The pharmacology of functional, biochemical, and recombinant receptor systems: [with 20 tables]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2000
|
| Schriftenreihe: | Handbook of experimental pharmacology
148 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 448 S. Ill., graph. Darst. |
| ISBN: | 3540661247 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV013189935 | ||
| 003 | DE-604 | ||
| 005 | 20140224 | ||
| 007 | t | ||
| 008 | 000530s2000 gw ad|| |||| 00||| eng d | ||
| 016 | 7 | |a 958733791 |2 DE-101 | |
| 020 | |a 3540661247 |9 3-540-66124-7 | ||
| 035 | |a (OCoLC)43854053 | ||
| 035 | |a (DE-599)BVBBV013189935 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c DE | ||
| 049 | |a DE-355 |a DE-12 |a DE-19 |a DE-188 |a DE-578 | ||
| 050 | 0 | |a QP905 | |
| 050 | 0 | |a RM301.41 | |
| 082 | 0 | |a 615/.7 |2 21 | |
| 084 | |a XI 1701 |0 (DE-625)152977:12907 |2 rvk | ||
| 084 | |a YI 1701 |0 (DE-625)153607:12907 |2 rvk | ||
| 084 | |a QV 4 |2 nlm | ||
| 245 | 1 | 0 | |a The pharmacology of functional, biochemical, and recombinant receptor systems |b [with 20 tables] |c contributors J. A. Angus ... Ed.: T. Kenakin ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2000 | |
| 300 | |a XX, 448 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 148 | |
| 650 | 7 | |a Receptors |2 cabt | |
| 650 | 7 | |a Drug |2 cabt | |
| 650 | 7 | |a Pharmaceutical Preparations |2 cabt | |
| 650 | 7 | |a Farmacologie |2 gtt | |
| 650 | 7 | |a Receptoren |2 gtt | |
| 650 | 4 | |a Récepteurs de médicaments - Recherche - Méthodologie | |
| 650 | 4 | |a Dose-Response Relationship, Drug | |
| 650 | 4 | |a Drug receptors |x Research |x Methodology | |
| 650 | 4 | |a Pharmaceutical Preparations |x metabolism | |
| 650 | 4 | |a Receptors, Cell Surface |x drug effects | |
| 650 | 4 | |a Receptors, Drug |x physiology | |
| 650 | 4 | |a Technology, Pharmaceutical |x methods | |
| 650 | 0 | 7 | |a Arzneimittelrezeptor |0 (DE-588)4305233-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Rezeptor |0 (DE-588)4049722-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pharmakologie |0 (DE-588)4045687-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Rezeptor |0 (DE-588)4049722-7 |D s |
| 689 | 0 | 1 | |a Pharmakologie |0 (DE-588)4045687-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Arzneimittelrezeptor |0 (DE-588)4305233-2 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Kenakin, Terrence P. |d 1949- |e Sonstige |0 (DE-588)121921239 |4 oth | |
| 700 | 1 | |a Angus, James A. |d 1949- |e Sonstige |0 (DE-588)121921247 |4 oth | |
| 830 | 0 | |a Handbook of experimental pharmacology |v 148 |w (DE-604)BV002390716 |9 148 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008988399&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008988399 | ||
Datensatz im Suchindex
| _version_ | 1804127892783759360 |
|---|---|
| adam_text | Contents
Introduction: Bioassays Past Uses and Future Potential
J.W. Black 1
Section I: Classical Pharmacology and Isolated Tissue Systems
CHAPTER 1
Human Vascular Receptors in Disease: Pharmacodynamic Analyses in
Isolated Tissue
J.A. Angus. With 25 Figures 15
A. Introduction 15
B. Receptors Mediating Coronary Artery Contraction: Role in
Variant Angina 16
I. Large Coronary Arteries 16
1. Ergometrine 16
2. 5 HT and Endothelium Derived Relaxing Factor 16
II. Small Resistance Arteries 21
III. Summary and Future Work 27
C. Vascular Reactivity in Human Primary Hypertension and
Congestive Heart Failure 28
I. The Technique, Function and Structure 28
II. Remodelling 29
III. Endothelial Dysfunction 31
IV. Forearm Veins in Primary Hypertension 33
V Chronic Heart Failure 34
D. Pharmacology of Vascular Conduits for Coronary Bypass
Graft Surgery 37
I. Introduction 37
II. Internal Mammary Artery 38
III. Saphenous Vein 41
E. Human Vascular to Cardiac Tissue Selectivity of L and T Type
VOCC Antagonists 41
References 47
I
XII Contents i
CHAPTER 2 j
Problems in Assigning Mechanisms: Reconciling the Molecular and
Functional Pathways in a Adrenoceptor Mediated Vasoconstriction
M.J. Lew. With 6 Figures 51
A. Introduction 51
B. Coupling Mechanisms at the Molecular and Cellular Levels 52
I. a, Adrenoceptors 52
II. a2 Adrenoceptors 54
C. Coupling Mechanisms in the Intact Animal 56
D. Reconciliation 59
E. Myogenic Activation 61
F. Autocrine and Paracrine Activation 62
G. Functional Antagonism 64
H. Adenylate Cyclase and a2 Adrenoceptors 66
I. Conclusions 68
References 69
CHAPTER 3
Gs Protein Coupled Receptors in Human Heart
A.J. Kaumann. With 10 Figures 73
A. Introduction 73
B. Receptor Subtypes 73
C. j3 Adrenoceptor Subtypes 74
I. Comparison of /3p and /Ji Adrenoceptors 74
1. Localisation 74
2. Function of /?, and ft Adrenoceptors 74
3. Selective Coupling of /^ Adrenoceptors 75
D. Is There a Functional role for Cardiac /J, Adrenoceptors? 80
I. Evidence Against Cardiostimulation 80
II. Evidence for Cardiostimulation 81
III. Evidence for Cardiodepression 81
IV. Evidence Against Cardiodepression 82
E. Cardiostimulant Effects Through the Putative /34 Adrenoceptor... 82
I. Non Conventional Partial Agonists 82
II. The Putative j34 Adrenoceptor Resembles But Is Distinct
from the /J, Adrenoceptor 84
III. Which Endogenous Agonist for the Putative /J4
Adrenoceptor? 87
IV. The Putative ^ Adrenoceptor is a Special State
of the /3rAdrenoceptor 88 ;
F 5 HT4 Receptors 90 :
I. Coupling to a cAMP Pathway 90 |
II. 5 HT4 like Receptors 91
Contents XIII
G. Cross Talk Between Cardiac Gs Coupled Receptors, as
Revealed by Chronic Blockade of /3rAdrenoceptors 95
H. Physiological, Pathophysiological and Therapeutic Relevance .... 101
I. pr and /^ Adrenoceptors 101
II. Putative /J4 Adrenoceptors 105
III. 5 HT4 Receptors 105
I. Epilogue 107
References 108
Section II: New Theoretical Concepts and Molecular Mechanisms of
Receptor Function
CHAPTER 4
Kinetic Modeling Approaches to Understanding Ligand Efficacy
J.J. Lindurman. With 19 Figures 119
A. Introduction 119
B. Background 120
I. Efficacy 120
II. Modeling 121
1. Equilibrium, Steady State, and Kinetic Models 122
2. Diffusion Versus Reaction Controlled Events 123
3. Model Structures and Dose Response Curves 124
C. Parameters Contributing to Ligand Efficacy 126
I. The Lifetime of the Individual Receptor Ligand Complex
(llkT) 126
II. The Receptor Desensitization Rate Constant k% 131
III. The Ligand Binding and Dissociation Rate Constants at
Endosomal pH 134
IV. Rate Constants in a Ternary Complex Model 139
D. Concluding Remarks 143
References 144
CHAPTER 5
The Evolution of Drug Receptor Models: The Cubic Ternary
Complex Model for G Protein Coupled Receptors
T. Kenakin. P. Morgan, M. Lutz. and J. Wkiss. With 7 Figures 147
A. Receptor Models 147
B. The Ternary Complex Model of Receptor Function 148
C. Two State Theory 149
D. The Extended Ternary Complex Model 151
E. The CTC Model 152
;
Xiv Contents i
E General Application of the Cubic Model 155 J
I. Evidence for the AriG Complex 158
G. Conclusion 163 ;
References 163 ;
CHAPTER 6
Inverse Agonism
R. Bond, G. Milligan, and M. Bouvier 167
A. Background 167
B. Overexpression, Spontaneous Activity and Inverse Agonism .... 168
C. Mutations and Diseases of Spontaneous Receptor Activity 173
D. Modulation of Receptor Function by Agonists and
Inverse Agonists 174
E. Models 177
F. Summary and Conclusions 178
References 178
CHAPTER 7
Efficacy: Molecular Mechanisms and Operational Methods of
Measurement. A New Algorithm for the Prediction of Side Effects
T. Kenakin. With 17 Figures 183
A. Introduction 183
B. The Molecular Nature of Efficacy 183
C. Positive and Negative Efficacy 186
D. The Operational Measurement of Relative Efficacy 188
I. Binding Studies 188
1. Guanosine Triphosphate yS Shift 188
2. High Affinity Selection Binding 191
II. Function 192
1. The Method of Furchgott 195
2. The Method of Stephenson 196
3. Comparison of Relative Maximal Responses 197
E. Limitations of Agonist Potency Ratios 201
F. Why Measure the Relative Efficacies of Agonists? 204
G. A Simple Algorithm for the Prediction of Agonist Side Effects
Using Efficacy and Affinity Estimates 206
I. Therapeutic Versus Secondary Agonism: Side Effect Versus
Coupling Constant Profiles 208
II. Algorithm for Calculation of Relative /35O 210 !
III. Application of the Algorithm to /J, Adrenoceptor t
Agonists 212 J
IV. Limitations of the Algorithm 214
Contents XV
H. Conclusions 215
References 215
CHAPTER 8
A Look at Receptor Efficacy. From the Signalling Network of
the Cell to the Intramolecular Motion of the Receptor
H.O. Onaran, A. Scheer, S. Cotecchia, and T. Costa.
With 12 Figures 217
A. Introduction 217
B. Biological Receptors and the Dualism of Affinity and Efficacy ... 217
I. Signal Transfer and Conformational Change in Membrane
Receptor 217
II. The Distinction Between Affinity and Efficacy 218
III. Generality of the Concept of Efficacy in Functional
Proteins 21l)
IV. Asking the Questions 219
V. Two Flavours in the Definition of Efficacy:
Biological and Molecular 220
C. Biological Definitions of Efficacy 221
I. The Nature of Signal Strength 221
II. Stimulus Response Relationships 222
III. The Scale of Agonism and Antagonism 223
IV. Steps of Signal Transduction and the Indeterminacy of
Stimulus Response Relationships 225
D. Molecular Definitions of Efficacy 227
I. A Molecular Link Between Affinity and Efficacy 227
II. Allosteric Equilibrium. Free Energy Coupling, and
Thermodynamic Definitions of Efficacy 227
III. Linkage Between Macroscopic Perturbations in the
Receptor 231
IV. Functional and Physical States in Proteins 233
V. Microscopic Interpretation of Allosteric Equilibrium 235
E. A Stochastic Model of Molecular Efficacy 238
I. Protein Motion and Fluctuations in Its Conformational
Space 238
II. Probability Distribution of Microscopic States and
Derivation of Macroscopic Constants 238
III. Probabilistic Interpretation of Ligand Efficacy 241
IV. Relationship Between Physical States and Biological
Function 244
V. Relationship Between Efficacy and Fluorescence Changes in
/JrAdrenoceptors 244
VI. Correlated Macroscopic Changes in Constitutively Active
Adrenoceptors 248
References 254
XVI Contents
CHAPTER 9
Mechanisms of Non Competitive Antagonism and Co Agonism
D.G. Trist and M. Corsi. With 9 Figures 261
A. Non Competitive Antagonism 261
I. Definition 261
II. Analysis of the Effect of Non Competitive Antagonists 261
B. Co Agonism 267
I. Theory as Applied to the Glutamate NMDA Receptor 267
1. Evidence for Co Agonism 267
2. The Theory of Co Agonism 268
3. The Effect of Competitive Antagonism on Co Agonism... 271
4. The Effect of a Non Competitive Antagonist on
the Response of Co Agonists 273
II. Experimental Data Supporting the Concept of Co Agonism
and Its Antagonism 274
1. Recombinant Experiments 274
2. Tissue Experiments 276
III. Implications of Co Agonism 278
C. General Observations 279
References 280
CHAPTER 10
Mechanisms of Receptor Activation and the Relationship to
Receptor Structure
D.M. Perez and S.S. Karnik. With 2 Figures 283
A. Introduction 283
B. Common GPCR Structure/Function 283
C. Rhodopsin and bR Activation: Light as the Ligand 286
I. Direct Structural Information 287
II. The Activation Mechanism 288
1. How Retinal Binds 288
2. Salt Bridge Constraining Factor: Movement of TM3 and
TM6 289
D. AR Activation: Small Organics as Ligands 291
I. Important Binding Contacts of the Endogenous Ligands .... 291
II. Insights on How Epinephrine Activates 293
1. Release of Constraining Factors 293
2. Evidence for a Salt Bridge as a Constraint: Movement of
TM3 and TM7 294
3. Evidence for Multiple Activation States or Mechanisms ... 296
4. Evidence for Additional Constraining Factors: Movement
of TM5 and TM6 296
E. Angiotensin Receptor Activation: Peptides as Ligands 298
Contents XVII
I. Peptide Hormone GPCRs: How the Peptide Binds 298
II. The Ang II Receptor 298
III. How Angll Peptides and Non Peptides Bind 299
IV. Insights into Angll Activation 300
1. Role of His256 in TM6 300
2. Release of Constraining Factors: Role of TM3 300
F. The Ties that Bind: Concluding Remarks 302
I. Conservation of Critical Binding Contacts and Resulting
Helical Movements 302
II. Conservation of Switches that Control Attainment of the
Active State(s) 302
References 304
Section III: New Technologies for the Study of Drug
Receptor Interaction
CHAPTER 11
The Assembly of Recombinant Signalling Systems and Their Use in
Investigating Signaling Dynamics
S.M. Lanier. With 4 Figures 313
A. Introduction 313
B. Assembly of Recombinant Signaling Systems 314
I. Stable Transfection 314
II. Transient Expression Systems 316
C. Drug Receptor Interactions in Recombinant Signaling
Systems 318
I. Cell Type Specific Signaling Events 318
II. Influence of Accessory Proteins 323
D. Perspective 328
References 328
CHAPTER 12
Insect Cell Systems to Study the Communication of Mammalian
Receptors and G Proteins
R.T. Windh, A.J. Barr, and D.R. Manning. With 4 Figures 335
A. Introduction 335
I. Selectivity of Receptor G Protein Interactions 335
II. Effector Modulation as a Measure of G Protein Activity .... 336
III. Direct Measures of G Protein Activity 337
B. Insect Cell Expression Systems 338
I. Expression of Receptors in Insect Cell Lines 338
XVIII Contents
II. Interaction of Receptors with Endogenous G Proteins and
Effectors 342
III. Quantitation of Coupling Using Radioligand Binding 343
C. Reconstitution of Mammalian Receptors and G Proteins:
Reconstituted Properties of Ligand Binding 345
I. Influence of Heterotrimeric G Proteins on Binding of
Agonists 346
II. Influence of Individual G Protein Subunits on Binding of
Agonists 348
III. Characterization of Inverse Agonism 349
D. Reconstitution of Mammalian Receptors and G Proteins:
G Protein Activation 350
I. Activation Following Co Expression of Receptor and
G Protein 350
II. Activation Following Addition of Purified G Protein to
Membranes 354
III. Limitations and Technical Considerations 355
E. Conclusions 356
F. References 356
CHAPTER 13
Altering the Relative Stoichiometry of Receptors, G Proteins and
Effectors: Effects on Agonist Function
G. MlLLIGAN 363
A. Introduction 363
I. Background 363
II. Systems to Modulate GPCR G Protein Effector
Stoichiometries 364
III. Cellular Distribution of Elements of G Protein Coupled
Signaling Cascades 365
B. GPCR G Protein Fusion Proteins. A Novel Means to Restrict
and Define the Stoichiometry of Expression of a GPCR and a
G Protein a Subunit 367
C. G Protein Coupled Receptors 370
D. Gsa 376
E. Effector Enzymes: Adenylyl Cyclase 380
F. Conclusions 383
References 383
i
I
Contents XIX
CHAPTER 14
The Study of Drug Receptor Interaction Using Reporter Gene
Systems in Mammalian Cells
D.M. Ignar and S. Rees. With 10 Figures 391
A. Reporter Systems 391
I. What is a Reporter Gene System? 391
II. Detection Methods 391
1. Enzymatic 391
2. Non Enzymatic 393
III. Measurement of Intracellular Signaling 393
1. Inducible Reporter Genes 393
a) Responsive Promoters 393
b) Chimeric Transcription Factors 395
2. Reporter Proteins 397
IV. Transient Versus Stable Expression of Reporter Genes 400
1. Transient Expression 400
2. Stable Expression 400
B. Use of Reporter Gene Systems in Pharmacology 401
I. Drug Discovery 401
II. Receptor Pharmacology 401
1. Use of Reporter Gene Assays to Assess Receptor
Agonism 402
a) Example 1. 6CRE Luciferase as a Reporter for
Gets Coupled Receptor Signaling 402
b) Example 2. Aequorin as a Reporter for
Gaaq/n Coupled Receptor Signaling 402
c) Example 3. The Use of a Gal4/Elk 1 Chimera to
Report Opioid Receptor Like Receptor 1 Activation
of MAPK 405
2. Use of Reporter Gene Assays to Evaluate Receptor
Antagonism 405
3. Simultaneous Detection of Multiple Signals 405
a) Example 1. Dual Reporter Assays 405
b) Example 2. Combination of Reporter Assays with
Other Assay Types 407
4. Measurement of Constitutive Activity 409
5. Measurement of Efficacy 411
6. Assessment of New Signaling Pathways 411
References 412
XX Contents
CHAPTER 15
Melanophore Recombinant Receptor Systems
C.K. Jayawickreme and M.R. Lerner. With 7 Figures 415
A. Introduction 415
B. Cellular Signaling in Melanophores 417
I. Signaling Pathways 417
II. Endogenous Receptor Signaling 419
1. Melatonin lc Receptor 421
2. a Melanocyte Stimulating Hormone (MSH) Receptor .... 421
3. Endothelin C Receptor 422
4. Serotonin Receptor 422
5. /3 Adrenoreceptor 422
6. VIP Receptor 423
C. Melanophore Assay Technology 423
I. Cell Culture and Related Techniques 423
1. Preparation of Cultures of Melanophore 423
2. Continuous Culturing of Xenopus laevis Melanophores ... 424
3. Receptor Expression 424
4. Preparation of Stable Melanophore Lines Expressing
Exogenous Receptors 425
II. Signal Detection 425
1. Transmittance Reading 425
2. Digital Imaging 426
III. Screening Formats 427
1. Microtiter Well Format 427
2. Lawn Format 428
IV. Receptor Cloning and Mutagenesis Studies 428
D. Receptor Studies and Applications 429
I. Characterization of Novel GPCRs 431
II. Lawn Format Screen System 432
III. Single Transmembrane Receptors 433
IV. Receptor Ligand Interaction Studies 434
E. Summary 435
References 435
Subject Index 441
I
i
|
| any_adam_object | 1 |
| author_GND | (DE-588)121921239 (DE-588)121921247 |
| building | Verbundindex |
| bvnumber | BV013189935 |
| callnumber-first | Q - Science |
| callnumber-label | QP905 |
| callnumber-raw | QP905 RM301.41 |
| callnumber-search | QP905 RM301.41 |
| callnumber-sort | QP 3905 |
| callnumber-subject | QP - Physiology |
| classification_rvk | XI 1701 YI 1701 |
| ctrlnum | (OCoLC)43854053 (DE-599)BVBBV013189935 |
| dewey-full | 615/.7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.7 |
| dewey-search | 615/.7 |
| dewey-sort | 3615 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02607nam a2200649 cb4500</leader><controlfield tag="001">BV013189935</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20140224 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">000530s2000 gw ad|| |||| 00||| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">958733791</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540661247</subfield><subfield code="9">3-540-66124-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)43854053</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV013189935</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-578</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP905</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM301.41</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615/.7</subfield><subfield code="2">21</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XI 1701</subfield><subfield code="0">(DE-625)152977:12907</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YI 1701</subfield><subfield code="0">(DE-625)153607:12907</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">QV 4</subfield><subfield code="2">nlm</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The pharmacology of functional, biochemical, and recombinant receptor systems</subfield><subfield code="b">[with 20 tables]</subfield><subfield code="c">contributors J. A. Angus ... Ed.: T. Kenakin ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2000</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XX, 448 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">148</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Receptors</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Drug</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmaceutical Preparations</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Farmacologie</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Receptoren</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Récepteurs de médicaments - Recherche - Méthodologie</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dose-Response Relationship, Drug</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drug receptors</subfield><subfield code="x">Research</subfield><subfield code="x">Methodology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmaceutical Preparations</subfield><subfield code="x">metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Receptors, Cell Surface</subfield><subfield code="x">drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Receptors, Drug</subfield><subfield code="x">physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Technology, Pharmaceutical</subfield><subfield code="x">methods</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Arzneimittelrezeptor</subfield><subfield code="0">(DE-588)4305233-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Rezeptor</subfield><subfield code="0">(DE-588)4049722-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Rezeptor</subfield><subfield code="0">(DE-588)4049722-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Arzneimittelrezeptor</subfield><subfield code="0">(DE-588)4305233-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kenakin, Terrence P.</subfield><subfield code="d">1949-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)121921239</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Angus, James A.</subfield><subfield code="d">1949-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)121921247</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">148</subfield><subfield code="w">(DE-604)BV002390716</subfield><subfield code="9">148</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008988399&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008988399</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV013189935 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:40:34Z |
| institution | BVB |
| isbn | 3540661247 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008988399 |
| oclc_num | 43854053 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 DE-19 DE-BY-UBM DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-12 DE-19 DE-BY-UBM DE-188 DE-578 |
| physical | XX, 448 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] contributors J. A. Angus ... Ed.: T. Kenakin ... Berlin [u.a.] Springer 2000 XX, 448 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 148 Receptors cabt Drug cabt Pharmaceutical Preparations cabt Farmacologie gtt Receptoren gtt Récepteurs de médicaments - Recherche - Méthodologie Dose-Response Relationship, Drug Drug receptors Research Methodology Pharmaceutical Preparations metabolism Receptors, Cell Surface drug effects Receptors, Drug physiology Technology, Pharmaceutical methods Arzneimittelrezeptor (DE-588)4305233-2 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Rezeptor (DE-588)4049722-7 s Pharmakologie (DE-588)4045687-0 s DE-604 Arzneimittelrezeptor (DE-588)4305233-2 s Kenakin, Terrence P. 1949- Sonstige (DE-588)121921239 oth Angus, James A. 1949- Sonstige (DE-588)121921247 oth Handbook of experimental pharmacology 148 (DE-604)BV002390716 148 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008988399&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] Handbook of experimental pharmacology Receptors cabt Drug cabt Pharmaceutical Preparations cabt Farmacologie gtt Receptoren gtt Récepteurs de médicaments - Recherche - Méthodologie Dose-Response Relationship, Drug Drug receptors Research Methodology Pharmaceutical Preparations metabolism Receptors, Cell Surface drug effects Receptors, Drug physiology Technology, Pharmaceutical methods Arzneimittelrezeptor (DE-588)4305233-2 gnd Rezeptor (DE-588)4049722-7 gnd Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4305233-2 (DE-588)4049722-7 (DE-588)4045687-0 (DE-588)4143413-4 |
| title | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] |
| title_auth | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] |
| title_exact_search | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] |
| title_full | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] contributors J. A. Angus ... Ed.: T. Kenakin ... |
| title_fullStr | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] contributors J. A. Angus ... Ed.: T. Kenakin ... |
| title_full_unstemmed | The pharmacology of functional, biochemical, and recombinant receptor systems [with 20 tables] contributors J. A. Angus ... Ed.: T. Kenakin ... |
| title_short | The pharmacology of functional, biochemical, and recombinant receptor systems |
| title_sort | the pharmacology of functional biochemical and recombinant receptor systems with 20 tables |
| title_sub | [with 20 tables] |
| topic | Receptors cabt Drug cabt Pharmaceutical Preparations cabt Farmacologie gtt Receptoren gtt Récepteurs de médicaments - Recherche - Méthodologie Dose-Response Relationship, Drug Drug receptors Research Methodology Pharmaceutical Preparations metabolism Receptors, Cell Surface drug effects Receptors, Drug physiology Technology, Pharmaceutical methods Arzneimittelrezeptor (DE-588)4305233-2 gnd Rezeptor (DE-588)4049722-7 gnd Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Receptors Drug Pharmaceutical Preparations Farmacologie Receptoren Récepteurs de médicaments - Recherche - Méthodologie Dose-Response Relationship, Drug Drug receptors Research Methodology Pharmaceutical Preparations metabolism Receptors, Cell Surface drug effects Receptors, Drug physiology Technology, Pharmaceutical methods Arzneimittelrezeptor Rezeptor Pharmakologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008988399&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT kenakinterrencep thepharmacologyoffunctionalbiochemicalandrecombinantreceptorsystemswith20tables AT angusjamesa thepharmacologyoffunctionalbiochemicalandrecombinantreceptorsystemswith20tables |