The neuropathology of schizophrenia: progress and interpretation
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2000
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Oxford medical publications
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 374 S. Ill., graph. Darst. |
| ISBN: | 0192629077 |
Internformat
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| 245 | 1 | 0 | |a The neuropathology of schizophrenia |b progress and interpretation |c ed. by Paul J. Harrison ... |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 2000 | |
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| 650 | 4 | |a Schizophrenia |x etiology | |
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Datensatz im Suchindex
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| adam_text | Contents
The colour plate section is located between pp. 174 175
List of contributors xi
Introduction 1
1 Structural Imaging Findings and Macroscopic Pathology, 5
Richard Hopkins and Shon Lewis
In vivo brain imaging in schizophrenia, 7
Brain morphology in schizophrenia, 8
Global versus regional changes, 17
Structural abnormalities as part of a neural network, 35
Timing and progression of structural abnormalities, 36
Diagnostic specificity of the findings, 38
Conclusions and future directions, 39
2 Hippocampal Pathology, 57
Steven E. Arnold
Neuroanatomy of the normal hippocampal formation, 58
Gross morphometry of the hippocampal formation in schizophrenia, 61
Hippocampal cytoarchitecture and neuronal morphometry in
schizophrenia, 62
Cognitive impairment, dementia, and investigations of neurodegeneration
in schizophrenia, 69
Regional specificity of hippocampal neuropathological findings, 71
Concluding remarks, 73
3 Cortical Pathology: a New Generation of Quantitative Microscopic Studies, 81
Francine M. Benes
Stereomorphometric studies, 82
The cortical GABA system, 86
The cortical glutamate system, 88
The cortical dopamine system, 91
Cortical pathology and the neurodevelopmental hypothesis, 94
Conclusions, 95
viii ) Contents
4 Synaptic Pathology, 105
William G. Honer, Clint Young, and Peter Falkai
Assessment of synapses, 105
Models of synaptic abnormalities in schizophrenia, 114
Studies of synapses in schizophrenia, 115
Discussion and conclusions, 124
5 Gliosis and its Implications for the Disease Process, 137
Gareth W. Roberts and Paul J. Harrison
Glia and gliosis, 137
Gliosis in schizophrenia, 140
The meaning of an absence of gliosis, 143
Conclusions, 145
6 Cerebral Asymmetry, 151
Dorothy P. Holinger, Albert M. Galaburda, and Paul J. Harrison
Structural cerebral asymmetries, 152
Cerebral asymmetry in schizophrenia, 155
Conclusions, 162
7 Functional Imaging and Neural Circuitry in Schizophrenia, 173
Susan K. Schultz and Nancy C. Andreasen
Applied neuroimaging and the neuropathology of schizophrenia, 173
Functional imaging techniques, 175
Functional imaging and neurocircuitry, 177
Corticothalamocerebellar circuitry and cognitive dysmetria in
schizophrenia, 182
Summary and conclusion, 184
8 Neuropathology and the Neurodevelopmental Model, 189
Mayada Akil and Daniel R. Weinberger
Evidence supporting a neurodevelopmental origin of schizophrenia, 190
Evidence against schizophrenia as a neurodegenerative disorder, 193
Neuropathological findings and the neurodevelopmental model, 195
Limitations of the neurodevelopmental model, 202
9 Cortical Development and Schizophrenia, 213
Jack Price and Gareth W. Roberts
Molecular basis for the organisation of the forebrain, 215
Pattern formation and its functional consequences, 223
Fate determination, 227
Concluding remarks, 229
Contents | ix
10 The Organization of Cortical Circuitry, 235
David A. Lewis
A model system for circuitry analysis: the primate dorsolateral prefrontal
cortex 236
Cortical neuron types, 237
Laminar arrangement of neurons, 239
Organization of efferent projections, 241
Organization and termination of afferent projections, 242
Vulnerable prefrontal cortex circuitry in schizophrenia, 245
11 Perspectives from other Diseases and Lesions, 257
Margaret M. Esiri and R. Carl A. Pearson
Neuropathology and diagnostic issues, 257
Diseases sharing non specific pathological features with
schizophrenia, 258
Disorders in which schizophrenia like symptoms may occur, 262
Normal determinants of neuronal parameters and the effects of
experimental lesions, 265
Suggestions for future studies, 268
12 Animal Models of Schizophrenia, 277
Barbara K. Lipska and Daniel R. Weinberger
Modeling schizophrenia in animals: some general considerations, 278
Neurodevelopmental animal models of schizophrenia, 280
Future approaches to modeling schizophrenia in animals, 285
13 A Sceptical View of the Neuropathology of Schizophrenia, 291
Siew E. Chua and Peter J. McKenna
Overall brain dimensions, 292
Lateral ventricular enlargement, 298
Regional cerebral volumes, 304
Temporal lobe limbic structures, 310
Other brain structures, 312
Histological findings, 321
Conclusions, 328
14 Methodological Issues, 339
Paul J. Harrison and Joel E. Weinman
Methodological issues in case collection and selection, 340
Methodological issues for studies of neurochemical pathology, 343
Methodological issues for morphometric studies, 345
x Contents
15 Neuropathological Consequences of Schizophrenia Treatments, 351
Paul J. Harrison
Neuropathological effects of antipsychotic drugs, 351
Neuropathological effects of other treatments, 361
Neuropathological effects of substance misuse, 362
Conclusions, 362
Index 369
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| spelling | The neuropathology of schizophrenia progress and interpretation ed. by Paul J. Harrison ... 1. publ. Oxford [u.a.] Oxford Univ. Press 2000 XII, 374 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Oxford medical publications Brain physiopathology Nervous System physiopathology Schizophrenia Etiology Schizophrenia Pathophysiology Schizophrenia etiology Schizophrenia physiopathology Harrison, P. J. 1960- Sonstige (DE-588)129083488 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009219681&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The neuropathology of schizophrenia progress and interpretation Brain physiopathology Nervous System physiopathology Schizophrenia Etiology Schizophrenia Pathophysiology Schizophrenia etiology Schizophrenia physiopathology |
| title | The neuropathology of schizophrenia progress and interpretation |
| title_auth | The neuropathology of schizophrenia progress and interpretation |
| title_exact_search | The neuropathology of schizophrenia progress and interpretation |
| title_full | The neuropathology of schizophrenia progress and interpretation ed. by Paul J. Harrison ... |
| title_fullStr | The neuropathology of schizophrenia progress and interpretation ed. by Paul J. Harrison ... |
| title_full_unstemmed | The neuropathology of schizophrenia progress and interpretation ed. by Paul J. Harrison ... |
| title_short | The neuropathology of schizophrenia |
| title_sort | the neuropathology of schizophrenia progress and interpretation |
| title_sub | progress and interpretation |
| topic | Brain physiopathology Nervous System physiopathology Schizophrenia Etiology Schizophrenia Pathophysiology Schizophrenia etiology Schizophrenia physiopathology |
| topic_facet | Brain physiopathology Nervous System physiopathology Schizophrenia Etiology Schizophrenia Pathophysiology Schizophrenia etiology Schizophrenia physiopathology |
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