Fumonisin B 1:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
2000
|
| Schriftenreihe: | Environmental health criteria
219 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 150 S. graph. Darst. |
| ISBN: | 9241572191 |
Internformat
MARC
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| 245 | 1 | 0 | |a Fumonisin B 1 |c by W. F. O. Marasas ... |
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| 490 | 1 | |a Environmental health criteria |v 219 | |
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| 650 | 0 | 7 | |a Vinylchlorid |0 (DE-588)4188331-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Fumonisine |0 (DE-588)4417155-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Toxizität |0 (DE-588)4078372-8 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR
FUMONISINB,
PREAMBLE viii
ABBREVIATIONS xvii
INTRODUCTION xix
1. SUMMARY, EVALUATION AND
RECOMMENDATIONS 1
1.1 Summary 1
1.1.1 Identity, physical and chemical properties,
and analytical methods 1
1.1.2 Sources of human exposure 1
1.1.3 Environmental transport, distribution and
transformation 1
1.1.4 Environmental levels and human exposure . 2
1.1.5 Kinetics and metabolism in animals 2
1.1.6 Effects on animals and in vitro test systems 2
1.1.7 Effects on humans 3
1.1.8 Effects on other organisms in the laboratory 3
1.2 Evaluation of human health risks 4
1.2.1 Exposure 4
1.2.2 Hazard identification 4
1.2.3 Dose response assessment 6
1.2.4 Risk characterization 6
1.3 Recommendations for protection of human health .. 6
2. IDENTITY, PHYSICAL AND CHEMICAL
PROPERTIES, AND ANALYTICAL METHODS 8
2.1 Identity 8
2.2 Physical and chemical properties of the pure
substance 9
2.3 Analytical methods 10
2.3.1 Sampling and preparation procedures .... 10
[ iii
EHC 219: Fumonisin B,
2.3.2 Extraction 10
2.3.3 Analysis 12
3. SOURCES OF HUMAN EXPOSURE 14
4. ENVIRONMENTAL TRANSPORT, DISTRIBUTION
AND TRANSFORMATION 19
5. ENVIRONMENTAL LEVELS AND HUMAN
EXPOSURE 20
6. KINETICS AND METABOLISM IN ANIMALS 24
6.1 Absorption 24
6.2 Distribution 25
6.3 Elimination, excretion and metabolic
transformation 26
6.4 Retention and turnover 28
6.5 Reaction with body components 29
7. EFFECTS ON LABORATORY MAMMALS
AND IN VITRO TEST SYSTEMS 30
7.1 Laboratory animals and in vitro test systems 30
7.1.1 Single exposure 30
7.1.2 Repeated exposure 30
7.1.2.1 Body weight loss 30
7.1.2.2 Hepatocarcinogenicity and
nephrotoxicity 32
7.1.2.3 Immunotoxicity 36
7.1.3 Skin and eye irritation 37
7.1.4 Reproductive toxicity, embryotoxicity
and teratogenicity 37
7.1.5 Mutagenicity and related end points 41
7.1.6 Carcinogenicity 42
7.1.6.1 Carcinogenicity bioassays 42
7.1.6.2 Short term assays for
carcinogenicity 48
7.2 Other mammals 50
7.2.1 Equine leukoencephalomalacia 50
|^^ iv
7.2.2 Porcine pulmonary oedema syndrome .... 53
7.2.3 Poultry toxicity 56
7.2.4 Non human primate toxicity 57
7.2.5 Other species 57
7.3 Mechanisms of toxicity mode of action 58
7.3.1 Disruption of sphingolipid metabolism ... 58
7.3.1.1 Sphingolipids and their
metabolism 58
7.3.1.2 Fumonisin induced disruption of
sphingolipid metabolism in vitro . 59
7.3.1.3 Fumonisin disruption of
sphingolipid metabolism in vivo . 64
7.3.1.4 Tissue and species specificity .... 68
7.3.1.5 Fumonisin induced sphingolipid
alterations: effects on growth,
differentiation and cell death .... 69
7.3.1.6 Sphingolipid mediated cellular
deregulation and fumonisin
diseases 74
7.3.2 Altered fatty acid metabolism in liver .... 76
7.3.3 Other biochemical changes 77
7.4 Factors modifying toxicity; toxicity of metabolites 79
8. EFFECTS ONHUMANS 82
8.1 Transkei, South Africa 82
8.2 China 84
8.3 Northern Italy 85
9. EFFECTS ON OTHER ORGANISMS IN THE
LABORATORY 86
9.1 Microorganisms 86
9.2 Plants 86
9.2.1 Duckweed and jimsonweed 86
9.2.2 Tomato 87
9.2.3 Maize 87
10. FURTHER RESEARCH 88
I V
EHC 219: Fumonisin B,
11. PREVIOUS EVALUATIONS BY
INTERNATIONAL ORGANIZATIONS 89
REFERENCES 90
APPENDIX 1. NATIONAL GUIDELINES FOR
FUMONISINS 126
APPENDIX 2. NATURAL OCCURRENCE OF
FUMONISIN B, (FB,) IN MAIZE BASED PRODUCTS .... 127
RESUME, EVALUATION ET RECOMMANDATIONS .... 135
RESUMEN, EVALUACION Y RECOMENDACIONES .... 143
|
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| id | DE-604.BV013410240 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:45:24Z |
| institution | BVB |
| isbn | 9241572191 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009151132 |
| oclc_num | 231858799 |
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| owner | DE-12 DE-Er8 |
| owner_facet | DE-12 DE-Er8 |
| physical | XIX, 150 S. graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | World Health Organization |
| record_format | marc |
| series | Environmental health criteria |
| series2 | Environmental health criteria International Programme on Chemical Safety |
| spelling | Fumonisin B 1 by W. F. O. Marasas ... Geneva World Health Organization 2000 XIX, 150 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 219 International Programme on Chemical Safety Vinylchlorid (DE-588)4188331-7 gnd rswk-swf Fumonisine (DE-588)4417155-9 gnd rswk-swf Toxizität (DE-588)4078372-8 gnd rswk-swf Vinylchlorid (DE-588)4188331-7 s Toxizität (DE-588)4078372-8 s DE-604 Fumonisine (DE-588)4417155-9 s Marasas, W. F. O. Sonstige oth Spengler, J. D. Verfasser aut Environmental health criteria 219 (DE-604)BV000011459 219 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009151132&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Spengler, J. D. Fumonisin B 1 Environmental health criteria Vinylchlorid (DE-588)4188331-7 gnd Fumonisine (DE-588)4417155-9 gnd Toxizität (DE-588)4078372-8 gnd |
| subject_GND | (DE-588)4188331-7 (DE-588)4417155-9 (DE-588)4078372-8 |
| title | Fumonisin B 1 |
| title_auth | Fumonisin B 1 |
| title_exact_search | Fumonisin B 1 |
| title_full | Fumonisin B 1 by W. F. O. Marasas ... |
| title_fullStr | Fumonisin B 1 by W. F. O. Marasas ... |
| title_full_unstemmed | Fumonisin B 1 by W. F. O. Marasas ... |
| title_short | Fumonisin B 1 |
| title_sort | fumonisin b 1 |
| topic | Vinylchlorid (DE-588)4188331-7 gnd Fumonisine (DE-588)4417155-9 gnd Toxizität (DE-588)4078372-8 gnd |
| topic_facet | Vinylchlorid Fumonisine Toxizität |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009151132&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000011459 |
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