Mouse brain development:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2000
|
| Schriftenreihe: | Results and problems in cell differentiation
30 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 339 S. Ill., graph. Darst. |
| ISBN: | 3540666648 |
Internformat
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| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2000 | |
| 300 | |a XIV, 339 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 0 | |a Results and problems in cell differentiation |v 30 | |
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| 650 | 4 | |a Neurologie du développement | |
| 650 | 7 | |a Ratos |2 larpcal | |
| 650 | 4 | |a Souris (Animaux de laboratoire) | |
| 650 | 4 | |a Brain |x embryology | |
| 650 | 4 | |a Developmental neurobiology | |
| 650 | 4 | |a Mice as laboratory animals | |
| 650 | 4 | |a Mice, Neurologic Mutants | |
| 650 | 4 | |a Molecular Biology | |
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Datensatz im Suchindex
| _version_ | 1804127783441399808 |
|---|---|
| adam_text | Contents
From Spontaneous to Induced Neurological Mutations:
A Personal Witness of the Ascent of the Mouse Model
Pasko Rakic 1
1 Introduction 1
2 Beginning: The Values and Limits of Spontaneous Mutations ... 3
3 Renaissance: New Opportunities and Induced Mutations 9
4 Epilogue 14
References 15
Mapping Genes that Modulate Mouse Brain Development:
A Quantitative Genetic Approach
Robert W. Williams 21
1 Introduction 21
2 Why Brain Weight and Neuron Number Matter 22
2.1 Metabolic Constraints 22
2.2 Functional Correlates 22
2.3 Insights into CNS Development 23
3 Biometric Analysis of the Size and Structure of the Mouse CNS . 24
3.1 Precedents 24
3.2 A New Opportunity 24
3.3 Brain Weight is Highly Variable 25
3.4 Sex and Age Effects on Brain Weight 25
3.5 Large Differences Between Substrains 27
4 Mapping Brain Weight QTLs 27
4.1 QTLs Versus Mendelian Loci 27
4.2 Step 1: Assessing Trait Variation 27
4.3 Step 2: Estimating Heritability 29
4.4 Step 3: Phenotyping and Genotyping Members
of an Experimental Cross 30
4.4.1 Phenotyping and Regression Analysis 31
4.4.2 Genotyping 33
4.5 Step 4: The Statistics of Mapping QTLs 34
VIII Contents
4.5.1 Permutation Analysis 36
4.6 Cloning QTLs 38
4.7 Probability of Success 38
5 Neuron and Glial Cell Numbers in Adult Mice 39
5.1 The Mouse Brain Library at http://nervenet.org/mbl/mbl/html . . 40
5.2 Numbers of Neurons and Glial Cells in the Brain of a Mouse ... 41
6 Mapping QTLs that Modulate Neuron Number 42
6.1 Mapping Cell Specific QTLs 42
6.2 The Nncl Locus 42
6.3 Mechanisms of QTL Action 43
6.4 Candidate Gene Analysis 43
7 Conclusion 44
References 44
Genetic Interactions During Hindbrain Segmentation
in the Mouse Embryo
Paul A. Trainor, Miguel Manzanares, and Robb Krumlauf 51
1 Introduction 51
1.1 Generation of Diversity in the Developing Nervous
System 51
1.2 Segmental Organisation of the Hindbrain 53
2 Patterns of Gene Expression During Hindbrain Development ... 55
2.1 Hox Genes 55
2.2 Upstream Regulators of Hox Genes 58
2.3 Other Gene Families 59
3 Genetic Control of Hindbrain Patterning 61
3.1 Retinoic Acid Pathways 62
3.2 Krox20 Targets 64
3.3 Kreisler Targets 66
3.4 Hox Gene Auto and Cross Regulation 67
4 Mutational Analyses of Gene Function 69
4.1 Segmentation Genes 69
4.2 Segment Identity Genes 72
5 Mechanisms of Hindbrain Segmentation 76
6 Conclusions 77
References 78
Contents IX
Neurogenetic Compartments of the Mouse Diencephalon
and some Characteristic Gene Expression Patterns
Salvador Martinez and Luis Puelles 91
1 Introduction 91
2 Origin and Definition of Diencephalon 94
3 Diencephalic Segmentation 96
4 Diencephalic Histogenetic Differentiation 98
5 Alar Plate Domains at E12.5 99
References 103
Neuronogenesis and the Early Events of the Neocortical Histogenesis
V. S. Caviness, Jr., T. Takahashi, and R. S. Nowakowski 107
1 Introduction 107
2 The Neocortical Pseudostratified Ventricular Epithelium 109
2.1 Cytologic and Architectonic Features of the PVE 109
3 Neocortex as Outcome of Neuronogenesis in the PVE Ill
3.1 The Radial Dimension of the Neocortex 113
3.2 The Tangential Dimensions of the Neocortex 114
4 The Proliferative Process Within the Murine Neocortical PVE . 115
4.1 There are Two Stages of Proliferative Activity
in the PVE (Fig. 2) 116
4.2 Neuron Production Advances in an Orderly Sequence 116
4.3 The Proliferative State of PVE Varies Across the Surface
of the Neocortex 117
4.4 The Cell Cycle in Histogenesis 117
4.5 A General Quantitative Model of Neuron Production 118
4.6 Parameters of the Model: Experiments in Mouse 121
4.6.1 The Number of Integer Cycles 119
4.6.2 The Q and P Fractions 121
4.6.3 Neuron Production Model 123
5 Higher Order Neuronogenetic Control 125
5.1 Number of Cell Cycles Regulated by Q 126
5.2 Propagation of the Neuronogenetic Sequence Regulated by Tc . 126
5.3 Propagation of Cell Cycle Domains 127
5.3.1 Initiation of Cycle at Origin 127
5.3.2 Propagation of Cycle Domains 129
6 The Proliferative Process and Histogenetic Specification 131
6.1 Cell Number, Cell Class and Laminar Fate 131
6.2 Regional Specification Within the PVE 134
7 The PVE: A Conserved Histogenetic Specification 136
References 138
X Contents
Programmed Cell Death in Mouse Brain Development
Chia Yi Kuan, Richard A. Flavell, and Pasko Rakic 145
1 Introduction 145
2 Conceptual Framework of Programmed Cell Death 145
3 Mechanistic Framework of Programmed Cell Death 147
4 Caspases 3 and 9 are Required for Developmental Apoptosis
of Neurons 148
5 The Bcl 2 Proteins Family Has Both Proapoptotic
and Antiapoptotic Effects 151
6 Apoptotic Defects in Founders and Postmitotic Neurons
Have Distinct Consequences 154
7 c Jun N Terminal Kinases Regulate Brain Region Specific
Apoptosis 156
8 Concluding Remarks 158
References 160
Neurotrophic Factors: Versatile Signals for Cell Cell Communication
in the Nervous System
Carlos F. Ibanez 163
1 Introduction 163
2 The Neurotrophic Hypothesis 164
3 Neurotrophic Factors 167
4 Beyond the Neurotrophic Hypothesis 168
5 Revisiting the Neurotrophic Hypothesis with Molecular Genetics. 171
6 Selective Neuronal Losses and Maturation Deficits Following
Inactivation of Genes Encoding Neurotrophic Factors
or Their Receptors 173
7 Neurotrophic Factors Regulate Target Invasion 178
8 BDNF as a Maturation Factor for the Cerebal Cortex 181
9 Conclusions 184
References 184
Growth Factor Influences on the Production
and Migration of Cortical Neurons
Janice E. Brunstrom and Alan L. Pearlman 189
1 Introduction 189
2 Trophic Factor Influences on Neurogenesis
in the Ventricular Zone 190
2.1 Neurotrophins 190
2.2 Fibroblast Growth Factors 191
Contents XI
2.3 Insulin Like Growth Factors 194
2.4 Trophic Collaborations 195
3 Trophic Factor Influences on Glial Guided Radial Migration . . 196
4 Trophic Factor Influences on Tangential Migration 197
4.1 NT4 Produces Heterotopic Accumulations of Neurons
in the MZ in vitro 198
4.2 NT4, But not BDNF, Produces Heterotopias
in a TrkB Mediated Response 198
4.3 NT4 Also Produces Heterotopic Neuronal Collections in vivo . . 200
5 Pathogenesis of NT4 Induced Heterotopias 200
5.1 NT4 Does Not Induce Cell Proliferation in the Marginal Zone . 201
5.2 NT4 Induced Heterotopias are Composed of Marginal
Zone Neurons 202
5.3 NT4 Induced Accumulation of Neurons is not at the Expense
of the Subplate 202
5.4 Heterotopic Neurons are not Misplaced Cortical Plate Cells . . . 202
5.5 Heterotopias do not Result from the Trauma
of Intraventricular Injection 203
5.6 Heterotopias are not Caused by Rescue of MZ Neurons
from Cell Death 203
6 What is the Source of the Excess Neurons that
Form NT4 Induced Heterotopias? 204
References 207
Signalling from Tyrosine Kinases in the Developing Neurons
and Glia of the Mammalian Brain
Elena Cattaneo and Massimo Gulisano 217
1 Introduction 217
2 Tyrosine Kinases During CNS Development 218
2.1 Growth Factors and Their Cell Surface Receptors 218
3 Phospho Tyrosines and Their SH2 Partners 221
4 Controlling the Activity of the Ras MAPK Pathway 223
4.1 The Players 223
4.2 MAPK: Proliferation or Differentiation? 225
4.3 Changing Adaptors for the Ras MAPK Pathway: The Shc(s) ... 226
5 Controlling Cell Survival Via PI3K 227
6 The JAK/STAT Pathway: A New Route to Proliferation
and Differentiation in the Brain 229
7 The Action of Phosphatases 232
8 Concluding Remarks 233
References 234
XII Contents
The Role of the p35/cdk5 Kinase in Cortical Development
Yong T. Kwon and Li Huei Tsai 241
1 Introduction 241
2 cdk5 241
3 p35 Family Members 242
4 Expression Patterns 243
5 Function of the cdk5 Kinase in Neurite Outgrowth 243
6 p35 and cdk5 Knockout Mice 244
7 p35/cdk5 and Reeler/Scrambler 247
8 Substrates 248
9 Regulation 248
10 Conclusion 249
References 251
The Reelin Signaling Pathway and Mouse Cortical Development
Isabelle Bar, Catherine Lambert de Rouvroit,
and Andre M. Goffmet 255
1 Introduction 255
2 Overview of Early Cortical Development in Normal Mice .... 255
2.1 The Preplate 257
2.2 Appearance of the Cortical Plate 257
3 Cortical Phenotype in Reeler Mutant Mice 258
4 Reelin (Rein) 262
4.1 The Rein Gene 262
4.2 Rein mRNA Expression During Cortical Development 265
4.3 Rein Protein 265
4.4 Studies of Rein Function 266
4.5 Reelin is Processed in vivo by a Metalloproteinase 266
4.6 Rein an Axonal Growth 267
5 Mouse Disabledl and Scrambler/Yotari Mutations 268
6 Very Low Density Lipoprotein Receptor
and Apolipoprote in E Receptor Type 2 271
References 274
The Subpial Granular Layer in the Developing Cerebral Cortex
of Rodents
Gundela Meyer, Rafael Castro, Jose Miguel Soria, and Alfonso Fairen 277
1 Introduction 277
2 Neuronal Populations of the Rodent Marginal Zone 279
2.1 Pioneer Neurons 279
Contents XIII
2.2 The Subpial Granular Layer 281
2.3 Reelin Expressing Cajal Retzius Cells of Rodent Cortex 284
3 Possible Origin of the Rodent Subpial Granular Layer 285
4 Radial and Tangential Migration Pathways into the Cortex . . . 286
5 Conclusions 288
References 289
Development of Thalamocortical Projections
in Normal and Mutant Mice
Zoltan Molnar and Anthony J. Hannan 293
1 Introduction 293
2 Neurogenesis and Formation of Mammalian Cortical Plate . . . 294
3 Introduction to Development of Thalamic Nuclei 295
4 Overview of Thalamocortical Projections in the Adult Mouse . . 296
5 Timing and Early Pattern of Thalamic Axon Outgrowth 296
5.1 The Waiting Period 298
5.2 Invasion of the Cortex and Establishment of Laminar
Termination Patterns 299
6 The Thalamocortical Pathways are Modified in Regions
Where Transient Cells are Located During Development 301
6.1 The Handshake Hypothesis 301
7 Introduction to the Development of Barrel Cortex 302
7.1 Mutant Mice Provide New Insights into Developmental
Mechanisms 303
8 Axonal Pathfinding at the Cortico Striatal Junction
in Tbr 1, Gbx 2 and Pax 6 KO Mice 304
8.1 The reeler Mouse 305
8.1.1 The reeler Phenotype 305
8.1.2 The reeler Mutant Mouse as a Model System to Explore
Mechanisms of Thalamocortical Development 305
8.2 The LI KO Mouse 309
8.2.1 Possible Inhibitory Factory in and Around the Internal
Capsule 309
9 Mutants with Disturbances in Thalamocortical Interactions ... 310
9.1 Barrel Formation in reeler Mouse 312
9.2 The Barrelless Mouse 313
9.2.1 The Barrelless Phenotype 313
9.2.2 Lack of Formation and Stabilisation of Barrel Patterns
in the Mutant 314
9.2.3 Similar Areal Differences in Thalamocortical Innervation
Patterns in Normal and Barrelless Mice 314
9.3 The MAO A KO Mouse 315
XIV Contents
9.4 The NMDA Receptor KO Mouse: Role of Activity
in Barrel Formation 316
9.5 A Specific Postsynaptic Defect in Barrel Formation Identified
in PLC Pl Knockout mice 317
9.6 The GAP 43 KO Mouse 318
9.7 Overview of Mutant Mice with Barrelless Phenotypes 319
10 Mutations Indirectly Affecting Thalamocortical Development . . 319
10.1 Thalamocortical Topography in Anophthalmic Mutants
and After Early Binocular Enucleation 320
10.2 Altered Thalamocortical Topography in Albinism
and After Early Monocular Enucleation 321
10.3 Extranumery Vibrissae 322
11 Conclusions 322
References 323
Subject Index 333
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| indexdate | 2024-07-09T18:38:50Z |
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| isbn | 3540666648 |
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| series2 | Results and problems in cell differentiation |
| spelling | Mouse brain development André M. Goffinet ... (eds.) Berlin [u.a.] Springer 2000 XIV, 339 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Results and problems in cell differentiation 30 Cérebro larpcal Neurologie du développement Ratos larpcal Souris (Animaux de laboratoire) Brain embryology Developmental neurobiology Mice as laboratory animals Mice, Neurologic Mutants Molecular Biology Gehirn (DE-588)4019752-9 gnd rswk-swf Histogenese (DE-588)4132943-0 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Gehirn (DE-588)4019752-9 s Histogenese (DE-588)4132943-0 s Maus (DE-588)4169148-9 s DE-604 Goffinet, André M. 1950- Sonstige (DE-588)120228130 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008914687&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mouse brain development Cérebro larpcal Neurologie du développement Ratos larpcal Souris (Animaux de laboratoire) Brain embryology Developmental neurobiology Mice as laboratory animals Mice, Neurologic Mutants Molecular Biology Gehirn (DE-588)4019752-9 gnd Histogenese (DE-588)4132943-0 gnd Maus (DE-588)4169148-9 gnd |
| subject_GND | (DE-588)4019752-9 (DE-588)4132943-0 (DE-588)4169148-9 (DE-588)4143413-4 |
| title | Mouse brain development |
| title_auth | Mouse brain development |
| title_exact_search | Mouse brain development |
| title_full | Mouse brain development André M. Goffinet ... (eds.) |
| title_fullStr | Mouse brain development André M. Goffinet ... (eds.) |
| title_full_unstemmed | Mouse brain development André M. Goffinet ... (eds.) |
| title_short | Mouse brain development |
| title_sort | mouse brain development |
| topic | Cérebro larpcal Neurologie du développement Ratos larpcal Souris (Animaux de laboratoire) Brain embryology Developmental neurobiology Mice as laboratory animals Mice, Neurologic Mutants Molecular Biology Gehirn (DE-588)4019752-9 gnd Histogenese (DE-588)4132943-0 gnd Maus (DE-588)4169148-9 gnd |
| topic_facet | Cérebro Neurologie du développement Ratos Souris (Animaux de laboratoire) Brain embryology Developmental neurobiology Mice as laboratory animals Mice, Neurologic Mutants Molecular Biology Gehirn Histogenese Maus Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008914687&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT goffinetandrem mousebraindevelopment |