Serotonin as a powerful modulator of the respiratory network during development: an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
1999
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 93 S. Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Serotonin as a powerful modulator of the respiratory network during development |b an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat |c vorgelegt von Aurelian Pestean |
| 264 | 1 | |c 1999 | |
| 300 | |a 93 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Göttingen, Univ., Diss., 1999 | ||
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Datensatz im Suchindex
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|---|---|
| adam_text |
CONTENT
1.
INTRODUCTION
1.1.
RESPIRATORY
CONTROL
IN
MAMMALS
1
1.2.
THE
MEDULLARY
RESPIRATORY
NETWORK
2
1.3.
DEVELOPMENT
OF
THE
RESPIRATORY
RHYTHM
4
1.4.
THE
SEROTONERGIC
SYSTEM
5
1.5.
SEROTONERGIC
MODULATION
OF
THE
RESPIRATORY
NETWORK
7
1.6.
THE
PRESENT
WORK
10
2.
MATERIALS
AND
METHODS
2.1.
PREPARATIONS
12
2.2.
CHEMICALS
AND
SOLUTIONS
14
2.3.
RECORDINGS
17
2.4.
PRESSURE
MICROINJECTION
21
2.5.
IONTOPHORESIS
23
2.6.
HISTOLOGY
24
3.
RESULTS
3.1.
MICROINJECTIONS
OF
SEROTONIN
(5-HT)
AND
5-HT
RECEPTOR
AGONISTS
INTO
THE
PRE-B6TZINGER
COMPLEX
(PBC)
25
3.1.1.
5-HT
RECEPTOR
MEDIATED
EFFECTS
BEFORE
THE
ONSET
OF
RESPIRATORY
RHYTHMIC
ACTIVITY
25
3.1.1.1.
EMBRYONIC
DAY
16
(EL
6)
27
3.1.1.2.
EMBRYONIC
DAY
17
(E
17)
28
3.1.2.
LATE
EMBRYONIC
(E18-E22)
AND
EARLY
POSTNATAL
(P1-P6)
DEVELOPMENT
28
3.2.
BATH
APPLICATION
OF
5-HT
3.2.1.
HYPOGLOSSAL
NERVE
ACTIVITY
3.2.2.
RESPIRATORY
HYPOGLOSSAL
MOTONEURONS
3.2.3.
NON-RESPLRATORY
HYPOGLOSSAL
MOTONEURONS
38
3.2.4.
RHYTHM-INDUCING
EFFECTS
OF
5-HT
40
3.2.5.
INSPIRATORY
PBC
NEURONS
40
3.2.6.
EXPIRATORY
PBC
NEURONS
42
8
3.3.
BATH
APPLICATION
OF
5-HT
RECEPTOR
AGONISTS
3.3.1.
5-HT
IA
RECEPTORS
3.3.2.
5-HTZ
RECEPTORS
3.4.
LONTOPHORETIC
APPLICATION
OF
5-HT
AND
5-HT
RECEPTOR
AGONISTS
3.4.1.
5-HT
MEDIATED
EFFECTS
3.4.1.1.
PBC
NEURONS
3.4.1.2.
RESPIRATORY
HYPOGLOSSAL
MOTONEURONS
3.4.2.
5-HT
IA
RECEPTOR
MEDIATED
EFFECTS
ON
PBC
NEURONS
3.4.3.
5-HT2
RECEPTOR
MEDIATED
EFFECTS
ON
PBC
NEURONS
3.5.
CONCLUDING
REMARKS
4.
DISCUSSION
AND
CONCLUSIONS
4.1.
METHODOLOGICAL
CONSIDERATIONS
4.1.1.
MEDULLARY
RHYTHMIC
SLICE
PREPARATION
4.1.2.
RECORDINGS
4.1.3.
DRUG
APPLICATION
4.1.4.
5-HT
RECEPTOR
AGONISTS
AND
ANTAGONISTS
4.2.
MODULATORY
EFFECTS
OF
5-HT
ON
THE
CENTRAL
RESPIRATORY
NETWORK
4.2.1.
5-HT
MODULATION
OF
RESPIRATORY
FREQUENCY
4.2.2.
5-HT-RECEPTORS
ON
PBC
INTERNEURONS
AND
HYPOGLOSSAL
MOTONEURONS
69
4.2.2.1.
PBC
INTERNEURONS
69
4.2.2.2.
RESPIRATORY
HYPOGLOSSAL
MOTONEURONS
72
4.3.
DEVELOPMENTALLY
REGULATED
EFFECTS
OF
5-HT
74
4.4.
CLINICAL
CONSIDERATIONS
76
4.5.
SUMMARY
PRESENTATION
79
O'
O
Q
O'
O"
CH
O'
CN
CD
CD
&
K
S
05
05
O'
UI
W
W
CD
05
-
*
00
XJ
S
S
5.
REFERENCES
82 |
| any_adam_object | 1 |
| author | Pestean, Aurelian 1967- |
| author_GND | (DE-588)122218140 |
| author_facet | Pestean, Aurelian 1967- |
| author_role | aut |
| author_sort | Pestean, Aurelian 1967- |
| author_variant | a p ap |
| building | Verbundindex |
| bvnumber | BV013314016 |
| ctrlnum | (OCoLC)247645793 (DE-599)BVBBV013314016 |
| format | Thesis Book |
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| indexdate | 2024-08-17T00:48:13Z |
| institution | BVB |
| language | English |
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| physical | 93 S. Ill., graph. Darst. |
| publishDate | 1999 |
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| spelling | Pestean, Aurelian 1967- Verfasser (DE-588)122218140 aut Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat vorgelegt von Aurelian Pestean 1999 93 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Göttingen, Univ., Diss., 1999 Ratte (DE-588)4177011-0 gnd rswk-swf Atemregulation (DE-588)4219519-6 gnd rswk-swf Neurohistologie (DE-588)4211744-6 gnd rswk-swf Serotonin (DE-588)4054614-7 gnd rswk-swf Ontogenie (DE-588)4043565-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Ratte (DE-588)4177011-0 s Atemregulation (DE-588)4219519-6 s Ontogenie (DE-588)4043565-9 s Neurohistologie (DE-588)4211744-6 s DE-604 Serotonin (DE-588)4054614-7 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009078372&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pestean, Aurelian 1967- Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat Ratte (DE-588)4177011-0 gnd Atemregulation (DE-588)4219519-6 gnd Neurohistologie (DE-588)4211744-6 gnd Serotonin (DE-588)4054614-7 gnd Ontogenie (DE-588)4043565-9 gnd |
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| title | Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat |
| title_auth | Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat |
| title_exact_search | Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat |
| title_full | Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat vorgelegt von Aurelian Pestean |
| title_fullStr | Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat vorgelegt von Aurelian Pestean |
| title_full_unstemmed | Serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat vorgelegt von Aurelian Pestean |
| title_short | Serotonin as a powerful modulator of the respiratory network during development |
| title_sort | serotonin as a powerful modulator of the respiratory network during development an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat |
| title_sub | an in vitro study in transversal rhythmically active medullary slices of the fetal and neonatal rat |
| topic | Ratte (DE-588)4177011-0 gnd Atemregulation (DE-588)4219519-6 gnd Neurohistologie (DE-588)4211744-6 gnd Serotonin (DE-588)4054614-7 gnd Ontogenie (DE-588)4043565-9 gnd |
| topic_facet | Ratte Atemregulation Neurohistologie Serotonin Ontogenie Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009078372&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pesteanaurelian serotoninasapowerfulmodulatoroftherespiratorynetworkduringdevelopmentaninvitrostudyintransversalrhythmicallyactivemedullaryslicesofthefetalandneonatalrat |