Biomolecular free radical toxicity: causes and prevention
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
2000
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 246 S. graph. Darst. |
| ISBN: | 0471490768 |
Internformat
MARC
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| 245 | 1 | 0 | |a Biomolecular free radical toxicity |b causes and prevention |c Helen Wiseman ... With contributions from Sek C. Chow ... |
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 2000 | |
| 300 | |a X, 246 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Antioxidants |x therapeutic use | |
| 650 | 4 | |a Cytochrome P-450 | |
| 650 | 4 | |a Free Radicals |x adverse effects | |
| 650 | 4 | |a Free Radicals |x chemistry | |
| 650 | 4 | |a Free radicals (Chemistry) |x Pathophysiology | |
| 650 | 4 | |a Molecular toxicology | |
| 650 | 4 | |a Oxidative Stress |x physiology | |
| 650 | 4 | |a Pathology, Molecular | |
| 650 | 0 | 7 | |a Freies Radikal |0 (DE-588)4137149-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Toxizität |0 (DE-588)4078372-8 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Freies Radikal |0 (DE-588)4137149-5 |D s |
| 689 | 0 | 1 | |a Toxizität |0 (DE-588)4078372-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Wiseman, Helen |e Sonstige |4 oth | |
| 700 | 1 | |a Chow, Sek C. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009163791&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1804128216953126912 |
|---|---|
| adam_text | Contents
Preface ix
MACROMOLECULAR MECHANISMS OF INJURY
AND THE ROLE OF ANTIOXIDANTS 1
1 Membrane Lipid and Lipoprotein Injury:
Prevention by Antioxidants 3
Helen Wiseman and Tim Ridgway
Membrane structural and functional features 3
Oxidative biomolecular injury to membrane lipids 4
Membrane fatty acids in oxidative biomolecular injury 6
Prevention of oxidative biomolecular injury by antioxidants
in the diet 7
Dietary modulation of membrane fluidity and of enzyme and
receptor activity 22
Dietary modulation of membranes in disease treatment and
prevention? 24
Lipoprotein particle injury in atherogenesis 29
Future prospects for antioxidant protection against membrane
lipid and lipoprotein injury and for dietary modulation
of membrane function in disease prevention 35
References 36
2. DNA Injury: Prevention by Antioxidants 47
Richard }. Hambly
Oxidative DNA damage 47
Endogenous cellular antioxidant defences 50
Oxidative DNA damage and cancer 51
Dietary antioxidants 53
Specific antioxidants 55
Vitamins 58
References 63
vi CONTENTS
3. Protein Injury: Prevention by Antioxidants 73
Barbara R. Evans and Jonathan Woodward
Oxidative damage to proteins: causes and mechanism 73
Antioxidants and their application 80
Two case studies of effects of oxidants 88
References 92
GENE EXPRESSION AND CELL MEDIATED MECHANISMS
OF TOXICITY EXPRESSION 101
4. Xenobiotic Metabolism and Bioactivation by Cytochromes P 450 103
Costas Ioannides
Metabolism of xenobiotics 104
Bioactivation of xenobiotics 104
Chemical carcinogenesis 111
Cytochromes P 450 113
Induction and inhibition of cytochromes P 450 116
Genetic polymorphism in cytochrome P 450 expression 119
Cytochrome P 450 dependent metabolism of drugs and
bioactivation of chemical carcinogens 119
Cytochrome P 450 induction and chemical carcinogenesis:
the Ah receptor 131
Conclusions 134
References 135
5. Apoptosis Triggered by Free Radicals: Role in Human Diseases 145
George E. N. Kass, Sek C. Chow and Sten Orrenius
Introduction 145
Cell death in tissues: apoptosis and programmed cell death 146
Apoptosis: morphological and biochemical considerations 148
Free radicals and apoptosis 150
Free radicals and cell death: apoptosis versus necrosis 152
Mechanisms of free radical induced apoptosis 153
Mitochondria as molecular convergence point for free
radical induced cell death: apoptosis versus necrosis 156
Caspases as targets for free radicals in necrosis 158
Conclusions and perspectives 159
References 160
CONTENTS vii
HUMAN AND ENVIRONMENTAL HEALTH EFFECTS 169
6. Dietary Phytoestrogens, Oestrogens and Tamoxifen:
Mechanisms of Action in Modulation of Breast Cancer
Risk and Prevention of Heart Disease 171
Helen Wiseman
Dietary phytoestrogens, oestrogens and tamoxifen: role in
modulation of breast cancer risk and in heart disease
prevention 171
Oestrogens and risk of breast cancer 172
Oestrogens in cardioprotection 176
The anticancer drug tamoxifen 177
Tamoxifen metabolism in humans 179
Tamoxifen as a protective agent against heart disease 180
Dietary phytoestrogens 185
Dietary sources, metabolism and bioactivity of isoflavone
and lignan phytoestrogens 185
Health protection by phytoestrogens 190
Protection by phytoestrogens against cardiovascular disease
and osteoporosis 195
Phytoestrogens: the dangers versus future dietary benefits
and use in nutraceutical supplements 197
References 199
7. Strategies for the Removal of Ecotoxicants: Environmental
Oestrogens and Oestrogen Mimics 209
Tim Ridgway and Helen Wiseman
Oestrogen mimicry in the environment 209
Development of replacement materials for xenoestrogen
avoidance 214
Activated carbon filtration of water in the removal of
environmental oestrogens and oestrogen mimics 215
Use of charged suspended particles to remove
environmental oestrogens and oestrogen mimics 215
Chemical catalysis for the removal of environmental
oestrogens and oestrogen mimics 216
Use of enzymic catalysis in the removal of environmental
oestrogens and oestrogen mimics 217
Microbial bioremediation of environmental oestrogens and
oestrogen mimics 222
viii CONTENTS
The use of plants for bioremediation of environmental
oestrogens and oestrogen mimics 223
A healthy biosphere: progress towards Techno Gaia 224
Biomonitoring of environmental oestrogens and oestrogen
mimics: leading to ecorestoration? 225
Prediction of oestrogen mimicry by biomolecular modelling
techniques 225
Conclusions on ecorestoration after biomonitoring of
environmental oestrogens and oestrogen mimics 227
Index 233
|
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| id | DE-604.BV013427559 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:45:43Z |
| institution | BVB |
| isbn | 0471490768 |
| language | English |
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| physical | X, 246 S. graph. Darst. |
| publishDate | 2000 |
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| spelling | Biomolecular free radical toxicity causes and prevention Helen Wiseman ... With contributions from Sek C. Chow ... Chichester [u.a.] Wiley 2000 X, 246 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Antioxidants therapeutic use Cytochrome P-450 Free Radicals adverse effects Free Radicals chemistry Free radicals (Chemistry) Pathophysiology Molecular toxicology Oxidative Stress physiology Pathology, Molecular Freies Radikal (DE-588)4137149-5 gnd rswk-swf Toxizität (DE-588)4078372-8 gnd rswk-swf Freies Radikal (DE-588)4137149-5 s Toxizität (DE-588)4078372-8 s DE-604 Wiseman, Helen Sonstige oth Chow, Sek C. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009163791&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biomolecular free radical toxicity causes and prevention Antioxidants therapeutic use Cytochrome P-450 Free Radicals adverse effects Free Radicals chemistry Free radicals (Chemistry) Pathophysiology Molecular toxicology Oxidative Stress physiology Pathology, Molecular Freies Radikal (DE-588)4137149-5 gnd Toxizität (DE-588)4078372-8 gnd |
| subject_GND | (DE-588)4137149-5 (DE-588)4078372-8 |
| title | Biomolecular free radical toxicity causes and prevention |
| title_auth | Biomolecular free radical toxicity causes and prevention |
| title_exact_search | Biomolecular free radical toxicity causes and prevention |
| title_full | Biomolecular free radical toxicity causes and prevention Helen Wiseman ... With contributions from Sek C. Chow ... |
| title_fullStr | Biomolecular free radical toxicity causes and prevention Helen Wiseman ... With contributions from Sek C. Chow ... |
| title_full_unstemmed | Biomolecular free radical toxicity causes and prevention Helen Wiseman ... With contributions from Sek C. Chow ... |
| title_short | Biomolecular free radical toxicity |
| title_sort | biomolecular free radical toxicity causes and prevention |
| title_sub | causes and prevention |
| topic | Antioxidants therapeutic use Cytochrome P-450 Free Radicals adverse effects Free Radicals chemistry Free radicals (Chemistry) Pathophysiology Molecular toxicology Oxidative Stress physiology Pathology, Molecular Freies Radikal (DE-588)4137149-5 gnd Toxizität (DE-588)4078372-8 gnd |
| topic_facet | Antioxidants therapeutic use Cytochrome P-450 Free Radicals adverse effects Free Radicals chemistry Free radicals (Chemistry) Pathophysiology Molecular toxicology Oxidative Stress physiology Pathology, Molecular Freies Radikal Toxizität |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009163791&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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