Verfügbarkeit: Evolutionary protein design

Evolutionary protein design:

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Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	San Diego [u.a.] Acad. Press 2001
Schriftenreihe:	Advances in protein chemistry 55
Schlagworte:	Eiwitsynthese Moleculaire evolutie Protéines Protéines - Évolution Enzymes > chemistry Protein Conformation Protein Engineering > methods Protein Folding Proteins Proteins > chemistry Evolution Proteindesign Aufsatzsammlung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XI, 438 S. Ill., graph. Darst.
ISBN:	0120342553

Internformat

MARC


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Datensatz im Suchindex

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adam_text	C ADVANCES IN PROTEIN CHEMISTRY EDITED BY FREDERIC M. RICHARDS DAVID S. EISENBERG DEPARTMENT OF MOLECULAR BIOPHYSICS DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY AND BIOCHEMISTRY UNIVERSITY OF CALIFORNIA, LOS ANGELES YALE UNIVERSITY LOS ANGELES, CALIFORNIA NEW HAVEN, CONNECTICUT PETER S. KIM DEPARTMENT OF BIOLOGY MASSACHUSETTS INSTITUTE OF TECHNOLOGY WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH HOWARD HUGHES MEDICAL INSTITUTE RESEARCH LABORATORIES CAMBRIDGE, MASSACHUSETTS VOLUME 55 EVOLUTIONARY PROTEIN DESIGN EDITED BY FRANCES H. ARNOLD CALIFORNIA INSTITUTE OF TECHNOLOGY PASADENA, CALIFORNIA ACADEMIC PRESS SAN DIEGO LONDON BOSTON NEW YORK SYDNEY TOKYO TORONTO CONTENTS PREFACE . . . . . . . . . . . IX NEW FUNCTIONS FROM OLD SCAFFOLDS: HOW NATURE REENGINEERS ENZYMES FOR NEW FUNCTIONS PATRICIA C. BABBITT AND JOHN A. GERLT I. INTRODUCTION . . . . . . . . . 1 II. DEFINING PROTEIN SUPERFAMILIES 3 III. THE ENOLASE SUPERFAMILY: A PARADIGM FOR UNDERSTANDING HOW NATURE EVOLVED ENZYMES FOR NEW FUNCTIONS. . . . . . . . . . 6 IV. STUDIES OF OTHER SUPERFAMILIES AND FOLD CLASSES . . 21 V. CONCLUSIONS . . . . . . . . . 26 VI. REFERENCES 26 EVOLUTION OF PROTEIN FUNCTON BY DOMAIN SWAPPING MARC OSTERMEIER AND STEPHEN J. BENKOVIC I. INTRODUCTION 29 II. TERMINOLOGY 30 III. EVOLUTION OF PROTEINS IN NATURE BY DOMAIN SWAPPING 31 IV. DOMAIN SWAPPING FOR PROTEIN ENGINEERING . . . 43 V. METHODOLOGIES. . . . . . . . . 59 VI. PERSPECTIVE . . . . . . . . . 67 REFERENCES 68 VI CONTENTS RATIONAL EVOLUTIONARY DESIGN: THE THEORY OF IN VITRO PROTEIN EVOLUTION CHRISTOPHER A. VOIGT, STUART KAUFFMAN, AND Z H E N - G A N G W A N G I. INTRODUCTION . . . . . . . . . II. SEQUENCE SPACE AND FITNESS LANDSCAPES . . . . III. MODELING DIRECTED EVOLUTION . . . IV. RATIONAL EVOLUTIONARY DESIGN V. SUMMARY AND CONCLUSIONS . . . . . . REFERENCES . . . . . . . . . TEMPERATURE ADAPTATION OF ENZYMES: LESSONS FROM LABORATORY EVOLUTION PATRICK L. WINTRODE AND FRANCES H. ARNOLD I. INTRODUCTION . . . . . . . . . 161 II. INFLUENCE OF TEMPERATURE ON ENZYMES . . . . 164 III. STUDIES OF NATURAL EXTREMOPHILIC ENZYMES . . . 167 IV. DIRECTED EVOLUTION 173 V. STABILITY, FLEXIBILITY, AND CATALYTIC ACTIVITY . . . 208 VI. WHY ARE PROTEINS MARGINALLY STABLE? . . . . 216 VII. WHY ARE THERMOPHILIC ENZYMES POORLY ACTIVE AT LOW TEMPERATURE? 218 VIII. CONCLUSIONS 219 REFERENCES 221 STRUCTURAL ANALYSIS OF AFFINITY MATURED ANTIBODIES AND LABORATORY-EVOLVED ENZYMES M. CECILIA ORENCIA, MICHAEL A. HANSON, AND RAYMOND C. STEVENS I. INTRODUCTION 227 II. STRUCTURAL STUDIES OF ANTIBODY AFFINITY MATURATION . . 228 III. STRUCTURAL STUDIES OF ENZYME DIRECTED EVOLUTION . . 244 IV. CONCLUSIONS 254 REFERENCES . . . . . . . . . 257 CONTENTS VU MOLECULAR BREEDING: THE NATURAL APPROACH TO PROTEIN DESIGN JON E. NESS, STEPHEN B. DEL CARDAYRE, JEREMY MINSHULL, AND WLLLEM P. C. STEMMER I. INTRODUCTION . . . . . . . . . 261 II. THE NEED FOR BETTER PROTEINS . . . . . . 263 III. STRATEGIES FOR OPTIMIZING PROTEINS 264 IV. SCREENING IS KEY 277 V. BEYOND PROTEINS 281 VI. CONCLUDING REMARKS 285 REFERENCES . . . . . . . . . 286 ANALYSIS OF LARGE LIBRARIES OF PROTEIN MUTANTS USING FLOW CYTOMETRY GEORGE GEORGIOU I. INTRODUCTION 293 II. LIBRARY SCREENING TECHNOLOGIES . . . . . 294 III. CELL SURFACE DISPLAY TECHNOLOGIES . . . . . 301 IV. LIBRARY SCREENING BY FLOW CYTOMETRY . . . . 303 V. CONCLUDING REMARKS . . . . . . . 311 REFERENCES . . . . . . . . . 311 FROM CATALYTIC ASYMMETRIC SYNTHESIS TO THE TRANSCRIPTIONAL REGULATION OF GENES: IN VIVO AND IN VITRO EVOLUTION OF PROTEINS CARLOS F. BARBAS III, CHRISTOPH RADER, DAVID J. SEGAL, BENJAMIN LIST, AND JAMES M. TURNER I. INTRODUCTION AND SCOPE OF REVIEW . . . . . 317 II. SELECTING AND EVOLVING THERAPEUTIC HUMAN ANTIBODIES 318 III. DIRECTING EVOLUTION AT THE LEVEL OF CHEMICAL MECHANISM: ALDOLASE ANTIBODIES AND ASYMMETRIC CATALYSIS 331 IV. MULTIPLE HAPTEN SELECTION: REFINING THE ACTIVE SITE OF A CATALYTIC ANTIBODY BY IN VITRO SELECTION . . . . 349 V. SELECTION AND EVOLUTION OF NOVEL DNA-BINDING PROTEINS: FROM PRINCIPLES TO APPLICATIONS . . . 350 REFERENCES . . . . . . . . . 363 VU1 CONTENTS IN VITRO SELECTION AND EVOLUTION OF PROTEINS ANDREAS PLUCKTHUN, CHRISTIANE SCHAFFITZEL, JOZEF HANES, AND LUTZ JERMUTUS I. INTRODUCTION 367 II. THE KEY TO IN VITRO PROTEIN EVOLUTION: CELL-FREE TRANSLATION . . . . . . . . . 372 III. IN VITRO SELECTION STRATEGIES . . . . . . 374 IV. APPLICATIONS OF RIBOSOME DISPLAY . . . . . 388 V. PERSPECTIVES OF DIRECTED IN VITRO EVOLUTION . . . 398 REFERENCES 399 AUTHOR INDEX 405 SUBJECT INDEX 429
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series	Advances in protein chemistry
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spelling	Evolutionary protein design ed. by Frances H. Arnold San Diego [u.a.] Acad. Press 2001 XI, 438 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in protein chemistry 55 Eiwitsynthese gtt Moleculaire evolutie gtt Protéines Protéines - Évolution ram Enzymes chemistry Protein Conformation Protein Engineering methods Protein Folding Proteins Proteins chemistry Evolution (DE-588)4071050-6 gnd rswk-swf Proteindesign (DE-588)4346801-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Proteindesign (DE-588)4346801-9 s Evolution (DE-588)4071050-6 s DE-604 Arnold, Frances Hamilton 1956- Sonstige (DE-588)128524359 oth Advances in protein chemistry 55 (DE-604)BV002527411 55 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009155871&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Evolutionary protein design Advances in protein chemistry Eiwitsynthese gtt Moleculaire evolutie gtt Protéines Protéines - Évolution ram Enzymes chemistry Protein Conformation Protein Engineering methods Protein Folding Proteins Proteins chemistry Evolution (DE-588)4071050-6 gnd Proteindesign (DE-588)4346801-9 gnd
subject_GND	(DE-588)4071050-6 (DE-588)4346801-9 (DE-588)4143413-4
title	Evolutionary protein design
title_auth	Evolutionary protein design
title_exact_search	Evolutionary protein design
title_full	Evolutionary protein design ed. by Frances H. Arnold
title_fullStr	Evolutionary protein design ed. by Frances H. Arnold
title_full_unstemmed	Evolutionary protein design ed. by Frances H. Arnold
title_short	Evolutionary protein design
title_sort	evolutionary protein design
topic	Eiwitsynthese gtt Moleculaire evolutie gtt Protéines Protéines - Évolution ram Enzymes chemistry Protein Conformation Protein Engineering methods Protein Folding Proteins Proteins chemistry Evolution (DE-588)4071050-6 gnd Proteindesign (DE-588)4346801-9 gnd
topic_facet	Eiwitsynthese Moleculaire evolutie Protéines Protéines - Évolution Enzymes chemistry Protein Conformation Protein Engineering methods Protein Folding Proteins Proteins chemistry Evolution Proteindesign Aufsatzsammlung
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work_keys_str_mv	AT arnoldfranceshamilton evolutionaryproteindesign

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