Oxidative, energy metabolism in neurodegenerative disorders:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
New York Acad. of Sciences
1999
|
| Schriftenreihe: | New York Academy of Sciences: Annals of the New York Academy of Sciences
893 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 443 S. Ill., graph. Darst. |
| ISBN: | 1573312096 157331210X |
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 893
OXIDATIVE/ENERGY METABOLISM IN
NEURODEGENERATIVE DISORDERS0
Editors and Conference Chairs
John P. Blass and Fletcher H. McDowell
CONTENTS
Preface. By John P. Blass xi
Part I. Fundamental Aspects of Energy Metabolism and
Free Radicals
Glutamate Excitotoxity and Neuronal Energy Metabolism. By David G.
NlCHOLLS, SAMANTHA L. BUDD, ROGER F. CASTILHO, AND
Manus W. ward 1
Fundamental Aspects of Reactive Oxygen Species, or What s the Matter with
Oxygen? By Irwin Fridovich 13
Part II. Mitochondrial Calcium Metabolism and the
Permeability Transition
Ca2+ Mediated Mitochondrial Dysfunction and the Protective Effects of
Bcl 2. By Anne N. Murphy 19
Mitochondrial Membrane Potential and the Permeability Transition in
Excitotoxicity. By Ian J. Reynolds 33
Part III. Abnormalities in mtDNA and gDNAs
Oxidative Phosphorylation Disease Diagnosis. By JOHN M. SHOFFNER .... 42
The a Ketoglutarate Dehydrogenase Complex. By Kwan Fu Rex Sheu
and John P. Blass 61
This volume is the result of a conference entitled Oxidative/Energy Metabolism in Neuro
degenerative Disorders, which was sponsored by the New York Academy of Sciences and the
Winifred Masterson Burke Medical Research Institute, Inc. and held on March 19 22, 1999 in
New York City.
Part IV. Experimental Models of Human Diseases
Oxidative Stress and a Key Metabolic Enzyme in Alzheimer Brains,
Cultured Cells, and an Animal Model of Chronic Oxidative Deficits. By
Gary E. Gibson, Larry C.H. Park, Hui Zhang, Sandro Sorbi,
and Noel Y. Calingasan 79
The Use of Transgenic and Mutant Mice to Study Oxygen Free Radical
Metabolism. By Ting Ting HUANG, ELAINE J. CARLSON,
Ines Raineri, Anne Marie Gillespie, Heather Kozy, and
Charles J. Epstein 95
Part V. Physiological Aspects of Energy Metabolism
The Blood Brain Barrier and Cerebrovascular Pathology in Alzheimer s
Disease. By Raj N. Kalaria 113
Neurological Changes Induced by Stress in Streptozotocin Diabetic Rats. By
Lawrence P. Reagan, Ana Maria Magarinos, and
Bruce S. McEwen 126
Part VI. Alzheimer s Disease
Functional Brain Imaging in the Resting State and during Activation in
Alzheimer s Disease: Implications for Disease Mechanisms Involving
Oxidative Phosphorylation. By Stanley I. Rapoport 138
Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabo¬
lism and Neuronal Degeneration in Alzheimer s and Parkinson s
Diseases. By Mark P. Mattson, Ward A. Pedersen, Wenzhen
Duan, Carsten Culmsee, and Simonetta Camandola 154
Use of Cytoplasmic Hybrid Cell Lines for Elucidating the Role of
Mitochondrial Dysfunction in Alzheimer s Disease and Parkinson s
Disease. By Soumitra S. Ghosh, Russell H. Swerdlow,
Scott W. Miller, Brina Sheeman, W. Davis Parker, Jr., and
Robert E. Davis 176
Part VII. Huntington s Disease
Polyglutamine Domain Proteins with Expanded Repeats Bind Neurofilament,
Altering the Neurofilament Network. By Yoshitaka Nagai, Osamu
Onodera, Warren J. Strittmatter, and James R. Burke 192
Bioenergetics in Huntington s Disease. By THOMAS GRUNEWALD AND
M. Flint Beal 203
Part VIII. Cerebrovascular Disease
An Integrated Strategy for Evaluation of Metabolic and Oxidative Defects in
Neurodegenerative Illness Using Magnetic Resonance Techniques. By
B.G. Jenkins, Y.I. Chen, E. Kuestermann, N.M. Makris, T.V.
Nguyen, E. Kraft, A.L. Brownell, H.D. Rosas, D.N. Kennedy,
B.R. Rosen, W.J. Koroshetz, and M.F. Beal 214
Apoptosis and Necrosis in Cerebrovascular Disease. By B. Joy Snider,
Frank J. Gottron, and Dennis W. Choi 243
Part IX. Poster Papers
Effects of Ebselen, a Glutathione Peroxidase Mimic, in Several Models of
Mitochondrial Dysfunction. By Alain Boireau, Pierre Dubedat,
Francoise Bordier, Madeleine Coimbra, Mireille Meunier,
assunta imperato, and saliha moussaoui 254
EDTA Induced Monovalent Fluxes through the Ca Uniporter in Brain Mi¬
tochondria. By NlCKOLAY BRUSTOVETSKY AND JANET M. DUBINSKY 258
Signaling Events in NMDA Receptor Induced Apoptosis in Cerebrocortical
Cultures. By Samantha L. Budd and Stuart A. Lipton 261
In Vitro and in Vivo Protein Oxidation Induced by Alzheimer s Disease
Amyloid p Peptide (1 42). By D. Allan Butterfield, Servet M.
Yatin, and Christopher D. Link 265
Depolarization of in Situ Mitochondria by Hydrogen Peroxide in Nerve
Terminals. By Christos Chinopoulos and Vera Adam Vizi 269
Monoamine Oxidase Inhibits Mitochondrial Respiration. By
Gerald Cohen and Natasa Kesler 273
Enhanced Acetate and Glucose Utilization during Graded Photic Stimula¬
tion: Neuronal Glial Interactions in Vivo. By Gerald A. Dienel,
Kenian Liu, David Popp, and Nancy F. Cruz 279
Calcium Overload Triggers Rod Photoreceptor Apoptotic Cell Death in
Chemical Induced and Inherited Retinal Degenerations. By
Donald A. Fox, Ann T. Poblenz, and Lihua He 282
Molecular Mechanisms of Free Radical Production and Protective Efficacies
of Antioxidants in in Vitro Ischemia Reperfusion. By
Marina V. Frantseva, Peter L. Carlen, and
Jose L. Perez Velazquez 286
A Disturbance in the Neuronal Insulin Receptor Signal Transduction in
Sporadic Alzheimer s Disease. By L. FROLICH, D. Blum Degen,
P. RlEDERER, AND S. HOYER 290
Modulation of Presenilin 1 Processing by Nitric Oxide during Apoptosis In¬
duced by Serum Withdrawal and Glucose Deprivation. By
Laura Gasparini, Roberta Ghidoni, Antonella C. Alberici,
Luisa Benussi, Daniele Moratto, Marco Trabucchi,
John H. Growdon, Roger M. Nitsch, and Giuliano Binetti ... 294
Metabolic and Glutamatergic Disturbances in the Huntington s Disease
Transgenic Mouse By DONALD S. HlGGlNS, Kari R. HOYT,
Corinne Baic, Jessica Vensel, and Matthew Sulka 298
Inhibition of the Neuronal Insulin Receptor Causes Alzheimer like Dis¬
turbances in Oxidative/Energy Brain Metabolism and in Behavior in
Adult Rats. By Siegfried Hoyer and Heinrich Lannert 301
Temporary Axonal Conduction Block and Axonal Loss in Inflammatory
Neurological Disease: A Potential Role for Nitric Oxide? By
R. Kapoor, M. Da vies, and K.J. Smith 304
Maturational Changes in Rabbit Brain Phosphocreatine and Creatine Kinase.
By T. Kekelidze, I. Khait, A.Togliatti, J. Benzycry,
R. MULKERN, AND D. HOLTZMAN 309
Neurotoxicity and Oxidative Damage of Beta Amyloid 1 42 versus Beta
Amyloid 1 40 in the Mouse Cerebral Cortex. By Autumn M. Klein,
Neil W. Kowall, and Robert J. Ferrante 314
Ganglioside GD3, the Mitochondrial Permeability Transition, and Apop¬
tosis. By Bruce S. Kristal and Abraham M. Brown 321
Interactions between Melatonin, Reactive Oxygen Species, and Nitric
Oxide. By D.K. Lahiri and C. Ghosh 325
Effect of Oxidative Stress on DNA Damage and |J Amyloid Precursor
Proteins in Lymphoblastoid Cell Lines from a Nigerian Population. By
D.K. Lahiri, Y. Xu, J. Klaunig, O. Baiyewu, A. Ogunniyi,
K. Hall, H. Hendrie, and A. Sahota 331
Evidence for Energy Failure following Irreversible Traumatic Brain Injury.
By Stefan M. Lee, Monica D. Wong, Amir Samii, and
David A. Hovda 337
Regulation of Mitochondrial Gene Expression in Differentiated PC 12 Cells.
By Li Ing Liu, S.I. Rapoport, and K. Chandrasekaran 341
Does Dopamine Contribute to Striatal Damage Caused by Impaired Mito¬
chondrial Function? By William F. Maragos, Rebekah J. Jakel,
M. Dathan Chesnut, James W. Geddes, and Linda P. Dwoskin 345
Discordance between Traditional Pathologic and Energy Metabolic Changes
in Very Early Alzheimer s Disease: Pathophysiological Implications.
By Satoshi Minoshima, Donna J. Cross, Norman L. Foster,
Thomas R. Henry, and David E. Kuhl 350
Low Frequencies of Mitochondrial DNA Mutations Cause Cardiac Disease
in the Mouse. By J.L. Mott, D. Zhang, P.L. Farrar, S.W. Chang,
and H.P. Zassenhaus 353
Effects of the Solvent 1,2,4 Trimethylcyclohexane on Respiratory Burst in
Human Neutrophil Granulocytes: A Chemiluminescence and Electron
Paramagnetic Resonance Spectrometry Study. By O. Myhre,
T. A. Vestad, E. Sagstuen, H. Aarnes, and F. Fonnum 358
Neuronal RNA Oxidation in Alzheimer s Disease and Down s Syndrome.
By Akihiko Nunomura, George Perry, Keisuke Hirai,
Gjumrakch Aliev, Atsushi Takeda, Shigeru Chiba, and
Mark A. Smith 362
Ca2+ Dependent Permeability Transition and Complex I Activity in Lym
phoblast Mitochondria from Normal Individuals and Patients with
Huntington s or Alzheimer s Disease. By Alexander Panov,
Tracy Obertone, Julie Bennett Desmelik, and
J. Timothy Greenamyre 365
Mitochondrial Porin, a Novel Target to Prevent Ischemia Induced Neurode
generation? By J.L. Perez Velazquez, M.V. Frantseva,
D. Huzar, C. Guezurian, and P.L. Carlen 369
Bcl 2 and p53: Role in Dopamine Induced Apoptosis and Differentiation. By
S. PORAT AND R. SlMANTOV 372
Mitochondria Mediate Nitric Oxide Induced Cell Death. By Anna
Bal Price, Vilma Borutaite, and Guy C. Brown 376
Induction of Apoptosis and Necrosis in Human Neuroblastoma Cells by
Cholesterol Oxides. By Marie Luise Rao, Dieter Lutjohan,
Michael Ludwig, and Heike Kolsch 379
Measurement of Oxidative DNA Damage in the Human p53 and PGK1 Gene
at Nucleotide Resolution. By Henry Rodriguez and
Steven A. Akman 382
The Glucose Paradox in Cerebral Ischemia: New Insights. By
AVITAL SCHURR, RALPHIEL S. PAYNE, MICHAEL T. TSENG,
James J. Miller, and Benjamin M. Rigor 386
Interactions of Chloromethyltetramethylrosamine (Mitotracker Orange )
with Isolated Mitochondria and Intact Cells. fly Luca Scorrano,
Valeria Petronilli, Rafpaele Colonna, Fabio Di Lisa, and
Paolo Bernardi 391
Attenuation of Neuronal Death by NMD A and Oxygen Glucose Deprivation
in Cortical Neurons Maintained in High Glucose. By So YOUNG SEO,
Eun Young Kim, Harriet Kim, Ilo Jou, and Byoung Joo Gwag 396
Astrocyte Nitric Oxide Causes Neuronal Mitochondrial Damage, but Anti
oxidant Release Limits Neuronal Cell Death. By R. STONE,
V.C. Stewart, R.D. Hurst, J.B. Clark, and S.J.R. Heales 400
Mechanisms of Selective Neuronal Cell Death due to Thiamine Deficiency.
By Kathryn G. Todd and Roger F. Butterworth 404
Inhibition of cc Ketoglutarate Dehydrogenase due to H2O2 Induced Oxida
tive Stress in Nerve Terminals. By Laszlo Tretter and
Vera Adam Vizi 412
ATPases of Synaptic Plasma Membranes and Vesicles from Rat Cerebral
Cortex during Aging and Hypoxia. By R.F. VILLA, A. D Angelo,
and A. Gorini 417
Mitochondrial Compartmentation at the Cellular Level: Astrocytes and
Neurons. By Helle S. Waagepetersen, Ursula Sonnewald,
Hong Qu, and Arne Schousboe 421
Detection of Respiratory Chain Defects in Cultivated Skin Fibroblasts and
Skeletal Muscle of Patients with Parkinson s Disease. By
Falk Robert Wiedemann, Kirstin Winkler, Hartmut Lins,
Claus W. Wallesch, and Wolfram S. Kunz 426
Prevention of Neurodegeneration by a Neuroprotective Radical Scavenger.
By Hiroshi Yasuda 430
Conference Summary: Mitochondria, Neurodegenerative Diseases, and
Selective Neuronal Vulnerability. By John P. Blass 434
^ Index of Contributors 441
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| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | New York Acad. of Sciences |
| record_format | marc |
| series | New York Academy of Sciences: Annals of the New York Academy of Sciences |
| series2 | New York Academy of Sciences: Annals of the New York Academy of Sciences |
| spelling | Oxidative, energy metabolism in neurodegenerative disorders ed. by John P. Blass ... New York, NY New York Acad. of Sciences 1999 XIII, 443 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New York Academy of Sciences: Annals of the New York Academy of Sciences 893 Energiestofwisseling gtt Métabolisme énergétique - Congrès Oxydation biologique - Congrès Oxygène actif - Physiopathologie - Congrès Système nerveux - Dégénérescence - Physiopathologie - Congrès Système nerveux - Métabolisme - Congrès Zenuwstelselaandoeningen gtt Energy Metabolism Congresses Energy metabolism Congresses Nervous system Degeneration Congresses Neurodegenerative Diseases Congresses Oxidative Stress Congresses Oxygen Metabolism Congresses Hirnkrankheit (DE-588)4025013-1 gnd rswk-swf Freies Radikal (DE-588)4137149-5 gnd rswk-swf Energiestoffwechsel (DE-588)4125217-2 gnd rswk-swf Sauerstoffstoffwechsel (DE-588)4392126-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1999 New York, NY gnd-content Hirnkrankheit (DE-588)4025013-1 s Sauerstoffstoffwechsel (DE-588)4392126-7 s DE-604 Energiestoffwechsel (DE-588)4125217-2 s Freies Radikal (DE-588)4137149-5 s Blass, John P. Sonstige oth New York Academy of Sciences: Annals of the New York Academy of Sciences 893 (DE-604)BV002532608 893 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008888124&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Oxidative, energy metabolism in neurodegenerative disorders New York Academy of Sciences: Annals of the New York Academy of Sciences Energiestofwisseling gtt Métabolisme énergétique - Congrès Oxydation biologique - Congrès Oxygène actif - Physiopathologie - Congrès Système nerveux - Dégénérescence - Physiopathologie - Congrès Système nerveux - Métabolisme - Congrès Zenuwstelselaandoeningen gtt Energy Metabolism Congresses Energy metabolism Congresses Nervous system Degeneration Congresses Neurodegenerative Diseases Congresses Oxidative Stress Congresses Oxygen Metabolism Congresses Hirnkrankheit (DE-588)4025013-1 gnd Freies Radikal (DE-588)4137149-5 gnd Energiestoffwechsel (DE-588)4125217-2 gnd Sauerstoffstoffwechsel (DE-588)4392126-7 gnd |
| subject_GND | (DE-588)4025013-1 (DE-588)4137149-5 (DE-588)4125217-2 (DE-588)4392126-7 (DE-588)1071861417 |
| title | Oxidative, energy metabolism in neurodegenerative disorders |
| title_auth | Oxidative, energy metabolism in neurodegenerative disorders |
| title_exact_search | Oxidative, energy metabolism in neurodegenerative disorders |
| title_full | Oxidative, energy metabolism in neurodegenerative disorders ed. by John P. Blass ... |
| title_fullStr | Oxidative, energy metabolism in neurodegenerative disorders ed. by John P. Blass ... |
| title_full_unstemmed | Oxidative, energy metabolism in neurodegenerative disorders ed. by John P. Blass ... |
| title_short | Oxidative, energy metabolism in neurodegenerative disorders |
| title_sort | oxidative energy metabolism in neurodegenerative disorders |
| topic | Energiestofwisseling gtt Métabolisme énergétique - Congrès Oxydation biologique - Congrès Oxygène actif - Physiopathologie - Congrès Système nerveux - Dégénérescence - Physiopathologie - Congrès Système nerveux - Métabolisme - Congrès Zenuwstelselaandoeningen gtt Energy Metabolism Congresses Energy metabolism Congresses Nervous system Degeneration Congresses Neurodegenerative Diseases Congresses Oxidative Stress Congresses Oxygen Metabolism Congresses Hirnkrankheit (DE-588)4025013-1 gnd Freies Radikal (DE-588)4137149-5 gnd Energiestoffwechsel (DE-588)4125217-2 gnd Sauerstoffstoffwechsel (DE-588)4392126-7 gnd |
| topic_facet | Energiestofwisseling Métabolisme énergétique - Congrès Oxydation biologique - Congrès Oxygène actif - Physiopathologie - Congrès Système nerveux - Dégénérescence - Physiopathologie - Congrès Système nerveux - Métabolisme - Congrès Zenuwstelselaandoeningen Energy Metabolism Congresses Energy metabolism Congresses Nervous system Degeneration Congresses Neurodegenerative Diseases Congresses Oxidative Stress Congresses Oxygen Metabolism Congresses Hirnkrankheit Freies Radikal Energiestoffwechsel Sauerstoffstoffwechsel Konferenzschrift 1999 New York, NY |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008888124&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT blassjohnp oxidativeenergymetabolisminneurodegenerativedisorders |