Gastrointestinal transport: molecular physiology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
2001
|
| Schriftenreihe: | Current topics in membranes
50 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 543 S. Ill., graph. Darst. |
| ISBN: | 0121533506 0120794101 |
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Datensatz im Suchindex
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| adam_text | Contents
Contributors xi
Preface xiii
Previous Volumes in Series xvii
CHAPTER 1 The Role of Volume Regulation in Intestinal Transport:
Insights from Villus Cells in Suspension
R. John MacLeod
I. Introduction 1
II. Two Models of Villus Cell Swelling 3
III. Intracellular pH Signaling During Modest Volume
Increases 6
IV. Intracellular pH and Na+ Solute Induced Volume
Increases 16
V. Regulation of Tight Junctions during Na+ Solute
Cotransport 25
VI. Concluding Comments 26
References 29
CHAPTER 2 Intestinal Absorption of Water Soluble Vitamins:
Cellular and Molecular Aspects
Hamid M. Said, Richard Rose, and Bellur Seetharam
I. Introduction 35
II. Ascorbic Acid 36
III. Biotin 39
IV. Cobalamin 43
V. Folate 53
VI. Pantothenic Acid 62
VII. Riboflavin 62
VIII. Thiamine 63
IX. Vitamin B6 65
X. Concluding Remarks 66
References 66
v
j.
vi Contents
CHAPTER 3 Specialized Properties of Colonic Epithelial
Membranes: Apparent Permeability Barrier in Colonic
Crypts
Satish K. Singh and Henry J. Binder
I. Introduction 77
II. Colonic Ion Transport Processes 78
III. Colonic Lumen Ecology—A Unique Acid Base
Environment 86
IV. Evidence for a Barrier to Neutral Molecules in
Crypts 90
V. Gas and Weak Electrolyte Permeability of Surface
Cells 101
VI. Concluding Remarks 104
References 105
CHAPTER 4 Genetic Regulation of Expression of Intestinal
Biomembrane Transport Proteins in Response to
Dietary Protein, Carbohydrate, and Lipid
Lon J. Van Winkle
I. Introduction and Scope 114
II. Regulation of Monosaccharide Transport 114
III. Regulation of Amino Acid and Peptide Transport 135
IV. Regulation of Fatty Acid Transport 146
V. Perspective: Why We Still Need to Perform Studies at
the Physiological as Well as the Molecular Level of
Investigation 151
References 154
CHAPTER 5 Molecular Structure and Regulation of Tight Junctions
Christina M. Van Itallie and James Melvin Anderson
I. Introduction 163
II. Characterizing Tight Junction Properties 164
III. Physiological Characteristics of the Tight Junction 168
IV. Structure of the Tight Junction 170
V. Components of the Tight Junction 173
VI. Tight Junctions in the Gastrointestinal Tract 179
VII. Future Research 181
References 182
Contents vjj
CHAPTER 6 The Cystic Fibrosis Transmembrane Conductance
Regulator in the Gastrointestinal System
Erik M. Schwiebert and Richard Rozmahel
I. Introduction 188
II. Function and Dysfunction of CFTR 189
III. Cystic Fibrosis and CFTR Expression in the
Gastrointestinal System 195
IV. Integration of CFTR and CF Gastrointestinal
Pathophy siology 213
V. The GI System as a Model for DF Therapeutics 224
VI. Genetics of CF Intestinal Disease 231
VII. Questions and Future Directions 233
References 233
CHAPTER 7 Integrated Signaling Mechanisms That Regulate
Intestinal Chloride Secretion
Stephen J. Keely and Kim E. Barrett
I. Introduction 249
II. Organization, Structure, and Function of the Intestinal
Epithelium 251
III. Basis of Epithelial Chloride Secretion 252
IV. Regulation of Intestinal Cl Secretion 259
V. Summary 28
VI. Concluding Remarks 285
References 285
CHAPTER 8 Anion Absorption in the Intestine: Anion
Transporters, Short Chain Fatty Acids, and the
Role of the DRA Gene Product
Marshall H. Montrose and Juha Kere
I. Introduction 301
II. Inorganic Anion Absorption 302
III. Organic Anions 310
IV. Disorders of Anion Absorption 317
References 321
i
viii Contents
CHAPTER 9 Molecular Mechanisms of Nudeoside and Nudeoside
Drug Transport
James D. Young, Christopher I. Cheeseman, John R. Mackey,
Carol E. Cass, and Stephen A. Baldwin
I. Introduction 330
II. Nudeoside Transport Processes of Mammalian
Cells 331
III. Nucleosides and the Small Intestine 332
IV. Nudeoside Drugs and the Small Intestine 339
V. Identification of NT Proteins: The CNT and ENT Gene
Families 345
VI. Functional Studies of Members of the CNT Protein
Family 350
VII. Functional Studies of Members of the ENT Protein
Family 355
VIII. Structure and Topology of the CNT Protein
Family 357
IX. Structure and Topology of the ENT Protein
Family 358
X. Relationship of Structure to Function in the CNT and
ENT Protein Families 359
XI. Other Nudeoside Transporters 367
XII. Concluding Remarks 368
References 370
CHAPTER 10 Intestinal Transport of Peptides and Amino Acids
Vadivel Ganapathy, Malliga E. Ganapathy, and
Frederick H. Leibach
I. Introduction 379
II. Peptide Transport 380
III. Amino Acid Transport 388
IV. Genetic Defects in Intestinal Peptide and Amino Acid
Transport 398
V. Concluding Remarks 401
References 402
CHAPTER 11 Electrogenic Transepithelial Na+ Transport in the
Colon
Jean Daniel Horisberger
I. Introduction 413
II. ENaC Structure 416
III. Functional Properties 416
Contents }x
IV. Tissue Distribution 418
V. ENaC Regulation 419
VI. Control of Channel Density 420
VII. Control of Channel Activity 423
VIII. ENaC and K Secretion 425
IX. Concluding Remarks 427
References 427
CHAPTER 12 Molecular Physiology of Mammalian Epithelial
Na+/H+ Exchangers NHE2 and NHE3
Mark Donowitz and Ming Tse
I. Overview 437
II. Cellular and Subcellular Location of NHE2 and
NHE3 448
III. Physiological Functions of Apical Membrane NHEs and
Those Attributed to NHE2 and/or NHE3 454
IV. Regulation 459
V. Diseases in Which the Epithelial NHEs Play a
Pathogenic Role 483
References 484
CHAPTER 13 Molecular Aspects of Intestinal Brush Border
Na+/Glucose Transport
Ernest M. Wright
I. Summary 499
II. Introduction 500
III. The Sodium/Glucose Cotransporter (SGLT1) 501
IV. Structure and Function of SGLT1 502
V. Kinetic Model 503
References 514
Index 517
|
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| series2 | Current topics in membranes |
| spelling | Gastrointestinal transport molecular physiology ed. by Kim E. Barrett ... San Diego [u.a.] Acad. Press 2001 XIX, 543 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in membranes 50 Absorption intestinale ram Intestins ram Membranes (biologie) ram Protéines de liaison - Physiologie Tractus gastro-intestinal - Physiologie Transport biologique Transport biologique ram Biological Transport Biological transport Physiology Carrier Proteins physiology Carrier proteins Physiology Digestive System Physiological Phenomena Gastrointestinal system Physiology Membrane proteins Physiology Carrier-Proteine (DE-588)4213127-3 gnd rswk-swf Darmepithel (DE-588)4220708-3 gnd rswk-swf Ionentransport (DE-588)4162351-4 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Stofftransport Biologie (DE-588)4443397-9 gnd rswk-swf Gastrointestinaltrakt (DE-588)4074445-0 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Gastrointestinaltrakt (DE-588)4074445-0 s Stofftransport Biologie (DE-588)4443397-9 s Physiologie (DE-588)4045981-0 s DE-604 Ionentransport (DE-588)4162351-4 s Signaltransduktion (DE-588)4318717-1 s Carrier-Proteine (DE-588)4213127-3 s Darmepithel (DE-588)4220708-3 s Barrett, Kim E. Sonstige oth Current topics in membranes 50 (DE-604)BV036839511 50 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009173968&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gastrointestinal transport molecular physiology Current topics in membranes Absorption intestinale ram Intestins ram Membranes (biologie) ram Protéines de liaison - Physiologie Tractus gastro-intestinal - Physiologie Transport biologique Transport biologique ram Biological Transport Biological transport Physiology Carrier Proteins physiology Carrier proteins Physiology Digestive System Physiological Phenomena Gastrointestinal system Physiology Membrane proteins Physiology Carrier-Proteine (DE-588)4213127-3 gnd Darmepithel (DE-588)4220708-3 gnd Ionentransport (DE-588)4162351-4 gnd Signaltransduktion (DE-588)4318717-1 gnd Stofftransport Biologie (DE-588)4443397-9 gnd Gastrointestinaltrakt (DE-588)4074445-0 gnd Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4213127-3 (DE-588)4220708-3 (DE-588)4162351-4 (DE-588)4318717-1 (DE-588)4443397-9 (DE-588)4074445-0 (DE-588)4045981-0 (DE-588)4143413-4 |
| title | Gastrointestinal transport molecular physiology |
| title_auth | Gastrointestinal transport molecular physiology |
| title_exact_search | Gastrointestinal transport molecular physiology |
| title_full | Gastrointestinal transport molecular physiology ed. by Kim E. Barrett ... |
| title_fullStr | Gastrointestinal transport molecular physiology ed. by Kim E. Barrett ... |
| title_full_unstemmed | Gastrointestinal transport molecular physiology ed. by Kim E. Barrett ... |
| title_short | Gastrointestinal transport |
| title_sort | gastrointestinal transport molecular physiology |
| title_sub | molecular physiology |
| topic | Absorption intestinale ram Intestins ram Membranes (biologie) ram Protéines de liaison - Physiologie Tractus gastro-intestinal - Physiologie Transport biologique Transport biologique ram Biological Transport Biological transport Physiology Carrier Proteins physiology Carrier proteins Physiology Digestive System Physiological Phenomena Gastrointestinal system Physiology Membrane proteins Physiology Carrier-Proteine (DE-588)4213127-3 gnd Darmepithel (DE-588)4220708-3 gnd Ionentransport (DE-588)4162351-4 gnd Signaltransduktion (DE-588)4318717-1 gnd Stofftransport Biologie (DE-588)4443397-9 gnd Gastrointestinaltrakt (DE-588)4074445-0 gnd Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Absorption intestinale Intestins Membranes (biologie) Protéines de liaison - Physiologie Tractus gastro-intestinal - Physiologie Transport biologique Biological Transport Biological transport Physiology Carrier Proteins physiology Carrier proteins Physiology Digestive System Physiological Phenomena Gastrointestinal system Physiology Membrane proteins Physiology Carrier-Proteine Darmepithel Ionentransport Signaltransduktion Stofftransport Biologie Gastrointestinaltrakt Physiologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009173968&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV036839511 |
| work_keys_str_mv | AT barrettkime gastrointestinaltransportmolecularphysiology |