955 Index 961
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title	Biochemical and physiological aspects of human nutrition
title_auth	Biochemical and physiological aspects of human nutrition
title_exact_search	Biochemical and physiological aspects of human nutrition
title_full	Biochemical and physiological aspects of human nutrition Martha H. Stipanuk [ed.]
title_fullStr	Biochemical and physiological aspects of human nutrition Martha H. Stipanuk [ed.]
title_full_unstemmed	Biochemical and physiological aspects of human nutrition Martha H. Stipanuk [ed.]
title_short	Biochemical and physiological aspects of human nutrition
title_sort	biochemical and physiological aspects of human nutrition
topic	Biochemie (DE-588)4006777-4 gnd Ernährung (DE-588)4015332-0 gnd Ernährungsphysiologie (DE-588)4152823-2 gnd
topic_facet	Biochemie Ernährung Ernährungsphysiologie Lehrbuch
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009235755&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT stipanukmarthah biochemicalandphysiologicalaspectsofhumannutrition

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