Principles of bacterial pathogenesis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Academic Press
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 826 S. Ill., graph. Darst. |
| ISBN: | 0123042208 |
Internformat
MARC
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| 245 | 1 | 0 | |a Principles of bacterial pathogenesis |c ed. by Eduardo A. Groisman |
| 264 | 1 | |a San Diego [u.a.] |b Academic Press |c 2001 | |
| 300 | |a XVI, 826 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Datensatz im Suchindex
| _version_ | 1804128153666322432 |
|---|---|
| adam_text | Contents
Contributors xi
Preface xv
1. Evolution of Bacterial Pathogens
Howard Ochman
I. Introduction 2
II. The Genetic Basis of Virulence 2
III. Identification of Sequences Involved in Bacterial Pathogenesis 6
IV. Recovery of Genes Contributing to Virulence 8
V. The Population Genetics of Pathogens 9
VI. Studying Bacterial Population Genetics 10
VII. The Organization of Genetic Diversity in Pathogenic Microorganisms 13
VIII. Population Genetics of Representative Bacterial Pathogens 14
IX. Conclusions 28
References 29
2. Germ Warfare: The Mechanisms of Virulence Factor Delivery
Jill Reiss Harper and Thomas J. Silhavy
I. Introduction 43
II. The General Secretory Pathway 45
III. Autotransporters: Type V 47
IV. Two Step Secretion: Type II 49
V. ABC Transporters: Type I 52
VI. Conjugal Transfer Systems: Type IV 55
VII. Contact Dependent Secretion: Type III 57
VIII. Concluding Remarks 61
References 61
V
vj Contents
3. Regulation of Virulence Gene Expression in
Bacterial Pathogens
Charles J. Dorman and Stephen G. J. Smith
I. Introduction 76
II. Transcription Initiation 77
III. Regulatory Protein Families 79
IV. Covalent Modification of Transcription Factors 82
V. Regulatory Networks 86
VI. The Oxidative Stress Response 87
VII. The Modular Nature of Bacterial Regulatory Proteins 89
VIII. The Overlap between Genome Structure and Gene Regulation 92
IX. Other Classes of Protein Regulators 94
X. DNA Structure and Gene Regulation 94
XI. Stereotypical and Stochastic Events in the Control of Gene Expression 97
XII. The Switch Controlling Type 1 Fimbrial Expression in E. coli 101
XIII. Pap Pilus Gene Transcription 103
XIV. Contact Dependent Gene Regulation 105
XV. The Virulence Gene Regulatory Cascade of S. flexneri 106
XVI. A Thermometer Protein from the Salmonella Virulence Plasmid 109
XVII. Cell Density Dependent Regulation 110
XVIII. Adaptive Mutation 114
XIX. Rare tRNAs and Translation Modulation 114
XX. Protein Splicing 115
XXI. AntisenseRNA 115
XXII. Perspective 116
References 117
4. Strategies to Identify Bacterial Pathogenicity Factors
Andrew Camilli, D. Scott Merrell, and John J. Mekalanos
I. Introduction 134
II. Biochemical Strategies 135
III. Genetic Screens 149
IV. Genetic Selections 159
V. Genomic Approaches 165
VI. Concluding Remarks 169
References 170
5. Mechanisms of Bacterial Pathogenesis in Plants:
Familiar Foes in a Foreign Kingdom
James R. Alfano and Alan Collmer
I. Introduction 180
II. An Overview of Bacterial Plant Pathogens and Plant Diseases 181
III. Tumorigenic Agrobacterium tumefaciens: Using the Type IV Secretion
System to Transform the Host into a Factory for Bacterial Nutrients 186
Contents vii
IV. Necrogenic, Stealth Pathogens: Parasites Strongly Dependent on the Hrp
(Type III) Protein Secretion System 189
V. Necrogenic, Brute Force Pathogens: Soft Rotters Dependent
on Type II Secretion of Pectic Enzymes 200
VI. Other Virulence Factors of Gram Negative Plant Pathogens Compared with
Those of Animal Pathogens 201
VII. Host Innate Immune Systems: Common Components in Pathogen Recognition
and Defense Signaling 206
VIII. The R Gene Surveillance System: An Innate Immune System with Elaborate
Recognition Specificity 207
IX. Pseudomonas aeruginosa: Dual Kingdom Pathogenesis 209
X. Conclusions 210
References 211
6. Yersinia
AOIFE P. BOYD AND GUY R. CORNELIS
I. Introduction 228
II. The Adhesive Factors 231
III. Iron Acquisition 236
IV. Pathogenicity Islands 237
V. Yst Enterotoxin 238
VI. The Yersinia Virulence Plasmid 238
VII. Conclusion 252
References 253
7. Molecular Pathogenesis of Salmonellae
Christina A. Scherer and Samuel I. Miller
I. Introduction 266
II. History 266
III. Taxonomy 267
IV Epidemiology and Clinical Disease 268
V. Clinical Course and Basic Immunology 272
VI. In Vitro Models of Salmonella Virulence 280
VII. Virulence Factors 290
VIII. Antibiotic Resistant Salmonellae 312
IX. Salmonella Based Vaccines 314
References 316
8. Shigellosis: From Disease Symptoms to Molecular
and Cellular Pathogenesis
Philippe J. Sansonetti, Coumaran Eoile, and Christine WennerAs
I. Introduction 336
II. Bacteriology 337
III. The Somatic Antigen 338
viii Contents
IV. Epidemiology and Transmission 338
V. Disease Symptoms and Complications: Orientations tor Future Research . 340
VI. Histopathology of Shigellosis: A Window on Pathogenesis 342
VII. Animal Models: Strengths and Weaknesses 343
VIII. Cellular Models of Infection: The Contribution of Shi^ella to the
Concept of Cellular Microbiology 344
IX. Pathogenic Mechanisms: In Vitro Expression of the Invasive Phenotype 345
X. Pathogenic Mechanisms: In Vivo Expression of the Invasive Phenotype 365
XI. Role of Chromosomally Encoded Genes in the Virulence of Shigellu 369
XII. Conclusions 373
References 373
9. Pathogenic Escherichia coli
Jose L. Puente and B. Brett Finlay
I. Introduction 388
II. Enterotoxigenic E. coli (ETEC) 390
III. Enteroinvasive E. coli (EIEC) 396
IV. Enteropathogenic E. coli (EPEC) 398
V. Enterohemorrhagic E. coli (EHEC) 408
VI. Enteroaggregative E. coli (EAEC) 414
VII. Diffusely Adhering E. coli (DAEC) 417
VIII. Uropathogenic E. coli 418
IX. E. coli That Cause Sepsis and Meningitis 426
X. Conclusions 428
References 428
10. Molecular Basis of Vibrio cholerae Pathogenesis
Victor J. DiRita
I. Introduction 457
II. Vibrio cholerae 458
III. Cholera 463
IV. Molecular Mechanisms of Disease 465
V. Natural and Induced Immunity against Vibrio cholerae Infection 489
VI. Future Studies: The Past Is Prologue 493
References 495
11.//. pylori Pathogenesis
Timothy L. Cover, Douglas E. Berg, Martin J. Blaser,
and Harry L. T. Mobley
I. Introduction 510
II. Epidemiology 510
III. Gastric Histology and Physiology 512
IV. Clinical Diseases Associated with H. pylori Infection 516
V. Microbiology 519
Contents ix
VI. Genetic Diversity and Population Structure of H. pylori 521
VII. Initial Gastric Colonization 524
VIII. Gastric Inflammation 529
IX. Interactions of H. pylori with the Gastric Epithelium 531
X. Vacuolating Cytotoxin 532
XI. Persistence of H. pylori Infection 536
XII. Factors Influencing Development of Clinically Evident Disease 539
References 542
12. Neisseria
Scott D. Gray Owen, Christoph Dehio, Thomas Rudf.l,
Michael Naumann, and Thomas F. Meyer
I. Introduction 559
II. Natural Competence for Transformation 566
HI. Surface Structures 567
IV. Tissue Colonization 570
V. PorB31 586
VI. IgAl Protease 590
VII. Iron Acquisition in Vivo 592
VIII. Immune Response 594
IX. Summary 599
, References 600
13. Bordetella
Peggy A. Cotter and Jeep F. Miller
I. Introduction 620
II. Respiratory Infections by Bordetella Species 621
III. Evolutionary Relationships among Bordetella Subspecies 624
IV. Bordetella Virulence Factors 628
V The Bondetella Hosl Interaction 639
VI. The BvgAS Sensory Transduction System 642
VII. Phenotypic Modulation 646
VIII. Transcriptional Control of Bvg Regulated Genes 640
IX. The Role of Bvg Mediated Signal Transduction in the Bordetella
Life Cycle 654
References 658
14. Pathogenesis of Haemophilus influenzae Infections
Christoph M. Tang. Derek W. Hcxid. and E. Richard Mo.xon
I. Introduction 676
II. Population Biology 680
III. Molecular Determinants of Pathogenicity 682
IV. Pathogenesis 699
V. Conclusions 705
References 705
X Contents
15. Pathogenic Mechanisms in Streptococcal Diseases
Michael Caparon
I. Introduction 717
II. Three Basic Mechanisms of Pathogenesis: Example of S. pyogenes 719
III. Steps Common to All Three Pathogenic Mechanisms 721
IV. First Mechanism: Invasion and Multiplication in Tissue 728
V. Second Mechanism: Toxin Mediated Disease 739
VI. Third Mechanism: Immunopathological Based Diseases 742
VII. Concluding Remarks 743
References 743
16. Listeria monocytogenes
Hafida Fsihi, Pierre Steffen, and Pascale Cossart
I. General Overview of Listeria monocytogenes and Listeriosis 752
II. Genetic Tools and Cell Biology Techniques to Study L. mono
cytogenes Infection 755
III. Molecular Mechanisms for Entry and Spread of L. mono¬
cytogenes in Nonphagocytic Cells 758
IV. Regulation of L. monocytogenes Virulence Gene Expression 782
V. Conclusion 787
References 787
Index 805
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| spelling | Principles of bacterial pathogenesis ed. by Eduardo A. Groisman San Diego [u.a.] Academic Press 2001 XVI, 826 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pathogenese (DE-588)4115512-9 gnd rswk-swf Bakterien (DE-588)4004296-0 gnd rswk-swf Bakterien (DE-588)4004296-0 s Pathogenese (DE-588)4115512-9 s DE-604 Groisman, Eduardo A. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009122937&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Principles of bacterial pathogenesis |
| title_auth | Principles of bacterial pathogenesis |
| title_exact_search | Principles of bacterial pathogenesis |
| title_full | Principles of bacterial pathogenesis ed. by Eduardo A. Groisman |
| title_fullStr | Principles of bacterial pathogenesis ed. by Eduardo A. Groisman |
| title_full_unstemmed | Principles of bacterial pathogenesis ed. by Eduardo A. Groisman |
| title_short | Principles of bacterial pathogenesis |
| title_sort | principles of bacterial pathogenesis |
| topic | Pathogenese (DE-588)4115512-9 gnd Bakterien (DE-588)4004296-0 gnd |
| topic_facet | Pathogenese Bakterien |
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