Neuronal nicotinic receptors: [with 22 tables]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2000
|
| Schriftenreihe: | Handbook of experimental pharmacology
144 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXXI, 821 S. Ill., graph. Darst. |
| ISBN: | 3540661239 |
Internformat
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| 245 | 1 | 0 | |a Neuronal nicotinic receptors |b [with 22 tables] |c contributors E. X. Albuquerque ... Ed. F. Clementi ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2000 | |
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Datensatz im Suchindex
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| adam_text | NEURONAL NICOTINIC RECEPTORS
CONTRIBUTORS
E.X. ALBUQUERQUE, M. ALKONDON, S.P. ARNERIC, M. BALLIVET,
D.K. BERG, D. BERTRAND, D.A. BROWN, B. BUISSON, K.T. CHANG,
J.-P. CHANGEUX, F. CLEMENTI, A.C. COLLINS, D. COLQUHOUN,
J. COURT, J. CUEVAS, E.S. DENERIS, G. DI CHIARA, H.M. EISENBERG,
M.M. FRANCIS, C. GOTTI, E.D. GUNDELFINGER, W. HANKE,
M.W. HOLLADAY, S. KAISER, S.H. KELLER, M. KELTON, S.S. LEONARD,
E.D. LEVIN, J. LINDSTROM, A. MAELICKE, S. MALANY, L.M. MARUBIO,
J.-M. MATTER, J.M. MCLNTOSH, N.S. MILLAR, B. MOLLES, P. NEWHOUSE,
A. NORDBERG, H. OSAKA, R.L. PAPKE, E. PERRY, F. PICARD,
P.B. SARGENT, A. SCHRATTENHOLZ, R. SCHULZ, R.D. SHOOP,
L.G. SIVILOTTI, L. SOLIAKOV, J.A. STITZEL, P. TAYLOR, S. WONNACOTT,
M. ZOLI
EDITORS
F. CLEMENTI, D. FORNASARI, AND C. GOTTI
SPRINGER
CONTENTS
SECTION I: INTRODUCTION TO NEURONAL NICOTINIC RECEPTORS
CHAPTER 1
THE HISTORY OF THE NEURONAL NICOTINIC RECEPTORS
D.A.
BROWN
3
A
. THE AUTONOMI
C GANGLION
: TH
E ARCHETYPICA
L NEURONA
L NICOTINIC
RECEPTO
R 3
B. NICOTINIC ACETYLCHOLIN
E RECEPTOR
S IN TH
E CENTRA
L NERVOU
S
SYSTEM 5
C. PRESYNAPTI
C NICOTINIC RECEPTOR
S 7
REFERENCE
S 8
CHAPTE
R 2
DISTRIBUTION OF CHOLINERGIC NEURONS IN THE MAMMALIAN BRAIN WITH
SPECIAL REFERENCE TO THEIR RELATIONSHIP WITH NEURONAL NICOTINIC
ACETYLCHOLINE RECEPTORS
M.
ZOLI
.
WITH 1 FIGURE 13
A
. DISTRIBUTIO
N OF CHOLINERGIC NEURON
S IN NEURA
L TISSUES 13
I. THE BASAL TELENCEPHALIC SYSTEM 13
II
. STRIATA
L INTERNEURON
S 15
III
. TH
E HABENULO-INTERPEDUNCULA
R SYSTEM 15
IV. THE MESOPONTIN
E TEGMENTAL SYSTEM 16
V. BRAINSTE
M AN
D SPINAL COR
D MOTO
R NUCLEI 16
VI
. MEDULLAR
Y TEGMENTUM 16
VII
. PERIPHERA
L GANGLIA AND RETIN
A 17
VIII
. PUTATIV
E CHOLINERGIC SYSTEMS 17
IX. COMPARATIV
E ASPECT
S 17
B. DISTRIBUTIO
N OF NICOTINIC RECEPTOR
S WITH RESPEC
T T
O
CHOLINERGIC NEURON
S 20
I. LOCATIO
N OF NACHR
S IN CHOLINERGIC AN
D CHOLINOCEPTIV
E
CELLS 20
1. HETERORECEPTOR
S 21
XIV CONTENTS
2. SUBUNI
T COMPOSITIO
N OF HETERORECEPTOR
S 22
3
. AUTORECEPTOR
S 23
4. SUBUNIT COMPOSITIO
N OF AUTORECEPTOR
S 24
II
. WIRING VS VOLUME TRANSMISSION IN CHOLINERGI
C SYSTEMS ...
. 24
REFERENCE
S 26
SECTION II: GENES, STRUCTURE, AND DISTRIBUTION OF NEURONAL
NICOTINIC RECEPTORS
CHAPTER 3
GENE STRUCTURE AND TRANSCRIPTIONAL REGULATION OF THE NEURONAL
NICOTINIC ACETYLCHOLINE RECEPTORS
J.-M.
MATTER
AND M.
BALLIVET.
WITH 4 FIGURES 33
A. BACKGROUND 33
B. FUNCTIONAL GROUPINGS AND GENE STRUCTURE 34
I. FUNCTION AND SEQUENCE HOMOLOGY SCORES 35
II. FUNCTION AND GENE STRUCTURE 36
C. EXPRESSION AND REGULATION OF THE NEURONAL NACHR GENES 39
I. NACHRS IN THE ADULT RETINA 39
II. NACHRS IN THE DEVELOPING RETINA 40
III. ROLE OF INNERVATION AND TARGET TISSUES ON NACHR
EXPRESSION 41
D. IDENTIFICATION OF CIS-ACTING REGULATORY ELEMENTS 43
I. NACHR GENES AS A MODEL FOR NEURON-SPECIFIC GENE
TRANSCRIPTION 43
II. TECHNICAL TOOLS TO INVESTIGATE TRANSCRIPTIONAL
REGULATION 43
III. IDENTIFICATION OF CIS-ACTING ELEMENTS THAT REGULATE
TRANSCRIPTION 44
1. THE
PI
GENE -TH
E ROLE OF SILENCING ELEMENTS 44
2. THE
AL
GENE 45
3. A3 AND J34 - THE ROLE OF UBIQUITOUS TRANSCRIPTION
FACTORS 46
IV. A NETWORK OF NEURONAL BHLH TRANSCRIPTION FACTORS
REGULATES J33 IN RETINA 47
REFERENCES 49
CONTENTS XV
CHAPTE
R 4
TRANSCRIPTIONAL REGULATION OF NEURONAL NACHR SUBUNIT GENES
E.S.
DENERIS
.
WITH 3 FIGURES 57
A
. INTRODUCTIO
N 57
B. CELL-TYPE SPECIFIC TRANSCRIPTION 59
C. DN
A REGULATOR
Y ELEMENT
S AN
D TRANSCRIPTION FACTORS 60
I.
DL
GEN
E 60
1. AVIAN
DL
REGULATOR
Y REGIO
N 60
2.
DL
SILENCER REGIO
N 60
II
.
AL
GEN
E 61
1. CHICKEN
DL
PROMOTE
R 61
2. BOVINE
AL
PROMOTE
R 61
III
.
PI
GEN
E 63
1. MOUS
E
PI
PROMOTE
R 63
2. TRANSGENIC ANALYSIS OF TH
E
PI
PROMOTE
R 63
3
.
PI
NEURO
N RESTRICTIV
E SILENCER ELEMEN
T 64
IV.
P ,
O3
, A
5 GEN
E CLUSTER 64
1. RA
T
P4
PROMOTE
R 65
2. RA
T AN
D HUMA
N A
3 PROMOTER
S 66
3. ACTIVATIO
N OF TH
E RA
T A
3 PROMOTE
R BY TH
E PO
U
FACTOR, SCI
P 68
4. TRANSGENIC ANALYSIS OF RA
T
O&
UPSTREA
M REGIO
N 69
5. RA
T
PA3
ENHANCE
R 69
D. CONCLUSIONS AND FUTUR
E DIRECTION
S 73
REFERENCE
S 73
CHAPTE
R 5
CONTRIBUTIONS OF STUDIES OF THE NICOTINIC RECEPTOR FROM MUSCLE
TO DEFINING STRUCTURAL AND FUNCTIONAL PROPERTIES OF LIGAND-GATED
ION CHANNELS
P.
TAYLOR,
H
.
OSAKA,
B.
MOLLES
,
S.H.
KELLER,
AND S.
MALANY.
WITH 4 FIGURES 79
A
. INTRODUCTIO
N 79
B. FUNCTIONA
L ASPECT
S OF THE NICOTINIC RECEPTO
R IN SKELETAL
MUSCLE 81
C. ISOLATION AND CHARACTERIZATIO
N OF NICOTINIC RECEPTOR
S 82
D. STRUCTUR
E OF THE MUSCLE NICOTINIC RECEPTO
R 83
E
. BIOPHYSICAL PROPERTIE
S OF MUSCLE RECEPTOR
S 88
F. NATURA
L TOXINS THA
T BLOCK MOTO
R ACTIVITY 89
G. CONGENITA
L MYASTHENIA SYNDROME
S FROM RECEPTO
R
MUTATION
S 91
XVI CONTENTS
H
. BIOSYNTHESIS AN
D ASSEMBLY OF TH
E RECEPTO
R SUBUNIT
S 93
I. REGULATIO
N OF NICOTINIC ACETYLCHOLIN
E RECEPTO
R EXPRESSIO
N 95
REFERENCE
S 96
CHAPTE
R 6
THE STRUCTURES OF NEURONAL NICOTINIC RECEPTORS
J.
LINDSTROM.
WITH 3 FIGURES 101
A
. MUSCLE ACHR
S PROVID
E TH
E MODE
L FOR NEURONA
L ACHR
S 101
I. SUBUNITS WHICH COMPRIS
E MUSCL
E ACHR
S 102
II. STRUCTURE
S OF TH
E MUSCLE ACH
R SUBUNIT
S 103
III
. ORGANIZATIO
N OF SUBUNIT
S AROUN
D TH
E CENTRA
L CATIO
N
CHANNE
L 110
IV. ACETYLCHOLIN
E BINDING SITES IN TH
E EXTRACELLULA
R
DOMAI
N 110
V. THE MAIN IMMUNOGENI
C REGIO
N IN TH
E EXTRACELLULA
R
DOMAI
N AN
D MYASTHENI
A GRAVI
S 112
VI
. CATION-SPECIFIC CHANNE
L AN
D IT
S GAT
E 123
VII
. LARGE CYTOPLASMI
C DOMAI
N 123
VIII
. ACH
R MUTATION
S IN CONGENITA
L MYASTHENI
C
SYNDROME
S 124
B. NEURONA
L ACHR
S WHICH CAN FUNCTIO
N AS HOMOMER
S 124
I. SUBUNIT
S WHICH COMPRIS
E HOMOMERI
C NEURONA
L
ACHR
S 125
II
. STRUCTURE
S OF TH
E HOMOMERI
C NEURONA
L ACH
R
SUBUNIT
S 127
III
. ORGANIZATIO
N OF SUBUNIT
S AROUN
D TH
E CENTRA
L CHANNE
L ...
. 128
IV. SPECIAL PROPERTIE
S OF HOMOMERI
C NEURONA
L ACHR
S 131
V. INVOLVEMEN
T OF HOMOMERI
C NEURONA
L ACHR
S IN
DISEASE
S 133
C. HETEROMERI
C NEURONA
L ACHR
S 134
I. STRUCTURE
S OF TH
E SUBUNIT
S OF HETEROMERI
C NEURONA
L
ACHR
S 137
II
. ORGANIZATIO
N OF SUBUNIT
S AROUN
D TH
E CENTRA
L CHANNE
L ...
. 139
III
. SPECIAL PROPERTIE
S OF HETEROMERI
C NEURONA
L ACHR
S 140
IV. INVOLVEMEN
T OF HETEROMERI
C NEURONA
L ACHR
S
IN DISEASES 144
D. CONCLUSIONS AN
D CURREN
T PROBLEM
S 146
REFERENCES 147
CONTENTS XVII
CHAPTE
R 7
THE DISTRIBUTION OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
P.B.
SARGENT.
WITH 3 FIGURE
S 163
A
. INTRODUCTIO
N 163
B. NICOTINIC ACHR
S IN NON-NEURONA
L CELLS 164
C. REGIONA
L DISTRIBUTIO
N OF ACHR
S WITHIN TH
E PERIPHERA
L
NERVOU
S SYSTEM 164
I. AUTONOMI
C GANGLIA 164
II. SENSORY GANGLIA 165
D. REGIONA
L DISTRIBUTIO
N OF ACHR
S WITHIN TH
E CENTRA
L NERVOU
S
SYSTEM 165
I. MAPPIN
G STUDIES WITH [
3
H]NICOTINE AN
D WITH LIGANDS
FOR
A4
AND
PI
166
II. MAPPIN
G STUDIES WITH
125
I-A-BGT AND WITH LIGANDS
FOR
AL
173
III
. MAPPIN
G STUDIES WITH LIGAND
S FOR A
3 174
IV. MAPPIN
G STUDIES WITH LIGANDS FOR /34 174
V. MAPPIN
G STUDIES WITH LIGANDS FOR
DL,
A5
,
AD,
AND
PI
174
VI
. SPECIES DIFFERENCES AMON
G MAMMAL
S 175
VII
. ACH
R MAPPIN
G IN CHICKE
N BRAIN 176
E
. DISTRIBUTIO
N OF ACHR
S ON TH
E NEURONA
L SURFACE 176
I. PERIPHERA
L NERVOU
S SYSTEM
(SEE ALSO CHAP
. 10, THIS VOLUME
) 176
II
. CENTRA
L NERVOU
S SYSTEM 180
F. PRESYNAPTI
C ACHRS/EXTRASYNAPTI
C ACHR
S 182
G. REGULATIO
N OF ACH
R DISTRIBUTIO
N 182
H
. CONCLUSION 184
REFERENCE
S 184
CHAPTE
R 8
PRESYNAPTIC NEURONAL NICOTINIC RECEPTORS:
PHARMACOLOGY, HETEROGENEITY, AND CELLULAR MECHANISMS
S.
KAISER
,
L.
SOLIAKOV.
AN
D S.
WONNACOTI
.
WITH 2 FIGURE
S 193
A
. INTRODUCTIO
N 193
B. PHARMACOLOG
Y AN
D HETEROGENEIT
Y OF PRESYNAPTI
C NICOTINI
C
RECEPTOR
S 195
I. ACETYLCHOLIN
E 195
II. DOPAMIN
E 196
III
. NORADRENALIN
E 197
IV. 5-HYDROXYTRYPTAMIN
E 198
V. Y-AMINOBUTYRI
C ACI
D 199
VI
. GLUTAMAT
E 199
XVIII CONTENTS
VII. ADENOSINE TRIPHOSPHATE 200
VIII. SUMMARY 200
C. MOLECULAR AND CELLULAR MECHANISMS UNDERLYING THE NICOTINIC
MODULATION OF TRANSMITTER RELEASE 201
I. NA
+
DEPENDENCE AND TETRODOTOXIN SENSITIVITY 201
II. CA
2+
DEPENDENCE AND INVOLVEMENT OF VOLTAGE OPERATE
D
CA
2+
CHANNELS 201
III. THE INVOLVEMENT OF SECOND MESSENGERS IN THE NICOTINIC
MODULATION OF NEUROTRANSMISSION 203
1. PROTEIN KINASE C 203
2. CAM KINASE II 205
3. TYROSINE KINASE SIGNALLING PATHWAYS 205
D. CONCLUDING REMARKS 206
REFERENCES 206
CHAPTE
R 9
NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN DEVELOPMENT
AND AGING
M.
ZOLI.
WITH 4 FIGURES 213
A. DEVELOPMENT OF NEURONAL NICOTINIC ACETYLCHOLINE
RECEPTORS 213
I. DEVELOPMENT OF NEURONAL NICOTINIC ACETYLCHOLINE
RECEPTORS IN THE PERIPHERAL NERVOUS SYSTEM 214
1. PHENOMENOLOGICAL ASPECTS 214
2. MECHANISTIC ASPECTS 215
3. CONCLUSIONS 216
II. DEVELOPMENT OF NEURONAL NICOTINIC ACETYLCHOLINE
RECEPTORS IN THE CENTRAL NERVOUS SYSTEM 217
1. AVIAN CENTRAL NERVOUS SYSTEM 218
2. RODEN
T CENTRAL NERVOUS SYSTEM 218
3. HUMAN CENTRAL NERVOUS SYSTEM 223
4. CONCLUSIONS 224
III. ROLE OF NEURONAL NICOTINIC ACETYLCHOLINE EECEPTORS IN THE
DEVELOPMENT OF NICOTINOCEPTIVE CELLS 224
1. EFFECTS OF NICOTINE EXPOSURE ON THE DEVELOPMENT OF
THE CENTRAL NERVOUS SYSTEM 225
2. MECHANISTIC ASPECTS OF THE MORPHOGENETIC ACTIONS OF
NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS 227
3. CONCLUSIONS 228
B. NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS DURING AGING 229
I. NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS DURING
NORMAL AGING 229
II. NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS DURING
PATHOLOGICAL AGING 231
CONTENTS XIX
III
. ROL
E OF NEURONA
L NICOTINIC RECEPTOR
S IN NORMA
L AND
PATHOLOGICA
L AGING 232
1. NEURONA
L NICOTINIC ACETYLCHOLINE RECEPTOR
S AN
D
AMYLOI
D 233
2. NEURONA
L NICOTINIC ACETYLCHOLINE RECEPTOR
S AND
APOLIPOPROTEI
N E 234
3. NEURONA
L NICOTINIC ACETYLCHOLINE RECEPTOR
S AN
D CELL
LOSS 234
4. CONCLUSIONS 235
C. GENERA
L CONCLUSIONS 236
REFERENCE
S 237
CHAPTE
R 10
NICOTINIC ACETYLCHOLINE RECEPTORS IN GANGLIONIC TRANSMISSION
D.K.
BERG,
R.D
.
SHOOP,
K.T.
CHANG
,
AND J.
CUEVAS.
WITH 4 FIGURES 247
A
. INTRODUCTIO
N 247
B. NICOTINIC RECEPTO
R COMPOSITIO
N IN GANGLIA 248
I. IMMUNOLOGICA
L IDENTIFICATION 248
II
. ELECTROPHYSIOLOGICAL FEATURE
S 249
C. SUBCELLULAR LOCATION
S AN
D POSTSYNAPTIC ROLE
S 250
I. SYNAPTIC CURRENT
S 250
II
. SOMATIC SPINES VERSUS POSTSYNAPTIC DENSITIE
S 252
III
. FUNCTIONA
L SIGNIFICANCE 254
D. PRESYNAPTI
C NICOTINIC RECEPTOR
S IN GANGLIA 257
E
. REGULATIO
N OF GANGLIONIC NICOTINIC RECEPTOR
S 258
I. RECEPTO
R REGULATIO
N BY CELL-CELL INTERACTION
S 258
II
. DEVELOPMENTA
L REGULATIO
N 259
III
. MOLECULA
R CONTROL
S 260
F. FUTUR
E CHALLENGE
S 262
G. REFERENCE
S 262
SECTION III: FUNCTIONAL PROPERTIES
CHAPTER 11
NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS:
FROM BIOPHYSICAL PROPERTIES TO HUMAN DISEASES
B.
BUISSON,
F.
PICARD.
AND D.
BERTRAND.
WITH 7 FIGURES 271
A
. INTRODUCTIO
N 271
B. RECONSTITUTIO
N AND RECORDIN
G OF NEURONA
L NACHR
S 274
C. THE ALLOSTERI
C MODEL 275
XX CONTENTS
D. FUNCTIONA
L DOMAIN
S OF TH
E NEURONA
L NACH
R 277
E
. THE AGONIST BINDIN
G SITE: STRUCTUR
E AN
D MODULATION
S 278
I. STRUCTURA
L DETERMINANT
S FOR ACETYLCHOLIN
E BINDIN
G 278
II
. ALLOSTERI
C MODULATIO
N OF TH
E NACH
R PHARMACOLOGICA
L
PROFILE 279
F. TH
E NACH
R IO
N CHANNEL
: STRATIFICATION, PERMEABILITY
,
CONDUCTANCE
, RECTIFICATION AN
D BLOCKAD
E 282
I. STRUCTUR
E OF TH
E IONI
C POR
E AT TH
E AMIN
O ACI
D LEVEL 282
II
. THE IONI
C SELECTIVITY 284
III
. SINGLE CHANNEL
S PROPERTIE
S OF NACHR
S 285
IV. MECHANISMS GOVERNIN
G TH
E NEURONA
L NACH
R
RECTIFICATION 288
V. CHANNE
L MUTATION
S IN NEUROLOGICA
L DISEASE
S 289
VI
. OPE
N CHANNE
L BLOCKER
S 290
G. CONCLUSION 292
REFERENCES 293
CHAPTE
R 12
THE FUNCTIONAL DIVERSITY OF NICOTINIC RECEPTORS IN THE NERVOUS
SYSTEM: PERSPECTIVES ON RECEPTOR SUBTYPES AND RECEPTOR
SPECIALIZATION
M.M.
FRANCIS
AN
D R.L
.
PAPKE.
WIT
H 2 FIGURE
S 301
A
. INTRODUCTIO
N 301
B. FUNCTIONA
L DOMAIN
S OF SINGLE SUBUNIT
S 304
C. CALCIUM AN
D NEURONA
L NACH
R 305
D. NEURONA
L NACH
R PHARMACOLOG
Y 306
E
. CHANGE
S IN GEN
E EXPRESSIO
N WITH DEVELOPMEN
T 308
F. FUNCTION
S SERVED BY NEURONA
L NACH
R IN TH
E PN
S 310
G. GANGLIONIC BLOCKER
S 312
H. FUNCTION
S SERVED BY NEURONA
L NACH
R IN TH
E CN
S 315
I. PRESYNAPTI
C RECEPTOR
S 317
J. SPECIAL PROPERTIE
S OF
AL
RECEPTOR
S 323
K. NEURONA
L NACH
R AN
D DEVELOPIN
G THERAPEUTIC
S 325
L. FUTUR
E PERSPECTIVE
S 329
REFERENCES 329
CHAPTE
R 13
NEURONAL NICOTINIC RECEPTORS AND SYNAPTIC TRANSMISSION IN THE
MAMMALIAN CENTRAL NERVOUS SYSTEM
E.X.
ALBUQUERQUE,
E.F.R.
PEREIRA,
M.
ALKONDON
,
H.M
.
EISENBERG,
AN
D A
.
MAELICKE.
WITH 6 FIGURE
S 337
A
. INTRODUCTIO
N 337
CONTENTS XXI
B. EXPERIMENTA
L REQUIREMENT
S T
O MONITO
R FUNCTIONA
L NICOTINI
C
RECEPTOR
S 338
C. NEURONA
L NICOTINI
C RECEPTOR
S PRESEN
T IN HIPPOCAMPA
L
NEURON
S IN CULTUR
E AN
D IN CONVENTIONA
L SLICES:
PHARMACOLOGICA
L AN
D KINETI
C PROPERTIE
S 339
I. NICOTINI
C RECEPTOR
S IN CULTURE
D HIPPOCAMPA
L NEURON
S ..
. 339
II
. NICOTINI
C RECEPTOR
S IN HIPPOCAMPA
L NEURON
S IN
CONVENTIONA
L SLICES 343
D
. NEURONA
L NICOTINI
C RECEPTOR
S CONTRO
L GABAERGI
C AN
D
GLUTAMATERGI
C SYNAPTI
C TRANSMISSIO
N IN TH
E HIPPOCAMPU
S 345
E
. NEURONA
L NICOTINI
C RECEPTOR
S BEARIN
G TH
E
AL
SUBUNI
T MEDIAT
E
SYNAPTI
C TRANSMISSIO
N IN TH
E CA
1 FIELD OF TH
E HIPPOCAMPU
S ...
. 348
F. TH
E ROL
E OF CHOLIN
E IN CONTROLLIN
G TH
E FUNCTIO
N OF NICOTINI
C
RECEPTOR
S BEARIN
G TH
E
AL
SUBUNI
T - PHYSIOLOGICA
L RELEVANC
E ...
. 350
G. CONCLUDIN
G REMARK
S 351
REFERENCE
S 353
CHAPTE
R 14
PROPERTIES O
F HETEROLOGOUSL
Y AND LIPID BILAYER RECONSTITUTE
D
NICOTINIC ACETYLCHOLIN
E RECEPTOR
S
C
.
GOTTI
,
W.
HANKE
,
AN
D F.
CLEMENTI
.
WITH 4 FIGURE
S 359
A
. INTRODUCTIO
N 359
B
. EXPERIMENTA
L REQUIREMENT
S FOR BILAYE
R RECONSTITUTIO
N 360
I. FORMATIO
N OF LIPI
D BILAYER
S 360
II
. PURIFICATIO
N OF NACH
R SUBTYPE
S FOR RECONSTITUTIO
N 360
III
. FUNCTIONA
L CHANNE
L RECONSTITUTIO
N 362
C. RECONSTITUTIO
N OF NACHR
S 363
I. MUSCLE-TYP
E RECEPTO
R 363
1.
A
2
PY8
NACH
R CHANNEL
S EXPRESSE
D IN VARIOU
S CELL
SYSTEM
S 364
A
) CALF AN
D TORPED
O
A
2
FIY8
NACH
R CHANNE
L 364
B
) MOUS
E
A
2
PY6
NACH
R CHANNE
L 365
2.
A
2
FLY8
NACH
R CHANNE
L RECONSTITUTE
D IN
LIPI
D BILAYE
R 365
3
.
A
2
PYS
NACH
R RECONSTITUTE
D IN OOCYTE
S 366
4. DESENSITISATIO
N AN
D PHOSPHORYLATIO
N OF
A
2
PY5
NACH
R
RECONSTITUTE
D IN LIPID BILAYER
S 367
II
. NEURONAL-TYP
E RECEPTO
R 367
1. INSEC
T A-BG
T RECEPTOR
S 36X
2. CHICK
AL,
A8
, AN
D A7-
8 SUBTYPE
S 368
3. CHIC
K A
6 SUBTYP
E 370
D
. CONCLUDIN
G REMARK
S 372
REFERENCE
S 375
XXII
CONTENTS
CHAPTER 15
COMPARISON OF NATIVE AND RECOMBINANT NEURONAL NICOTINIC
RECEPTORS: PROBLEMS OF MEASUREMENT AND EXPRESSION
L.G.
SIVILOTTI,
D
.
COLQUHOUN,
AN
D N.S.
MILLAR
.
WIT
H 3 FIGURE
S 379
A
. INTRODUCTIO
N 379
B. METHOD
S FOR COMPARIN
G NATIV
E AN
D RECOMBINAN
T RECEPTOR
S ...
. 381
I. MEASUREMENT
S OF TH
E RELATIV
E POTENCY OF AGONIST
S 381
II
. MEASUREMENT
S OF TH
E RELATIV
E EFFECTIVENESS OF
ANTAGONIST
S 382
III
. SINGLE CHANNE
L MEASUREMENT
S 383
IV. SPECIES DIFFERENCES 384
C. HETEROGENEIT
Y OF NATIV
E RECEPTOR
S 385
I. THE CHICK CILIARY GANGLIO
N 385
II
. INTRACARDIA
C GANGLIA 388
III
. THE RA
T SUPERIO
R CERVICA
L GANGLIO
N - MACROSCOPI
C
CURRENT
S 389
IV. SINGLE CHANNE
L STUDIE
S OF NATIV
E GANGLIONI
C RECEPTOR
S ..
. 390
V. ANTISENS
E METHOD
S O
N EMBRYONI
C CHICK SYMPATHETI
C
GANGLIO
N NEURONE
S 392
D. HETEROLOGOU
S EXPRESSIO
N OF RECOMBINAN
T RECEPTOR
S 393
I. MUSCLE NICOTINIC RECEPTOR
S 394
II
. GLUTAMAT
E (NMDA-TYPE
) RECEPTOR
S 395
III
. NEURONA
L NICOTINIC RECEPTOR
S 395
1. POTENCY RATIO
S 396
2. SINGLE CHANNE
L PROPERTIE
S 397
IV. RECEPTOR
S WITH MOR
E THA
N TWO TYPES OF SUBUNI
T 401
E
. FOLDING, ASSEMBL
Y AN
D POSTTRANSLATIONA
L MODIFICATION 403
F. CONCLUSIONS AN
D PROSPECT
S 407
REFERENCE
S 407
SECTION IV: PHARMACOLOGICAL PROPERTIES
CHAPTER 16
AGONISTS AND ANTAGONISTS OF NICOTINIC ACETYLCHOLINE RECEPTORS
S.P.
ARNERIC
AN
D M.W.
HOLLADAY.
WITH 2 FIGURES 419
A. INTRODUCTIO
N 419
B. NACH
R SUBTYP
E CLASSIFICATION 421
I. HISTORICAL PERSPECTIV
E 421
II. MOLECULA
R BIOLOGY OF NACH
R SUBUNIT
S 423
III
. RADIOLIGAND
S USE
D T
O IDENTIFY NACH
R SUBTYPE
S 424
C. SITES AND MODULATIO
N OF NACH
R - LIGAND INTERACTIO
N 425
I. TRANSITION STATE
S 425
II
. TH
E NICOTINIC PHARMACOPHOR
E 425
CONTENTS XXIII
III
. TH
E AC
H BINDING SITE 426
IV. CHANNE
L ACTIVATOR
SITES 427
V. LIGAND-BINDIN
G SITES THA
T INHIBIT NACH
R FUNCTIO
N 427
1. NONCOMPETITIV
E (NEGATIV
E ALLOSTERI
C MODULATORS
)
BLOCKER
S 427
2. STEROI
D BINDING SITES 428
3. DIHYDROPYRIDIN
E BINDING SITE 429
4. ARACHIDONI
C ACID SITE 430
5. PERSISTEN
T MODULATIO
N OF TH
E NACH
R COMPLEX 430
D. PHARMACOLOGI
C PROPERTIE
S OF NEURONA
L NACHR
S 431
I. BIOCHEMICAL AN
D BIOPHYSICAL PROPERTIE
S OF NACHR
S
CONTRIBUTIN
G T
O PHARMACOLOG
Y 431
II
. SELECTIVE RESPONSIVITY OF NACH
R SUBUNIT
COMBINATION
S 432
E
. SA
R OF KEY SMALL MOLECULES LEADIN
G T
O ACTIVATIO
N OR INHIBITION
OF NACHR
S 434
I. INHIBITOR
S 434
1. PEPTID
E TOXINS 434
2. METHYLLYCACONITINE (MLA
) 435
3. 4-OXYSTILBENES 435
4. OTHE
R NATURA
L PRODUCT
S 435
II
. POSITIVE ALLOSTERI
C MODULATOR
S 436
III
. ACTIVATOR
S 436
1. AC
H 436
2. NICOTINE 437
A) PYRIDINE RING MODIFIED ANALOG
S 437
B
) PYRROLIDINE RING MODIFIED ANALOG
S 438
C) CONFORMATIONALLY RESTRICTE
D ANALOG
S 438
3. ANABASIN
E AND ANABASEIN
E 439
4.
TRANS-META-NICOTINE
439
5. EPIBATIDIN
E 440
6. ANATOXI
N 440
7. PYRIDYL ETHERS
: HYBRI
D COMPOUND
S OF ACH AND
NICOTINE 441
F. CHOLINERGIC CHANNE
L MODULATORS
: RATIONA
L FOR AN ALTERNATIV
E
NOMENCLATUR
E 441
G. PERSPECTIVE
S ON TH
E FUTUR
E OF NEURONA
L NACH
R
PHARMACOLOG
Y 442
REFERENCE
S 443
CHAPTE
R 17
TOXIN ANTAGONISTS OF THE NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR
J.M.
MCINTOSH.
WITH 1 FIGURE 455
A
. GENERA
L INTRODUCTIO
N 455
B. CAUTIONAR
Y NOT
E REGARDIN
G SPECIES DIFFERENCES 455
XXIV CONTENTS
C. SMALL MOLECULE TOXINS 456
I. GENERAL BACKGROUND 456
II
. PLANT TOXINS 457
1. D-TUBORCURARINE 457
2. DIHYDRO-/J-ERYTHROIDINE 458
3. METHYLLYCACONITINE 459
4. STRYCHNINE 459
III. MARINE TOXINS 460
1. NEOSURUGATOXIN 460
2. LOPHOTOXIN 460
D. SNAKE VENOM POLYPEPTIDES 461
I. GENERAL BACKGROUND 461
II. SNAKE A-NEUROTOXINS 461
A-BUNGAROTOXIN 461
III. SNAKE K-NEUROTOXINS 462
JE-BUNGAROTOXIN 462
E.
CONUS
VENOM PEPTIDES 464
I. GENERAL BACKGROUND 464
II. A-CONOTOXINS 465
1. A-CONOTOXIN MI
L 465
2. A-CONOTOXIN IM
L 467
3. A-CONOTOXIN AUIB 469
4. A-CONOTOXINS PNLA/PNI
B AND ANALOGS 469
5. A-CONOTOXIN EPI 469
6. A-CONOTOXIN MI 470
F. CONCLUSION AND FUTUR
E PROSPECTS 470
REFERENCES 470
CHAPTE
R 18
NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN NON-NEURONAL CELLS,
EXPRESSION AND RENATURATION OF LIGAND BINDING DOMAIN, AND
MODULATORY CONTROL BY ALLOSTERICALLY ACTING LIGANDS
A.
MAELICKE,
A.
SCHRATTENHOLZ,
AND E.X.
ALBUQUERQUE.
WITH 4 FIGURES 477
A. INTRODUCTION 477
B. EXPRESSION OF NEURONAL NICOTINIC RECEPTORS IN MAMMALIAN
MUSCLE AND TEGUMENTAL CELLS 478
C. ECTOPICALLY EXPRESSED N-TERMINAL EXTRACELLULAR DOMAIN OF
NACHR
A
SUBUNIT 481
D. MODULATORY CONTROL OF NICOTINIC RECEPTORS BY ALLOSTERICALLY
ACTING LIGANDS 483
E. ALLOSTERIC MODULATORS AS DRUG CANDIDATES 487
F. CONCLUDING REMARKS 490
REFERENCES 490
CONTENTS XXV
CHAPTER 19
INSECT NICOTINIC ACETYLCHOLINE RECEPTORS: GENES, STRUCTURE,
PHYSIOLOGICAL AND PHARMACOLOGICAL PROPERTIES
E.D
.
GUNDELFINGER
AN
D R.
SCHULZ
.
WITH 4 FIGURES 497
A
. INTRODUCTIO
N 497
B. IDENTIFIED SUBUNIT
S OF INSECT NACHR
S 498
I. MOLECULA
R CLONING OF INSEC
T NACH
R GENE
S AND
CDNA
S 498
II
. DISTRIBUTIO
N PATTER
N OF IDENTIFIED NACH
R SUBUNIT
S IN TH
E
CNS 504
III
. EFFORTS T
O STUDY SUBUNIT ASSEMBLY 506
1. PURIFICATION OF A-BGT-BINDING RECEPTO
R COMPLEXES 506
2. CORRELATIO
N OF CLONED SUBUNITS WITH A-BGT BINDING
SITES 507
3. CHARACTERIZATIO
N OF CLONE
D SUBUNIT
S BY FUNCTIONA
L
EXPRESSIO
N IN HETEROLOGOU
S SYSTEMS 508
C. PHYSIOLOGY AN
D PHARMACOLOGY OF NATIVE INSECT NACHR
S 510
I. ELECTROPHYSIOLOGICAL CHARACTERIZATIO
N OF INSECT NEURONA
L
RECEPTOR
S 511
II
. NICOTINIC RECEPTOR
S AS TARGETS FOR INSECTICIDES 512
D. NICOTINIC RECEPTOR
S OF OTHE
R INVERTEBRATE
S 513
E
. CONCLUSIONS AND PERSPECTIVES 515
REFERENCE
S 516
SECTION V: THE ROLE OF NICOTINIC ACETYLCHOLINE RECEPTORS IN
NEURONAL FUNCTIONS
CHAPTER 20
KNOCKOUT MICE AS ANIMAL MODELS FOR STUDYING NICOTINIC
ACETYLCHOLINE RECEPTOR FUNCTION
L.M.
MARUBIO
AND J.-P.
CHANGEUX
525
A
. INTRODUCTIO
N 525
B. USING KNOCKOU
T MICE AS MODELS 525
C. KNOCKOU
T OF MUSCLE NACH
R SUBUNITS 526
D. THE PHARMACOLOG
Y OF NEURONA
L NACHR
S REVEALE
D USING
KNOCKOU
T MICE: THE INCOMPLET
E STORY 530
E. BEHAVIOURA
L ANALYSIS OF KNOCKOU
T MICE 533
F. CONCLUSIONS AND FUTUR
E DIRECTION
S 534
REFERENCE
S 535
XXVI CONTENTS
CHAPTE
R 21
NONINVASIVE EXPLORATION OF NICOTINIC ACETYLCHOLINE RECEPTORS
IN VIVO
A.
NORDBERG.
WITH 8 FIGURES 539
A. INTRODUCTION 539
I. IN VITRO RECEPTOR BINDING STUDIES 539
II. IN VIVO AND EX VIVO STUDIES 540
III
. FUNCTIONAL BRAIN IMAGING 540
B. NACHR LIGANDS FOR PE
T AND SPECT STUDIES 541
C. IN VIVO [
N
C]NICOTINE BINDING IN HUMAN BRAIN 545
I. QUANTIFICATION OF NICOTINE BINDING USING K*
2
RATE
CONSTANT 546
D. [
N
C]NICOTINE BINDING IN THE BRAIN OF SMOKERS 549
E. PE
T STUDIES OF NACHRS IN ALZHEIMER S DISEASE 549
I. VISUALIZATION OF NACHRS IN ALZHEIMER PATIENTS 549
II. EFFECT OF DRUG TREATMENT ON NACHRS IN ALZHEIMER
PATIENTS AS STUDIED BY PE
T 550
1. GROWTH FACTORS 551
2. ONDANSETRON 552
3. CHOLINESTERASE INHIBITORS 553
F. CONCLUSIONS 554
REFERENCES 555
CHAPTE
R 22
GENETIC REGULATION OF NICOTINE-RELATED BEHAVIORS AND BRAIN
NICOTINIC RECEPTORS
J.A.
STITZEL,
S.S.
LEONARD,
AND A.C.
COLLINS
563
A. INTRODUCTION 563
B. HUMAN TOBACCO USE 563
I. GENETICS OF SMOKING 563
II. POTENTIAL MECHANISMS FOR GENETIC INFLUENCES ON
SMOKING 564
C. ANIMAL STUDIES OF ACUTE NICOTINE SENSITIVITY 566
I. GENETICS OF ACUTE SENSITIVITY 566
1. INBRED STRAIN ANALYSES OF ACUTE SENSITIVITY TO
NICOTINE 566
2. ANALYSIS OF ACUTE SENSITIVITY TO NICOTINE USING GENETIC
CROSSES 567
3. POTENTIAL ROLE FOR NACHRS IN REGULATING ACUTE
SENSITIVITY TO NICOTINE 568
II. GENETIC INFLUENCES ON THE DEVELOPMENT OF TOLERANCE TO
NICOTINE 569
1. COMPARISONS OF TOLERANCE DEVELOPMENT USING INBRED
MOUSE STRAINS 569
CONTENTS XXVII
2. ROL
E OF CHANGE
S IN NACH
R NUMBER
S IN TOLERANCE
DEVELOPMEN
T 570
III
. ANIMA
L STUDIES OF REINFORCING EFFECTS OF NICOTINE 571
1. GENETIC
S OF ORA
L SELF-ADMINISTRATION 571
2. GENETI
C INFLUENCES ON CONDITIONE
D PLACE
PREFERENC
E 572
D. TOBACCO US
E AND PSYCHOPATHOLOGY 572
I. PREVALENC
E OF TOBACCO US
E AMON
G TH
E MENTALLY
111 572
II
. BRAI
N NACH
R BINDING IN SCHIZOPHRENICS 574
III
. ANIMA
L MODEL
S OF AUDITOR
Y GATIN
G 574
E
. GENETIC
S OF NICOTINIC RECEPTOR
S AN
D SEIZURE DISORDER
S 575
I. HUMA
N STUDIES 575
1. THE A
4 NACH
R AND SEIZURE DISORDER
S 575
2. TH
E A
7 GEN
E AN
D SEIZURE DISORDER
S 576
II
. ANIMA
L STUDIES 576
1. NATURALL
Y OCCURRING SEIZURES 576
2. NICOTINE-INDUCE
D SEIZURES 577
F. SUMMARY AN
D CONCLUSIONS 579
REFERENCE
S 579
CHAPTE
R 23
THE ROLE OF NICOTINIC ACETYLCHOLINE RECEPTORS IN COGNITIVE FUNCTION
E.D
.
LEVIN.
WITH 3 FIGURES 587
A
. INTRODUCTIO
N 587
I. EFFECTS IN HUMAN
S 587
II
. LABORATOR
Y ANIMAL
S 588
III
. TH
E NEURA
L BASIS OF NICOTINIC EFFECTS ON COGNITION 589
IV. NEUROTRANSMITTE
R INTERACTION
S 592
B. THERAPEUTI
C POSSIBILITIES 593
I. ALZHEIMER
S DISEAS
E 594
II
. ATTENTIO
N DEFICIT/HYPERACTIVITY DISORDE
R 594
III
. SCHIZOPHRENI
A 594
C. SUMMAR
Y AN
D CONCLUSIONS 594
REFERENCE
S 595
CHAPTE
R 24
BEHAVIOURAL PHARMACOLOGY AND NEUROBIOLOGY OF NICOTINE REWARD
AND DEPENDENCE
G. DI
CHIARA.
WITH 12 FIGURES 603
A
. INTRODUCTIO
N 603
I. DEFINING DEPENDENC
E AN
D ADDICTIO
N 603
B. BEHAVIOURA
L STIMULUS EFFECTS OF NICOTINE 606
I. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTIN
E 607
XXVIII CONTENTS
1. ANIMA
L STUDIES 607
2. INTRACEREBRA
L SITE OF TH
E DISCRIMINATIV
E STIMULU
S
EFFECTS OF NICOTIN
E 610
3. ROL
E OF DOPAMIN
E IN TH
E DISCRIMINATIV
E STIMULU
S
EFFECTS OF NICOTIN
E 611
4. NICOTINE AS A DISCRIMINATIV
E STIMULUS IN HUMAN
S 614
5. TOLERANCE T
O TH
E DISCRIMINATIV
E STIMULU
S EFFECTS OF
NICOTIN
E 616
6. SUMMAR
Y 617
II
. MOTIVATIONA
L STIMULU
S EFFECTS OF NICOTIN
E 618
III
. AVERSIVE PROPERTIE
S OF NICOTIN
E 618
1. ANIMA
L STUDIES 619
2. HUMA
N STUDIES 621
3. SUMMAR
Y 622
IV. EFFECTS OF NICOTIN
E O
N OPERAN
T BEHAVIOU
R 622
1. INTRACRANIA
L SELF-STIMULATION 623
2. EFFECT OF NICOTIN
E ON OPERAN
T BEHAVIOU
R MAINTAINE
D
BY CONVENTIONA
L REINFORCER
S 624
V. NICOTIN
E SELF-ADMINISTRATIO
N 625
1. PHARMACOKINETI
C FACTOR
S 625
2. INTRAVENOU
S SELF-ADMINISTRATIO
N 626
3. NICOTIN
E ANTAGONIST
S O
N NICOTIN
E SELF-ADMINISTRATIO
N
IN ANIMAL
S 632
4. EXTINCTIO
N OF NICOTIN
E SELF-ADMINISTRATIO
N 632
5. ROL
E OF DOPAMIN
E IN NICOTIN
E SELF-ADMINISTRATIO
N ...
. 636
6. HUMA
N STUDIES 639
7. REINSTATEMEN
T OF DRU
G SELF-ADMINISTRATIO
N AS A MODE
L
OF CRAVING 639
8. REINSTATEMEN
T OF INTRAVENOU
S NICOTIN
E SELF
ADMINISTRATIO
N 640
9. ORA
L NICOTIN
E SELF-ADMINISTRATIO
N 643
10. SMOKING IN ANIMAL
S 644
11. NICOTIN
E INTRAVENOU
S SELF-ADMINISTRATIO
N IN
HUMAN
S 645
12. NICOTIN
E SELF-ADMINISTRATIO
N BY NASA
L SPRAY IN
HUMAN
S 646
13. NICOTIN
E AS TH
E REINFORCIN
G PRINCIPLE OF TOBACC
O
SMOK
E 648
14. ROL
E OF PERIPHERA
L AN
D NON-NICOTIN
E FACTORS IN
TOBACC
O SMOKIN
G 649
15. NICOTIN
E SELF-ADMINISTRATIO
N IN ANIMAL
S AS A MODE
L OF
HUMA
N NICOTIN
E ADDICTIO
N 650
VI
. CONDITIONE
D PLACE-PREFERENC
E 654
C. LOCOMOTIO
N 656
I. NEURA
L MECHANIS
M 659
CONTENTS XXIX
D. LATEN
T INHIBITIO
N AN
D PRE-PULS
E INHIBITIO
N 660
E
. ADAPTATIO
N T
O NICOTINE 661
I. TOLERANCE AN
D SENSITIZATION 662
1. ACUT
E TOLERANCE 662
2. CHRONI
C TOLERANCE AN
D SENSITIZATION 663
3. CELLULAR BASIS OF ADAPTATIO
N T
O NICOTINE 664
4. NICOTIN
E RECEPTO
R UPREGULATIO
N 665
5. BIOCHEMICAL CORRELATE
S OF NICOTINE TOLERANCE IN
HUMAN
S 667
6. BEHAVIOURA
L TOLERANCE 667
7. ACUT
E AND CHRONI
C TOLERANCE T
O NICOTINE IN
HUMAN
S 668
8. ROL
E OF TOLERANCE T
O NICOTINE IN TOBACCO SMOKING ...
. 670
9. ROL
E OF SENSITIZATION 672
II
. PHYSIOLOGICAL DEPENDENC
E ON AND WITHDRAWAL FROM
NICOTIN
E 672
1. ANIMA
L STUDIE
S 673
2. WITHDRAWA
L FROM NICOTIN
E IN HUMAN
S 676
3. ROL
E OF PHYSIOLOGICAL DEPENDENC
E IN TOBACCO
SMOKING 678
F. NEUROCHEMICA
L AND NEUROPHYSIOLOGICAL ACTION
S OF NICOTINE
RELATE
D T
O ADDICTIO
N 680
I. DOPAMIN
E 680
1. EXPRESSIO
N OF NACHR
S BY DOPAMIN
E NEURON
S 681
2. IN VITR
O DOPAMIN
E RELEAS
E STUDIES 682
3. IN VIVO AN
D EX VIVO STUDIES 684
4. ELECTROPHYSIOLOGICAL EFFECTS OF NICOTINE ON DOPAMIN
E
NEURON
S 688
5. ROL
E OF A7-CONTAININ
G NACHR
S AN
D OF GLUTAMAT
E ...
. 689
6. ADAPTIV
E CHANGES OF DOPAMIN
E TRANSMISSION AFTER
NICOTIN
E EXPOSUR
E 690
7. DESENSITIZATIO
N 691
8. DESENSITIZATIO
N OF SOMATO-DENDRITI
C NACHR
S ON
DOPAMIN
E NEURON
S 692
9. INACTIVATIO
N OF SOMATO-DENDRITI
C NACHR
S ON
DOPAMIN
E NEURON
S 692
10. TOLERANCE AN
D DEPENDENC
E OF DOPAMIN
E
TRANSMISSION 693
11. SENSITIZATION OF DOPAMIN
E TRANSMISSION T
O
NICOTINE 698
12. RELATIONSHI
P BETWEEN STIMULATION OF IN VIVO
DOPAMIN
E TRANSMISSION BY NICOTINE AND
BEHAVIOU
R 701
II
. NORADRENALIN
E 704
III
. SEROTONI
N 706
CONTENTS
IV. OPIOID PEPTIDES
7()
6
V. AMINO ACID TRANSMITTERS 708
VI. IMMEDIATE/EARLY GENES 708
G. A MODEL OF NICOTINE DEPENDENCE BY TOBACCO SMOKING 710
REFERENCES
5
CHAPTER 25
INVOLVEMENT OF NEURONAL NICOTINIC RECEPTORS IN DISEASE
F.
CLEMENTI,
J.
COURT,
AND E.
PERRY
751
A. INTRODUCTION 751
B. DISEASES AFFECTING THE NERVOUS SYSTEM 751
I. DEVELOPMENTAL DISORDERS 751
1. TOURETTE S SYNDROME 751
2. SCHIZOPHRENIA 752
II
. AGE-INDEPENDENT DISORDERS 753
1. EPILEPSY 753
2. HEAD INJURY 754
3. DEPRESSION 754
4. ALCOHOLISM 754
III. AGE-RELATED DEGENERATIVE DISEASES OF THE BRAIN 754
1. AGING 754
2. ALZHEIMER S AND PARKINSON S DISEASES - CORTICAL
INVOLVEMENT 755
3. DEMENTIA WITH LEWY BODIES AND PARKINSON S DISEASE -
SUBCORTICAL INVOLVEMENT 757
4. EVIDENCE FOR AN AETIOPATHOLOGICAL ROLE FOR NACHR IN
ALZHEIMER S AND PARKINSON
S DISEASES BASED ON HUMAN
PATHOLOGY AND TOBACCO USE 758
5. SYMPTOMATIC BENEFIT OF NICOTINIC AGONISTS 760
IV. PATHOLOGIES IN NON-NEURONAL TISSUES AND CELLS 761
1. LUNG CELLS 761
A) SMALL CELL LUNG CARCINOMA 761
B) OTHER LUNG CELLS 762
2. VASCULAR SMOOTH MUSCLE AND ENDOTHELIAL CELLS 762
3. HYPERTENSION 763
4. KERATINOCYTES 764
5. INTESTINAL EPITHELIUM 765
6. LYMPHOCYTES 765
C. CONCLUSION 766
REFERENCES 767
CONTENTS XXXI
CHAPTE
R 26
CLINICAL ASPECTS OF NICOTINIC AGENTS: THERAPEUTIC APPLICATIONS IN
CENTRAL NERVOUS SYSTEM DISORDERS
PA
.
NEWHOUS
E
AND M.
KELTON
779
A
. INTRODUCTIO
N 779
B. PHARMACOKINETIC
S AN
D PHARMACODYNAMIC
S 781
C. COGNITIVE AN
D BEHAVIORA
L EFFECTS OF NICOTINE IN HUMAN
S 782
D. POTENTIA
L CLINICAL APPLICATION
S 783
I. MOVEMEN
T DISORDER
S 783
1. PARKINSON
S DISEAS
E 783
2. TOURETTE
S SYNDROME 785
3. OTHE
R MOVEMEN
T DISORDER
S 786
II
. COGNITIVE DISORDER
S 787
1. NICOTINIC INVOLVEMEN
T IN THE REGULATIO
N OF COGNITIVE
PROCESSES 787
2. ALZHEIMER
S DISEASE 788
A) STUDIES OF NICOTINIC ANTAGONIST
S IN ALZHEIMER
S
DISEAS
E 790
B
) STUDIES OF NICOTINIC AGONISTS IN ALZHEIMER
S
DISEAS
E 791
3. PARKINSON
S DISEAS
E 793
4. NICOTINIC SYSTEM INVOLVEMEN
T IN TH
E COGNITIVE
DISORDER
S OF TH
E CORTICAL DEMENTIAS
: SYNTHESIS AND
THERAPEUTI
C MODEL 795
5. SCHIZOPHRENIA 796
6. ATTENTIO
N DEFICIT HYPERACTIVIT
Y DISORDE
R 798
III
. OTHE
R POTENTIA
L CLINICAL APPLICATION
S 799
1. ANALGESIA 799
2. CYTOPROTECTIO
N 800
3. SMOKING CESSATION 802
4. ANXIETY/DEPRESSIO
N 802
5. EPILEPSY 803
E
. FURTHE
R DIRECTION
S 803
REFERENCE
S 804
SUBJECT INDE
X 813
|
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| callnumber-search | QP905 |
| callnumber-sort | QP 3905 |
| callnumber-subject | QP - Physiology |
| classification_rvk | XI 1701 |
| ctrlnum | (OCoLC)43555027 (DE-599)BVBBV013227263 |
| dewey-full | 612.8/042 615/.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology 615 - Pharmacology and therapeutics |
| dewey-raw | 612.8/042 615/.1 |
| dewey-search | 612.8/042 615/.1 |
| dewey-sort | 3612.8 242 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV013227263 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:42:04Z |
| institution | BVB |
| isbn | 3540661239 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009014353 |
| oclc_num | 43555027 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 DE-19 DE-BY-UBM DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-12 DE-19 DE-BY-UBM DE-188 DE-578 |
| physical | XXXI, 821 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Neuronal nicotinic receptors [with 22 tables] contributors E. X. Albuquerque ... Ed. F. Clementi ... Berlin [u.a.] Springer 2000 XXXI, 821 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 144 Nicotinic Receptors cabt Neurons cabt Neuronen gtt Nicotine gtt Receptoren gtt Nicotinic receptors Receptors, Nicotinic Nervenzelle (DE-588)4041649-5 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Nicotin (DE-588)4131089-5 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Nicotinischer Acetylcholinrezeptor (DE-588)4316564-3 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nicotinischer Acetylcholinrezeptor (DE-588)4316564-3 s Pharmakologie (DE-588)4045687-0 s DE-604 Physiologie (DE-588)4045981-0 s Nervenzelle (DE-588)4041649-5 s Nicotin (DE-588)4131089-5 s Rezeptor (DE-588)4049722-7 s Clementi, Francesco 1936- Sonstige (DE-588)12173420X oth Albuquerque, Edson X. Sonstige (DE-588)122195248 oth Handbook of experimental pharmacology 144 (DE-604)BV002390716 144 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009014353&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neuronal nicotinic receptors [with 22 tables] Handbook of experimental pharmacology Nicotinic Receptors cabt Neurons cabt Neuronen gtt Nicotine gtt Receptoren gtt Nicotinic receptors Receptors, Nicotinic Nervenzelle (DE-588)4041649-5 gnd Rezeptor (DE-588)4049722-7 gnd Nicotin (DE-588)4131089-5 gnd Physiologie (DE-588)4045981-0 gnd Nicotinischer Acetylcholinrezeptor (DE-588)4316564-3 gnd Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4041649-5 (DE-588)4049722-7 (DE-588)4131089-5 (DE-588)4045981-0 (DE-588)4316564-3 (DE-588)4045687-0 (DE-588)4143413-4 |
| title | Neuronal nicotinic receptors [with 22 tables] |
| title_auth | Neuronal nicotinic receptors [with 22 tables] |
| title_exact_search | Neuronal nicotinic receptors [with 22 tables] |
| title_full | Neuronal nicotinic receptors [with 22 tables] contributors E. X. Albuquerque ... Ed. F. Clementi ... |
| title_fullStr | Neuronal nicotinic receptors [with 22 tables] contributors E. X. Albuquerque ... Ed. F. Clementi ... |
| title_full_unstemmed | Neuronal nicotinic receptors [with 22 tables] contributors E. X. Albuquerque ... Ed. F. Clementi ... |
| title_short | Neuronal nicotinic receptors |
| title_sort | neuronal nicotinic receptors with 22 tables |
| title_sub | [with 22 tables] |
| topic | Nicotinic Receptors cabt Neurons cabt Neuronen gtt Nicotine gtt Receptoren gtt Nicotinic receptors Receptors, Nicotinic Nervenzelle (DE-588)4041649-5 gnd Rezeptor (DE-588)4049722-7 gnd Nicotin (DE-588)4131089-5 gnd Physiologie (DE-588)4045981-0 gnd Nicotinischer Acetylcholinrezeptor (DE-588)4316564-3 gnd Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Nicotinic Receptors Neurons Neuronen Nicotine Receptoren Nicotinic receptors Receptors, Nicotinic Nervenzelle Rezeptor Nicotin Physiologie Nicotinischer Acetylcholinrezeptor Pharmakologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009014353&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT clementifrancesco neuronalnicotinicreceptorswith22tables AT albuquerqueedsonx neuronalnicotinicreceptorswith22tables |