Modern management of cancer of the rectum:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Springer
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 234 S. Ill., graph. Darst. |
| ISBN: | 1852332875 |
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| 245 | 1 | 0 | |a Modern management of cancer of the rectum |c Riccardo A. Audisio ... (eds.) |
| 264 | 1 | |a London [u.a.] |b Springer |c 2001 | |
| 300 | |a XX, 234 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 650 | 4 | |a Rectum - Cancer | |
| 650 | 4 | |a Rectal Neoplasms |x diagnosis | |
| 650 | 4 | |a Rectal Neoplasms |x surgery | |
| 650 | 4 | |a Rectal Neoplasms |x therapy | |
| 650 | 4 | |a Rectum |x Cancer | |
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Datensatz im Suchindex
| _version_ | 1804128199036108800 |
|---|---|
| adam_text | List of Contributors xvii
Introduction xxi
1. Evolution of the Surgical Management of Rectal Cancer
A.A. Shelton and S.M. Goldberg 1
Introduction 1
Perineal Approach 1
Transanal Excision 2
Transsacral Resection 2
Abdominosacral Resection 3
Abdominoperineal Resection 3
Abdominoanal Approach 3
Anterior Resection 4
The Present 5
References 5
2. Pathology and Staging
K.F. Birbeck, A. Cairns and P. Quirke 7
Introduction 7
Resection Specimen 7
Total Mesorectal Excision 7
Histological Features of Rectal Cancer and Their Prognostic Significance .... 8
Histological Type 8
Tumour Differentiation 9
Invasive Growth Pattern and Peritumoral 9
Lymphocytic Infiltration 9
Completeness of Excision 9
Serosal Involvement 9
Lymph Node Metastases 9
Extramural Vascular Invasion 9
Surgical Resection Margins and Local Recurrence 10
Local Recurrence 10
Longitudinal Resection Margin 10
Circumferential Resection Margin 10
Staging of Rectal Cancer 11
Staging Systems Currently in Existence 11
Dukes Staging 12
TNM Staging System 12
Dukes Staging Versus TNM 14
Role of Pathology in Assessing the Quality of Rectal Cancer Surgery 14
Quality of Preoperative Imaging and Pathology Reporting, and the
Use of Reporting Proformas 16
Conclusions 18
References 18
ix
x Contents
3. Genetics, Screening and Chemoprevention
}. Puig La Calle and J.G. Guillem 21
Introduction 21
Genetics 21
Tumor Suppressor Genes 22
MMR Genes 24
Oncogenes 24
Screening 25
Average Risk 26
Moderate Risk 26
Increased Risk 26
Chemoprevention 28
NSAIDs 28
Calcium 29
Antioxidant Vitamins 30
Circumin 30
Perillyl Alcohol 30
Oltipraz 30
Selenium 30
References 31
4. The Role of Imaging in the Diagnosis and Staging of Primary and
Recurrent Rectal Cancer
S. Sironi, C. Ferrero, L. Gianolli, C. Landoni, A. Del Maschio, F. Fazio and
A.P.Zbar 33
Introduction 33
Diagnostic Imaging in the Staging of Primary Rectal Cancer 33
Clinical Evaluation 33
Contrast Examinations 34
Endorectal Ultrasound 35
Computed Tomography 36
Magnetic Resonance Imaging 38
Positron Emission Tomography 41
Radioimmunoscintigraphy 43
Diagnostic Imaging in the Diagnosis and Staging of Recurrent Rectal
Cancer 43
Ultrasound Techniques 44
Computed Tomography 44
Magnetic Resonance Imaging 44
Positron Emission Tomography and Immunoscintigraphy 45
Conclusions 45
References 46
5. Neo adjuvant Therapy
B.D. Minsky, C.H. Kohne and C. Greco 51
Introduction 51
Preoperative Therapy 51
Rationale 51
Predictors of Response to Preoperative Therapy 51
Results of Preoperative Therapy 52
Intensive Short Course Preoperative Radiation 53
Sphincter Preservation with Preoperative Radiation 54
Is Adjuvant Therapy Necessary in Patients Undergoing a Total Mesorectal
Resection? 57
Investigational Approaches 58
Altered Radiation Fractionation Schemes 58
New Chemotherapeutic Agents 58
Contents xi
Summary 58
References 59
6. Restorative Procedures
J.W. Milsom and H.J. Cho 63
Introduction 63
Relevant Anatomy of the Rectum and Perirectal Tissues 63
Surgical Options in Restorative Procedures 65
Preoperative Evaluation and Patient Preparation 66
Oncologic Principles in Rectal Surgery 67
Extent of Resection 67
Radial Margin and Complete Mesorectal Resection 69
Final Preparations for Restorative Procedures 70
Technical Details 71
Proctosigmoidectomy 71
Low Anterior Resection 73
Special Consideration: Coloanal Anastomosis 74
Special Consideration: Colonic Reservoir (J Pouch) 75
Outcome After Low Anterior Resection Versus Abdominoperineal resection... 75
Laparoscopic Rectal Cancer Surgery 76
Conclusions 76
References 76
7. Abdominoperineal Resection
D.J. Schoetz and P.I. Roberts 79
Introduction 79
Selection Factors for Abdominoperineal Resection 79
Tumor Related Factors 80
Patient Factors 80
Intraoperative Considerations 80
Preoperative Preparation 80
Operative Technique 81
Intraoperative and Postoperative Complications 85
Bleeding 85
Unhealed Perineal Wound 85
Inadvertent Perforation of the Rectum 86
Perineal Hernia 86
Urogenital Complications 86
Urethral Injury 87
Colostomy Complications 87
Other complaints 87
Concluding Remarks 87
References 87
8. Total Mesorectal Excision with Autonomic Nerve Preservation: Optimized
Surgery
N.J. Kafka and W.E. Enker 89
Introduction 89
Rationale of Total Mesorectal Excision and its Relationship to the Anatomy
of Spread of Rectal Cancer 89
Technique of Total Mesorectal Excision with Autonomic Nerve
Preservation 91
Outcome of Total Mesorectal Excision 93
Morbidity of Total Mesorectal Excision 96
Sexual and Urinary Function After Total Mesorectal Excision 96
Extended Lateral Lymphadenectomy 97
Role of the Colonic J Pouch 97
xii Modern Management of Cancer of the Rectum
Role of Total Mesorectal Excision in Upper Rectal Cancer 98
Summary 98
References 98
9. Laparoscopic Resections for Large Bowel Malignancy:
Laparoscopic Colectomy
D. Rosenfeld and R.W. Beart 101
Introduction 101
Laparoscopic Colectomy 101
Physiologic Aspects of Laparoscopic Surgery 102
Laparoscopic Surgery for Benign Colonic Disease 103
Laparoscopic Surgery for Malignant Colonic Disease 106
Summary 108
Laparoscopic Rectal Cancer Surgery
H.J. Cho and J.W. Milsom 108
Laparoscopic Surgery for Rectal Carcinoma 108
Procedures of Laparoscopic Proctosigmoidectomy 109
Conclusion 112
References 112
10. Minimal Access Surgery for Rectal Cancer
V.W. Fazio and F. Lopez Kostner 115
Introduction 115
Preoperative Assessment 115
Tumor Invasion 115
Patient Selection for Local Treatment 116
Size 116
Exophytic Lesions 116
Mobile Lesions 116
Depth 117
Favorable Histology 117
Margin of Excision 118
Therapeutic Modalities for Local Treatment 118
Local Excision 118
Contact Radiotherapy 120
Electrocoagulation 121
Adjuvant Therapy after Local Treatment 122
Salvage Treatment 123
Palliative Local Surgery 123
Summary 123
References 124
11. Postoperative Adjuvant Combined Modality Therapy
B.D. Minsky, C.H. Kohne and C. Greco 127
Introduction 127
Postoperative Therapy 127
Rationale of Postoperative Combined Modality Therapy 127
Results of Postoperative Therapy 127
Functional Results with Postoperative Therapy 129
Decreasing the Toxicity of Pelvic Radiation Therapy 129
Is Adjuvant Therapy Necessary after Total Mesorectal Excision? 130
Investigational Approaches 131
Altered Radiation Fractionation Schemes 131
New Chemotherapeutic Agents 131
Summary 131
References 131
Contents xiii
12. Follow up After Potentially Curative Therapy for Rectal Cancer
D.E. Nadig, K.S. Virgo, W.E. Longo and RE. Johnson 135
Introduction 135
Background 136
Methods of Recurrence Detection 137
History and Physical Examination 137
Laboratory Investigations 137
Endoscopy 139
Issues Specifically Regarding Rectal Cancer 142
Recommendations 142
Conclusions 143
References 143
13. Surgical Approach to Locally Recurrent Disease
C.A. Paterson and H. Nelson 147
Introduction 147
Clinical Presentation 147
Diagnostic Evaluation 148
Preoperative Therapies 149
Preoperative Planning 150
Operative Strategy 150
Intraoperative Radiation 153
Intraoperative Electron Radiation Therapy 153
Intraoperative High Dose Brachytherapy 154
Results 154
Extended Resection 154
Future Directions 155
Novel Therapeutics 155
References 155
14. Metastatic Rectal Cancer
K.A. Sumpter and D. Cunningham 157
Introduction 157
Surgery for Metastatic Rectal Cancer 157
Surgical Resection of Liver Metastases 157
Surgical Resection of Lung Metastases 158
Surgical Resection of Brain Metastases 158
Chemotherapy Versus Best Supportive Care for Patients with Advanced
Colorectal Cancer 158
5 Fluorouracil 159
Mechanism of Action 159
Modulation of 5 Fluorouracil with Leucovorin 160
Modulation of 5 Fluorouracil with Methotrexate 161
Protracted Venous Infusional 5 Fluorouracil 161
Other Continuous Infusional 5 Fluorouracil Schedules 163
Chronomodulated Chemotherapy 164
5 Fluorouracil and Mitomycin C 165
Oral Fluoropyrimidimes 165
Uracil Tegafur and Oral Leucovorin 165
Capecitabine 166
Eniluracil 167
S l 167
Irinotecan 167
Raltitrexed 170
Oxaliplatin 171
xiv Modern Management of Cancer of the Rectum
Intra Arterial Hepatic Chemotherapy for Isolated Liver Metastases 172
Biological Therapy 172
Immunotherapy 172
Cytokines 173
Gene Therapy 173
Conclusion 173
References 174
15. Rare Histiotypes
E.M. Grossmann, R.A. Audisio, J.G. Geraghty and W.E. Longo 179
Introduction 179
Carcinoid Tumors of the Rectum 179
Clinical Presentation and Diagnosis 180
Treatment and Prognosis 180
Lymphoma of the Rectum 182
Primary Lymphoma of the Rectum 182
Secondary Lymphoma of the Rectum 183
Anorectal Melanoma 183
Clinical Presentation and Diagnosis 183
Treatment and Prognosis 184
Neuroendocrine Carcinoma of the Rectum 184
Pathology 185
Clinical Presentation and Diagnosis 185
Treatment and Prognosis 185
Vascular Lesions 186
Diffuse Cavernous Hemangioma 186
Lymphangiomas 187
Hemangiopericytoma 187
Squamous Cell and Adenosquamous Carcinoma of the Rectum 187
Squamous Cell Carcinoma of the Rectum 187
Adenosquamous Carcinoma of the Rectum 188
Sarcoma of the Rectum 189
Leiomyosarcoma 189
Kaposi s Sarcoma 189
References 190
16. Quality of Life and Palliative Care in Rectal Cancer Patients
A. Filiberti, A. Sbanotto and R.A. Audisio 193
Introduction 193
Quality of Life: Defining and Measurement Issues 193
Multidimensional Quality of Life Questionnaires 194
Psychosocial Aspects of Rectal Cancer: A Brief Historical Review 195
Symptoms Associated with Rectal Surgery 195
Sexual and Urological Dysfunction 195
Bowel Dysfunction 196
Mood and Social Life 196
Quality of Life Studies 197
Chemotherapy 197
Radiotherapy 198
Surgery 198
Rehabilitation Needs 199
Palliative Care in Rectal Cancer Patients 199
Evaluation 199
Pain 200
Cachexia Anorexia 203
Ascites 205
Nausea and Vomiting 206
Contents xv
Dyspnea 207
Conclusions 207
References 208
17. Costs of Rectal Cancer Patient Management
K.S. Virgo, W.E. Longo and RE. Johnson 215
Introduction 215
Methods 216
Literature review 216
Cost Analyses 216
Results 217
Initial Care Phase 217
Continuing Care Phase 223
Conclusion 228
References 228
Index 231
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| indexdate | 2024-07-09T18:45:26Z |
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| isbn | 1852332875 |
| language | English |
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| spelling | Modern management of cancer of the rectum Riccardo A. Audisio ... (eds.) London [u.a.] Springer 2001 XX, 234 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Rectum - Cancer Rectal Neoplasms diagnosis Rectal Neoplasms surgery Rectal Neoplasms therapy Rectum Cancer Therapie (DE-588)4059798-2 gnd rswk-swf Mastdarmkrebs (DE-588)4169067-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Mastdarmkrebs (DE-588)4169067-9 s Therapie (DE-588)4059798-2 s DE-604 Audisio, Riccardo A. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009152274&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Modern management of cancer of the rectum Rectum - Cancer Rectal Neoplasms diagnosis Rectal Neoplasms surgery Rectal Neoplasms therapy Rectum Cancer Therapie (DE-588)4059798-2 gnd Mastdarmkrebs (DE-588)4169067-9 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4169067-9 (DE-588)4143413-4 |
| title | Modern management of cancer of the rectum |
| title_auth | Modern management of cancer of the rectum |
| title_exact_search | Modern management of cancer of the rectum |
| title_full | Modern management of cancer of the rectum Riccardo A. Audisio ... (eds.) |
| title_fullStr | Modern management of cancer of the rectum Riccardo A. Audisio ... (eds.) |
| title_full_unstemmed | Modern management of cancer of the rectum Riccardo A. Audisio ... (eds.) |
| title_short | Modern management of cancer of the rectum |
| title_sort | modern management of cancer of the rectum |
| topic | Rectum - Cancer Rectal Neoplasms diagnosis Rectal Neoplasms surgery Rectal Neoplasms therapy Rectum Cancer Therapie (DE-588)4059798-2 gnd Mastdarmkrebs (DE-588)4169067-9 gnd |
| topic_facet | Rectum - Cancer Rectal Neoplasms diagnosis Rectal Neoplasms surgery Rectal Neoplasms therapy Rectum Cancer Therapie Mastdarmkrebs Aufsatzsammlung |
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