Applied biopharmaceutics & pharmacokinetics:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Stamford, Conn.
Appleton & Lange
1999
|
| Ausgabe: | 4. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 768 S. Ill., graph. Darst. |
| ISBN: | 0838502784 |
Internformat
MARC
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| 100 | 1 | |a Shargel, Leon |d 1941- |e Verfasser |0 (DE-588)1145926010 |4 aut | |
| 245 | 1 | 0 | |a Applied biopharmaceutics & pharmacokinetics |c Leon Shargel ; Andrew Yu |
| 246 | 1 | 3 | |a Applied biopharmaceutics and pharmacokinetics |
| 250 | |a 4. ed. | ||
| 264 | 1 | |a Stamford, Conn. |b Appleton & Lange |c 1999 | |
| 300 | |a XIV, 768 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Biopharmacie | |
| 650 | 4 | |a Pharmacocinétique | |
| 650 | 4 | |a Biopharmaceutics | |
| 650 | 4 | |a Biopharmaceutics |v Problems and Exercises | |
| 650 | 4 | |a Pharmacokinetics | |
| 650 | 4 | |a Pharmacokinetics |v Problems and Exercises | |
| 650 | 0 | 7 | |a Biopharmazie |0 (DE-588)4006890-0 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Yu, Andrew B. |d 1945- |e Verfasser |0 (DE-588)172470196 |4 aut | |
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Datensatz im Suchindex
| _version_ | 1804127782994706432 |
|---|---|
| adam_text | CONTENTS Preface / XIII
1. REVIEW OF MATHEMATICAL FUNDAMENTALS / 1
Estimation and the Use of Calculators and Computers / 1
Calculus / 6
Graphs / 9
Units in Pharmacokinetics / 16
Measurement and the Use of Significant Figures / 17
Units for Expressing Blood Concentrations / 18
Statistics / 18
Rates and Orders of Reactions / 21
Frequently Asked Questions / 26
Learning Questions / 26
References / 28
Bibliography / 28
2. INTRODUCTION TO B1OPHARMACEUTICS AND
PHARMACOKINETICS / 29
Biopharmaceutics / 29
Pharmacokinetics / 30
Clinical Pharmacokinetics / 30
Pharmacodynamics / 31
Toxicokinetics and Clinical Toxicology / 31
Measurement of Drug Concentrations / 32
Basic Pharmacokinetics and Pharmacokinetic Models / 36
Frequently Asked Questions / 43
Learning Questions / 43
References / 44
Bibliography / 45
3. ONE COMPARTMENT OPEN MODEL / 47
Intravenous Route of Administration of Drug / 47
Elimination Rate Constant / 48
V
CONTENTS Apparent Volume of Distribution / 49
Clearance / 52
Calculation of k from Urinary Excretion Data / 58
Clinical Application / 62
Frequently Asked Questions / 63
Learning Questions / 64
Bibliography / 66
4. MULTICOMPARTMENTAL MODELS / 67
Two Compartment Open Model / 69
Three Compartment Open Model / 85
Determination of Compartment Models / 88
Frequently Asked Questions / 95
Learning Questions / 95
References / 98
Bibliography / 98
5. PHYSIOLOGIC FACTORS RELATED TO
DRUG ABSORPTION / 99
Nature of the Cell Membrane / 99
Passage of Drugs Across Cell Membranes / 101
Route of Drug Administration / 108
Frequently Asked Questions / 125
Learning Questions / 126
References / 127
Bibliography / 128
6. BIOPHARMACEUTIC CONSIDERATIONS IN DRUG
PRODUCT DESIGN / 129
Rate Limiting Steps in Drug Absorption / 130
Pharmaceutic Factors Affecting Drug Bioavailability / 131
Physicochemical Nature of the Drug / 133
Formulation Factors Affecting Drug Dissolution / 135
In Vitro Dissolution Testing / 138
Compendial Methods of Dissolution / 140
Methods for Testing Enteric Coated Products / 143
Meeting Dissolution Requirements / 143
Unofficial Methods of Dissolution Testing / 144
Problems of Variable Control in Dissolution Testing / 145
CONTENTS VII
In Vitro In Vivo Correlation of Dissolution / 146
Failure of Correlation of In Vitro Dissolution to In Vivo Absorption / 150
Biopharmaceutic Considerations / 151
Pharmacodynamic Considerations / 152
Drug Considerations / 152
Drug Product Considerations / 152
Patient Considerations / 154
Route of Drug Administration / 154
Clinical Example / 160
Frequently Asked Questions / 164
Learning Questions / 164
References / 165
Bibliography / 165
7. MODIFIED RELEASE DRUG PRODUCTS / 169
Modified Release Drug Products / 169
Biopharmaceutic Factors / 172
Dosage Form Selection / 174
Drug Release from Matrix / 174
Advantages and Disadvantages of Extended Release Products / 175
Kinetics of Controlled Release Dosage Forms / 176
Pharmacokinetic Simulation of Extended Release Products / 178
Types of Extended Release Products / 180
Considerations in the Evaluation of Modified Release Products / 193
Regulatory Studies for the Evaluation of Modified Release Products / 195
Evaluation of In Vivo Bioavailability Data / 198
Frequently Asked Questions / 200
Learning Questions / 200
References / 201
Bibliography / 202
8. TARGETED DRUG DELIVERY SYSTEMS AND
BIOTECHNOLOGICAL PRODUCTS / 205
Targeted Drug Delivery / 205
Biotechnology / 207
Bioequivalence of Biotechnology Products / 219
Frequently Asked Questions / 220
Learning Questions / 220
References / 220
Bibliography / 221
VIII CONTENTS 9. PHARMACOKINETIC MODEL OF ORAL ABSORPTION / 223
Pharmacokinetics of Drug Absorption / 223
Zero Order Absorption Model / 224
First Order Absorption Model / 225
Significance of Absorption Rate Constants / 242
Frequently Asked Questions / 242
Learning Questions / 243
References / 244
Bibliography / 245
10. BIOAVAILABILITY AND BIOEQUIVALENCE / 247
Definitions / 247
Purpose of Bioavailability Studies / 249
Relative and Absolute Availability / 250
Methods for Assessing Bioavailability / 252
Bioequivalence Studies / 256
Design and Evaluation of Bioequivalence Studies / 259
Bioequivalence Example / 265
Generic Substitution / 271
Frequently Asked Questions / 272
Learning Questions / 273
References / 278
Bibliography / 279
11. PHYSIOLOGIC DRUG DISTRIBUTION AND PROTEIN
BINDING/281
Physiologic Factors / 281
Calculation of Apparent Volume of Distribution / 299
Protein Binding of Drugs / 303
Kinetics of Protein Binding / 306
Determination of Binding Constants and Binding Sites
by Graphic Methods / 309
Clinical Significance of Drug Protein Binding / 313
Frequently Asked Questions / 320
Learning Questions / 320
References / 322
Bibliography / 323
12. DRUG ELIMINATION AND CLEARANCE CONCEPTS / 325
Drug Elimination / 325
The Kidney / 326
Drug Clearance / 333
CONTENTS IX
Physiologic Approach to Clearance / 335
Renal Clearance / 336
Renal Drug Excretion / 337
Drug Clearance / 340
Determination of Renal Clearance / 341
Relationship of Clearance Elimination Half Life and
Volume of Distribution / 347
Frequently Asked Questions / 349
Learning Questions / 350
References / 351
Bibliography / 351
13. HEPATIC ELIMINATION OF DRUGS / 353
Fraction of Drug Excreted Unchanged (fe) and Fraction of Drug
Metabolized (1 /e) / 354
Clinical Focus / 355
Pharmacokinetics of Drugs and Metabolites / 355
Anatomy and Physiology of the Liver / 362
Hepatic Enzymes Involved in the Biotransformation of Drugs / 365
Drug Biotransformation Reactions / 366
Route of Drug Administration and Extrahepatic Drug Metabolism / 376
First Pass Effects / 377
Hepatic Clearance / 383
Significance of Drug Metabolism / 389
Biliary Excretion of Drugs / 390
Frequently Asked Questions / 393
Learning Questions / 393
References / 396
Bibliography / 397
14. INTRAVENOUS INFUSION / 399
One Compartment Model Drugs / 399
Infusion Method for Calculating Patient Elimination Half Life / 404
Loading Dose Plus IV Infusion / 406
Estimation of Drug Clearance and Vn from Infusion Data / 412
Estimation of k and Vn of Aminoglycosides in Clinical Situations / 412
Intravenous Infusion of Two Compartment Model Drugs / 413
Frequently Asked Questions / 414
Learning Questions / 415
References / 417
Bibliography / 417
CONTENTS 15. MULTIPLE DOSAGE REGIMENS / 419
Drug Accumulation / 419
Repetitive Intravenous Injections / 424
Intermittent Intravenous Infusion / 430
Multiple Oral Dose Regimen / 433
Loading Dose / 436
Determination of Bioavailability and Bioequivalence in a
Multiple Dose Regimen / 437
Bioequivalence Studies / 438
Dosage Regimen Schedules / 441
Frequently Asked Questions / 445
Learning Questions / 445
References / 446
Bibliography / 447
16. NONLINEAR PHARMACOKINETICS / 449
Saturable Enzymatic Elimination Processes / 451
Drug Elimination by Capacity Limited Pharmacokinetics:
One Compartment Model, IV Bolus Injection / 454
Equations for Drugs Distributed as One Compartment Model and
Eliminated by Nonlinear Pharmacokinetics / 467
Time Dependent Pharmacokinetics / 468
Bioavailability of Drugs That Follow Nonlinear Pharmacokinetics / 469
Nonlinear Pharmacokinetics Due to Drug Protein Binding / 469
Frequently Asked Questions / 472
Learning Questions / 472
References / 473
Bibliography / 474
17. APPLICATION OF PHARMACOKINETICS IN CLINICAL
SITUATIONS / 475
Individualization of Drug Dosage Regimen / 475
Therapeutic Drug Monitoring / 476
Design of Dosage Regimens / 484
Conversion From Intravenous Infusion to Oral Dosing / 485
Determination of Dose / 487
Effect of Changing Dose and Dosing Interval on Q,lax°c, (^,1,,°°,
and Cav3c / 489
Determination of Frequency of Drug Administration / 490
Determination of Both Dose and Dosage Interval / 491
Nomograms and Tabulations in Designing Dosage Regimens / 492
CONTENTS XI
Determination of Route of Administration / 493
Dosing of Drugs in Infants and Children / 494
Dosing of Drugs in the Elderly / 496
Dosing of Drugs in the Obese Patient / 500
Pharmacokinetics of Drug Interactions / 501
Inhibition of Drug Metabolism / 504
Inhibition of Biliary Excretion / 506
Induction of Drug Metabolism / 506
Altered Renal Reabsorption Due to Changing Urinary pH / 506
Inhibition of Drug Absorption / 507
Effect of Food on Drug Disposition / 507
Adverse Viral Drug Interactions / 508
Population Pharmacokinetics / 508
Frequently Asked Questions / 522
Learning Questions / 523
References / 526
Bibliography / 528
18. DOSAGE ADJUSTMENT IN RENAL AND
HEPATIC DISEASE / 531
Pharmacokinetic Considerations / 531
General Approaches for Dose Adjustment in Renal Disease / 532
Dose Adjustment Based on Drug Clearance / 533
Method Based on Changes in the Elimination Rate Constant / 534
Measurement of Glomerular Filtration Rate / 535
Serum Creatinine Concentration and Creatinine Clearance / 536
Dosage Adjustment for Uremic Patients / 541
Extracorporeal Removal of Drugs / 554
Dialysis / 555
Hemoperfusion / 561
Hemofiltration / 561
Effect of Hepatic Disease on Pharmacokinetics / 562
Frequently Asked Questions / 567
Learning Questions / 568
References / 569
Bibliography / 570
19. RELATIONSHIP BETWEEN PHARMACOKINETIC AND
PHARMACODYNAMICS / 573
Pharmacodynamics and Pharmacokinetics / 573
Relation of Dose to Pharmacologic Effect / 575
CONTENTS Relationship Between Dose and Duration of Activity (ieff).
Single IV Bolus Injection / 577
Effect of Both Dose and Elimination Half Life on the
Duration of Activity / 579
Effect of Elimination Half Life on Duration of Activity / 580
Rate of Drug Absorption and Pharmacodynamic Response / 584
Drug Tolerance and Physical Dependency / 585
Hypersensitivity and Adverse Response / 586
Drug Distribution and Pharmacologic Response / 587
Pharmacodynamic Models / 590
Frequently Asked Questions / 603
Learning Questions / 603
References / 604
Bibliography / 605
20. PHYSIOLOGIC PHARMACOKINETIC MODELS, MEAN
RESIDENCE TIME, AND STATISTICAL MOMENT THEORY / 607
Physiologic Pharmacokinetic Models / 608
Mean Residence Time (MRT) / 619
Statistical Moment Theory / 624
Mean Absorption Time (MAT) and Mean Dissolution Time (MDT) / 635
Selection of Pharmacokinetic Models / 637
Frequently Asked Questions / 639
Learning Questions / 639
References / 640
Bibliography / 641
Appendix A Statistics / 643
Appendix B Application of Computers in Pharmacokinetics / 653
Appendix C Solutions to Frequently Asked Questions (FAQ) and Learning Questions / 667
Appendix D Guiding Principles for Human and Animal Research / 727
Appendix E Popular Drugs and Pharmacokinetic Parameters / 731
Appendix F Glossary / 737
Index / 739
|
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| author | Shargel, Leon 1941- Yu, Andrew B. 1945- |
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| id | DE-604.BV013085943 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:38:50Z |
| institution | BVB |
| isbn | 0838502784 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008914372 |
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| owner | DE-29 DE-19 DE-BY-UBM |
| owner_facet | DE-29 DE-19 DE-BY-UBM |
| physical | XIV, 768 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Appleton & Lange |
| record_format | marc |
| spelling | Shargel, Leon 1941- Verfasser (DE-588)1145926010 aut Applied biopharmaceutics & pharmacokinetics Leon Shargel ; Andrew Yu Applied biopharmaceutics and pharmacokinetics 4. ed. Stamford, Conn. Appleton & Lange 1999 XIV, 768 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biopharmacie Pharmacocinétique Biopharmaceutics Biopharmaceutics Problems and Exercises Pharmacokinetics Pharmacokinetics Problems and Exercises Biopharmazie (DE-588)4006890-0 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Biopharmazie (DE-588)4006890-0 s DE-604 Pharmakokinetik (DE-588)4115557-9 s Yu, Andrew B. 1945- Verfasser (DE-588)172470196 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008914372&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Shargel, Leon 1941- Yu, Andrew B. 1945- Applied biopharmaceutics & pharmacokinetics Biopharmacie Pharmacocinétique Biopharmaceutics Biopharmaceutics Problems and Exercises Pharmacokinetics Pharmacokinetics Problems and Exercises Biopharmazie (DE-588)4006890-0 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4006890-0 (DE-588)4115557-9 |
| title | Applied biopharmaceutics & pharmacokinetics |
| title_alt | Applied biopharmaceutics and pharmacokinetics |
| title_auth | Applied biopharmaceutics & pharmacokinetics |
| title_exact_search | Applied biopharmaceutics & pharmacokinetics |
| title_full | Applied biopharmaceutics & pharmacokinetics Leon Shargel ; Andrew Yu |
| title_fullStr | Applied biopharmaceutics & pharmacokinetics Leon Shargel ; Andrew Yu |
| title_full_unstemmed | Applied biopharmaceutics & pharmacokinetics Leon Shargel ; Andrew Yu |
| title_short | Applied biopharmaceutics & pharmacokinetics |
| title_sort | applied biopharmaceutics pharmacokinetics |
| topic | Biopharmacie Pharmacocinétique Biopharmaceutics Biopharmaceutics Problems and Exercises Pharmacokinetics Pharmacokinetics Problems and Exercises Biopharmazie (DE-588)4006890-0 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Biopharmacie Pharmacocinétique Biopharmaceutics Biopharmaceutics Problems and Exercises Pharmacokinetics Pharmacokinetics Problems and Exercises Biopharmazie Pharmakokinetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008914372&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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