Lung surfactants: basic science and clinical applications
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Dekker
2000
|
| Schriftenreihe: | Lung biology in health and disease
149 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 444 S. Ill. |
| ISBN: | 0824704010 |
Internformat
MARC
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Datensatz im Suchindex
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| adam_text | CONTENTS
Introduction Claude Lenfant in
Preface v
1. Introduction 1
Summary of Chapter Organization 6
2. Introduction to Surface Tension and Surfactants 7
I. Overview 7
II. Interfaces 7
III. Surface Tension 9
IV. Surface Active Agents: Definition and Behavior 12
V. Surface Films (Surfactant Monolayers) 14
VI. Behavior of Surfactant Films at the Air Water Interface 16
VII. Langmuir Blodgett Multilayers 32
VIII. Wetting, Contact Angles, and Spreading 32
IX. Adsorption and Behavior of Surfactants Suspended in the
Liquid Phase 34
X. Chapter Summary 39
3. Phospholipids: Introduction to Structure and Biophysics 45
I. Overview 45
II. Phospholipids as Lung Surfactant Constituents 45
III. Phospholipid Classes and Their Molecular Structure 46
IV. Distribution of Phospholipid Classes in Cell Membranes
and Lung Surfactant 48
vii
vüi Contents
V. Fatty Chains in Individual Compounds Within a
Phospholipid Class 50
VI. Biophysical Importance of Phospholipid Fatty Chains 51
VII. Phospholipid Surface Films and Their Characteristics 53
VIII. Dynamic versus Equilibrium Surface Tension Lowering
in Compressed Phospholipid Films 56
IX. Phospholipid Bilayers and Their Properties 59
X. Effects of Cholesterol in Phospholipid Films and Bilayers 64
XI. Phospholipid Aggregates in the Aqueous Phase 65
XII. Phospholipid Adsorption 68
XIII. Chapter Summary 70
4. Physicochemical Methods for Studying Lung Surfactants 73
I. Overview 73
II. Overview of Analytical and Preparatory Methods Used
with Lung Surfactants 73
III. Methods of Measuring Surface Tension 75
IV. Methods of Measuring the Surface Active Properties
of Surfactants 78
V. Wilhelmy Surface Balance 78
VI. Adsorption with Minimized Diffusion Resistance 82
VII. The Pulsating Bubble Surfactometer 84
VIII. Captive Bubble Apparatus 87
IX. Molecular Biophysical Methods Used in Lung Surfactant
Research 89
X. Chapter Summary 92
5. Lung Surfactant Materials, Research Complexities, and
Interdisciplinary Correlations 95
I. Overview 95
II. Complexities in Lung Surfactant Research and the
Need for Correlated Measurements 95
III. Mulüdisciplinary Approaches in Lung Surfactant Research 97
IV. Overview of Materials Used in Lung Surfactant Research 97
V. Categories of Animal Models for Studying the
Physiological Activity of Lung Surfactants 116
VI. Chapter Summary 118
Contents ix
6. Discovery of Endogenous Lung Surfactant and Overview of
Its Metabolism and Actions 119
I. Overview 119
II. Pulmonary Surface Area 119
III. The Alveolar Hypophase and Surface Tension 121
IV. Importance of Surface Tension Forces in Lung Mechanics 121
V. Alveolar Stability and the Laplace Equation 122
VI. Pulmonary Surface Tension Is Much Less Than
Thatof Water 125
VII. Discovery of Pulmonary Surfactant 127
VIII. Overview of the Composition of Endogenous
Lung Surfactant 129
IX. The Pulmonary Surfactant System: Lung Surfactant
and the Type II Pneumocyte 130
X. Alveolar Type I and Type II Epithelial Cells 132
XI. Overview of Lung Surfactant Synthesis and
Metabolism in Type ü Cells 135
XII. Lung Surfactant Microstructure and Subtypes 143
XIII. Tubular Myelin and Lung Surfactant Adsorption 143
XIV. Summary of Physiological Actions of Lung Surfactant 144
XV. Summary of the Biophysical Properties of Active
Lung Surfactant 146
XVI. Correlating Composition, Surface Activity, and
Physiological Activity in Lung Surfactants 148
XVII. Chapter Summary 149
7. Analyses of Surfactant Activity and Its Contribution to
Lung Mechanics and Stability 151
I. Overview 151
II. Relationships Between Surface Tension Area and
Pulmonary P V Behavior 151
III. Experiments Correlating Surface Active Properties with
Effects on Mechanics 155
IV. Theories and Experiments on Minimum Surface Tensions
1 Mn/M in Dynamically Compressed Lung Surfactant
Films 159
V. Theoretical Modeling of Lung Surfactant Adsorption and
Dynamic Film Behavior 163
x Contents
VI. Theoretical Analyses of the Role of Lung Surfactant in
Alveolar Stability 165
VII. The Alveolar Hypophase and Theories of Lung Surfactant
Action 166
VIII. Theoretical Roles of Lung Surfactant in the Airways 167
IX. Chapter Summary 168
8. Functional Composition and Component Biophysics of
Endogenous Lung Surfactant 171
I. Overview 171
II. Overview of Materials and Methods Used in Studying
Functional Composition 171
III. Concept of Functional Composition 172
IV. Lung Surfactant Phospholipids and Their Contributions
to Surface Activity 174
V. Lung Surfactant Neutral Lipids and Their Contributions to
Surface Active Biophysics 182
VI. Lung Surfactant Proteins and Their Molecular
Biophysical Characteristics 183
VII. Effects of Lung Surfactant Apoproteins on
Phospholipid Surface Activity 197
VIII. Summary of Functional Lung Surfactant Components and
Their Actions 203
IX. Chapter Summary 206
9. Lung Surfactant Dysfunction 207
I. Overview 207
II. Concept of Lung Surfactant Inhibition or Inactivation 207
III. Endogenous Compounds Able to Directly Inhibit
Lung Surfactant Activity 208
IV. Characteristic Surface Activity Changes Found During
Inactivation of Endogenous Lung Surfactant 210
V. Inactivation of Exogenous Lung Surfactants 214
VI. Clinical Relevance of Concentration Dependent
Surfactant Inactivation 218
VII. Mechanisms of Lung Surfactant Inactivation 219
VIII. Physiological Correlates of Lung Surfactant Inhibition 227
IX. Chapter Summary 231
Contents xi
10. Diseases of Lung Surfactant Deficiency or Dysfunction 233
I. Overview 233
II. The Neonatal Respiratory Distress Syndrome (RDS, HMD) 233
III. Congenital Deficiency of Functional Surfactant
Components (SP B Deficiency) 238
IV. Acute Lung Injury and ARDS 239
V. Chapter Summary 247
11. Lung Surfactant Replacement in Animal Models 249
I. Overview 249
II. Overview of Animal Models for Evaluating Surfactant
Therapy in RDS 249
III. Surfactant Deficient Animal Models Primarily
Emphasizing Static P V Mechanics 250
IV. General Aspects of Animal Models of Prematurity
Emphasizing Lung Functional Responses to
Exogenous Surfactants 256
V. Studies of Surfactant Replacement in Premature
Lambs with RDS 257
VI. Overview of Animal Models of ARDS Related Acute
Lung Injury with Surfactant Dysfunction 265
VII. Surfactant Replacement in Animal Models of Acute
Lung Injury and ARDS 269
VIII. Chapter Summary 279
12. Clinical Surfactant Replacement Therapy for Neonatal RDS 281
I. Overview 281
II. Mortality in Premature Infants in the Mid 1950 s 281
III. Hyaline Membrane Disease Before Neonatal Intensive Care 282
IV. Impact of Mechanical Ventilation and Intensive Care on
HMD in Premature Infants 283
V. Bronchopulmonary Dysplasia (BPD) in Premature Infants 284
VI. Initial Unsuccessful Clinical Surfactant Therapy for RDS 285
VII. Basic Research Leading to Successful Surfactant Therapy
for RDS 286
VIII. Initial Positive Uncontrolled or Nonrandomized Surfactant
Replacement Studies in RDS in the Early 1980 s 287
IX. Successful Controlled Clinical Studies of Exogenous
Surfactant Therapy for RDS 288
xii Contents
X. Clinical Endpoints in Trials of Lung Surfactant
Replacement Therapy for RDS 290
XI. Clinical Trials Comparing Different Exogenous
Surfactant Preparations 291
XII. Retrospective Assessments of Clinical Surfactant Trials
and Exogenous Surfactants: Meta Analyses 294
XIII. Prophylaxis versus Treatment (Rescue) Strategies for
Exogenous Surfactant Therapy 295
XIV. Delivery Methods for Exogenous Surfactant 295
XV. Follow up Analyses of Premature Infants and
Surfactant Trials 297
XVI. Chapter Summary 298
13. Surfactant and Combined Modality Therapies for
Clinical ARDS and Acute Lung Injury 299
I. Overview 299
II. Overview of ARDS and Its Pathophysiology 299
III. Rationale for Surfactant Therapy in Clinical ARDS 300
IV. Factors Complicating Clinical Assessments of Surfactant
Therapy for ARDS 301
V. Surfactant Therapy in Full Term Infants with
ARDS Related Respiratory Failure 303
VI. Surfactant Therapy in Children with Respiratory Failure 303
VII. Surfactant Therapy in Adults with ARDS 305
VIII. Summary of Current Status of Clinical Surfactant Therapy
for ARDS 308
IX. Overview of Multimodal Therapy for Clinical ARDS 309
X. Inhaled Nitric Oxide (INO) and Other Vasoactive Agents
for Use in ARDS 311
XI. Anti Inflammatory Agents and Antioxidants for
Use in ARDS 313
XII. Specialized Modes of Ventilation for Treating ARDS 316
XIII. Chapter Summary 317
14. Exogenous Lung Surfactants: Current and Future 319
I. Overview 319
II. Classification and Summary of Current Clinical
Exogenous Surfactants 319
III. Basic Science Comparisons of Activity in Clinical
Exogenous Surfactants 325
Contents xiii
IV. Overview of Approaches for New Surfactant Development
or Increasing the Activity of Existing Preparations 331
V. Exogenous Surfactants Containing Recombinant Surfactant
Apoproteins 332
VI. Synthetic Exogenous Surfactants Containing
Synthetic Peptides 333
VII. Addition of Recombinant Apoproteins or Synthetic Peptides
to Existing Exogenous Surfactants 335
VIII. Phospholipid Components in Synthetic Exogenous
Surfactants 338
IX. Novel Phospholipase Resistant Phospholipid and
Phosphonolipid Analogs in Synthetic Exogenous
Surfactants 340
X. Additional Strategies in Exogenous Surfactant
Development 344
XI. Chapter Summary 344
Glossary of Common Terms and Abbreviations 347
References 355
Index 431
|
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| language | English |
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| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Notter, Robert H Verfasser aut Lung surfactants basic science and clinical applications Robert H. Notter New York Dekker 2000 444 S. Ill. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 149 Pulmonary Surfactants Pulmonary surfactant Lunge (DE-588)4036651-0 gnd rswk-swf Surfactant-Faktor (DE-588)4125206-8 gnd rswk-swf Lunge (DE-588)4036651-0 s Surfactant-Faktor (DE-588)4125206-8 s DE-604 Lung biology in health and disease 149 (DE-604)BV000008326 149 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009102973&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Notter, Robert H Lung surfactants basic science and clinical applications Lung biology in health and disease Pulmonary Surfactants Pulmonary surfactant Lunge (DE-588)4036651-0 gnd Surfactant-Faktor (DE-588)4125206-8 gnd |
| subject_GND | (DE-588)4036651-0 (DE-588)4125206-8 |
| title | Lung surfactants basic science and clinical applications |
| title_auth | Lung surfactants basic science and clinical applications |
| title_exact_search | Lung surfactants basic science and clinical applications |
| title_full | Lung surfactants basic science and clinical applications Robert H. Notter |
| title_fullStr | Lung surfactants basic science and clinical applications Robert H. Notter |
| title_full_unstemmed | Lung surfactants basic science and clinical applications Robert H. Notter |
| title_short | Lung surfactants |
| title_sort | lung surfactants basic science and clinical applications |
| title_sub | basic science and clinical applications |
| topic | Pulmonary Surfactants Pulmonary surfactant Lunge (DE-588)4036651-0 gnd Surfactant-Faktor (DE-588)4125206-8 gnd |
| topic_facet | Pulmonary Surfactants Pulmonary surfactant Lunge Surfactant-Faktor |
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