Environmental endocrine disrupters: an evolutionary perspective
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Taylor & Francis
2000
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 355 S. graph. Darst. |
| ISBN: | 1560325712 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Preface jx
Acknowledgments x
Chapter 1: Endocrine Disrupting Contaminants and 1
Hormone Dynamics: Lessons from Wildlife
D. Andrew Crain, Andrew A. Rooney, Edward F. Orlando,
and Louis J. Guiilette, Jr.
Introduction 1
EDCs and Hormone Production 2
EDCs and Hormone Availability 6
EDCs and Hormone Action 7
EDCs and Hormone Excretion and Biotransformation 11
Summary and Conclusions 14
References 15
Chapter 2: The Importance of Comparative Endocrinology 22
in Examining the Endocrine Disrupter Problem
Tyrone B. Hayes
Introduction 22
Evidence for Endocrine Disruption 23
Role of Sex Steroids, Glucocorticoids, and Thyroid Hormones 25
Regulation of Sex Steroid, Glucocorticoid, and Thyroid 28
Hormone Synthesis, Secretion, Action, and Degradation
The Need for Comparative Studies 3 5
Conclusion 37
References 37
Chapter 3: Bioaccumulation, Storage, and Mobilization 52
of Endocrine Altering Contaminants
Charles F. Facemire
Introduction 52
Bioavailability 53
Bioaccumulation, Bioconcentration, and Biomagnification 55
Storage in Adipose Tissue 59
Biotransformation 66
Xenobiotic Lipids 66
Mobilization 68
References 71
Chapter 4: Contaminant Interactions with Steroid Receptors: 82
Evidence for Receptor Binding
Andrew A. Rooney and Louis J. Guillette, Jr.
Introduction 82
vi Contents
Typical Steroid/Receptor Interactions 83
Steroid/Receptor Interactions—Other Factors 83
Endocrine Disrupting Contaminants/Receptor Effects 90
Factors Affecting Endocrine Disrupting 93
Contaminants/Receptor Interactions
Conclusion 114
References 115
Chapter 5: Steroid Hormone Regulated Processes 126
in Invertebrates and their Susceptibility
to Environmental Endocrine Disruption
Gerald A. LeBlanc
Introduction 126
Steroid Hormones in Invertebrates 128
Function of Vertebrate Type Sex Steroid 133
Hormones in Invertebrates
Terpenoids 135
Phylogenic Analysis of Steroid Hormone 136
Utilization by Invertebrates
Effects of Endocrine Disrupting Xenobiotics 138
on Invertebrates
Conclusions 144
Acknowledgment 144
References 144
Chapter 6: Contaminant Altered Thyroid Function in Wildlife 155
John F. Leatheriand
Introduction 155
Thyroid Hormone Homeostasis and Economy: 158
Potential Sites of Impact of Environmental Thyroid
Hormone Disrupting Toxicants
Principal Functions of the Thyroid Hormones Related 164
to the Potential for Actions of Environmental
Thyroid Hormone Disrupting Toxicants
Actions of Toxicants on Thyroid Hormone Homeostasis 165
and Economy
Thyroid Tumors in Wildlife Species as Indicators 171
of Environmental Antithyroid Agents
Summary and Conclusions 172
References 173
Chapter 7: Biomarkers of Immunotoxidty: An Evolutionary Perspective 182
Michel Fournier, Pauline Brousseau, Helen Tryphonas,
and Daniel Cyr
Introduction 182
Structure and Function of the Immune System 183
Influence of Hormones on the Immune System 185
Pollutant Immunotoxicity 190
Contents vii
Immunologic Biomarkers 191
Discussion—Possibilities 200
Conclusion 201
References 201
Chapter 8: Ethotoxicology: An Evolutionary Approach 217
to Behavioral Toxicology
Stefano ParmigLani, Paaila Palanza, and Frederick S. mm Saal
Introduction 217
Ethotoxicology 217
The Hormonal Control of Brain and Behavioral Development 218
What Is the Evidence for Effects of Endocrine Disruption 219
in Wildlife and Human Populations?
Estrogenic Endocrine Disrupters: Evolutionary 220
Conservation of Estrogen Receptors
The Fragile Fetus: Effects of Endocrine Disruptors 221
on Fetal Development
The House Mouse as a Model Animal for Studying 222
Endocrine Disruptors
Development of Sociosexual Behaviors and Accessory 223
Reproductive Organs in Mice Prenatally Exposed
to Estrogenic Endocrine Disruptors
The Merging of Ethopharmacology and Ethotoxicology 226
for Understanding the Neurochemical Effects
of Endocrine Disruptors
Summary 227
References 228
Chapter 9: Embryonic and Neonatal Exposure 234
to Endocrine Altering Contaminants:
Effects on Mammalian Female Reproduction
Taisen Iguchi
Introduction 234
Estrogen Receptor Interactions 235
Oncogene Expression 237
Growth Factor Expression 238
Steroidogenesis 239
Polyovular Follicles 240
Reduction of Fertilizability 242
Oviducal Effects on Embryos 243
Alterations of Decidual Reaction 245
Complications of Pregnancy 245
Mammary Gland Abnormalities 246
Perinatal Effects of Phytoestrogens 247
Perinatal Effects of Xenoestrogens 249
Abnormalities in Skeletal Tissue and Muscle 250
The Threat of Environmental Estrogens 251
Acknowledgments 252
References 252
viii Contents
Chapter 10: Endocrine Disruption in Male Human Reproduction 269
Jorma Toppari and Niels E. Skakkebask
Introduction 269
Semen Quality 270
Testicular Cancer 273
Cryptorchidism 276
Hypospadias 279
Prostatic Diseases 280
Male Breast Cancer 281
Conclusions 281
References 282
Chapter 11: Xenoestrogens in the Context of Cardnogenesis 291
Ana M. Sato and Carlos Sonnenschein
Introduction 291
Xenoestrogens 291
Neoplasia 293
Theories on the Mechanisms of Carcdnogenesis 294
Hormonal Cardnogenesis 296
Animal Models for Hormonal Cardnogenesis 301
Endocrine Disrupters and Neoplasia in Animal Models 307
Pestiddes and Breast Cancer 307
Conclusions 309
Acknowledgments 311
References 311
Chapter 12: An Anthropological Interpretation of Endocrine 322
Disruption in Children
Elizabeth A. GuiUette
Introduction 322
Reproductive Rights 323
Evaluating Risk 329
The Future 332
References 334
Index 339
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| spelling | Environmental endocrine disrupters an evolutionary perspective ed. by Louis J. Guillette ... New York [u.a.] Taylor & Francis 2000 X, 355 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Umwelttoxizität (DE-588)4577864-4 gnd rswk-swf Umweltchemikalie (DE-588)4117281-4 gnd rswk-swf Hormon (DE-588)4025864-6 gnd rswk-swf Antihormon (DE-588)4002285-7 gnd rswk-swf Gesundheitsgefährdung (DE-588)4071808-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hormon (DE-588)4025864-6 s Umweltchemikalie (DE-588)4117281-4 s Gesundheitsgefährdung (DE-588)4071808-6 s DE-604 Antihormon (DE-588)4002285-7 s Umwelttoxizität (DE-588)4577864-4 s Guillette, Louis J. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009013952&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Environmental endocrine disrupters an evolutionary perspective Umwelttoxizität (DE-588)4577864-4 gnd Umweltchemikalie (DE-588)4117281-4 gnd Hormon (DE-588)4025864-6 gnd Antihormon (DE-588)4002285-7 gnd Gesundheitsgefährdung (DE-588)4071808-6 gnd |
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| title | Environmental endocrine disrupters an evolutionary perspective |
| title_auth | Environmental endocrine disrupters an evolutionary perspective |
| title_exact_search | Environmental endocrine disrupters an evolutionary perspective |
| title_full | Environmental endocrine disrupters an evolutionary perspective ed. by Louis J. Guillette ... |
| title_fullStr | Environmental endocrine disrupters an evolutionary perspective ed. by Louis J. Guillette ... |
| title_full_unstemmed | Environmental endocrine disrupters an evolutionary perspective ed. by Louis J. Guillette ... |
| title_short | Environmental endocrine disrupters |
| title_sort | environmental endocrine disrupters an evolutionary perspective |
| title_sub | an evolutionary perspective |
| topic | Umwelttoxizität (DE-588)4577864-4 gnd Umweltchemikalie (DE-588)4117281-4 gnd Hormon (DE-588)4025864-6 gnd Antihormon (DE-588)4002285-7 gnd Gesundheitsgefährdung (DE-588)4071808-6 gnd |
| topic_facet | Umwelttoxizität Umweltchemikalie Hormon Antihormon Gesundheitsgefährdung Aufsatzsammlung |
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