Hematologic problems in obstetrics, pregnancy, and gynecology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2000
|
| Schriftenreihe: | Hematology, oncology clinics of North America
14,5 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X S., S. 999 - 1203 Ill., graph. Darst. |
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| adam_text | HEMATOLOGIC PROBLEMS IN OBSTETRICS,
PREGNANCY, AND GYNECOLOGY
CONTENTS
Preface xiii
Rodger L. Bick
Syndromes of Disseminated Intravascular Coagulation
in Obstetrics, Pregnancy, and Gynecology: Objective
Criteria for Diagnosis and Management 999
Rodger L. Bick
This article provides a general review of the origin and patho
physiology of disseminated intravascular coagulation (DIC) in
obstetric and gynecologic settings. It gives specific, objective
guidelines and criteria for the clinical and laboratory diagnosis of
DIC and objective systems for assessing the efficacy of any given
specific therapeutic modality (independent of the influences of
the underlying disease causing DIC) in obstetric, pregnant, or
gynecologic patients. This approach allows objective decisions to
be made regarding diagnosis and management.
Oral Contraceptive Pills and Hormonal Replacement
Therapy and Thromboembolic Disease 1045
Eberhard F. Mammen
The risk of thromboembolic complications with the use of second
and third generation oral contraceptives is minimal and probably
related to underlying congenital or acquired thrombophilic states.
Estrogen dose dependency leads to increased thrombin genera¬
tion and increased plasmin generation. There is no convincing
evidence that the balance between clotting and fibrinolysis is
HEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA
VOLUME 14 • NUMBER 5 • OCTOBER 2000 vii
disturbed. The risk of venous thromboembolism with pregnancy
is greater than with oral contraceptives. Hormone replacement
therapy is safe for healthy women, and the benefits far outweigh
the potential risks.
Iron Deficiency in Pregnancy, Obstetrics, and
Gynecology 1061
William F. Baker, Jr
Iron deficiency is the most frequently encountered health problem
in the world and is particularly common in premenopausal and
pregnant women. Without diagnosis and treatment, the conse¬
quences to mother and infant are significant. An understanding of
iron homeostasis can result in successful diagnosis and treatment.
Clinical and Laboratory Features and Sequelae of
Deficiency of Folic Acid (Folate) and Vitamin B12
(Cobalamin) in Pregnancy and Gynecology 1079
Eugene P. Frenkel and Denise A. Yardley
Classically, deficiency of folic acid (folate) or vitamin B12 (cobala¬
min) was recognized by the presence of a macrocytic anemia
resulting from megaloblastic changes in the bone marrow. A
markedly changing paradigm has identified both new mecha¬
nisms for altered folate and cobalamin status and new sequelae
and clinical interrelationships that include altered mechanisms of
absorption, a changing pattern of neurologic deficits, an increased
risk of vascular occlusive lesions, and an important relationship
with the mechanisms of neoplastic transformation. Several of
these newer characterizations relate to issues of neoplasia in the
nonpregnant woman and to issues in pregnancy, such as the
potential for developmental abnormalities of the fetal nervous
system.
Gestational Thrombocytopenia and Immune
Thrombocytopenias in Pregnancy 1101
Kenneth A. Schwartz
An apparently healthy pregnant patient presenting with thrombo¬
cytopenia may have a gestational benign thrombocytopenia of
pregnancy or an immune autoantibody mediated thrombocyto¬
penia. Differentiating these two types is critical for appropriate
management of mother and fetus. Similarly, the pregnant patient
with a normal platelet count and a past history of delivering a
baby with neonatal alloimmune thrombocytopenia must have
appropriate testing to determine the risk of fetal thrombocyto¬
penia.
viii CONTENTS
Recurrent Miscarriage Syndrome and Infertility Caused
by Blood Coagulation Protein or Platelet Defects 1117
Rodger L. Bick
Recurrent miscarriage syndrome (RMS) and infertility are com¬
mon problems in the United States. The most common singular
defect in women with RMS is a hemostasis defect, which is
usually found if a thorough antiphospholipid syndrome evalua¬
tion is performed. Hemorrhagic defects are rare hemostasis causes
of RMS, but these defects are treatable in many instances. It is
important to evaluate women with RMS appropriately because
most women will achieve normal term delivery if a cause for
RMS is found. If the woman with RMS is properly screened
through a cost effective protocol, the cause will be found in al¬
most all cases.
Antithrombotic Therapy in High Risk Pregnancy 1133
Lothar Heilmann, Dirk M. Schneider, and
Georg Friedrich von Tempelhoff
Venous thromboembolism remains a major cause of morbidity
and mortality associated with pregnancy and puerperium. Spe¬
cific risk factors for this disorder can be identified before or
during pregnancy and delivery. The heritable defects believed to
be associated with venous thrombosis are factor V Leiden muta¬
tion; elevated anitphospholipid antibodies; and deficiencies of
antithrombin, protein C, and protein S. Women with a history of
thromboembolism and thrombophilia should receive antenatal
and postpartum thrombosis prophylaxis.
Antithrombotic Therapy in Gynecologic Surgery and
Gynecologic Oncology 1151
Georg Friedrich von Tempelhoff and Lothar Heilmann
The European Consensus Conference has assessed the risk for
thrombotic complications for most women undergoing gyneco¬
logic surgery and found it to be moderate. Nonetheless, it is
important to analyze a patient s individual risk before surgery so
that appropriate thrombosis prophylaxis can be given if increased
risk is determined. Malignancy accounts for most thrombotic
complications among gynecologic patients. Patients with known
malignancies should receive prophylaxis during surgery, and
some patients with breast cancer should receive prophylaxis dur¬
ing chemotherapy. Heparin, and low molecular weight heparin
in particular, may favorably influence the outcome of cancer in
some patients and treatment with these agents is currently under
investigation in a number of trials as a new approach to antican
cer therapy.
CONTENTS **
Hemorrhagic Problems in Obstetrics, Exclusive of
Disseminated Intravascular Coagulation 1171
Frank A. Nizzi, Jr and Gabriele Mues
During pregnancy many physiologic changes occur that result in
an increase in coagulation factors and a decrease in fibrinolytic
activity. Because hemorrhage during pregnancy is a major cause
of maternal morbidity, it is important to recognize and under¬
stand the pathophysiology of hereditary and acquired bleeding
disorders. This article reviews von Willebrand s disease types 1,
2, and 3 and acquired hemophilia.
Special Article
Human Platelet Thrombin Receptors: Roles in
Platelet Activation 1185
Frederick A. Ofosu and Kwasi A. Nyarko
Platelets are essential participants in hemostasis and thrombosis.
Platelets normally circulate in blood as discoid resting cells that
become critical constituents of hemostatic plugs or arterial
thrombi only after specific receptors on platelet membranes inter¬
act with their ligands (agonists) to initiate the reactions that lead
to platelet activation. The well characterized events associated
with platelet activation include activation of membrane receptors,
shape change, granular secretion, cytoskeletal reassembly, platelet
cohesion, and aggregation. The plasma protease a thrombin is
the most potent physiologic platelet agonist; this enzyme has
other key roles in hemostasis, in the genesis of arterial thrombi,
and in embryonic development, inflammation, wound healing,
and cell proliferation.
Index 1199
Subscription Information Inside back cover
X CONTENTS
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| spelling | Hematologic problems in obstetrics, pregnancy, and gynecology Rodger L. Bick guest ed. Philadelphia [u.a.] Saunders 2000 X S., S. 999 - 1203 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Hematology, oncology clinics of North America 14,5 Bloedziekten gtt Complications de la grossesse - Sang Grossesse - Sang Gynaecologie gtt Intervention chirurgicale gynécologique Verloskunde gtt Zwangerschap gtt Gynecologic Surgical Procedures Hemorrhage Iron deficiency anemia Miscarriage Pregnancy Complications blood Pregnancy Nutritional aspects Pregnancy blood Thromboembolism Prevention & control Koagulopathie (DE-588)4007276-9 gnd rswk-swf Schwangerschaft (DE-588)4053724-9 gnd rswk-swf Gynäkologie (DE-588)4018225-3 gnd rswk-swf Geburtshilfe (DE-588)4019604-5 gnd rswk-swf Hämatologie (DE-588)4022796-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Gynäkologie (DE-588)4018225-3 s Hämatologie (DE-588)4022796-0 s DE-604 Schwangerschaft (DE-588)4053724-9 s Geburtshilfe (DE-588)4019604-5 s Koagulopathie (DE-588)4007276-9 s Bick, Rodger L. Sonstige oth Hematology, oncology clinics of North America 14,5 (DE-604)BV000625446 14,5 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009110674&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hematologic problems in obstetrics, pregnancy, and gynecology Hematology, oncology clinics of North America Bloedziekten gtt Complications de la grossesse - Sang Grossesse - Sang Gynaecologie gtt Intervention chirurgicale gynécologique Verloskunde gtt Zwangerschap gtt Gynecologic Surgical Procedures Hemorrhage Iron deficiency anemia Miscarriage Pregnancy Complications blood Pregnancy Nutritional aspects Pregnancy blood Thromboembolism Prevention & control Koagulopathie (DE-588)4007276-9 gnd Schwangerschaft (DE-588)4053724-9 gnd Gynäkologie (DE-588)4018225-3 gnd Geburtshilfe (DE-588)4019604-5 gnd Hämatologie (DE-588)4022796-0 gnd |
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| title | Hematologic problems in obstetrics, pregnancy, and gynecology |
| title_auth | Hematologic problems in obstetrics, pregnancy, and gynecology |
| title_exact_search | Hematologic problems in obstetrics, pregnancy, and gynecology |
| title_full | Hematologic problems in obstetrics, pregnancy, and gynecology Rodger L. Bick guest ed. |
| title_fullStr | Hematologic problems in obstetrics, pregnancy, and gynecology Rodger L. Bick guest ed. |
| title_full_unstemmed | Hematologic problems in obstetrics, pregnancy, and gynecology Rodger L. Bick guest ed. |
| title_short | Hematologic problems in obstetrics, pregnancy, and gynecology |
| title_sort | hematologic problems in obstetrics pregnancy and gynecology |
| topic | Bloedziekten gtt Complications de la grossesse - Sang Grossesse - Sang Gynaecologie gtt Intervention chirurgicale gynécologique Verloskunde gtt Zwangerschap gtt Gynecologic Surgical Procedures Hemorrhage Iron deficiency anemia Miscarriage Pregnancy Complications blood Pregnancy Nutritional aspects Pregnancy blood Thromboembolism Prevention & control Koagulopathie (DE-588)4007276-9 gnd Schwangerschaft (DE-588)4053724-9 gnd Gynäkologie (DE-588)4018225-3 gnd Geburtshilfe (DE-588)4019604-5 gnd Hämatologie (DE-588)4022796-0 gnd |
| topic_facet | Bloedziekten Complications de la grossesse - Sang Grossesse - Sang Gynaecologie Intervention chirurgicale gynécologique Verloskunde Zwangerschap Gynecologic Surgical Procedures Hemorrhage Iron deficiency anemia Miscarriage Pregnancy Complications blood Pregnancy Nutritional aspects Pregnancy blood Thromboembolism Prevention & control Koagulopathie Schwangerschaft Gynäkologie Geburtshilfe Hämatologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009110674&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000625446 |
| work_keys_str_mv | AT bickrodgerl hematologicproblemsinobstetricspregnancyandgynecology |