GPI-anchored membrane proteins and carbohydrates:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Austin, Tex.
Landes
1999
|
| Schriftenreihe: | Neuroscience intelligence unit
7 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 215 S. graph. Darst. |
| ISBN: | 1570595577 |
Internformat
MARC
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Datensatz im Suchindex
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|---|---|
| adam_text | MOLECULAR BIOLOGY
INTELLIGENCE
UNIT 7
GPI-Anchored
Membrane Proteins
and Carbohydrates
Daniel C Hoessli, M D
Department of Pathology
University of Geneva
Geneva, Switzerland
Subburaj Ilangumaran, B V Sc, Ph D
Department of Pathology
University of Geneva
Geneva, Switzerland
R G LANDES
COMPANY
AUSTIN, TEXAS
U S A
CONTENTS
1 GPI-Anchored Biomolecules—
An Overview 1
Martin G Low
Discovery of GPI Anchors 1
Distribution of GPI Anchors 3
Why Use a GPI Molecule for Membrane Anchoring? 5
Does the GPI Anchor Have Additional Functions
Besides Anchoring Proteins to the Cell Surface? 7
Summary 11
2 Biosynthesis of GPIs in Mammalian Cells 15
Anant K Menon and Peter Butikofer
GPI Anchor Assembly 15
GPI Lipid Remodeling 19
Inhibitors of GPI Biosynthesis 20
Attachment of GPI to Protein 20
Subcellular Location and Membrane Topology
of GPI Biosynthesis 21
3 Organization of GPI-Anchored Proteins in Mammalian
Cell Membranes 29
Satyajit Mayor and Teymuras V Kurzchalia
Lateral Heterogeneity in Cell Membranes 29
Association of GPI-Anchored Proteins with Domains,
Detergent-Insoluble Complexes and Caveolae 30
Mechanisms of Detergent Insolubility 33
Direct Evidence for GPI-Anchored Protein Domains
in Living Cell Membranes 34
Functional Implications of GPI-Anchored Protein Domains 35
Summary 38
4 Signaling through GPI-Anchored Receptors 43
Subburaj Ilangumaran, Peter} Robinson and Daniel C Hoessli
Association of GPI-Linked Receptors with Transmembrane
Proteins into Receptor Complexes 43
Detergent-Resistant Sphingolipid Microdomains as Signaling
Platforms for GPI-Anchored Receptors 48
Sphingolipid Microdomains and Caveolae 51
Localization and Regulation of Src Family PTKs in Sphingolipid
Microdomains 52
Transmembrane Receptors Requiring the Participation
of Sphingolipid Microdomains for Signaling 55
Interactions of the Sphingolipid Microdomains
with Transmembrane Proteins: Implications
for Proximal
Signaling Events 56
Role of the GPI Anchor in Signaling 56
GPI Anchor-Derived Second Messengers 57
Signaling via GPI-Anchored Glycoproteins of the Lymphocytes 57
Summary 59
5 GPI-Anchored Proteins of Leucocytes: Inventory, Structural
Properties and Functions 71
Vacldv Horejsi, Petr DrAber and Hannes Stockinger
CD14 71
CD16b 73
CD24 74
CD48 75
CD52 75
CD55 75
CD58(LFA-3) 75
CD59 76
CD66 76
CD73 76
CD87 77
CD90 78
CDwlO8 79
CD109 79
CD157 (Mo5, BST-1) 79
RT6 79
Melanotransferrin 80
Ly-6 80
Other Leucocyte GPI-anchored Proteins 81
6 GPI-Anchored Proteins in the Nervous System 93
David A Harris
Growth Factor Receptors 93
Molecules Involved in Axonal and Synaptic Adhesion 95
Caveolae and Detergent-Resistant Rafts 96
Possible Functions of Rafts in the Nervous System 97
Prions 99
Summary 104
7 GPI-Anchored Complement Regulatory Molecules 109
Carmen W van den Berg and B Paul Morgan
The Complement System 109
Decay Accelerating Factor (DAF, CD55) 110
CD59 116
Homologous Restriction Factor 121
Why Are So Many C-Regulatory Molecules Anchored
through a GPI Anchor? 122
8 GPI-Containing Molecules of Pathogenic Mycobacteria
and Protozoa 131
Pascal Schneider and Daniel C Hoessli
Mycobacterial GPI-Linked Molecules 131
GPI in Protozoa 133
Summary 149
9 Enzymes Cleaving the Phosphodiester Bond in the GPI Anchor 167
Martin G Low and Urs Brodbeck
GPI Anchor-Cleaving Phospholipases from Bacteria 167
GPI Anchor-Cleaving Phospholipase C (GPI-PLC)
from Trypanosomes 169
GPI Anchor-Cleaving Activity in Plants 170
Mammalian GPI-PLC 171
Mammalian GPI-PLD 172
Summary 180
10 Intercellular Transfer of GPI-Anchored Molecules 187
Isabelle A Rooney
Possible Functions of the GPI Anchor 187
Evidence that GPI-Anchored Proteins can Transfer
between Cell Membranes 188
Mechanisms by which Cells Acquire Exogenous
GPI-Anchored Proteins 189
Mechanisms by which Cells Release GPI-Anchored Proteins 190
Importance of Intercellular GPI-Anchored Protein Transfer 192
11 Engineering GPI-Anchored Proteins 197
Periasamy Selvaraj, Rebecca S McHugh and Shanmugam Nagarajan
Naturally Occurring Membrane Isoforms of Cell Surface
Glycoproteins 197
Transmembrane Proteins Engineered
into GPI-Anchored Forms 198
Comparative Studies Using Naturally Occurring
and Genetically Engineered Membrane Isoforms 199
GPI-Mediated Protein Transfer 201
Potential Application of GPI-Protein Transfer
in Tumor Immunotherapy 203
Summary 205
Index 213
|
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV013251611 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:42:30Z |
| institution | BVB |
| isbn | 1570595577 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009031982 |
| oclc_num | 260047980 |
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| owner | DE-12 |
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| physical | 215 S. graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Landes |
| record_format | marc |
| series | Neuroscience intelligence unit |
| series2 | Neuroscience intelligence unit |
| spelling | GPI-anchored membrane proteins and carbohydrates Daniel C. Hoessli ... Austin, Tex. Landes 1999 215 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neuroscience intelligence unit 7 Inositphosphatide (DE-588)4161829-4 gnd rswk-swf Membranproteine (DE-588)4130026-9 gnd rswk-swf Glykokonjugate (DE-588)4131221-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Inositphosphatide (DE-588)4161829-4 s Glykokonjugate (DE-588)4131221-1 s Membranproteine (DE-588)4130026-9 s DE-604 Hoessli, Daniel C. Sonstige oth Steinkraus, Holly B. Sonstige oth Langer, Pamela J. Sonstige oth Neuroscience intelligence unit 7 (DE-604)BV012895694 7 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009031982&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | GPI-anchored membrane proteins and carbohydrates Neuroscience intelligence unit Inositphosphatide (DE-588)4161829-4 gnd Membranproteine (DE-588)4130026-9 gnd Glykokonjugate (DE-588)4131221-1 gnd |
| subject_GND | (DE-588)4161829-4 (DE-588)4130026-9 (DE-588)4131221-1 (DE-588)4143413-4 |
| title | GPI-anchored membrane proteins and carbohydrates |
| title_auth | GPI-anchored membrane proteins and carbohydrates |
| title_exact_search | GPI-anchored membrane proteins and carbohydrates |
| title_full | GPI-anchored membrane proteins and carbohydrates Daniel C. Hoessli ... |
| title_fullStr | GPI-anchored membrane proteins and carbohydrates Daniel C. Hoessli ... |
| title_full_unstemmed | GPI-anchored membrane proteins and carbohydrates Daniel C. Hoessli ... |
| title_short | GPI-anchored membrane proteins and carbohydrates |
| title_sort | gpi anchored membrane proteins and carbohydrates |
| topic | Inositphosphatide (DE-588)4161829-4 gnd Membranproteine (DE-588)4130026-9 gnd Glykokonjugate (DE-588)4131221-1 gnd |
| topic_facet | Inositphosphatide Membranproteine Glykokonjugate Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009031982&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV012895694 |
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