Neonatal hematology:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2000
|
Schriftenreihe: | Clinics in perinatology
27,3 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XIV S., S. 507 - 760 Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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adam_text | NEONATAL HEMATOLOGY
CONTENTS
Preface xiii
Robert D. Christensen
The Switch From Fetal to Adult Erythropoiesis * . 507
Christof Dame and Sandra E. Juul ¦
The switch from fetal to adult erythropoiesis is complex and
includes several components, all of which change as development
proceeds from the embryo to the fetus, and from the fetus to the
adult. These components include (1) the type of erythropoiesis
(primary versus definitive); (2) the primary site of erythropoiesis;
(3) the number and function of the hematopoietic stem cells and
erythropoietic precursors; (4) red cell morphology and biochemis¬
try; (5) the types of hemoglobin produced at different sites and
stages; and (6) the regulation of erythropoiesis. Changes in these
aspects of erythropoiesis with development are discussed.
Nonerythropoietic Roles of Erythropoietin in the Fetus
and Neonate 527
Sandra E. Juul
Erythropoietin (Epo) is the primary growth factor involved in the
regulation of erythropoiesis and was once thought to be unique
to the hematopoietic system. Like other cytokines that have been
discovered in one system, only then to have unrelated functions
attributed to it, Epo has now been found to have nonerythropoi¬
etic effects. These effects are mediated by Epo binding to its
specific cell surface receptor. Functional Epo receptors are present
on many nonerythropoietic cell types. This article reviews the cell
types on which the Epo receptor is found, and the nonerythropoi¬
etic functions that can be attributed to Epo. Emphasis is placed
on the vascular, gastrointestinal, and neurologic effects of Epo.
CLINICS IN PERINATOLOGY
VOLUME 27 • NUMBER 3 • SEPTEMBER 2000 V
Congenital Bone Marrow Failure Syndromes Associated
with Protean Developmental Defects and Leukemia 543
William B. Slayton and Kurt R. Schibler
Congenital bone marrow failure syndromes are frequently associ¬
ated with pleiotropic defects that occur during fetal development.
These disorders increase the risk of developing leukemia, particu¬
larly acute myelogenous leukemia. This article summarizes the
common abnormalities associated with congenital bone marrow
failure syndromes, and discusses the molecular mechanisms un¬
derlying the pathogenesis of representative disorders.
Human Developmental Biology of Granulocyte Colony
Stimulating Factor 559
Darlene A. Calhoun and Robert D. Christensen
The availability of granulocyte colony stimulating factor (G CSF)
has influenced the management of neonates with neutropenia.
Since the first use of G CSF in a neonate with neutropenia, much
has been learned about the cellular sources and physiologic roles
of G CSF. This article reviews our present understanding of G
CSF and its cognate receptor in the fetus and neonate.
A Practical Approach to Evaluating and Treating
Neutropenia in the Neonatal Intensive Care Unit 577
Robert D. Christensen, Darlene A. Calhoun,
and Lisa M. Rimsza
Neutropenia was first described in 1902, but it was not recognized
as a problem among neonates until the late 1930s. Neutropenia is
now known to be a relatively common problem among ill neo¬
nates. In most instances, neutropenia among neonatal intensive
care unit patients is of short duration and probably has little or
no influence on outcome. In other cases it is severe or prolonged,
and constitutes a serious antimicrobial defense deficiency. When
a neonatologist discovers a low blood neutrophil count, choices
must be made regarding further evaluation and treatment. This
article provides information that is useful in making these
choices.
Eosinophilia in the Neonatal Intensive Care Unit 603
Sandra E. Sullivan and Darlene A. Calhoun
Although common in the neonatal intensive care unit, eosino¬
philia is often overlooked or ignored. The latter might be, at least
in part, because evaluating the neonate with eosinophilia can be
a complex process. This article reviews the physiologic features
of eosinophilia, reference ranges, and clinical conditions associ¬
ated with eosinophilia in the neonate. Recommendations for the
evaluation of the neonate with eosinophilia are presented.
vi CONTENTS
Evaluation and Treatment of Thrombosis in the
Neonatal Intensive Care Unit 623
Cynthia S. Edstrom and Robert D. Christensen
Thromboses are infrequent but serious complications of patients
in the neonatal intensive care unit. Thromboses tend to occur in
very sick neonates, particularly preterm neonates, and the major¬
ity of such thromboses are related to central vascular catheters.
Other risk factors for neonatal thromboses include infants of
diabetic mothers, sepsis, small for gestational age, congenital
heart disease, maternal antiphospholipid syndrome, and possibly
inherited prothrombotic disorders. Appropriate treatment, dos¬
age, and duration of therapy for neonatal thromboses has not
been studied in clinical trials. Treatment options include observa¬
tion, anticoagulation, thrombolysis, and surgical thrombectomy.
Regardless of the treatment chosen, all neonates with thromboses
require frequent reassessment of the thromboses by angiography,
echocardiography, or ultrasound until thrombus resolution oc¬
curs.
Performing and Interpreting the Bleeding Time in the
Neonatal Intensive Care Unit 643
Antonio Del Vecchio and Martha C. Sola
The bleeding time is performed to evaluate the platelet interaction
with the vessel wall. It is a helpful clinical tool to detect and
investigate certain hemostatic defects in neonates and to evaluate
the adequacy of treatments. A prolonged bleeding time indicates
either a quantitative or qualitative platelet disorder or microvas
cular defectiveness. Platelet hyporeactivity in the first days of
life, gestational age, platelet dysfunction secondary to various
neonatal or maternal pathologic conditions, neonatal or maternal
drug administration, and hematocrit must be considered for the
correct interpretation of the bleeding time test in neonates.
Evaluation and Treatment of Thrombocytopenia in the
Neonatal Intensive Care Unit 655
Martha C. Sola, Antonio Del Vecchio, and Lisa M. Rimsza
Thrombocytopenia is a very frequent problem among sick neo¬
nates. This article provides neonatologists with a practical ap¬
proach to the thrombocytopenic neonate, with an emphasis on
conditions that could be life threatening or could have significant
implications for further pregnancies. An overview of the current
therapeutic modalities is also presented, including a discussion
of the possible use of recombinant thrombopoietic cytokines to
treat certain groups of thrombocytopenic neonates.
CONTENTS vii
The Use of Erythropoietin in Neonates 681
Robin K. Ohls
Human recombinant erythropoietin (Epo) has been studied exten¬
sively as treatment for a variety of anemias. Numerous clinical
trials have reported various levels of success in the treatment of
the anemia of prematurity. Recently, Epo has been used in the
first weeks of life to alleviate the anemia caused by excessive
phlebotomy losses and to prevent the anemia of prematurity. In
addition, Epo has been tried clinically in a variety of neonatal
populations to decrease or eliminate transfusions. This article
describes mechanisms of erythropoiesis in the fetus and in the
preterm and term infant, and the use of Epo to prevent and treat
anemia in neonates.
Necrotizing Enterocolitis and Hematopoietic Cytokines 697
Daniel J. Ledbetter and Sandra E. Juul
Although hematopoietic cytokines were first identified based on
their effects in the hematopoietic or immunologic systems, they
are now known to have important effects in other somatic sys¬
tems. This article focuses on the effects of these cytokines on the
gastrointestinal tract. As might be expected of factors largely
defined by their effects on inflammatory cells, the hematopoietic
cytokines are intimately involved in the processes of bowel injury.
Not all of their effects are inflammatory, however, with several
factors having protective and even trophic effects in the bowel.
Further investigations are needed to define the role of hematopoi¬
etic cytokines in the human neonates balance between local gas¬
trointestinal host defense and bowel wall injury. This could lead
to effective strategies for the treatment and prevention of necrotiz¬
ing enterocolitis.
Infection, Neutrophils, and Hematopoietic Growth
Factors in the Pathogenesis of Neonatal Chronic Lung
Disease 717
Paola Papoff
Continued definition of the biochemical and molecular mecha¬
nisms underlying the development of chronic lung disease (CLD)
has persuaded investigators that inflammatory cells and media¬
tors are key factors in the pathophysiology of the disease. High
numbers of inflammatory cells and their products are present
in the airways of ventilated neonates with respiratory distress
syndrome and precede the development of CLD. This article
reviews the mechanisms underlying neutrophil recruitment in
the lungs of ventilated preterm infants with respiratory distress
syndrome and the injurious effects that these cells can produce
on lung parenchyma with special emphasis on the development
of CLD. The role of granulocyte colony stimulating factor and
granulocyte macrophage colony stimulating factor is stressed as
a pivotal mechanism of neutrophil recruitment and activation.
Viii CONTENTS
Appendix: Consistent Approaches to Procedures and
Practices in Neonatal Hematology 733
Darlene A. Calhoun, Robert D. Christensen,
Cynthia S. Edstrom, Sandra E. Juul, Robin K. Ohls,
Kurt R. Schibler, Martha C. Sola, and Sandra E. Sullivan
Index 755
Subscription Information Inside back cover
CONTENTS 1X
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spelling | Neonatal hematology Robert D. Christensen, guest ed. Philadelphia [u.a.] Saunders 2000 XIV S., S. 507 - 760 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Clinics in perinatology 27,3 Hematologie gtt Hémopathie Maladies du nourrisson et du nouveau-né Pasgeborenen gtt Hematologic Diseases Infant, Newborn Neonatal hematology Newborn infants Diseases Hämatologie (DE-588)4022796-0 gnd rswk-swf Blutkrankheit (DE-588)4007281-2 gnd rswk-swf Neugeborenes (DE-588)4041781-5 gnd rswk-swf Blut (DE-588)4007259-9 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Blutkrankheit (DE-588)4007281-2 s Neugeborenes (DE-588)4041781-5 s DE-604 Hämatologie (DE-588)4022796-0 s Blut (DE-588)4007259-9 s Physiologie (DE-588)4045981-0 s Christensen, Robert D. Sonstige (DE-588)1076853773 oth Clinics in perinatology 27,3 (DE-604)BV000003382 27,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009094412&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Neonatal hematology Clinics in perinatology Hematologie gtt Hémopathie Maladies du nourrisson et du nouveau-né Pasgeborenen gtt Hematologic Diseases Infant, Newborn Neonatal hematology Newborn infants Diseases Hämatologie (DE-588)4022796-0 gnd Blutkrankheit (DE-588)4007281-2 gnd Neugeborenes (DE-588)4041781-5 gnd Blut (DE-588)4007259-9 gnd Physiologie (DE-588)4045981-0 gnd |
subject_GND | (DE-588)4022796-0 (DE-588)4007281-2 (DE-588)4041781-5 (DE-588)4007259-9 (DE-588)4045981-0 (DE-588)4143413-4 |
title | Neonatal hematology |
title_auth | Neonatal hematology |
title_exact_search | Neonatal hematology |
title_full | Neonatal hematology Robert D. Christensen, guest ed. |
title_fullStr | Neonatal hematology Robert D. Christensen, guest ed. |
title_full_unstemmed | Neonatal hematology Robert D. Christensen, guest ed. |
title_short | Neonatal hematology |
title_sort | neonatal hematology |
topic | Hematologie gtt Hémopathie Maladies du nourrisson et du nouveau-né Pasgeborenen gtt Hematologic Diseases Infant, Newborn Neonatal hematology Newborn infants Diseases Hämatologie (DE-588)4022796-0 gnd Blutkrankheit (DE-588)4007281-2 gnd Neugeborenes (DE-588)4041781-5 gnd Blut (DE-588)4007259-9 gnd Physiologie (DE-588)4045981-0 gnd |
topic_facet | Hematologie Hémopathie Maladies du nourrisson et du nouveau-né Pasgeborenen Hematologic Diseases Infant, Newborn Neonatal hematology Newborn infants Diseases Hämatologie Blutkrankheit Neugeborenes Blut Physiologie Aufsatzsammlung |
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