Transcription regulation in prokaryotes:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2000
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 365 S. Ill., graph. Darst. |
| ISBN: | 0198503547 |
Internformat
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| 245 | 1 | 0 | |a Transcription regulation in prokaryotes |c Rolf Wagner |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 2000 | |
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| 650 | 4 | |a Cytogenetics | |
| 650 | 4 | |a Génétique microbienne | |
| 650 | 4 | |a Procaryotes | |
| 650 | 4 | |a Transcription génétique - Régulation | |
| 650 | 4 | |a Gene Expression Regulation | |
| 650 | 4 | |a Genetic transcription |x Regulation | |
| 650 | 4 | |a Microbial genetics | |
| 650 | 4 | |a Prokaryotes | |
| 650 | 4 | |a Prokaryotic Cells |x physiology | |
| 650 | 4 | |a Transcription Factors | |
| 650 | 4 | |a Transcription, Genetic | |
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| 650 | 0 | 7 | |a Regulation |0 (DE-588)4049075-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Genregulation |0 (DE-588)4122166-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Prokaryoten |0 (DE-588)4201051-2 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804127813815500800 |
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| adam_text | TRANSCRIPTION REGULATION IN PROKARYOTES ROLF WAGNER HEINRICH-HEINE
UNIVERSITY, DIISSELDORF, GERMANY TECHNISCHE UNIVERSITAT DARMSTADT
FACHBEREICH 10 * BIOLOGIE * BIBLIOTHEK * SCHNITTSPAHNSTRABE 10 D-6 4287
D A R M S T A D T IRRV.-NR. OXFORD UNIVERSITY PRESS CONTENTS 1 GENERAL
INTRODUCTION I 1.1 FLOW OF GENETIC INFORMATION O 4 1.2 DISTINCTIVE
FEATURES OF PROKARYOTIC GENE REGULATION 8 1.3 BIOCHEMICAL NATURE OF THE
TRANSCRIPTION REACTION IO 1.4 WHAT MAKES RNA TRANSCRIPTION DIFFERENT
FROM DNA REPLICATION? 12 1.5 THE PRODUCTS OF TRANSCRIPTION . . , * - *
13 2 THE PLAYERS OR CELLULAR COMPONENTS NECESSARY FOR TRANSCRIPTION ,
* 16 2.1 TRANSCRIPTION START SITES: THE PROMOTER . 16 2.1.1 CORE
PROMOTER ELEMENTS * IT. 2.1.2 THE IMPORTANCE OF FLANKING SEQUENCES 19
2.1.3 THE START SITE POSITION . - . * . 20 2.1.4 COMPLEX PROMOTERS
22 2.2 RNA POLYMERASE * - 22 2.2.1 THE A SUBUNIT , 26 2.2.2 THE P
SUBUNIT 31 2.2.3 THE (3 SUBUNIT 33 2.2.4 THE A 70 SUBUNIT 36 2.3
ALTERNATIVE A FACTORS . . 40 2.3.1 STATIONARY PHASE-SPECIFIC A FACTORS A
S (A 38 ) 43 2.3.2 HEAT SHOCK A FACTORS A (O 32 ) AND O E (A 24 ) 43
2.3.3 O F (A 28 ), FACTOR FOR FLAGELLA GENE EXPRESSION AND CHEMOTAXIS 44
2.3.4 A H (A 54 ), FACTOR FOR NITROGEN : REGULATED GENES .. 44 2.3.5 A
MINOR A FACTOR, FEEL (A 19 ) 45 2.3.6 PHAGE-SPECIFIC A FACTORS GP55,
GP2S AND GP33/GP34- 45 2.3.7 ANTI-SIGMA FACTORS . . 46 2.4 THE
THREE-DIMENSIONAL STRUCTURE OF RNA POLYMERASE - . 48 2.5 IS RNA
POLYMERASE MODIFIED DURING DIFFERENT STAGES OF TRANSCRIPTION? 50 3
INITIATION OF TRANSCRIPTION 58 3.1 PROMOTER LOCATION . - . ,, , : 59 3.2
THE CLOSED RNA POLYMERASE-PROMOTER COMPLEX * 62 3.3 FORMATION OF OPEN
COMPLEXES * 63 3.4 BINDING OF SUBSTRATE NTPS*THE TERNARY COMPLEXES 67
3.4.1 ABORTIVE INITIATION 69 3.4.2 TRANSCRIPT SLIPPAGE 70 XI L CONTENTS
3.5 PROMOTER CLEARANCE AND THE FORMATION OF ELONGATION COMPLEXES 72 3.6
THE KINETICS AND THERMODYNAMICS OF TRANSCRIPTION INITIATION 75 3.6.1
ANALYSIS OF THE RATE-LIMITING STEPS OF PRODUCTIVE TRANSCRIPTION
COMPLEXES 76 4 TRANSCRIPTION ELONGATION 84 4.1 THE ARCHITECTURE OF
ELONGATING COMPLEXES*WHAT IS KNOWN ABOUT THE DIFFERENT FUNCTIONAL SITES?
85 4.1.1 MODELS FOR TRANSLOCATION - 88 4.2 THE RATE OF ELONGATION * 91
4.3 RNA POLYMERASE PAUSES DURING TRANSCRIPTION 92 4.3.1 FACTORS
INFLUENCING RNA POLYMERASE PAUSING 93 4.3.2 EFFECTS OF THE TRANSCRIPT
STRUCTURE 93 4.3.3 EFFECTS OF DNA STRUCTURE AND TOPOLOGY ON ELONGATION
97 4.3.4 EFFECTS CAUSED BY SUBSTRATE NTPS, TRANSCRIPTION FACTORS OR
SMALL LIGANDS : 98 4.4 TRANSCRIPT CLEAVAGE FACTORS 100 4.4.1 ARE THERE
PROOFREADING STEPS DURING TRANSCRIPTION ELONGATION? 101 4.5 TRAFFIC
PROBLEMS AT THE BACTERIAL GENOME: COLLISIONS BETWEEN TRANSCRIPTION AND
REPLICATION MACHINERIES 104 5 TERMINATION OF TRANSCRIPTION . 109 5.1
FACTOR-INDEPENDENT TERMINATION 109 5.1.1 THE ROLE OF THE RNA 3 END
STRUCTURE IN TRANSCRIPT STABILITY 114 5.2 FACTOR-DEPENDENT TERMINATION
118 5.2.1 STRUCTURE AND FUNCTION OF THE RHO FACTOR 119 5.2.2 THE ROLE OF
RNA STRUCTURE IN RHO FACTOR FUNCTION 120 5.2.3 CHARACTERIZATION OF
RHO-DEPENDENT TERMINATION SITES 122 5.2.4 RHO FACTOR IS AN RNA: DNA
HELICASE . 122 5.2.5 NUSG, AN AUXILIARY FACTOR FOR RHO-DEPENDENT
TERMINATION 124 5.2.6 ALTERNATIVE TERMINATION FACTORS 126 5.2.7 THE ROLE
OF RHO FACTOR IN TRANSCRIPTIONAL POLARITY 127 5.2.8 AN ALTERNATIVE
FUNCTION OF RHO: STABILIZATION OF MRNAS 128 5.3 ATTENUATION OF
TRANSCRIPTION 128 5.4 ANTITERMINATION 136 5.4.1 ANTITERMINATION IN PHAGE
A GENE EXPRESSION 137 5.4.2 THE PHAGE A N PROTEIN SYSTEM 137 5.4.3 THE
PHAGE A Q PROTEIN SYSTEM 142 5.4.4 RRNA TRANSCRIPTION AND
ANTITERMINATION 143 5.4.5 NUT SITE-INDEPENDENT ANTITERMINATION
MECHANISMS 146 CONTENTS XIII 6 THE ROLE OF DNA STRUCTURE IN
TRANSCRIPTION REGULATION 155 6.1 IS DNA METHYLATION INVOLVED IN
REGULATION? 156 6.2 EFFECTS OF DNA CURVATURE ON TRANSCRIPTION INITIATION
157 6.2.1 UPSTREAM ACTIVATING SEQUENCES 166 6.2.2 TRANSCRIPTION
FACTOR-INDUCED BENDS IN DNA 171 6.3 DNA SUPERCOILING AND TRANSCRIPTION
175 6.3.1 THE TWIN-SUPERCOILED DOMAIN MODEL 185 7 REGULATION BY
TRANSCRIPTION FACTORS . 193 7.1 REPRESSORS AND OPERATORS*THE CLASSICAL
MODEL * 193 7.2 THE MODULAR STRUCTURE OF TRANSCRIPTION FACTORS 199 7.2.1
TO ACTIVATE OR TO REPRESS: WHAT MAKES THE DIFFERENCE? 200 7.3 LYSR, A
REPRESENTATIVE OF A LARGE FAMILY OF TRANSCRIPTION FACTORS 208 7.3.1 THE
TYRR REGULON - ** * * 210 7.3.2 THE CATABOLITE REGULATOR PROTEIN
CRP*MANY TASKS FOR A SMALL PROTEIN ^ 211 7.4 DNA LOOPS*REGULATION
THROUGH DYNAMIC STRUCTURES 217 7.4.1 NEGATIVE REGULATION OF THE GO/7K
OPERON 218 7.4.2 REGULATION OF THE ARABAD OPERON 223 7.5 REGULATION BY
DNA STRUCTURING PROTEINS 226 7.5.1 THE MASTER-BENDER INTEGRATION HOST
FACTOR (IHF) AND ITS FAMILY OF DNA-BINDING. PROTEINS 227 7.5.2 THE
GROWTH PHASE-DEPENDENT ACTIVATOR FACTOR FOR INVERSION STIMULATION (FIS)
232 7.5.3 HISTONE-LIKE NUCLEOID STRUCTURING PROTEIN (H-NS), A VERSATILE
REGULATOR THROUGH DNA CONFORMATIONS 238 7.6 TWO-COMPONENT REGULATORY
SYSTEMS 246 7.6.1 SENSOR KINASES AND RESPONSE REGULATORS 246 7.6.2
REGULATION OF NITROGEN-FIXATION GENES 250 8 REGULATORY NETWORKS 264 8.1
THE SOS RESPONSE 266 8.2 THE HEAT-SHOCK RESPONSE 270 8.3 STATIONARY
PHASE CONTROL 275 8.4 THE LRP REGULON 282 8.5 THE STRINGENT CONTROL 287
8.5.1 SYNTHESIS OF THE EFFECTOR NUCLEOTIDES (P)PPCPP 289 8.5.2 EFFECTS
OF INCREASED PPCPP LEVELS 291 8.5.3 WHERE DOES PPCPP ACT? 293 8.5.4 THE
MAJOR TARGET OFTSTRINGENT REGULATION: STABLE RNA SYNTHESIS 295 XIV
CONTENTS 8.5.5 PPGPP AFFECTS THE RATE OF RNA CHAIN ELONGATION 299 8.5.6
POSITIVE STRINGENT CONTROL 302 8.6 GROWTH RATE REGULATION 303 8.7
LESSONS FROM A MANIFOLD REGULATED SYSTEM*THE SYNTHESIS OF RIBOSOMAL RNA
; H . * 309 8.7.1 THE IMPORTANCE OF RRNA SYNTHESIS FOR RIBOSOME
FORMATION AND CELL GROWTH * * 310 8.7.2 IMPLICATIONS FROM THE STRUCTURE
AND ARRANGEMENT OF RRNA OPERORIS . . 312 8.7.3 UPSTREAM ACTIVATING
SEQUENCES . . . 317 8.7.4 EFFECTS OF TRANSCRIPTION FACTORS . . . 319
8.7.5 STRINGENT AND GROWTH RATE REGULATION * ^ 323 * 8.7.6 PAUSING,
ATTENUATION AND ANTITERMINATION ; 326 8.7.7 COUPLING OF RRNA
TRANSCRIPTION TO POST-TRANSCRIPTIONAL EVENTS AND RIBOSOME BIOGENESIS :
328 GLOSSARY 336 INDEX . 347
|
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| spelling | Wagner, Rolf Verfasser aut Transcription regulation in prokaryotes Rolf Wagner 1. publ. Oxford [u.a.] Oxford Univ. Press 2000 XIV, 365 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cytogenetics Génétique microbienne Procaryotes Transcription génétique - Régulation Gene Expression Regulation Genetic transcription Regulation Microbial genetics Prokaryotes Prokaryotic Cells physiology Transcription Factors Transcription, Genetic Transkription Genetik (DE-588)4185906-6 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Prokaryoten (DE-588)4201051-2 gnd rswk-swf Prokaryoten (DE-588)4201051-2 s Transkription Genetik (DE-588)4185906-6 s Regulation (DE-588)4049075-0 s DE-604 Genregulation (DE-588)4122166-7 s HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008935115&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wagner, Rolf Transcription regulation in prokaryotes Cytogenetics Génétique microbienne Procaryotes Transcription génétique - Régulation Gene Expression Regulation Genetic transcription Regulation Microbial genetics Prokaryotes Prokaryotic Cells physiology Transcription Factors Transcription, Genetic Transkription Genetik (DE-588)4185906-6 gnd Regulation (DE-588)4049075-0 gnd Genregulation (DE-588)4122166-7 gnd Prokaryoten (DE-588)4201051-2 gnd |
| subject_GND | (DE-588)4185906-6 (DE-588)4049075-0 (DE-588)4122166-7 (DE-588)4201051-2 |
| title | Transcription regulation in prokaryotes |
| title_auth | Transcription regulation in prokaryotes |
| title_exact_search | Transcription regulation in prokaryotes |
| title_full | Transcription regulation in prokaryotes Rolf Wagner |
| title_fullStr | Transcription regulation in prokaryotes Rolf Wagner |
| title_full_unstemmed | Transcription regulation in prokaryotes Rolf Wagner |
| title_short | Transcription regulation in prokaryotes |
| title_sort | transcription regulation in prokaryotes |
| topic | Cytogenetics Génétique microbienne Procaryotes Transcription génétique - Régulation Gene Expression Regulation Genetic transcription Regulation Microbial genetics Prokaryotes Prokaryotic Cells physiology Transcription Factors Transcription, Genetic Transkription Genetik (DE-588)4185906-6 gnd Regulation (DE-588)4049075-0 gnd Genregulation (DE-588)4122166-7 gnd Prokaryoten (DE-588)4201051-2 gnd |
| topic_facet | Cytogenetics Génétique microbienne Procaryotes Transcription génétique - Régulation Gene Expression Regulation Genetic transcription Regulation Microbial genetics Prokaryotes Prokaryotic Cells physiology Transcription Factors Transcription, Genetic Transkription Genetik Regulation Genregulation Prokaryoten |
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